{"id":18215,"date":"2023-05-12T11:13:33","date_gmt":"2023-05-12T03:13:33","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=18215"},"modified":"2025-02-09T12:58:42","modified_gmt":"2025-02-09T04:58:42","slug":"%e4%b8%80%e6%96%87%e8%ae%b2%e6%b8%85%e4%b9%b3%e8%85%ba%e7%99%8c%e6%b2%bb%e7%96%97%e9%87%8d%e7%a3%85%e6%96%b0%e8%8d%aft-dxd","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e4%b8%80%e6%96%87%e8%ae%b2%e6%b8%85%e4%b9%b3%e8%85%ba%e7%99%8c%e6%b2%bb%e7%96%97%e9%87%8d%e7%a3%85%e6%96%b0%e8%8d%aft-dxd\/","title":{"rendered":"\u4e00\u6587\u8bb2\u6e05\u4e73\u817a\u764c\u6cbb\u7597\u91cd\u78c5\u65b0\u836fT-DXd\uff1a\u201c\u65b0\u5e0c\u671b\u201d\u8ba9\u533b\u7597\u754c\u91cd\u65b0\u5bf9\u4e73\u817a\u764c\u8fdb\u884c\u5206\u7c7b\uff0c\u663e\u8457\u63d0\u5347\u60a3\u8005\u6cbb\u7597\u6548\u679c"},"content":{"rendered":"\n<p>\u4e73\u817a\u764c\u662f\u4e00\u79cd\u8f83\u4e3a\u5e38\u89c1\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u4e5f\u662f\u6bcf\u4e00\u4f4d\u5973\u6027\u670b\u53cb\u7684\u5669\u68a6\uff0c\u56e0\u4e3a\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5b83\u662f\u5168\u7403\u5987\u5973\u9ad8\u53d1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002<br><br>\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u751f\u6d3b\u65b9\u5f0f\u7684\u53d8\u5316\u548c\u4eba\u53e3\u8001\u9f84\u5316\uff0c\u4e73\u817a\u764c\u7684\u53d1\u75c5\u7387\u9010\u5e74\u4e0a\u5347\u3002\u636e\u6570\u636e\u7edf\u8ba1\uff0c\u5168\u7403\u6bcf\u5e74\u6709\u8d85\u8fc7200\u4e07\u4eba\u88ab\u8bca\u65ad\u51fa\u60a3\u6709\u4e73\u817a\u764c\uff0c\u5176\u4e2d\u7ea615%\u7684\u60a3\u8005\u6700\u7ec8\u65e0\u6cd5\u533b\u6cbb\u3002 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srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_1-1024x668.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_1-300x196.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_1-768x501.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_1.png 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/noscript><\/figure><\/div>\n\n\n\n<p><em><strong>\u4e73\u817a\u764c\u7684\u4e0d\u540c\u4e9a\u578b<\/strong><\/em> <br>\u4e73\u817a\u764c\u6709\u4e0d\u540c\u7684\u4e9a\u578b\uff0c\u6839\u636e\u57fa\u56e0\u8868\u8fbe\u8c31\u7684\u4e0d\u540c\uff0c\u53ef\u4ee5\u5206\u4e3a\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff0cPR+\uff09\u4e73\u817a\u764c\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532 \u9633\u6027&nbsp;(HER2+)\u4e73\u817a\u764c\uff0c\u4ee5\u53ca\u4e09\u9634\u6027\u4e73\u817a\u764c\u7b49\u3002    <\/p>\n\n\n\n<p>\u8fd9\u5176\u4e2d\uff0c<strong>\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c<\/strong>\u662f\u6700\u5e38\u89c1\u7684\u7c7b\u578b\uff0c\u7ea6\u5360\u6240\u6709\u4e73\u817a\u764c\u7684<strong>70%<\/strong>\u3002\u8fd9\u79cd\u7c7b\u578b\u7684\u4e73\u817a\u764c\u7684\u53d1\u751f\u4e0e\u96cc\u6fc0\u7d20\u548c\u5b55\u6fc0\u7d20\u7684\u4f5c\u7528\u6709\u5173\uff0c\u901a\u5e38\u5bf9\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u7684\u836f\u7269\u654f\u611f\u3002<br><br>HER2\u9633\u6027\u4e73\u817a\u764c\u7ea6\u5360\u4e73\u817a\u764c\u768420%\uff0c\u8fd9\u79cd\u7c7b\u578b\u7684\u4e73\u817a\u764c\u60a3\u8005\u9884\u540e\u8f83\u5dee\uff0c\u4f46\u901a\u8fc7\u9488\u5bf9HER2\u7684\u9776\u5411\u6cbb\u7597\u53ef\u4ee5\u6709\u6548\u63a7\u5236\u75c5\u60c5\u3002\u4e09\u9634\u6027\u4e73\u817a\u764c\u662f\u6307\u4e0d\u8868\u8fbe\u96cc\u6fc0\u7d20\u53d7\u4f53\u3001\u5b55\u6fc0\u7d20\u53d7\u4f53\u548cHER2\u7684\u4e73\u817a\u764c\uff0c\u8fd9\u79cd\u7c7b\u578b\u7684\u4e73\u817a\u764c\u901a\u5e38\u5177\u6709\u8f83\u9ad8\u7684\u6076\u6027\u7a0b\u5ea6\uff0c\u6cbb\u7597\u96be\u5ea6\u4e5f\u76f8\u5bf9\u8f83\u5927\u3002<br><br>\u8fd9\u51e0\u79cd\u4e9a\u578b\u4e4b\u4e2d\uff0c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532 \uff08HER2\uff09\u9633\u6027\u7684\u4e73\u817a\u764c\uff0c\u4e4b\u6240\u4ee5\u4f1a\u6709\u8fd9\u6837\u4e00\u4e2a\u540d\u5b57\uff0c\u662f\u56e0\u4e3a\u5176\u53d1\u751f\u4e0eHER2\u8fd9\u4e00\u4e2a\u57fa\u56e0\u7684\u8fc7\u5ea6\u8868\u8fbe\u6216\u7a81\u53d8\u6709\u5173\u3002<br><br>HER2\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u901a\u5e38\u5305\u62ec\u5316\u7597\u3001\u5185\u5206\u6ccc\u6cbb\u7597\u548c\u9776\u5411\u6cbb\u7597\u7b49\u591a\u79cd\u624b\u6bb5\uff0c\u5176\u4e2d\u9776\u5411\u6cbb\u7597\u662f\u6700\u91cd\u8981\u7684\u6cbb\u7597\u624b\u6bb5\u4e4b\u4e00\u3002\u9776\u5411\u6cbb\u7597\u836f\u7269\u5305\u62ec\u66f2\u59a5\u73e0\u5355\u6297\u3001\u5e15\u59a5\u73e0\u5355\u6297\u7b49\uff0c\u5b83\u4eec\u901a\u8fc7\u7279\u5f02\u6027\u5730\u7ed3\u5408HER2\u53d7\u4f53\uff0c\u963b\u6b62\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u548c\u589e\u6b96\u3002<br><br>\u76f8\u6bd4\u4f20\u7edf\u5316\u7597\u548c\u5185\u5206\u6ccc\u6cbb\u7597\uff0c\u9776\u5411\u6cbb\u7597\u7684\u4f18\u70b9\u5728\u4e8e\u6cbb\u7597\u6548\u679c\u66f4\u597d\uff0c\u526f\u4f5c\u7528\u66f4\u5c0f\u3002\u4f46\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u4e0d\u540c\u60a3\u8005\u5bf9\u9776\u5411\u6cbb\u7597\u7684\u53cd\u5e94\u53ef\u80fd\u6709\u6240\u4e0d\u540c\uff0c\u56e0\u6b64\u9700\u8981\u6839\u636e\u5177\u4f53\u60c5\u51b5\u8fdb\u884c\u4e2a\u4f53\u5316\u7684\u6cbb\u7597\u65b9\u6848\u3002<br><br>\u7136\u800c\u5c3d\u7ba1\u5982\u6b64\uff0c\u4e00\u4e9bHER2\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u75c5\u60c5\u4ecd\u7136\u65e0\u6cd5\u5f97\u5230\u6709\u6548\u7684\u63a7\u5236\uff0c\u56e0\u6b64\u9700\u8981\u4e0d\u65ad\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u624b\u6bb5\u3002        <\/p>\n\n\n\n<p><strong>\u4e73\u817a\u764c\u65b0\u836fT-DXd<\/strong> <br>T-DXd\uff08Trastuzumab