{"id":20896,"date":"2024-12-12T16:27:38","date_gmt":"2024-12-12T08:27:38","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=20896"},"modified":"2024-12-16T15:26:42","modified_gmt":"2024-12-16T07:26:42","slug":"%e7%ac%ac%e5%9b%9b%e4%bb%a3%e9%9d%b6%e5%90%91%e8%8d%af%e5%9f%83%e4%b8%87%e5%a6%a5%e5%8d%95%e6%8a%97%ef%bc%9a%e5%bc%80%e5%90%af%e5%8f%8c%e9%80%9a%e8%b7%af%e9%9d%b6%e5%90%91%e6%96%b0%e7%ba%aa%e5%85%83","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e7%ac%ac%e5%9b%9b%e4%bb%a3%e9%9d%b6%e5%90%91%e8%8d%af%e5%9f%83%e4%b8%87%e5%a6%a5%e5%8d%95%e6%8a%97%ef%bc%9a%e5%bc%80%e5%90%af%e5%8f%8c%e9%80%9a%e8%b7%af%e9%9d%b6%e5%90%91%e6%96%b0%e7%ba%aa%e5%85%83\/","title":{"rendered":"\u7b2c\u56db\u4ee3\u9776\u5411\u836f\u57c3\u4e07\u59a5\u5355\u6297\uff1a\u5f00\u542f\u53cc\u901a\u8def\u9776\u5411\u65b0\u7eaa\u5143\uff0c\u5e94\u5bf9EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u96be\u70b9"},"content":{"rendered":"\n

\u8fd1\u4e8c\u5341\u5e74\u6765\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e34\u5e8a\u8bca\u7597\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u7279\u522b\u662f\u5728\u9a71\u52a8\u57fa\u56e0\u9633\u6027\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u9776\u5411\u6cbb\u7597\u4e0d\u4ec5\u5f15\u9886\u7740\u6cbb\u7597\u7b56\u7565\u7684\u7cbe\u51c6\u5316\uff0c\u66f4\u6df1\u523b\u91cd\u5851\u4e86\u4e34\u5e8a\u5b9e\u8df5\u683c\u5c40\u3002<\/p>\n\n\n\n

EGFR\u4f5c\u4e3aNSCLC\u7684\u91cd\u8981\u9a71\u52a8\u57fa\u56e0\uff0c\u4e00\u76f4\u5907\u53d7\u5b66\u754c\u5173\u6ce8\uff0c\u65e0\u8bba\u662f\u8f85\u52a9\u6cbb\u7597\u3001\u665a\u671f\u4e00\u7ebf\u6cbb\u7597\u8fd8\u662f\u8010\u836f\u540e\u7684\u6cbb\u7597\uff0c\u5747\u6709\u91cd\u78c5\u6570\u636e\u53d1\u5e03\u3002\u7136\u800c\uff0cEGFR\u7a81\u53d8NSCLC\u4ecd\u9762\u4e34\u7740\u91cd\u91cd\u6311\u6218\uff0c\u8be5\u9886\u57df\u4ecd\u6709\u8bb8\u591a\u95ee\u9898\u4e9f\u5f85\u89e3\u51b3\uff0c\u5305\u62ec\u4e09\u4ee3EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u8010\u836f\u540e\u7684\u6cbb\u7597\u7b56\u7565\u3001EGFR 20\u5916\u663e\u5b50\u63d2\u5165\uff08EGFR ex20ins\uff09\u7a81\u53d8\u7684\u9776\u5411\u6cbb\u7597\u3001\u8111\u8f6c\u79fb\u7684\u6cbb\u7597\u7b49\u3002<\/p>\n\n\n\n

\u4f17\u591a\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5c1d\u8bd5\u7a81\u7834\u8fd9\u4e9b\u6cbb\u7597\u74f6\u9888\uff1aACHIEVE\u7814\u7a76\u3001FURTHER\u7814\u7a76\u5747\u5c55\u73b0\u4e86\u9ad8\u5242\u91cf\u4e09\u4ee3EGFR-TKI\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u800cMARIPOSA\u7814\u7a76\u3001PAPILLON\u7814\u7a76\u5219\u5206\u522b\u8bc1\u5b9e\u4e86\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u2014\u2014\u57c3\u4e07\u59a5\u5355\u6297\uff08Amivantamab\uff09\u5728EGFR\u654f\u611f\u7a81\u53d8\u3001EGFR ex20ins\u7a81\u53d8\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u51fa\u8272\u7597\u6548\u548c\u826f\u597d\u5b89\u5168\u6027\uff0c\u8fd9\u610f\u5473\u7740\u57c3\u4e07\u59a5\u5355\u6297\u6709\u671b\u6210\u4e3a\u8fd9\u4e9b\u60a3\u8005\u7684\u6cbb\u7597\u65b0\u9009\u62e9\u3002<\/p>\n\n\n\n

