Dr. Chan Siu Hong, Oscar

Consultant Clinical Oncologist

Specialist in Clinical Oncology

MBChB(CUHK)

FRCR

FHKCR

FHKAM (Radiology)

PDipID(HK)

PDip Epidemiology and Biostatistics(CUHK)

Research & Publications

List of Publications
First authored papers:

The Role of Radiotherapy in EGFR Mutation Positive Patient with Oligoprogression: A Matched Cohort Analysis
Clinical Oncology (Royal College of Radiologists) 2017; 29(9):568-575 OSH Chan, VHF Lee, TSK Mok, F Mo, ATY Chang, RMW Yeung

Characterization of PD-L1 expression and immune cell infiltration in nasopharyngeal cancer
Oral Oncology 2017; 67:52-60
OSH Chan, M Kowanetz, WT Ng, H Koeppen, LK Chan, RMW Yeung, H Wu, L Amler, C Mancao

Sustained Response to Standard Dose Osimertinib in a Patient with Plasma T790M-Positive Leptomeningeal Metastases from Primary Lung Adenocarcinoma
Asia-Pacific Journal of Clinical Oncology. 2017; 13(6):428-430
Chan OSH, Leung WKW, Yeung RMW

Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma.
Head & Neck 2017; 39(3):533-540.
Chan OS, Sze HC, Lee MC, Chan LL, Chang AT, Lee SW, Hung WM, Lee AW, Ng WT.

Individualized Treatment in Stage IVC Nasopharyngeal Carcinoma
Oral Oncology 50 (2014) pp. 791-797
Oscar S. H. Chan, Roger K.C. Ngan

Maintenance therapy in advanced non-small cell lung cancer: a prime-time for change?
Chinese Medical Journal 2013;126(12):2390-8
Oscar S.H. Chan, R.M.W. Yeung, A.W.M.Lee

Stereotactic ablative radiotherapy for medically inoperable early stage lung cancer: early outcomes.
Hong Kong Medical Journal 2012; 18(5): 412-8.
Oscar S.H. Chan, R.M.W. Yeung, Hung, M.C.H Lee, A.T.Y Chang, C.C.C. Chan, A.W.M.Lee

The Superiority of Hybrid-Volumetric Arc Therapy (VMAT) Technique Over Double Arcs VMAT and 3D-Conformal Technique in the Treatment of Locally Advanced Non-small Cell Lung Cancer – A Planning Study
Radiotherapy & Oncology 2011; 101 p.298-302
Oscar S.H. Chan, M.C.H. Lee; A.W.M. Hung; A.T. Chang; R.M.W. Yeung; A.W.M. Lee

Can the Analysis of ERCC1 Expression Contribute to Individualized Therapy in Nasopharyngeal Carcinoma?
International Journal of Radiation Oncology, Physics & Biology 2011; 79(5): 1414-20
Chan SH,Cheung MF,Ng WT,Choi CW,Cheng KN,Yao KH,Lee AWM

Sensorineural Hearing Loss after Treatment of Nasopharyngeal Carcinoma: A Longitudinal Analysis
International Journal of Radiation Oncology, Physics & Biology 2009; 73(5): 1335-42
Chan SH,Ng WT,Kam KL,Lee MCH,Choi CW,Yau TK,Lee AWM,Chow SK.

Co-authored papers:

Comparison of planning quality and efficiency between conventional and knowledge-based algorithms in nasopharyngeal cancer patients using intensity-modulated radiotherapy
International Journal of Radiation Oncology, Physics & Biology 2016; 95(3): 981-90
Amy TY Chang, Albert Hung, Fion Cheung, Michael Lee, Oscar SH Chan, Helen Phillips, YT Cheng, WT Ng

Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fractionation in patients with locoregionally advanced nasopharyngeal carcinoma.
Cancer 2015; 121(8): 1328-38
Lee AW, Ngan RK, Tung SY, Cheng A, Kwong DL, Lu T, Chan AT, Chan LL, Yiu H, Ng W, Wong F, Yuen K, Yau S, Cheung F, Chan OS, Choi H, Chappell R
NPC-0501

Should all nasopharyngeal carcinoma with masticator space involvement be staged as T4?
Oral Oncology 2014 Dec;50(12):1188-95
Sze HC, Chan LL, Ng WT, Hung AW, Lee MC, Chang AT, Chan OS, Cheung FY, Yeung RM, Lee AW.

The impact of dosimetric inadequacy on treatment outcome of nasopharyngeal carcinoma with IMRT.
Oral Oncology 2014 May;50(5):506-12
Ng WT, Lee MC, Chang AT, Chan OS, Chan LL, Cheung FY, Hung WM, Chan CC, Lee AW.

Evolution of treatment for nasopharyngeal cancer – Success and setback in the intensity-modulated radiotherapy era.
Radiotherapy & Oncology. 2014; 110(3): 337-84
Lee AW, Ng WT, Chan LL, Hung WM, Chan CC, Sze HC, Chan OS, Chang AT, Yeung RM.