Deruxtecan\u3001\u5fb7\u559c\u66f2\u59a5\u73e0\u5355\u6297\u3001DS-8201\uff09\uff0c\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\uff0c\u8fd1\u5e74\u6765\u5907\u53d7\u5173\u6ce8\uff0c\u5c31\u5728\u53bb\u5e74\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u5728\u9488\u5bf9\u201cHER2\u4f4e\u8868\u8fbe\u201d\u4e73\u817a\u764c\u76843\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u53d1\u5e03\u540e\uff0c\u53c2\u4f1a\u4eba\u5458\uff08\u4e3b\u8981\u662f\u533b\u751f\u548c\u5236\u836f\u5708\u4eba\u58eb\uff09\u4e3b\u52a8\u7ad9\u8d77\u6765\u957f\u65f6\u95f4\u9f13\u638c\uff0c\u8fd9\u79cd\u53cd\u5e94\u5728\u4e13\u4e1a\u4f1a\u8bae\u4e0a\u662f\u6781\u4e3a\u5c11\u89c1\u7684\u3002   <\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-1024x526.png\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-1024x526.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-300x154.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-768x395.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2.png 1080w\" decoding=\"async\" width=\"1024\" height=\"526\" alt=\"\" class=\"wp-image-18219 lazyload\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><noscript><img decoding=\"async\" width=\"1024\" height=\"526\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-1024x526.png\" alt=\"\" class=\"wp-image-18219\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-1024x526.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-300x154.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2-768x395.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_2.png 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/noscript><figcaption> \uff08\u56fe\u7247\u6765\u6e90\u7f51\u7edc&nbsp;&nbsp;ASCO2022\u5e74\u4f1a\u89c6\u9891\u622a\u56fe\uff09 <\/figcaption><\/figure><\/div>\n\n\n\n<p>\u90a3\u4e48T-DXd\u7684\u201c\u65b0\u201d\u8868\u73b0\u5728\u4ec0\u4e48\u65b9\u9762\u5462\uff1f\u4e0e\u4e4b\u524d\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u6709\u4ec0\u4e48\u4e0d\u540c\u5462\uff1f\u53c8\u4e3a\u4ec0\u4e48\u8ba9\u8fd9\u4e48\u4e13\u5bb6\u5bf9\u5b83\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u500d\u611f\u60ca\u559c\u4e0e\u5174\u594b\uff1f <\/p>\n\n\n\n<p>\u8981\u8c08T-DXd\u7684\u72ec\u7279\u4e4b\u5904\uff0c\u5c31\u8981\u4ece ADC\u836f\u7269\u8bf4\u8d77\uff0c\u5b83\u662f\u4e00\u7c7b\u65b0\u578b\u7684\u6297\u764c\u836f\uff0c\u53eb\u201c\u6297\u4f53\u5076\u8054\u836f\u7269\uff08\u7f29\u5199\u662fADC\uff09\u201d\u3002\u8fd9\u4e00\u7c7b\u836f\u7269\u6709\u4e09\u4e2a\u7ec4\u6210\u90e8\u5206\uff1a<strong>\u80fd\u8bc6\u522b\u80bf\u7624\u7684\u6297\u4f53\uff0c\u80fd\u6740\u6b7b\u7ec6\u80de\u7684\u6bd2\u7d20\uff0c\u4ee5\u53ca\u94fe\u63a5\u4e24\u8005\u7684\u5316\u5b66\u7269\u8d28\u3002<\/strong><br><br><strong>\u5b83\u7528\u8fd9\u6837\u7279\u5b9a\u65b9\u5f0f\u5c06\u5c0f\u5206\u5b50\u7ec6\u80de\u6bd2\u836f\u7269\u7ed3\u5408\u8d77\u6765\uff0c\u65e2\u80fd\u4fdd\u6301\u5355\u6297\u836f\u7269\u7684\u9776\u5411\u6027\uff0c\u53c8\u4e0d\u4e22\u5931\u5c0f\u5206\u5b50\u836f\u7269\u7684\u6297\u764c\u6bd2\u6027\uff0c\u5f62\u6210\u4e86\u4e00\u4e2a\u201c\u7cbe\u51c6\u6295\u653e\u201d\u4e14\u201c\u5a01\u529b\u5f3a\u5927\u201d\u7684\u5230\u8fbe\u7cfb\u7edf\uff0c\u5b9a\u5411\u6295\u653e\uff0c\u6d88\u706d\u80bf\u7624\u7ec6\u80de\uff0c\u51cf\u5c11\u6bd2\u526f\u4f5c\u7528\u3002<\/strong>   <\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-1024x501.png\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-1024x501.