{"id":22560,"date":"2025-06-12T12:09:47","date_gmt":"2025-06-12T04:09:47","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=22560"},"modified":"2025-11-10T13:42:30","modified_gmt":"2025-11-10T05:42:30","slug":"asco-2025-%e9%87%8d%e7%a3%85%ef%bc%9a%e8%82%bf%e7%98%a4%e8%a3%82%e8%a7%a3%e7%97%85%e6%af%92-pelareorep-%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e8%83%b0%e8%85%ba%e7%99%8c%e4%b8%ad%e6%9c%9f%e6%95%b0","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/asco-2025-%e9%87%8d%e7%a3%85%ef%bc%9a%e8%82%bf%e7%98%a4%e8%a3%82%e8%a7%a3%e7%97%85%e6%af%92-pelareorep-%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e8%83%b0%e8%85%ba%e7%99%8c%e4%b8%ad%e6%9c%9f%e6%95%b0\/","title":{"rendered":"ASCO 2025 \u91cd\u78c5\uff1a\u80bf\u7624\u88c2\u89e3\u75c5\u6bd2 pelareorep \u4e00\u7ebf\u6cbb\u7597\u80f0\u817a\u764c\u4e2d\u671f\u6570\u636e\u516c\u5e03\uff0c\u603b\u7f13\u89e3\u7387\u8fbe 62%\uff01\u6216\u7a81\u7834\u514d\u75ab\u6cbb\u7597\u56f0\u5883"},"content":{"rendered":"\n<p>2025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a, \u6709Oncolytics Biotech\u516c\u53f8pelareorep (\u8fd9\u662f\u4e00\u79cd\u80bf\u7624\u88c2\u89e3\u75c5\u6bd2\uff0c\u5b83\u80fd\u9009\u62e9\u6027\u5730\u611f\u67d3\u548c\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u540c\u65f6\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u6765\u8fdb\u4e00\u6b65\u653b\u51fb\u80bf\u7624) \u516c\u5e03\u4f5c\u4e3a\u4e00\u7ebf\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u671f\u7ed3\u679c\u3002<\/p>\n\n\n\n<p>\u8fd9\u9879GOBLET\uff08\u80c3\u80a0\u9053\u80bf\u7624\u63a2\u7d22anti-retrovirus\u4e0e\u6297PD-L1\u8054\u5408\u6cbb\u7597\uff09\u7684\u65b0\u4e34\u5e8a\u6570\u636e\uff0c\u4ee3\u8868\u4e86\u80f0\u817a\u764c\u6cbb\u7597\u65b9\u9762\u4e00\u4e2a\u6f5c\u5728\u7684\u91cd\u8981\u7a81\u7834\u3002\u636e\u62a5\u9053\uff0c\u4e00\u7ebf\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u7684\u603b\u7f13\u89e3\u7387\u4e3a62%\uff0c\u4e0e\u6807\u51c6\u6cbb\u7597\u7684\u5386\u53f2\u7f13\u89e3\u7387\uff08\u901a\u5e38\u572820-30%\u5de6\u53f3\uff09\u76f8\u6bd4\uff0c\u8fd9\u4e00\u6570\u636e\u5c24\u5176\u503c\u5f97\u5173\u6ce8 \u3002<\/p>\n\n\n\n<p>\u80f0\u817a\u764c\u662f\u6700\u5177\u6311\u6218\u6027\u4e14\u81f4\u6b7b\u7387\u6781\u9ad8\u7684\u764c\u75c7\u7c7b\u578b\u4e4b\u4e00\uff0c\u521b\u65b0\u7684pelareorep\u88ab\u8bc1\u5b9e\u80fd\u591f\u5c06\u514d\u75ab\u201c\u51b7\u201d\u80bf\u7624\uff08\u901a\u5e38\u5bf9\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\uff09\u8f6c\u5316\u4e3a\u201c\u70ed\u201d\u80bf\u7624\u3002\u9019\u7a2e\u80bf\u7624\u88c2\u89e3\u75c5\u6bd2\u7684\u673a\u5236\u4e0a\u63ed\u793a\u4e86\u4e00\u4e2a\u591a\u6b65\u9aa4\u7684\u514d\u75ab\u6fc0\u6d3b\u8fc7\u7a0b\uff1a\u9996\u5148\u64f4\u5927\u5176anti-retrovirus\u75c5\u6bd2\u4e0a\u7684T\u7ec6\u80de\u7684\u653b\u51fb\u80fd\u529b\uff0c\u7136\u540e\u4e0a\u8c03\u8d8b\u5316\u56e0\u5b50\uff0c\u8bf1\u5bfc\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u514b\u9686\u7684\u6269\u589e\uff0c\u968f\u540e\u653b\u51fb\u80bf\u7624\u3002\u85c9\u7531\u80bf\u7624\u88c2\u89e3\u75c5\u6bd2\u6709\u9009\u62e9\u6027\u5730\u611f\u67d3\u548c\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u540c\u65f6\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u6765\u8fdb\u4e00\u6b65\u653b\u51fb\u5b9e\u4f53\u80bf\u7624, \u63d0\u4f9b\u4e86\u4e00\u4e2a\u6f5c\u5728\u7684\u6709\u6548\u89e3\u51b3\u514d\u75ab\u6cbb\u7597\u4e0d\u8db3\u7684\u65b9\u6848\u3002<\/p>\n\n\n\n<p>GOBLET