Treatment Outcomes of Primary Pulmonary Lymphoepithelioma-like Carcinoma: a Series of 22 Patients and Treatment Strategy Review.
Hong Kong Jouranl of Radioliologists 2013 16:270-7
FST Mok, OSH Chan, ATY Chang, LLK Chan, IS Soong, WT Ng, FY Cheung, RMW Yeung

Staging of nasopharyngeal carcinoma – The past, the present and the future.
Oral Oncology 2014: 50(6): 549-54
Ng WT, Yuen KT, Au KH, Chan OS, Lee AW.

If concurrent–adjuvant chemoradiotherapy is beneficial for locoregionally advanced nasopharyngeal carcinoma, would changing the sequence to induction–concurrent achieve better outcome?
Journal of Radiation Oncology 2012 1:107-115
Anne W. M. Lee, W. T. Ng, Oscar S. H. Chan, Henry C. K. Sze

The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement
Oral Oncology 2012: 48(10): 1007-13
Anne W.M. Lee, W.T. Ng, L.K. Chan, Oscar S.H. Chan, W.M. Hung, C.C. Chan, P.T.C. Cheng, Henry Sze, T.S. Lam, T.K. Yau

The prognostic value of histological typing in nasopharyngeal carcinoma
Oral Oncology 2012: 48(5): 429-33
F Cheung, O Chan, WT Ng, L Chan, A Lee, SW Pang

Radical radiotherapy for nasopharyngeal carcinoma in elderly patients: The importance of co-morbidity assessment
Oral Oncology 2012: 48(2): 162-7
Sze HC, Ng WT, Chan OS, Shum TC, Chan LL, Lee AW

Clinical Outcomes and Patterns of Failure after Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma
International Journal of Radiation Oncology, Physics & Biology 2011; 79(2): 420-8
Ng WT, Lee MC, Hung WM, Choi CW, Lee KC, Chan OS, Lee AW

Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening.
Familial Cancer, 2009; 8(2):103-8.
Ng WT, Choi CW, Lee MCH, Chan SH, Yau TK, Lee AWM

Parapharyngeal Extension of Nasopharyngeal Carcinoma: Still a significant Factor in Era of Modern Radiotherapy?
International Journal of Radiation Oncology, Physics & Biology 2008; 72(4):1082-9
Ng WT, Chan SH, Lee AW, Lau KY, Yau TK, Hung WM, Lee MC, Choi CW

Book chapters:

Oligometastatic Disease p121-136
ATY Chang, Oscar S.H.Chan, Simon Lo, WT Ng
In Nasopharyngeal Carcinoma: Management Strategies
Future Medicine Limited, UK

Management of nasopharyngeal carcinoma. In: Head and Neck Cancer:
Multimodality Management. 2nd edition.
J. Bernier (Ed). Springer, 2015.
Ng WT, Ngan RKC, Chan OSH, Sze HCK, Chan JYW, Lee AWM.

Poster/ Oral Presentations (First & Presenting Author):

Poster presentation in 33rd International Society for Quality in Health Care (2016)
Implementation of a Dedicated Fast Track System Reduces Antibiotics Door-to-needle time in Suspected Chemotherapy Induced Febrile Neutropenia

Poster presentation in 16th World Conference on Lung Cancer (2015)
Clinical Outcome of Hybrid-Volumetric Arc Therapy (H-VMAT) for Advanced Non-Small Cell Lung Cancer (NSCLC)

Poster presentation in European Cancer Congress 2015
Characterization of PD-L1 expression and immune cell infiltration in Nasopharyngeal Cancer (NPC)

Oral Presentation in the 7th Pan-Pearl-River Area Conference of Radiation Oncology & Multicenter Cooperative Radiation Therapy Seminar (2012)
Early Treatment Outcome of Stereotactic Ablative Radiotherapy in Medically Inoperable Early Lung Cancer

Poster Presentation in 52th Annual Congress of American Society of Therapeutic Radiology & Oncology
The Superiority of Hybrid-RapidArc Radiotherapy Technique in the Treatment of Advanced Non-small Cell Lung Cancer: A Planning Study

Poster Presentation in 27th Annual Congress of European Society of Therapeutic Radiology & Oncology
Sensorineural Hearing Loss after Treatment of Nasopharyngeal Carcinoma: A Qualitative and Quantitative Longitudinal Analysis

Oral Presentation in 2008 Prize for Best Original Research of Trainee, Hong Kong Academy of Medicine
Sensorineural Hearing Loss after Treatment of Nasopharyngeal Carcinoma: A Longitudinal Analysis

Oral Presentation in 15th Annual Scientific Meeting of Hong Kong College of Radiologists
Parapharyngeal Extension of Nasopharyngeal Carcinoma: Still a significant Factor in Era of Modern Radiotherapy?

Oral Presentation in 13th Annual Scientific Meeting of Hong Kong College of Radiologists
A Review of Malignancy Related Haemophagocytic Lymphohistiocytosis

International studies/ Investigator initiated studies (Selected, Site Principle Investigators):

A molecular ePIdemiOlogy study in Asia patients with advanced NSCLC of adEno
histology to assess EGFR mutation status: PIONEER study
2010 – 2012

Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC)
2011 – 2014

Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic non-small cell lung cancers by next generation sequencing analysis
2014 – 2016