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-300x147.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-768x375.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3.png 1080w\" decoding=\"async\" width=\"1024\" height=\"501\" alt=\"\" class=\"wp-image-18222 lazyload\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><noscript><img decoding=\"async\" width=\"1024\" height=\"501\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-1024x501.png\" alt=\"\" class=\"wp-image-18222\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-1024x501.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-300x147.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3-768x375.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_3.png 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/noscript><\/figure><\/div>\n\n\n\n<p>\u4e0e\u5148\u524d\u7684\u6297HER2\u9633\u6027\u4e73\u817a\u764c\u7684ADC (T-DM1)\u836f\u7269\u76f8\u6bd4, T-DXD \u5728\u8bbe\u8ba1\u4e0a\u505a\u4e86\u66f4\u591a\u6539\u826f\u548c\u5347\u7ea7:  <br><br>\u9996\u5148, T-DXd\u6240\u643a\u5e26\u7684\u6bd2\u7d20\u836f\u7269\u66f4\u591a, &nbsp;\u6bcf\u4e00\u4e2aT-DXd \u5206\u5b50\u8d1f\u8f7d\u4e86\u5927\u7ea68\u4e2a\u6bd2\u7d20\u836f\u7269( T-DM1 \u53ea\u67093.5\u4e2a\u6bd2\u7d20\u836f\u7269)\u3002\u800c\u4e14T-DXd \u836f\u7269\u7684\u8fde\u63a5\u4e5f\u66f4\u52a0\u7a33\u5b9a, \u53ea\u4f1a\u96c6\u4e2d\u4e8e\u76ee\u6807\u764c\u7ec6\u80de\u5185\u91ca\u653e\u51fa\u6bd2\u7d20\u836f\u7269, \u4ece\u800c\u63d0\u9ad8\u836f\u7269\u7684\u6548\u679c, \u540c\u65f6\u51cf\u5c11\u5bf9\u5065\u5eb7\u7ec4\u7ec7\u7684\u635f\u4f24\u548c\u526f\u4f5c\u7528\u3002T-DXD\u6700\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\u5f53\u5176\u6bd2\u7d20\u836f\u7269\u6740\u6b7b\u76ee\u6807\u764c\u7ec6\u80de\u540e, \u80fd\u6e17\u900f\u5e76\u6740\u6b7b\u90bb\u8fd1\u7684\u764c\u7ec6\u80de (\u5373\u4f7f\u4e0d\u662fHER2\u53d7\u4f53\u9633\u6027\u7684\u764c\u7ec6\u80de)\uff0c\u4ece\u800c\u8fbe\u5230&#8221;\u706b\u70e7\u8fde\u73af\u8239&#8221;\u7684\u6548\u679c\u3002 <br><br>\u6b63\u662f\u8fd9\u72ec\u4e00\u65e0\u4e8c&#8221;\u706b\u70e7\u8fde\u73af\u8239&#8221;\u7684\u7279\u6027, T-DXd \u836f\u7269\u5f00\u542f\u4e86\u4e00\u4e2a\u65b0\u65f6\u4ee3\uff0c\u90a3\u5c31\u662f\u201cHER2\u4f4e\u8868\u8fbe\u201d\u4e73\u817a\u764c\u7684\u7cbe\u51c6\u6cbb\u7597\u65f6\u4ee3\u3002<br><br>\u56e0\u4e3a\u6309\u7167\u4e0a\u6587\u7684\u4e73\u817a\u764c\u5206\u7c7b\u65b9\u5f0f\uff0c\u5176\u4e2d\u201cHER2\u9634\u6027\u201d \u5176\u5b9e\u662f\u4e00\u79cd\u8f83\u4e3a\u7c97\u7cd9\u7684\u8bf4\u6cd5\u3002HER2\u662f\u4e00\u79cd\u819c\u4e0a\u53d7\u4f53\u86cb\u767d\uff0c\u7528\u6765\u63a5\u6536\u8eab\u4f53\u5185\u7684\u751f\u4fe1\u53f7\uff0c\u63d0\u793a\u7ec6\u80de\u751f\u957f\u548c\u5206\u88c2\u3002\u5f53\u4e73\u817a\u7ec6\u80de\u8868\u8fbe\u8fc7\u591aHER2\u53d7\u4f53\uff0c\u4fbf\u4f1a\u8fc7\u5ea6\u63a5\u6536\u751f\u957f\u4fe1\u53f7\uff0c\u6162\u6162\u53d1\u5c55\u4e3a\u80bf\u7624\u3002\u201cHER2\u9633\u6027\u201d\u4e73\u817a\u764c\u8868\u793a\u80bf\u7624\u7ec6\u80de\u4e2dHER2\u53d7\u4f53\u7684\u8868\u8fbe\u91cf\u9ad8\u4e8e\u6b63\u5e38\u7ec6\u80de\uff0c\u800c\u201cHER2\u9634\u6027\u201d\u4e73\u817a\u764c\u5219\u8868\u793a\u80bf\u7624\u7ec6\u80de\u4e2dHER2\u53d7\u4f53\u7684\u8868\u8fbe\u91cf\u6b63\u5e38\u6216\u4f4e\u4e8e\u6b63\u5e38\u3002<br><br>\u5728HER2\u9634\u6027\u4e73\u817a\u764c\u4e2d\uff0c\u6709\u65f6\u5019\u53ef\u4ee5\u8fdb\u4e00\u6b65\u7ec6\u5206\u4e3a\u4f4e\u8868\u8fbe\u548c\u4e0d\u8868\u8fbe\u4e24\u7c7b\u3002\u4f4e\u8868\u8fbe\u662f\u6307HER2\u53d7\u4f53\u7684\u8868\u8fbe\u91cf\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u4f4e\u4e8e\u9633\u6027\u4e73\u817a\u764c\uff1b\u800c\u4e0d\u8868\u8fbe\u5219\u8868\u793a\u80bf\u7624\u7ec6\u80de\u4e2d\u5b8c\u5168\u6ca1\u6709HER2\u53d7\u4f53\u7684\u8868\u8fbe\u3002<br><br>T-DXd \u836f\u7269\u7684\u51fa\u73b0\u5219\u8ba9\u201cHER2\u9634\u6027\u201d\u5f53\u4e2d\uff0c\u4f4e\u8868\u8fbe\u7684\u60a3\u8005\u4e5f\u6709\u836f\u53ef\u533b\uff0c\u7ee7\u7eed\u8fdb\u884c\u6cbb\u7597\u3002\u800c\u5728\u6b64\u4e4b\u524d\uff0cHER2\u4f4e\u8868\u8fbe\u7684\u60a3\u8005\uff0c\u5e76\u672a\u4ece\u76f8\u5173\u9776\u5411\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002      <\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-1024x485.png\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-1024x485.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-300x142.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-768x363.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4.png 1080w\" decoding=\"async\" width=\"1024\" height=\"485\" alt=\"\" class=\"wp-image-18225 lazyload\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><noscript><img decoding=\"async\" width=\"1024\" height=\"485\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-1024x485.png\" alt=\"\" class=\"wp-image-18225\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-1024x485.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-300x142.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4-768x363.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_4.png 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/noscript><figcaption> T-DXd\u7684\u4f5c\u7528\u539f\u7406\u56fe <\/figcaption><\/figure><\/div>\n\n\n\n<p>\u90a3\u4e48T-DXd\u5bf9\u4e8eHER2\u4f4e\u8868\u8fbe\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u5df2\u6709\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u8868\u73b0\u5982\u4f55\u5462\uff1f <br><br>2022\u5e746\u6708\uff0c\u9996\u4e2a\u9488\u5bf9HER2\u4f4e\u8868\u8fbe\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u968f\u673aIII\u671f\u4e34\u5e8a\u8bd5\u9a8cDESTINY-Breast04 \u516c\u5e03\u5176\u6700\u65b0\u7814\u7a76\u6210\u679c\u3002&nbsp;\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u533b\u751f\u9009\u62e9\u7684\u6807\u51c6\u5316\u7597\u65b9\u6848\u76f8\u6bd4\uff0c\u5728\u7ecf\u6cbb\u6fc0\u7d20\u53d7\u4f53(HR)\u9633\u6027\u6216HR\u9634\u6027\u3001HER2\u4f4e\u8868\u8fbe\u4e0d\u53ef\u5207\u9664\u548c\/\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u548c\u603b\u751f\u5b58\u671f(OS)\u65b9\u9762, \u5747\u8868\u73b0\u51fa\u4f18\u8d8a\u4e14\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\u3002      <br><br>\u5176\u4e2d\uff0cT-DXd\u5c06HR\u9633\u6027\u3001HER2\u4f4e\u8868\u8fbe\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8649%\u3002\u6b64\u5916,\u7814\u7a76\u6570\u636e\u663e\u793aT-DXd\u5728HR\u9633\u6027\u6216HR\u9634\u6027\u3001HER2\u4f4e\u8868\u8fbe\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u603b\u4f53\u8bd5\u9a8c\u4eba\u7fa4\u4e2d\u5747\u5c55\u793a\u51fa\u4e00\u81f4\u7684\u7597\u6548,\u65e0\u8bbaHER2\u8868\u8fbe\u6c34\u5e73\u5982\u4f55(IHC 1+ \u548c IHC 2+\/ISH-)\u3002<br><br>\u800c\u9488\u5bf9HR\u9634\u6027\u60a3\u8005(n=58)\u7684\u63a2\u7d22\u6027\u5206\u6790\u7ed3\u679c\u663e\u793a,T-DXd\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dPFS\u4e3a8.5\u4e2a\u6708,\u800c\u5316\u7597\u7ec4\u4e3a2.9\u4e2a\u6708(PFS HR 0.46;95% CI:0.24-0.89),T-DXd\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4e3a18.2\u4e2a\u6708,\u800c\u5316\u7597\u7ec4\u4e3a8.3\u4e2a\u6708(OS HR 0.48;95% CI:0.24-0.95)\u3002   <br><br><em>\u6ce8\uff1aDESTINY-Breast04 \u662f\u4e00\u9879\u5168\u7403\u6027\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u6ce8\u518c III \u671f\u8bd5\u9a8c,\u8bc4\u4f30T-DXd(5.4 mg\/kg)\u4e0e\u533b\u751f\u9009\u62e9\u7684\u5316\u7597(\u5361\u57f9\u4ed6\u6ee8\u3001\u827e\u65e5\u5e03\u6797\u3001\u5409\u897f\u4ed6\u6ee8\u3001\u7d2b\u6749\u9187\u6216\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187),\u5bf9\u5df2\u63a5\u53d7\u8fc7\u4e00\u79cd\u6216\u4e24\u79cd\u5316\u7597\u65b9\u6848\u7684\u4e0d\u53ef\u5207\u9664\u548c\/\u6216\u8f6c\u79fb\u6027HR \u9633\u6027\u6216HR \u9634\u6027HER2\u4f4e\u8868\u8fbe\u4e73\u817a\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u60a3\u8005\u6309 2:1 \u968f\u673a\u5206\u914d\u63a5\u53d7T-DXd\u6216\u5316\u7597\u3002 <\/em><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-1024x553.png\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-1024x553.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-300x162.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-768x415.