{"id":20030,"date":"2024-07-15T16:01:30","date_gmt":"2024-07-15T08:01:30","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=20030"},"modified":"2024-07-15T16:01:33","modified_gmt":"2024-07-15T08:01:33","slug":"%e6%96%b0%e7%8e%8b%e7%99%bb%e5%9f%ba%ef%bc%8c%e7%ac%ac%e5%9b%9b%e4%bb%a3%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e9%9d%b6%e5%90%91%e8%8d%af%e5%9f%83%e4%b8%87%e5%a6%a5%e5%8d%95%e6%8a%97","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e6%96%b0%e7%8e%8b%e7%99%bb%e5%9f%ba%ef%bc%8c%e7%ac%ac%e5%9b%9b%e4%bb%a3%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e9%9d%b6%e5%90%91%e8%8d%af%e5%9f%83%e4%b8%87%e5%a6%a5%e5%8d%95%e6%8a%97\/","title":{"rendered":"\u65b0\u738b\u767b\u57fa\uff0c\u7b2c\u56db\u4ee3\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9776\u5411\u836f\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u62c9\u6cfd\u66ff\u5c3cvs\u5965\u5e0c\u66ff\u5c3c\u4e00\u7ebf\u7528\u836f\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u7597\u6548\u66f4\u4f18"},"content":{"rendered":"\n<p>\u81ea\u4ece2015\u5e74\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM\uff09\u53d1\u88681\u671f\u8bd5\u9a8cAURA\u7ed3\u679c\u4ee5\u6765\uff0c\u57fa\u4e8e\u540c\u4e00\u4ee3 EGFR-TKI \u7684\u968f\u673a\u5bf9\u7167 III \u671f FLAURA \u7814\u7a76\u7684\u5353\u8d8a\u6210\u679c\uff0c\u7b2c\u4e09\u4ee3EGFR\u7a81\u53d8\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\u5965\u5e0c\u66ff\u5c3c\u4e0d\u65ad\u5347\u7ea7\u5df2\u5728\u591a\u56fd\u83b7\u6279\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597 EGFR ex19del \u53ca L858R \u7a81\u53d8\u7684\u665a\u671f NSCLC \u60a3\u8005\uff0c\u7531\u6b64\u5965\u5e0c\u66ff\u5c3c\u83b7\u5f97\u4e86 NCCN \u8bca\u7597\u6307\u5357\u7684\u4f18\u5148\u63a8\u8350\u5730\u4f4d\u3002<\/p>\n\n\n\n<p>\u7136\u800c\u51e0\u4e4e\u6240\u6709\u60a3\u8005\u6700\u7ec8\u90fd\u4f1a\u5bf9\u4e09\u4ee3 EGFR-TKI \u4ea7\u751f\u8010\u836f\u6027\uff0c\u6700\u5e38\u89c1\u7684\u53ef\u6d4b\u91cf\u8010\u836f\u673a\u5236\u662f\u7ee7\u53d1\u6027 EGFR \u901a\u8def\u6539\u53d8\u548c MET \u901a\u8def\u6fc0\u6d3b\u3002\u90a3\u4e48\uff0c\u540e\u5965\u5e0c\u66ff\u5c3c\u65f6\u4ee3\u4f1a\u662f\u5982\u4f55\uff1f<\/p>\n\n\n\n<p>\u65e9\u57282022\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u62a5\u9053\u7684CHRYSALIS\u7814\u7a76\u961f\u5217E\u7ed3\u679c\u5c31\u521d\u6b65\u8868\u660e\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u62c9\u6cfd\u66ff\u5c3c\u7528\u4e8eEGFR\u7a81\u53d8\u665a\u671fNSCLC\u4e00\u7ebf\u6cbb\u7597\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u548c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u8d85\u8fc728\u4e2a\u6708\uff0c\u4e14\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4e8b\u4ef6\u3002<\/p>\n\n\n\n<p>\u800c2024\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u4e0a\u516c\u5e03\u4e86\u57c3\u4e07\u59a5\u5355\u6297\uff08Amivantamab\uff09\u8054\u5408\u62c9\u6cfd\u66ff\u5c3c\uff08Lazertinib\uff09\u6cbb\u7597EGFR\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u8fbe\u523018.2\u4e2a\u6708\u3002<\/p>\n\n\n\n<p>6\u670826\u65e5\uff0c\u300a\u65b0\u82f1\u683c\u5170\u6742\u5fd7\u300b\u5728\u7ebf\u53d1\u5e03\u4e86MARIPOSA\u7814\u7a76\u7684III\u671f\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6216\u8bb8\u62c9\u5f00\u4e86\u540e\u5965\u5e0c\u66ff\u5c3c\u65f6\u4ee3\u7684\u5e37\u5e55\uff1a<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-1024x480.jpg\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-1024x480.jpg 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-300x141.