{"id":19623,"date":"2024-05-08T17:18:51","date_gmt":"2024-05-08T09:18:51","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=19623"},"modified":"2024-12-11T14:48:37","modified_gmt":"2024-12-11T06:48:37","slug":"mirvetuximab-soravtansine-%e6%b2%bb%e7%96%97fr%ce%b1%e9%98%b3%e6%80%a7%e3%80%81%e9%93%82%e7%b1%bb%e8%80%90%e8%8d%af%e7%9a%84%e5%8d%b5%e5%b7%a2%e7%99%8c","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/mirvetuximab-soravtansine-%e6%b2%bb%e7%96%97fr%ce%b1%e9%98%b3%e6%80%a7%e3%80%81%e9%93%82%e7%b1%bb%e8%80%90%e8%8d%af%e7%9a%84%e5%8d%b5%e5%b7%a2%e7%99%8c\/","title":{"rendered":"Mirvetuximab\u00a0Soravtansine\u00a0\u6cbb\u7597FR\u03b1\u9633\u6027\u3001\u94c2\u7c7b\u8010\u836f\u7684\u5375\u5de2\u764c"},"content":{"rendered":"\n

Mirvetuximab soravtansine-gynx (MIRV) \u662f\u4e00\u79cd\u9488\u5bf9\u53f6\u9178\u53d7\u4f53 \u03b1 (FR\u03b1) \u7684\u9996\u521b\u65b0\u836f\u5076\u8054\u7269\uff0c\u5728\u7f8e\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u94c2\u8010\u836f\u5375\u5de2\u764c\u3002<\/p>\n\n\n\n

\u5b9e\u9a8c\u8fdb\u884c\u4e86\u4e00\u9879 3 \u671f\u3001\u5168\u7403\u6027\u3001\u9a8c\u8bc1\u6027\u3001\u5f00\u653e\u6807\u7b7e\u3001\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u4ee5\u6bd4\u8f83 MIRV \u4e0e\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u6cbb\u7597\u94c2\u7c7b\u8010\u836f\u3001\u9ad8\u7ea7\u522b\u6d46\u6db2\u6027\u5375\u5de2\u764c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u4e4b\u524d\u63a5\u53d7\u8fc7\u4e00\u5230\u4e09\u7ebf\u6cbb\u7597\u4e14\u5177\u6709\u9ad8 FR\u03b1 \u80bf\u7624\u8868\u8fbe\uff08\u226575% \u7684\u7ec6\u80de\u5177\u6709\u22652+ \u67d3\u8272\u5f3a\u5ea6\uff09\u7684\u53c2\u4e0e\u8005\u4ee5 1:1 \u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u63a5\u53d7 MIRV\uff08\u8c03\u6574\u540e\u7684\u7406\u60f3\u5242\u91cf\u4e3a\u6bcf\u516c\u65a4 6 \u6beb\u514b\uff09 \u6bcf 3 \u5468\u6d4b\u91cf\u4e00\u6b21\u4f53\u91cd\uff09\u6216\u5316\u7597\uff08\u7d2b\u6749\u9187\u3001\u805a\u4e59\u4e8c\u9187\u8102\u8d28\u4f53\u963f\u9709\u7d20\u6216\u6258\u6cca\u66ff\u5eb7\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff1b\u5173\u952e\u7684\u6b21\u8981\u5206\u6790\u7ec8\u70b9\u5305\u62ec\u5ba2\u89c2\u53cd\u5e94\u3001\u603b\u4f53\u751f\u5b58\u7387\u548c\u53c2\u4e0e\u8005\u62a5\u544a\u7684\u7ed3\u679c\u3002<\/p>\n\n\n\n

\u5171\u6709 453 \u540d\u53c2\u4e0e\u8005\u63a5\u53d7\u4e86\u968f\u673a\u5206\u7ec4\uff1b227 \u4f8b\u88ab\u5206\u914d\u5230 MIRV \u7ec4\uff0c226 \u4f8b\u88ab\u5206\u914d\u5230\u5316\u7597\u7ec4\u3002MIRV \u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a 5.62 \u4e2a\u6708\uff0895% \u7f6e\u4fe1\u533a\u95f4 [CI]\uff0c4.34 \u81f3 5.95\uff09\uff0c\u5316\u7597\u7ec4\u4e3a 3.98 \u4e2a\u6708\uff0895% CI\uff0c2.86 \u81f3 4.47\uff09\uff08P<0.001\uff09\u3002MIRV \u7ec4\u6709 42.3% \u7684\u53c2\u4e0e\u8005\u51fa\u73b0\u5ba2\u89c2\u7f13\u89e3\uff0c\u5316\u7597\u7ec4\u6709 15.9% \u7684\u53c2\u4e0e\u8005\u51fa\u73b0\u5ba2\u89c2\u7f13\u89e3\uff08\u6bd4\u503c\u6bd4\uff0c3.81\uff1b95% CI\uff0c2.44 \u81f3 5.94\uff1bP<0.001\uff09\u3002MIRV \u7684\u603b\u751f\u5b58\u671f\u660e\u663e\u957f\u4e8e\u5316\u7597\uff08\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a 16.46 \u4e2a\u6708 vs 12.75 \u4e2a\u6708\uff1b\u6b7b\u4ea1\u98ce\u9669\u6bd4\u4e3a 0.67\uff1b95% CI\uff0c0.50 \u81f3 0.89\uff1bP = 0.005\uff09\u3002\u5728\u6cbb\u7597\u671f\u95f4\uff0cMIRV \u7ec4\u53d1\u751f\u7684 3 \u7ea7\u6216\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u6bd4\u5316\u7597\u7ec4\u5c11\uff0841.7% \u6bd4 54.1%\uff09\uff0c\u4efb\u4f55\u7ea7\u522b\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0823.9% \u6bd4 32.9%\uff09\u548c\u5bfc\u81f4\u505c\u836f\u7684\u4e8b\u4ef6\u4e5f\u66f4\u5c11\uff08 9.2% \u5bf9\u6bd4 15.9%\uff09\u3002<\/p>\n\n\n\n

\u7ed3\u8bba\uff1a\u5728\u60a3\u6709\u94c2\u8010\u836f\u3001FR\u03b1 \u9633\u6027\u5375\u5de2\u764c\u7684\u53c2\u4e0e\u8005\u4e2d\uff0c\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3001\u603b\u751f\u5b58\u671f\u548c\u5ba2\u89c2\u7f13\u89e3\u65b9\u9762\uff0cMIRV \u6cbb\u7597\u6bd4\u5316\u7597\u5177\u6709\u663e\u8457\u76ca\u5904\u3002 <\/p>\n\n\n\n

\u539f\u6587\u51fa\u5904\uff1a<\/p>\n\n\n\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/38055253\/<\/p>\n","protected":false},"excerpt":{"rendered":"

Mirvetuximab soravtansine-gynx (MIRV) \u662f\u4e00<\/p>\n","protected":false},"author":4,"featured_media":19817,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769],"tags":[],"yst_prominent_words":[],"class_list":["post-19623","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/19623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=19623"}],"version-history":[{"count":2,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/19623\/revisions"}],"predecessor-version":[{"id":19827,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/19623\/revisions\/19827"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/19817"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=19623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=19623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=19623"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=19623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}