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5.png 1080w\" decoding=\"async\" width=\"1024\" height=\"553\" alt=\"\" class=\"wp-image-18228 lazyload\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><noscript><img decoding=\"async\" width=\"1024\" height=\"553\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-1024x553.png\" alt=\"\" class=\"wp-image-18228\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-1024x553.png 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-300x162.png 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5-768x415.png 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_5.png 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/noscript><figcaption> FDA\u63d0\u524d4\u4e2a\u6708\u6279\u51c6, \u9996\u4e2aHER2\u4f4e\u8868\u8fbe\u4e73\u817a\u764c\u9776\u5411\u7597\u6cd5\u57282022\u5e74\u4e0a\u5e02 <\/figcaption><\/figure>\n\n\n\n<p>T-DXd\u7684\u5b89\u5168\u6027\u4e0e\u4e4b\u524d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e00\u81f4,\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u95ee\u9898\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u6216\u66f4\u9ad8\u7ea7\u522b\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11 (13.7%)\u3001\u8d2b\u8840 (8.1%)\u3001\u75b2\u52b3 (7.5%)\u3001\u767d\u7ec6\u80de\u51cf\u5c11 (6.5%)\u3001\u8840\u5c0f\u677f\u51cf\u5c11 (5.1%) \u548c\u6076\u5fc3 (4.6%)\u3002<br><br>\u8bc4\u4f30T-DXd\u5355\u836f\u5728\u591a\u79cdHER2\u9776\u5411\u764c\u75c7(\u5305\u62ec\u4e73\u817a\u764c\u3001\u80c3\u764c\u3001\u80ba\u764c\u548c\u7ed3\u76f4\u80a0\u764c)\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u5168\u9762\u7814\u53d1\u8ba1\u5212\u6b63\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u3002\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7b49\u5176\u4ed6\u6297\u80bf\u7624\u6cbb\u7597\u7684\u8bd5\u9a8c\u4e5f\u5728\u8fdb\u884c\u4e2d\u3002<br><br>\u800c\u9664\u4e86\u5728\u4e3a\u4e73\u817a\u764c\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u4e4b\u5916\uff0c\u5b83\u4e5f\u4e3a\u5176\u4ed6\u7c7b\u578b\u7684\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u4e86\u5de8\u5927\u7684\u5e0c\u671b\uff0c\u8bc4\u4f30T-DXd\u5355\u836f\u5728\u591a\u79cdHER2\u9776\u5411\u764c\u75c7\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u5168\u9762\u7814\u53d1\u8ba1\u5212\uff0c\u5df2\u7ecf\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\uff0c\u5305\u62ec\u4e86\u80c3\u764c\u3001\u80ba\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7b49\uff0c\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7b49\u5176\u4ed6\u6297\u80bf\u7624\u6cbb\u7597\u7684\u8bd5\u9a8c\u4e5f\u540c\u6837\u5728\u8fdb\u884c\u4e2d\u3002    <\/p>\n\n\n\n<p>\u5c0f\u7f16\u6709\u7406\u7531\u76f8\u4fe1\uff0c\u5c31\u5728\u4e0d\u4e45\u7684\u5c06\u6765\uff0c\u6211\u4eec\u53ef\u4ee5\u542c\u5230\u66f4\u591a\u5173\u4e8eT-DXd\u7684\u597d\u6d88\u606f\uff0c\u4ee4\u5230\u5168\u7403\u8303\u56f4\u66f4\u591a\u7684\u60a3\u8005\u53d7\u76ca\u3002<br>\u4e5f\u8981\u7279\u522b\u5728\u6b64\uff0c\u81f4\u656c\u5728\u6297\u764c\u8def\u4e0a\u6240\u6709\u4ed8\u51fa\u52aa\u529b\u7684\u4eba\u4eec\uff01 <\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6.jpg\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6.jpg 780w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6-300x150.