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-768x360.jpg 768w\" decoding=\"async\" width=\"1024\" height=\"480\" alt=\"\" class=\"wp-image-20031 lazyload\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><noscript><img decoding=\"async\" width=\"1024\" height=\"480\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-1024x480.jpg\" alt=\"\" class=\"wp-image-20031\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-1024x480.jpg 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-300x141.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/\u65b0\u738b\u767b\u57fa1-768x360.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/noscript><\/figure><\/div>\n\n\n\n<p>\u57282020 \u5e74 11 \u6708\u81f3 2022 \u5e74 5 \u6708\u671f\u95f4\uff0c\u7814\u7a76\u5171\u7eb3\u5165 1074 \u4f8b\u60a3\u8005\uff1a\u57c3\u4e07\u59a5\u5355\u6297+\u62c9\u6cfd\u66ff\u5c3c\u7ec4 429 \u4f8b\uff0c\u5965\u5e0c\u66ff\u5c3c\u7ec4 429 \u4f8b\uff0c\u62c9\u6cfd\u66ff\u5c3c\u7ec4 216 \u4f8b\u3002\u5165\u7ec4\u60a3\u8005\u4e2d\u5973\u6027\u3001\u4e9a\u88d4\u3001\u767d\u4eba\u3001\u672a\u5438\u70df\u8005\u6bd4\u4f8b\u8f83\u5927\u3002\u5404\u7ec4\u60a3\u8005\u57fa\u7ebf\u7279\u5f81\u5747\u8861\u53ef\u6bd4\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7814\u7a76\u7ed3\u679c<\/strong><\/h3>\n\n\n\n<p>\u8bd5\u9a8c\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a 22.0 \u4e2a\u6708\uff0c\u7ed3\u679c\u663e\u793a\uff1a\u8054\u5408\u7528\u836f\u7ec4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u8fd12\u5e74\u65f6\u95f4\uff0c\u663e\u8457\u957f\u4e8e\u5965\u5e0c\u66ff\u5c3c\u7ec4\uff0c\u5206\u522b\u4e3a23.7\u4e2a\u6708\u548c16.6\u4e2a\u6708\uff0c\u62c9\u6cfd\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u7ec4\u4e3a18.5\u4e2a\u6708\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u5b58\u6d3b1.5\u5e74\u4e14\u65e0\u8fdb\u5c55\u7684\u60a3\u8005\u6bd4\u4e3a60%\uff0c2\u5e74\u7684\u60a3\u8005\u6bd4\u4e3a48%\u3002\u5965\u5e0c\u66ff\u5c3c\u7ec4\u5206\u522b\u4e3a48%\u548c34%\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-1024x711.jpg\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-1024x711.jpg 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-300x208.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-768x534.jpg 768w\" decoding=\"async\" width=\"1024\" height=\"711\" alt=\"\" class=\"wp-image-20034 lazyload\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><noscript><img decoding=\"async\" width=\"1024\" height=\"711\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-1024x711.jpg\" alt=\"\" class=\"wp-image-20034\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-1024x711.jpg 1024w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-300x208.jpg 300w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2024\/07\/MARIPOSA-\u7814\u7a76-3-\u7ec4-PFS-\u7ed3\u679c-768x534.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/noscript><figcaption>MARIPOSA \u7814\u7a76 3 \u7ec4 PFS \u7ed3\u679c<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u603b\u751f\u5b58\u671f\uff1a\u8054\u5408\u7528\u836f\u7ec41.5\u5e74\u751f\u5b58\u60a3\u8005\u8fbe82%\uff0c\u4e24\u5e74\u5b58\u6d3b\u60a3\u8005\u4e3a74%\u3002\u5965\u5e0c\u66ff\u5c3c\u7ec4\u751f\u5b581.5\u5e74\u7684\u60a3\u8005\u4e3a79%\uff0c2\u5e74\u60a3\u8005\u4e3a69%\u3002<\/p>\n\n\n\n<p>\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8054\u5408\u7528\u836f\u7ec4\u548c\u5965\u5e0c\u66ff\u5c3c\u4e24\u7ec4\u76f8\u8fd1\uff0c\u5206\u522b\u4e3a86%\u548c85%\u3002\u8054\u5408\u7528\u836f\u7ec4\u7684\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u8d852\u5e74\uff0c\u8fbe\u5230\u4e8625.8\u4e2a\u6708\uff0c\u5965\u5e0c\u66ff\u5c3c\u7ec4\u4e3a16.8\u4e2a\u6708\u3002\u8be5\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u62c9\u6cfd\u66ff\u5c3c\u7597\u6548\u4f18\u4e8e\u5965\u5e0c\u66ff\u5c3c\u3002<\/p>\n\n\n\n<p>\u5728\u5bf9\u9ad8\u98ce\u9669\u4e9a\u7ec4\u7684\u5206\u6790\u4e2d\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u62c9\u6cfd\u66ff\u5c3c\u8054\u5408\u7597\u6cd5\u5728\u591