{"id":18842,"date":"2023-08-16T14:19:57","date_gmt":"2023-08-16T06:19:57","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=18842"},"modified":"2023-08-16T14:30:46","modified_gmt":"2023-08-16T06:30:46","slug":"%e5%9c%a8%e5%b1%80%e9%83%a8%e6%99%9a%e6%9c%9f%e9%bc%bb%e5%92%bd%e7%99%8c%e4%b8%ad%e5%8c%96%e7%96%97%e5%8a%a0%e7%94%a8sintilimab%e5%8d%95%e6%8a%97%e5%8f%af%e5%b8%a6%e6%9d%a5%e7%9b%8a%e5%a4%84","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e5%9c%a8%e5%b1%80%e9%83%a8%e6%99%9a%e6%9c%9f%e9%bc%bb%e5%92%bd%e7%99%8c%e4%b8%ad%e5%8c%96%e7%96%97%e5%8a%a0%e7%94%a8sintilimab%e5%8d%95%e6%8a%97%e5%8f%af%e5%b8%a6%e6%9d%a5%e7%9b%8a%e5%a4%84\/","title":{"rendered":"CONTINUUM\u8a00\uff1a\u201c\u5728\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u4e2d\uff0c\u5316\u7597\u52a0\u7528sintilimab\u5355\u6297\u53ef\u5e26\u6765\u76ca\u5904\u201d"},"content":{"rendered":"\n<p>\u201c\u5728\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u4e2d\uff0c\u5316\u7597\u52a0\u7528sintilimab\u5355\u6297\u53ef\u5e26\u6765\u76ca\u5904\u201d<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640.jpg\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640.jpg 800w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-300x200.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-768x512.jpg 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-670x446.jpg 670w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-600x400.jpg 600w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-480x320.jpg 480w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-390x260.jpg 390w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-285x190.jpg 285w\" decoding=\"async\" width=\"800\" height=\"533\" alt=\"\" class=\"wp-image-18847 lazyload\" sizes=\"(max-width: 800px) 100vw, 800px\"><noscript><img decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640.jpg\" alt=\"\" class=\"wp-image-18847\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640.jpg 800w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-300x200.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-768x512.jpg 768w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-670x446.jpg 670w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-600x400.jpg 600w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-480x320.jpg 480w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-390x260.jpg 390w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2023\/08\/640-285x190.jpg 285w\" sizes=\"(max-width: 800px) 100vw, 800px\"><\/noscript><\/figure><\/div>\n\n\n\n<p>\u6839\u636e\u968f\u673aIII\u671f\u8bd5\u9a8cCONTINUUM\u7684\u9996\u6279\u7ed3\u679c\uff0c<strong>\u5728\u6807\u51c6\u8bf1\u5bfc\u5316\u7597\u548c\u5316\u7597\u653e\u7597\u7684\u57fa\u7840\u4e0a\u52a0\u7528PD-1\u6291\u5236\u5242sintilimab\u53ef\u663e\u8457\u63d0\u9ad8\u201c\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u60a3\u8005\u201d\u76843\u5e74\u201c\u65e0\u4e8b\u4ef6\u201d\u751f\u5b58\u671f\uff0c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u751f\u6d3b\u8d28\u91cf\u4e0e\u6807\u51c6\u6cbb\u7597\u76f8\u5f53\u3002<\/strong>\u4e2d\u56fd\u5e7f\u5dde\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u653e\u5c04\u80bf\u7624\u79d1\u6559\u6388\u3001\u533b\u5b66\u535a\u58eb\u3001\u7406\u5b66\u7855\u58eb\u9a6c\u9a8f\u57282023\u5e74ASCO\u5e74\u4f1a\u4e0a\u62a5\u544a\u4e86\u8fd9\u9879\u5728\u4e2d\u56fd\u8fdb\u884c\u7684\u7814\u7a76\u7ed3\u679c\u3002<br><br>\u52a0\u5165sintilimab\u5355\u6297\u540e\uff0c\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u660e\u663e\u6539\u5584\u3002<strong>\u4e2d\u4f4d\u968f\u8bbf 