Cohort 1\u6cbb\u7597\u7d44\u7814\u7a76 &#8211; \u5373\u4e00\u7ebf\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\u663e\u793a\u4e8685%\u75be\u75c5\u63a7\u5236\u7387\u548c45%\u768412\u4e2a\u6708\u751f\u5b58\u7387, \u5c3d\u7ba1\u8fd9\u4e9b\u662f\u6765\u81ea\u76f8\u5bf9\u8f83\u5c0f\u7684\u6cbb\u7597\u7d44\u65e9\u671f\u9636\u6bb5\u7ed3\u679c\uff0c\u4f46\u8fd9\u7ed3\u679c\u5b9e\u5728\u4ee4\u4eba\u9f13\u821e\u3002pelareorep\u4e0e\u6807\u51c6\u5316\u7597\uff08\u7eb3\u7c73\u7d2b\u6749\u9187nab-paclitaxel\u3001\u5409\u897f\u4ed6\u6ee8gemcitabine\uff09\u52a0\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08atezolizumab\uff09\u8054\u5408\u4f7f\u7528\uff0c\u6709\u53ef\u80fd\u6539\u5584\u5386\u53f2\u9884\u540e\u8f83\u5dee\u7684\u75be\u75c5\u7684\u6cbb\u7597\u7ed3\u679c\u3002\u6b64\u5916, \u57fa\u4e8e\u8840\u6db2\u7684TIL\u514b\u9686\u786e\u5b9a\u4e3a\u6f5c\u5728\u7684\u53cd\u5e94\u751f\u7269\u6807\u5fd7\u7269\u4e5f\u5177\u6709\u4e34\u5e8a\u4ef7\u503c\uff0c\u4ee5\u540e\u53ef\u80fd\u53ea\u9700\u8981\u901a\u8fc7\u5fae\u521b\u8840\u6db2\u91c7\u6837\u800c\u975e\u80bf\u7624\u6d3b\u68c0\u6765\u8fdb\u884c\u60a3\u8005\u9009\u62e9\u548c\u6cbb\u7597\u53cd\u5e94\u76d1\u6d4b\u3002&nbsp;<\/p>\n\n\n\n<p><strong>\u4e00\u3001\u8be5\u6b21\u516c\u62a5\u7684\u7814\u7a76\u7ed3\u679c\u91cd\u70b9<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Pelareorep\u542f\u52a8reovirus\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u6269\u589e\uff0c\u8fd9\u4e0e\u7b2c24\u5468\u65f6\u7684\u826f\u597d\u4e34\u5e8a\u53cd\u5e94\u76f8\u5173 &nbsp;<\/li>\n\n\n\n<li>Pelareorep\u589e\u52a0\u4e0e\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u76f8\u5173\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\uff0c\u4f7f\u6297\u75c5\u6bd2\u548c\u6297\u80bf\u7624T\u7ec6\u80de\u80fd\u591f\u653b\u51fb\u80bf\u7624<\/li>\n\n\n\n<li>\u6cbb\u7597\u524d\u8840\u6db2\u4e2d\u5b58\u5728TIL\u514b\u9686\uff0c\u4ee5\u53ca\u6cbb\u7597\u540e\u8840\u6db2\u4e2d\u8fd9\u4e9b\u514b\u9686\u7684\u6269\u589e\uff0c\u5747\u4e0e\u826f\u597d\u7684\u4e34\u5e8a\u53cd\u5e94\u76f8\u5173<\/li>\n\n\n\n<li>\u5148\u524d\u62a5\u9053\u7684GOBLET&nbsp;Cohort 1\u7684\u6cbb\u7597\u7ec4\u7ed3\u679c\u663e\u793a\uff0c\u5728\u8bc4\u4f30pelareorep\u3001\u7eb3\u7c73\u7d2b\u6749\u9187\u3001\u5409\u897f\u4ed6\u6ee8\u548c\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u4e00\u7ebf\u8f6c\u79fb\u6027PDAC\u60a3\u8005\u7684\u65b9\u6848\u4e2d\uff0c\u603b\u7f13\u89e3\u7387\u4e3a62%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a85%\uff0c12\u4e2a\u6708\u751f\u5b58\u7387\u4e3a45% &nbsp;<\/li>\n<\/ul>\n\n\n\n<p>\u672c\u7814\u7a76\u4e3a