\u57c3\u4e07\u59a5\u5355\u6297\u662f\u4e00\u79cd\u9776\u5411EGFR\u548cc-MET\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u4e3b\u8981\u901a\u8fc73\u4e2a\u6f5c\u5728\u7684\u4f5c\u7528\u673a\u5236\u6fc0\u53d1\u5176\u6297\u80bf\u7624\u6d3b\u6027\uff1a\u914d\u4f53\u963b\u65ad\u3001\u53d7\u4f53\u964d\u89e3\u3001\u514d\u75ab\u7ec6\u80de\u5bfc\u5411\u6d3b\u6027\uff0c\u201c\u4e0e\u4e24\u4e2a\u5355\u836f\u7684\u53e0\u52a0\u76f8\u6bd4\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u5b9e\u73b0\u4e861+1\uff1e2\u7684\u6548\u679c\uff0c\u540c\u65f6\u4e0d\u826f\u53cd\u5e94\u66f4\u5c0f\u3002<\/p>\n\n\n\n

\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5728EGFR\u7a81\u53d8NSCLC\u4e2d\u7684\u5e94\u7528<\/strong><\/p>\n\n\n\n

\u57c3\u4e07\u59a5\u5355\u6297\u4e0d\u4ec5\u9002\u7528\u4e8eEGFR\u654f\u611f\u7a81\u53d8NSCLC\uff0c\u66f4\u5728EGFR ex20ins\u7a81\u53d8\u4ee5\u53ca\u4e09\u4ee3EGFR-TKI\u8010\u836f\u540e\u7684\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u4e86\u5353\u8d8a\u7597\u6548\u3002<\/p>\n\n\n\n

\u5728\u4eca\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0cPAPILLON\u7814\u7a76[1]\u516c\u5e03\u4e86\u4e2d\u56fd\u60a3\u8005\u7684\u6570\u636e\u3002\u5bf9\u4e8e\u521d\u6cbb\u7684EGFR ex20ins\u7a81\u53d8\u665a\u671fNSCLC\u60a3\u8005\uff0c\u4e00\u7ebf\u57c3\u4e07\u59a5\u5355\u6297+\u5316\u7597\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u4e3a12.3\u4e2a\u6708\uff0c\u5355\u7eaf\u5316\u7597\u4e3a6.7\u4e2a\u6708\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u4e00\u7ebf\u57c3\u4e07\u59a5\u5355\u6297+\u5316\u7597\u8ba9\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\u4e0b\u964d\u4e8653%\uff08HR=0.47\uff09\u3002<\/p>\n\n\n\n

\u5728\u7f13\u89e3\u7387\u65b9\u9762\uff0c\u5bf9\u6bd4\u5355\u7eaf\u5316\u7597\u7ec4\u768448.9%\uff0c\u57c3\u4e07\u59a5\u5355\u6297+\u5316\u7597\u7ec4\u7684\u7f13\u89e3\u7387\u63d0\u9ad8\u5230\u4e8671.8%\u3002\u201c\u57fa\u4e8e\u4e2d\u56fd\u4e9a\u7ec4\u7684\u6570\u636e\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u5316\u7597\u672a\u6765\u4e5f\u4f1a\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u4ece\u800c\u4e3a\u4e2d\u56fdEGFR ex20ins\u7a81\u53d8\u665a\u671f\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9\u3002\u201d\u827e\u661f\u6d69\u6559\u6388\u8868\u793a\u3002\u800c\u65e9\u57282021\u5e74\uff0c\u57fa\u4e8eCHRYSALIS\u7814\u7a76\u7684\u6570\u636e\uff0cFDA\u5c31\u5df2\u83b7\u6279\u4e86\u57c3\u4e07\u59a5\u5355\u6297\u7528\u4e8eEGFR ex20ins\u7a81\u53d8\u665a\u671fNSCLC\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\u3002<\/p>\n\n\n\n

\u57282023\u5e74\u6b27\u6d32\u80ba\u764c\u5927\u4f1a\uff08ELCC\uff09\u4e0a\uff0cCHRYSALIS\u7814\u7a76[2]\u516c\u5e03\u4e86\u6700\u65b0\u7ed3\u679c\u3002\u5728114\u4f8b\u94c2\u7c7b\u5316\u7597\u540e\u53d1\u751f\u8fdb\u5c55\u7684EGFR ex20ins\u7a81\u53d8\u60a3\u8005\u4e2d\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u7ec4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09\u8fbe\u523023\u4e2a\u6708\uff0c47.2%\u7684\u60a3\u8005\u751f\u5b58\u671f\u8d85\u8fc72\u5e74\u3002<\/p>\n\n\n\n