a\u4e2a\u7ef4\u5ea6\u4e0a\u5747\u5c55\u73b0\u51fa\u4f18\u4e8e\u5965\u5e0c\u66ff\u5c3c\u7684\u7597\u6548\uff0c\u7279\u522b\u662f\u5728\u90a3\u4e9b\u6cbb\u7597\u521d\u671f\u5373\u6709ctDNA\u53ef\u68c0\u6d4b\u3001\u4f34\u6709TP53\u5171\u7a81\u53d8\u6216\u809d\u810f\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\u3002\u8fd9\u4e0d\u4ec5\u4f53\u73b0\u5728PFS\u7684\u663e\u8457\u5ef6\u957f\uff0c\u4e5f\u4f53\u73b0\u5728\u5bf9\u75be\u75c5\u8fdb\u5c55\u65f6\u95f4\u7684\u6709\u6548\u63a7\u5236\uff0c\u4e3a\u8fd9\u4e9b\u9884\u540e\u4e0d\u4f73\u7684\u60a3\u8005\u7fa4\u4f53\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u5e0c\u671b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5173\u4e8e\u57c3\u4e07\u59a5\u5355\u6297&amp;\u62c9\u6cfd\u66ff\u5c3c<\/strong><\/h3>\n\n\n\n<p>\u57c3\u4e07\u59a5\u5355\u6297 (Amivantamab) \u662f\u57282021\u5e745\u6708\u88ab\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02, \u662f\u4e00\u79cd\u9488\u5bf9\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR) \u548c\u95f4\u8d28\u8868\u76ae\u8f6c\u5316\u56e0\u5b50\u53d7\u4f53(METR) \u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u7528\u4e8eEGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u5e74\u60a3\u8005\u3002\u5b83\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u80fd\u540c\u65f6\u4e0eEGFR\uff08\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09\u548cMET\uff08\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09\u7684\u7ec6\u80de\u5916\u7ed3\u6784\u57df\u7ed3\u5408\uff0c\u8fd8\u53ef\u4ee5\u901a\u8fc7Fc\u4ecb\u5bfc\u7684ADCC\u6548\u5e94\u7b49\u673a\u5236\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u4e0e\u5c0f\u5206\u5b50EGFR-TKI\u7684\u8054\u5408\u53ef\u4ee5\u5b9e\u73b0EGFR\u901a\u8def\u4e0a\u4e0b\u6e38\u4ee5\u53caMET\u65c1\u8def\u7684\u4e09\u65b9\u9762\u963b\u65ad\uff0c\u4ece\u800c\u66f4\u5f3a\u5730\u6291\u5236\u80bf\u7624\u5e76\u5ef6\u8fdf\u8010\u836f\u65f6\u95f4\u3002<\/p>\n\n\n\n<p>\u62c9\u6cfd\u66ff\u5c3c\uff08Lazertinib\uff09\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u6e17\u900f\u6027\u7684\u7b2c\u4e09\u4ee3 EGFR-TKI\uff0cIII \u671f LASER301 \u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5409\u975e\u66ff\u5c3c\u76f8\u6bd4\uff0c\u62c9\u6cfd\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u6539\u5584\u4e86 EGFR \u7a81\u53d8\u665a\u671f NSCLC \u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7ed3\u8bba\u4e0e\u610f\u4e49<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u62c9\u6cfd\u66ff\u5c3c\u7684\u8054\u5408\u5e94\u7528\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u66f4\u9ad8\u6548\u3001\u66f4\u6301\u4e45\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u4e14\u6709\u53ef\u80fd\u6210\u4e3a\u4e00\u7ebf\u6cbb\u7597EGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u65b0\u6807\u51c6\u3002\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0c\u6211\u4eec\u671f\u5f85\u8fd9\u4e00\u521b\u65b0\u7ec4\u5408\u80fd\u591f\u4e3a\u66f4\u591a\u80ba\u764c\u60a3\u8005\u5e26\u6765\u751f\u547d\u7684\u6625\u5929\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u7ae0\uff1a<\/strong><\/p>\n\n\n\n<p>1.Amivantamab plus lazertinib vs osimertinib in first-line EGFR-mutant advanced non-small cell lung cancer (NSCLC) with biomarkers of high-risk disease: A secondary analysis from the phase 3 MARIPOSA study. | Journal of Clinical Oncology (ascopubs.org)<\/p>\n\n\n\n<p>2.Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC | New England Journal of Medicine (nejm.org)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u81ea\u4ece2015\u5e74\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM\uff09\u53d1\u88681\u671f\u8bd5\u9a8cAURA\u7ed3\u679c\u4ee5\u6765\uff0c\u57fa\u4e8e\u540c\u4e00\u4ee3 EGFR-TKI 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