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6-768x384.jpg 768w\" decoding=\"async\" width=\"780\" height=\"390\" alt=\"\" class=\"wp-image-18231 lazyload\" sizes=\"(max-width: 780px) 100vw, 780px\"><noscript><img decoding=\"async\" width=\"780\" height=\"390\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6.jpg\" alt=\"\" class=\"wp-image-18231\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6.jpg 780w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6-300x150.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/05\/33_6-768x384.jpg 768w\" sizes=\"(max-width: 780px) 100vw, 780px\"><\/noscript><\/figure><\/div>\n\n\n\n<p><em><strong>\u53c2\u8003\u6587\u7ae0\uff1a<\/strong><\/em><br><em>1.&nbsp; World Health Organization. &#8220;Breast cancer.&#8221;&nbsp; <a href=\"https:\/\/www.who.int\/zh\/news-room\/fact-sheets\/detail\/breast-cancer\">https:\/\/www.who.int\/zh\/news-room\/fact-sheets\/detail\/breast-cancer<\/a><\/em><a href=\"https:\/\/www.who.int\/zh\/news-room\/fact-sheets\/detail\/breast-cancer\"> <\/a><br><em>2.&nbsp; Hurvitz SA, Hegg R, Chung WP, et al. Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial [published correction appears in Lancet. 2023 Feb 18;401(10376):556].&nbsp;Lancet. 2023;401(10371):105-117. doi:10.1016\/S0140-6736(22)02420-5<\/em> <br><em>3.&nbsp; Wei Cao, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 2021 Apr 5; 134(7): 783\u2013791.<\/em> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u89e3\u8bfb\u764c\u6307\u6570\u764c\u75c7\u75c5\u4eba\u9700\u8981\u5b9a\u671f\u68c0\u67e5\u764c\u6307\u6570\uff0c\u4ee5\u76d1\u5bdf\u6cbb\u7597\u6210\u6548\u3002\u5230\u5e95\u4ec0\u4e48\u662f\u764c\u6307\u6570\uff1f\u764c\u6307\u6570200\u5c5e\u5f02\u5e38\u98d9\u9ad8\uff1f\u8c01\u9700\u8981\u63a5\u53d7\u764c\u80da\u6297\u539f\u68c0\u67e5\uff1f\u764c\u80da\u6297\u539fCEA\u6b63\u5e38\u503c\u662f\u591a\u5c11\uff1f\u4e13\u79d1\u533b\u751f\u4e3a\u4f60\u89e3\u7b54<\/p>\n","protected":false},"author":10,"featured_media":18238,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1735],"tags":[],"yst_prominent_words":[1048,1054,1113,1501,1511,1512,5481,6232,6250],"class_list":["post-18215","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-breast-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/18215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=18215"}],"version-history":[{"count":5,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/18215\/revisions"}],"predecessor-version":[{"id":18246,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/18215\/revisions\/18246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/18238"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=18215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=18215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=18215"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=18215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}