\u5728\u6570\u636e\u622a\u6b62\u65f6\uff0c15\u4f8b\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597\uff0c\u8fd9\u610f\u5473\u7740\u4ed6\u4eec\u63a5\u53d7\u57c3\u4e07\u59a5\u5355\u6297\u6cbb\u7597\u8d85\u8fc7\u4e862\u5e74\u3002\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0c\u65e0\u8bba\u60a3\u8005\u7684\u65e2\u5f80\u6cbb\u7597\u7c7b\u578b\u5982\u4f55\uff0c\u63a5\u53d7\u57c3\u4e07\u59a5\u5355\u6297\u7684\u7f13\u89e3\u7387\u90fd\u8d85\u8fc7\u4e8640%\uff0c\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7EGFR-TKI\u7684\u60a3\u8005\u7f13\u89e3\u7387\u9ad8\u8fbe52.2%\u3002<\/p>\n\n\n\n

\u4e09\u4ee3EGFR-TKI\u8010\u836f\u540e\u7684\u6cbb\u7597\u65b0\u6807\u51c6<\/strong><\/p>\n\n\n\n

\u800c\u5bf9\u4e8eEGFR\u654f\u611f\u7a81\u53d8NSCLC\uff0c\u5373\u4f7f\u4e09\u4ee3EGFR-TKI\u663e\u8457\u6539\u5584\u4e86\u60a3\u8005\u7684\u9884\u540e\uff0c\u4f46EGFR\u7684\u83b7\u5f97\u6027\u8010\u836f\u5f80\u5f80\u4f1a\u5bfc\u81f4\u75be\u75c5\u51fa\u73b0\u8fdb\u5c55\u3002\u4ee4\u4eba\u6b23\u559c\u7684\u662f\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u5728\u4e09\u4ee3EGFR-TKI\u8010\u836f\u540e\u7684\u6cbb\u7597\u4e2d\u4e5f\u663e\u73b0\u51fa\u4e86\u524d\u6240\u672a\u6709\u7684\u7597\u6548\u7ed3\u679c\u3002<\/p>\n\n\n\n

MARIPOSA-2\u7814\u7a76\u662f\u4e00\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u7b56\u7565\u6cbb\u7597\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u540eNSCLC\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u30022023 ESMO Asia\u5927\u4f1a\u516c\u5e03\u4e86MARIPOSA-2\u7814\u7a76\u4e9a\u6d32\u4e9a\u7ec4\u7684\u5206\u6790\u7ed3\u679c\u3002\u57fa\u4e8e\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\uff08BICR\uff09\u8bc4\u4f30\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u7ec4\u76f8\u6bd4\uff0c\u57c3\u4e07\u59a5\u5355\u6297+\u5316\u7597\u663e\u8457\u6539\u5584\u4e86\u4e9a\u6d32\u60a3\u8005\u7684mPFS\uff084.2\u4e2a\u6708 vs 6.8\u4e2a\u6708\uff1bHR=0.54\uff09\u3002<\/p>\n\n\n\n

2024 ELCC\u62a5\u9053\u4e86MARIPOSA-2\u7814\u7a76\u75be\u75c5\u8fdb\u5c55\u540e\u7684\u60a3\u8005\u7ed3\u5c40\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u7eaf\u5316\u7597\u76f8\u6bd4\uff0c\u57c3\u4e07\u59a5\u5355\u6297+\u5316\u7597\u663e\u8457\u5ef6\u957f\u4e86\u4e2d\u4f4dTTD\u548c\u4e2d\u4f4dTTST\uff0c\u5206\u522b\u4e3a4.5\u4e2a\u6708 vs 11.0\u4e2a\u6708\uff08HR=0.37\uff1bP<0.0001\uff09\uff0c6.6\u4e2a\u6708 vs 12.1\u4e2a\u6708\uff08HR=0.42\uff1bP<0.0001\uff09\u3002<\/p>\n\n\n\n

\u4e0e\u5355\u7528\u5316\u7597\u76f8\u6bd4\uff0c\u57c3\u4e07\u59a5\u5355\u6297\u8054\u5408\u5316\u7597\u5448\u73b0\u51fa\u663e\u8457\u7684\u66f4\u4f18\u7ed3\u679c\uff0c\u53ef\u4f5c\u4e3aEGFR\u7a81\u53d8\u665a\u671fNSCLC\u60a3\u8005\u5728\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u8fdb\u5c55\u540e\u7684\u5168\u65b0\u6807\u51c6\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u57c3\u4e07\u59a5\u5355\u6297\u6cbb\u7597\u4e2a\u6848\u5206\u4eab<\/strong><\/p>\n\n\n\n