I\/II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e2d\u671f\u7ed3\u679c\uff0c\u76f8\u5173\u6cbb\u7597\u65b9\u6848\u5c1a\u672a\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\uff0c\u76ee\u524d\u6682\u672a\u5728\u4e34\u5e8a\u4e2d\u6b63\u5f0f\u63a8\u5e7f\u53ca\u4e0a\u5e02\u9500\u552e\u3002\u7814\u7a76\u6570\u636e\u4ec5\u53cd\u6620\u9636\u6bb5\u6027\u8fdb\u5c55\uff0c\u540e\u7eed\u7597\u6548\u53ca\u5b89\u5168\u6027\u4ecd\u9700\u66f4\u5927\u6837\u672c\u91cf\u548c\u957f\u671f\u968f\u8bbf\u9a8c\u8bc1\u3002&nbsp;<\/p>\n\n\n\n<p><strong>\u4e8c\u3001<\/strong><strong>\u5173\u4e8eGOBLET\u8bd5\u9a8c<\/strong><strong><\/strong><\/p>\n\n\n\n<p>GOBLET\uff08\u80c3\u80a0\u9053\u80bf\u7624\u63a2\u7d22reovirus &#8211; pelareorep\u4e0e\u6297PD-L1\u8054\u5408\u6cbb\u7597\uff09\u7814\u7a76\u662f\u4e00\u9879\u9488\u5bf9\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u80a0\u9053\u80bf\u7624\u76841\/2\u671f\u591a\u9002\u5e94\u75c7\u7814\u7a76\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u7b2c16\u5468\u8bc4\u4f30\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\/\u6216\u75be\u75c5\u63a7\u5236\u7387\uff0c\u4ee5\u53ca\u5b89\u5168\u6027\u3002\u5173\u952e\u7684\u6b21\u8981\u548c\u63a2\u7d22\u6027\u7ec8\u70b9\u5305\u62ec\u989d\u5916\u7684\u7597\u6548\u8bc4\u4f30\u548c\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u7684\u8bc4\u4f30\u3002\u8be5\u7814\u7a76\u5305\u62ec\u4e94\u4e2a\u6cbb\u7597\u7ec4\uff1a&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e00\u7ebf\u665a\u671f\/\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u4e2dpelareorep\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\u3001\u5409\u897f\u4ed6\u6ee8\u548c\u7eb3\u7c73\u7d2b\u6749\u9187 &nbsp;<\/li>\n\n\n\n<li>\u4e00\u7ebf\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u9ad8\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2dpelareorep\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297 &nbsp;<\/li>\n\n\n\n<li>\u4e09\u7ebf\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2dpelareorep\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\u548cTAS-102&nbsp;<\/li>\n\n\n\n<li>\u4e8c\u7ebf\u665a\u671f\u4e0d\u53ef\u5207\u9664\u809b\u95e8\u764c\u60a3\u8005\u4e2dpelareorep\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297&nbsp;<\/li>\n\n\n\n<li>\u65b0\u8bca\u65ad\u7684\u8f6c\u79fb\u6027PDAC\u60a3\u8005\u4e2dpelareorep\u8054\u5408\u6539\u826fFOLFIRINOX\u65b9\u6848\uff08\u542b\u6216\u4e0d\u542b\u963f\u66ff\u5229\u73e0\u5355\u6297\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a, \u6709Oncolytics Biotech\u516c\u53f8pelareorep<\/p>\n","protected":false},"author":4,"featured_media":22616,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1750],"tags":[],"yst_prominent_words":[],"class_list":["post-22560","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pancreatic-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/22560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=22560"}],"version-history":[{"count":3,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/22560\/revisions"}],"predecessor-version":[{"id":22574,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/22560\/revisions\/22574"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/22616"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=22560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=22560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=22560"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=22560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}