42 \u4e2a\u6708\u540e\uff0c\u5728\u610f\u5411\u6cbb\u7597\u5206\u6790\u4e2d\uff0c\u4f7f\u7528sintilimab\u5355\u6297\u7684 3 \u5e74\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u4e3a 86.1%\uff0c\u4f7f\u7528\u6807\u51c6\u6cbb\u7597\u7684 3 \u5e74\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u4e3a 76.0%<\/strong>\uff08\u5371\u9669\u6bd4 [HR] = 0.59\uff1bP = .019\uff09\u76f8\u6bd4\u4e4b\u4e0b\uff0cSintilimab\u7d44\u7684\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387<strong>\u589e\u52a0\u4e86\u60ca\u4eba\u768410\uff05\u3002\u6574\u4f53\u800c\u8a00\uff0c\u7eb3\u5165sintilimab\u5355\u6297\u5bf9\u65e0\u8fdc\u5904\u8f6c\u79fb\u751f\u5b58\u7387\u548c\u65e0\u5c40\u90e8\u590d\u53d1\u751f\u5b58\u7387\u6709\u79ef\u6781\u5f71\u54cd\uff0c\u4f46\u76ee\u524d\u603b\u751f\u5b58\u7387\u4ecd\u7136\u76f8\u4f3c\u3002<\/strong>  <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5173\u4e8e CONTINUUM   <\/h2>\n\n\n\n<p>&#8220;<strong>\u52a0\u5165sintilimab\u5355\u6297\u540e\uff0c\u75be\u75c5\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u663e\u8457\u964d\u4f4e\u4e8641%\uff0c\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u8f83\u9ad8\uff0c\u4f46\u8fd9\u4e9b\u4e8b\u4ef6\u662f\u53ef\u63a7\u7684\uff0c<\/strong>&#8220;\u9a6c\u535a\u58eb\u8bc4\u8bba\u9053\u3002<strong>\u201cCONTINUUM\u8bd5\u9a8c\u652f\u6301\u5c06sintilimab\u8054\u5408\u653e\u5316\u7597\u4f5c\u4e3a\u6cbb\u7597\u9ad8\u98ce\u9669\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u7684\u65b0\u6807\u51c6\u3002\u201d<\/strong>\u4f5c\u4e3aPD-1\u6291\u5236\u5242\uff0cSintilimab\u5728\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u6cbb\u7597\u4e2d\u5c55\u73b0\u4e86\u7a81\u51fa\u7684\u8868\u73fe\uff0c\u5176\u7597\u6548\u548c\u5b89\u5168\u6027\u5c07\u4e3a\u514d\u75ab\u7597\u6cd5\u7684\u672a\u4f86\u5e94\u7528\u5e26\u4f86\u66f4\u591a\u5e0c\u671b\u3002 <br><br>\u5728sintilimab\u5355\u6297\u6cbb\u7597\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e2d\uff0c\u5c3d\u7ba1\u5206\u522b\u670974%\u548c65%\u7684\u60a3\u8005\u51fa\u73b0\u4e863\u7ea7\u62164\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c<strong>\u4e14\u5176\u4e2dsintilimab\u5355\u6297\u6cbb\u7597\u7ec4\u670910%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff0c\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u8f83\u9ad8\uff0c\u4f46\u8fd9\u4e9b\u4e8b\u4ef6\u662f\u53ef\u63a7\u7684<\/strong>\u3002<strong>\u6574\u4f53\u800c\u8a00\uff0c\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u5728Sintilimab\u6cbb\u7597\u7ec4\u4e0e\u6807\u51c6\u6cbb\u7597\u7ec4\u4e4b\u95f4\u6ca1\u6709\u660e\u663e\u5dee\u5f02\u3002<\/strong><br><br><strong>Sintilimab\u7684\u52a0\u5165\u5bf9\u8fdc\u5904\u8f6c\u79fb\u65e0\u75c5\u751f\u5b58\u548c\u5c40\u90e8\u533a\u57df\u590d\u53d1\u65e0\u75c5\u751f\u5b58\u4ea7\u751f\u79ef\u6781\u5f71\u54cd\uff0c\u6709\u6548\u63d0\u9ad8\u5c40\u90e8\u533a\u57df\u7684\u6cbb\u7597\u6548\u679c<\/strong>\u3002CONTINUUM III \u671f\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u5728\u8bf1\u5bfc\u5316\u7597\u548c\u653e\u5316\u7597\u4e2d\u52a0\u5165sintilimab\u5355\u6297\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002CONTINUUM\u5171\u62db\u52df\u4e86\u6765\u81ea\u4e2d\u56fd9\u4e2a\u4e2d\u5fc3\u7684425\u540d\u975e\u8f6c\u79fb\u6027\u3001\u9ad8\u5371\u3001\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u60a3\u8005\u3002\u60a3\u8005\u5747\u4e3aIII\u671f\u6216IV\u671f\uff0870%\u4e3aIV\u671f\uff09\uff0c\u4e0d\u5305\u62ecT3-4N0\/T3N1\u80bf\u7624\u3002<strong>\u8fd9\u4e3a\u9f3b\u54bd\u764c\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u672c\u571f\u4e34\u5e8a\u7ecf\u9a8c\uff0c\u4e3a\u8be5\u5730\u533a\u60a3\u8005\u63d0\u4f9b\u4e86\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/strong>  <\/p>\n\n\n\n<p>\u60a3\u8005\u6309 1:1 \u968f\u673a\u5206\u914d\u63a5\u53d7\u6807\u51c6\u7597\u6cd5\uff08\u5305\u62ec\u8bf1\u5bfc\u5316\u7597\u548c\u5316\u7597\u653e\u7597\uff09\u6216\u6807\u51c6\u7597\u6cd5\u52a0sintilimab\u5355\u6297\uff08200 \u6beb\u514b\uff0c\u9759\u8109\u6ce8\u5c04\uff0c\u6bcf 3 \u5468\u4e00\u6b21\uff0c\u6700\u591a 12 \u4e2a\u5468\u671f\uff09\uff083 \u4e2a\u5468\u671f\u4e3a\u8bf1\u5bfc\u7597\u6cd5\uff0c3 \u4e2a\u5468\u671f\u4e0e\u5316\u7597\u653e\u7597\u540c\u65f6\u8fdb\u884c\uff0c6 \u4e2a\u5468\u671f\u4f5c\u4e3a\u8f85\u52a9\u7597\u6cd5\uff09\u3002\u8bf1\u5bfc\u6cbb\u7597\u5305\u62ec\u4e09\u4e2a\u5468\u671f\u7684gemcitabine\u548ccisplatin\uff0c\u6839\u636e\u9a6c\u535a\u58eb\u7814\u7a76\u5c0f\u7ec4\u4e4b\u524d\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u53d1\u8868\u7684\u4e00\u9879III\u671f\u8bd5\u9a8c\u7ed3\u679c\uff0c\u8bf1\u5bfc\u6cbb\u7597\u662f\u76ee\u524d\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002<br><br>\u4e24\u7ec4\u60a3\u8005\u7684\u4f9d\u4ece\u6027\u90fd\u5f88\u597d\uff0c\u53ea\u662fsintilimab\u5355\u6297\u6cbb\u7597\u7ec4\u7684\u540c\u671f\u5316\u7597\u4f9d\u4ece\u6027\u7565\u4f4e\uff1bsintilimab\u5355\u6297\u6cbb\u7597\u7ec4\u8d85\u8fc7 70% \u7684\u60a3\u8005\u63a5\u53d7\u4e86\u5168\u90e8 12 \u4e2a\u5468\u671f\u7684sintilimab\u5355\u6297\u6cbb\u7597\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08\u5373\u514d\u4e8e\u5c40\u90e8\u3001\u533a\u57df\u6216\u8fdc\u5904\u8870\u7aed\u6216\u6b7b\u4ea1\uff09\u3002    <\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e\uff1a<br>1. Ma J, Sun Y, Liu X, et al: PD-1 blockade with sintilimab plus induction chemotherapy and concurrent chemoradiotherapy (IC-CCRT) versus IC-CCRT in locoregionally advanced nasopharyngeal carcinoma.&nbsp;2023 ASCO Annual Meeting. Abstract LBA6002. Presented June 5, 2023. <br>2. Zhang Y, Chen L, Hu GQ, et al: Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma.&nbsp;N Engl J Med 381:1124-1135, 2019. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201c\u5728\u5c40\u90e8\u665a\u671f\u9f3b\u54bd\u764c\u4e2d\uff0c\u5316\u7597\u52a0\u7528sintilimab\u5355\u6297\u53ef\u5e26\u6765\u76ca\u5904\u201d \u6839\u636e\u968f\u673aIII\u671f\u8bd5\u9a8cCONTINUUM\u7684\u9996<\/p>\n","protected":false},"author":10,"featured_media":18843,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1763],"tags":[],"yst_prominent_words":[1163,1176,1183,1501,1511,1512,1901,6122,6413,6414,6415,6416,6417,6418],"class_list":["post-18842","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nasopharyngeal-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/18842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=18842"}],"version-history":[{"count":4,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/18842\/revisions"}],"predecessor-version":[{"id":18895,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/18842\/revisions\/18895"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/18843"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=18842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=18842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=18842"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=18842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}