Articles


Why Screening

U.S. Preventive Services Task Force Seeks Comments on Draft Recommendation Statement on Screening for Prostate Cancer

You're Not Alone

PD-1抑制劑為患者帶來希望

New Drug Info

癌症免疫療法

New Drug Info

FDA Approves Maintenance Niraparib for Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

The U.S. Food and Drug Administration (FDA) has approved niraparib (Zejula) for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, whose tumors have achieved complete or partial response to platinum-based chemotherapy.

Living With Cancer

3-Year Follow-up of Japanese Trial of Alectinib in ALK-Positive NSCLC

Promising 3-year outcomes were found in patients from a Japanese phase I/II study of alectinib (Alecensa) in previously treated patients with ALK-positive non–small cell lung cancer (NSCLC). The findings were reported by Tamura et al in the Journal of Clinical Oncology.

Living With Cancer

Interleukin-15 Levels Associated With Lymphoma Response to CAR T-Cell Treatment

As reported by Kochenderfer et al in the Journal of Clinical Oncology, remission in patients with advanced lymphoma induced by treatment with chimeric antigen receptor (CAR) T cells targeting CD19 (CAR-19) is associated with elevated serum interleukin-15 (IL-15) levels.

Living With Cancer

New Study Finds Most Cancer Mutations Due to Random DNA-Copying Errors

Johns Hopkins Kimmel Cancer Center scientists report data from a new study providing evidence that random, unpredictable DNA copying “mistakes” account for nearly two-thirds of the mutations that cause cancer. Their research is grounded on a novel mathematic model based on DNA sequencing and epidemiologic data from around the world. Tomasetti and Vogelstein conducted the new study described in a report published March 24 in the journal Science.

Living With Cancer

【知癌知癒】

肺癌仍是不可忽視的頭號癌症殺手

New Drug Info

Effect of Polypharmacy on Adherence to Adjuvant Endocrine Therapy for Breast Cancer

Overall, polypharmacy was associated with increased adherence to adjuvant endocrine therapy for breast cancer. Adherence was reduced with frequent use of some medication classes.

Living With Cancer

Palliative Care Consultations for Patients With Advanced Cancers May Reduce Hospitalization and Improve Quality of Care

· Consultation with the palliative care team included establishment of goals of care, advance care plans using standardized communication protocols, transition planning, and symptom assessment and treatment using the Edmonton Symptom Assessment Scale. · When researchers compared patients in the intervention group with control subjects, there were increases in palliative care consultations (39% to 80%) and hospice referrals (14% to 26%). · There were declines in 30-day readmission rates (35% to 18%) and receipt of chemotherapy after discharge (44% to 18%).

Why Screening

Making the Case for Sentinel Node Biopsy in Early Cancers of the Oral Cavity

“The majority of patients with oral cavity cancers will undergo an unnecessary operation,” ­Sandeep Samant, MD, stated at a session on managing N0 neck cancer at the 2016 Lurie Cancer Center Multidisciplinary Head & Neck Symposium in Chicago.1 That operation is elective neck dissection, and it is unnecessary in most patients, he said, because metastatic disease occurs in only 20% to 30% of these patients. “So how do you avoid overtreating 70% of these patients?” The solution he proposed is sentinel lymph node biopsy for patients with early-stage disease (T1, N2).

Why Screening

Mammography-Detected Small Breast Cancers May Represent Overdiagnosis, With Declining Mortality Reflecting Improved Systemic Therapy

In a study using Surveillance, Epidemiology, and End Results (SEER) data reported in The New England Journal of Medicine, H. Gilbert Welch, MD, of Dartmouth Institute for Health Policy and Clinical Practice, and colleagues found that screening mammography has resulted in a substantial increase in the detection of small breast tumors, many of which represent overdiagnosis, accompanied by only a modest decrease in the detection of larger breast tumors.1 Their analysis also indicated that the reduction in breast cancer mortality after implementation of screening is mainly the result of improved systemic therapy.

Living With Cancer

Acupuncture for the Management of Hot Flashes

Mary is a 49-year-old woman diagnosed with stage II estrogen receptor–positive cancer 2 years ago. She has finished surgery, chemotherapy, and radiotherapy and is currently on tamoxifen. Chemotherapy put her into premature menopause, and since then, she has been having frequent hot flashes, 8 to10 times during the day. The hot flashes are worst at night and wake her up three to four times, where she finds the sheet soaked in sweat. She tried venlafaxine for a few weeks; however, she did not like the fact that it decreased her libido and so stopped taking the drug. She asks you, “Women in my support group told me to try acupuncture. What do you think?”

Living With Cancer

Predicting Acute Cardiac Events in Patients With Breast Cancer Receiving Radiotherapy

In a Dutch study reported in the Journal of Clinical Oncology, van den Bogaard et al found that a model including the volume of the left ventricle receiving 5 Gy (LV-V5) might provide improved prediction of acute cardiac events in patients with breast cancer receiving radiotherapy.

Living With Cancer

Hypofractionated vs Conventional Radiotherapy for Localized Prostate Cancer

· In men with localized prostate cancer treated with hypofractionated radiotherapy or standard radiotherapy, 5-year biochemical-clinical failure disease-free survival was 85% in both groups. · Hypofractionated radiotherapy was not associated with an increased risk of late toxicity.

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