\n\n\u60a3\u8005\u80cc\u666f\u60c5\u51b5\n\n<\/p>\n\n\n\n

53\u5c81\u5973\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u5728\u9999\u6e2f\u7efc\u5408\u80bf\u7624\u4e2d\u5fc3\u6cbb\u7597\uff0c\u8be5\u60a3\u8005\u643a\u5e26EGFR L858R\u7a81\u53d8\uff0c\u5e76\u57282020\u5e74\u88ab\u8bca\u65ad\u51fa\u60a3\u6709\u80ba\u764c\u4f34\u6709\u9aa8\u8f6c\u79fb\u3002\u81ea2020\u5e74\u8d77\u63a5\u53d7\u963f\u7f8e\u66ff\u5c3c\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u4f46\u52302023\u5e74\u75c5\u60c5\u6301\u7eed\u8fdb\u5c55\uff08PD\uff09\u3002<\/p>\n\n\n\n

\u4e4b\u540e\u5c1d\u8bd5\u4e86\u57f9\u7f8e\u66f2\u585e\u3001\u5361\u94c2\u3001\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u7b49\u5316\u7597\u836f\u7269\u8fdb\u884c\u6cbb\u7597\uff0cCT\u663e\u793a\u80ba\u90e8\u3001L3\u690e\u4f53\u53ca\u9aa8\u76c6\u7ee7\u53d1\u6027\u75c5\u53d8\u7ee7\u7eed\u8fdb\u5c55\uff0c\u6ca1\u6709\u8111\u90e8\u8fdb\u5c55\u3002<\/p>\n\n\n\n

\u533b\u751f\u7684\u9996\u6b21\u5efa\u8bae\u4e0e\u8ddf\u8fdb<\/p>\n\n\n\n

2024\u5e744\u6708\uff0c\u5efa\u8bae\u4f7f\u7528\u591a\u897f\u4ed6\u8d5b\u548cPD-1\u6291\u5236\u5242\u6cbb\u7597\u30025\u6708\u65f6\uff0c\u60a3\u8005\u53d8\u5f97\u4f9d\u8d56\u6c27\u6c14\u4e14\u96be\u4ee5\u8010\u53d7\u591a\u897f\u4ed6\u8d5b\u6cbb\u7597\uff0cECOG\u8bc4\u5206\u4e3a3\u3002<\/p>\n\n\n\n

\u60a3\u8005\u4e3b\u6cbb\u533b\u751f\u8bc4\u4f30\u540e\u8ba4\u4e3a\u9002\u5408\u5f00\u59cb\u4f7f\u7528\u57c3\u4e07\u59a5\u5355\u6297\u8fdb\u884c\u6cbb\u7597\u3002\u60a3\u8005\u5728\u63a5\u53d7\u7b2c\u4e00\u6b21\u8f93\u6ce8\u540e\u56e0\u9700\u8981\u6c27\u6c14\u6cbb\u7597\u800c\u4f4f\u9662\uff0c\u4f46\u5728\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u540e\u51fa\u9662\uff0c\u5e76\u7ee7\u7eed\u95e8\u8bca\u8f93\u6ce8\u3002<\/p>\n\n\n\n

\u57c3\u4e07\u59a5\u5355\u6297\u6cbb\u7597\u540e\u7684\u8ddf\u8fdb<\/p>\n\n\n\n

\u5728\u63a5\u53d7\u6cbb\u7597\u4e00\u5468\u540e\uff0c\u60a3\u8005\u4e0d\u518d\u4f9d\u8d56\u6c27\u6c14\u3002<\/p>\n\n\n\n

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\u5927\u90e8\u5206IRRs\u53d1\u751f\u5728\u9996\u6b21\u8f93\u6ce8\u65f6\uff0c97%\u7684Amivantamab IRRs\u4e3a1-2\u7ea7\uff0c\u901a\u5e38\u572860\u5206\u949f\u5185\u81ea\u884c\u7f13\u89e3\u3002
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[1]Ke-Jing Tang, Baogang Liu, Yu Yao, et al. Amivantamab plus chemotherapy vs chemotherapy as first-line treatment among patients with EGFR exon 20 insertion\u2013mutated advanced non-small cell lung cancer (NSCLC): PAPILLON Chinese subgroup analysis. 2024 ASCO, 8606.
[2]Garrido Lopez P\uff0cet al. Long-term efficacy\uff0csafety\uff0cand predictors of response to amivantamab among patients with post-platinum EGFR Ex20ins-mutated advanced NSCLC.2023 ELCC, 3O. <\/p>\n\n\n\n

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