{"id":22809,"date":"2025-07-10T20:54:08","date_gmt":"2025-07-10T12:54:08","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=22809"},"modified":"2025-07-10T20:54:10","modified_gmt":"2025-07-10T12:54:10","slug":"%e6%9c%80%e7%88%b1%e8%ba%b2%e8%97%8f%e7%9a%84%e8%83%83%e8%82%a0%e9%97%b4%e8%b4%a8%e7%98%a4-%e8%bf%99%e7%a7%8d%e7%8b%a1%e7%8c%be%e6%80%8e%e4%b9%88","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e6%9c%80%e7%88%b1%e8%ba%b2%e8%97%8f%e7%9a%84%e8%83%83%e8%82%a0%e9%97%b4%e8%b4%a8%e7%98%a4-%e8%bf%99%e7%a7%8d%e7%8b%a1%e7%8c%be%e6%80%8e%e4%b9%88\/","title":{"rendered":"\u6700\u7231\u201c\u8eb2\u85cf\u201d\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u2014\u2014\u8fd9\u79cd\u201c\u72e1\u733e\u201d\u600e\u4e48\u6cbb\uff1f"},"content":{"rendered":"\n

Q1\u4ec0\u4e48\u662f\u80c3\u80a0\u95f4\u8d28\u7624\uff1f<\/strong><\/p>\n\n\n\n

\u80c3\u80a0\u95f4\u8d28\u7624\uff08Gastrointestinal Stromal Tumor\uff0c\u4ee5\u4e0b\u7b80\u79f0GIST\uff09\u662f\u4e00\u79cd\u8d77\u6e90\u4e8e\u95f4\u8d28\u7ec6\u80de\u7684\u8f6f\u7ec4\u7ec7\u8089\u7624\uff0c\u6700\u7231\u201c\u8eb2\u85cf\u201d\u7684\u90e8\u4f4d\u662f\u80c3\u548c\u5c0f\u80a0\uff0c\u4e5f\u53ef\u53d1\u751f\u4e8e\u80c3\u80a0\u9053\u5916\u3001\u7f51\u819c\u548c\u80a0\u7cfb\u819c\u7b49\u5904\u3002\u5c3d\u7ba1\u5c11\u89c1\uff0c\u7ea6\u5360\u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624\u76841%-3%\uff0c\u4f46\u4e2d\u56fd\u6bcf\u5e74\u53d1\u75c5\u4eba\u6570\u7ea6\u4e3a2-3\u4e07\u3002\u4e00\u822c\u7684\u53d1\u75c5\u5e74\u9f84\u572855–60\u5c81\uff0c\u7537\u5973\u53d1\u75c5\u7387\u63a5\u8fd1\u3002<\/p>\n\n\n\n

GIST\u65e9\u671f\u53ef\u80fd\u65e0\u75c7\u72b6\uff0c\u5927\u591a\u60a3\u8005\u90fd\u662f\u5728\u80c3\u4e0d\u8212\u670d\u3001\u80c3\u80c0\u3001\u80c3\u75bc\uff0c\u6216\u8fdb\u884c\u4f53\u68c0\u3001\u624b\u672f\u65f6\u53d1\u73b0\u7684\u3002\u5373\u4fbf\u51fa\u73b0\u4e86\u80c3\u80a0\u9053\u51fa\u8840\u3001\u8d2b\u8840\u3001\u8179\u90e8\u75bc\u75db\u7b49\u4e34\u5e8a\u75c7\u72b6\uff0c\u56e0\u4e3a\u4e0e\u5176\u4ed6\u6d88\u5316\u9053\u75be\u75c5\u76f8\u4f3c\uff0c\u533b\u751f\u6709\u65f6\u4e5f\u5f88\u96be\u8bca\u65ad\u3002<\/p>\n\n\n\n

Q2\u80c3\u80a0\u95f4\u8d28\u7624\u7684\u201c\u524d\u4e16\u4eca\u751f\u201d\u4f60\u4e86\u89e3\u5417\uff1f<\/strong><\/strong><\/p>\n\n\n\n

\u4ece\u53d1\u5c55\u5386\u7a0b\u6765\u770b\uff0c\u80c3\u80a0\u95f4\u8d28\u7624\uff08GIST\uff09\u65e0\u7591\u662f\u4e00\u79cd\u201c\u5e74\u8f7b\u201d\u7684\u80bf\u7624\u300220\u4e16\u7eaa60\u5e74\u4ee3\u4ee5\u524d\uff0c\u4eba\u4eec\u5728\u663e\u5fae\u955c\u4e0b\u770b\u5230\u8fd9\u7c7b\u80bf\u7624\u7684\u7ec6\u80de\u5f62\u6001\u5448\u201c\u68ad\u5f62\u201d\uff0c\u548c\u5e73\u6ed1\u808c\u53ca\u795e\u7ecf\u675f\u975e\u5e38\u76f8\u4f3c\uff0c\u4e00\u5ea6\u8ba4\u4e3a\u5b83\u662f\u5e73\u6ed1\u808c\u80bf\u7624\u6216\u795e\u7ecf\u6e90\u6027\u80bf\u7624\u30021983\u5e74\uff0c\u7ebd\u7ea6\u5dde\u7acb\u5927\u5b66\u6559\u6388Mazur\u9996\u6b21\u63d0\u51fa\u201c\u80c3\u80a0\u95f4\u8d28\u7624\u201d\u7684\u6982\u5ff5\u3002\u4f46GIST\u5bf9\u5316\u7597\u548c\u653e\u7597\u90fd\u4e0d\u654f\u611f\uff0c\u5f53\u65f6\u9664\u4e86\u624b\u672f\uff0c\u4eba\u4eec\u5bf9GIST\u4e00\u5ea6\u675f\u624b\u65e0\u7b56\u30021998\u5e74\uff0c\u65e5\u672c\u5b66\u8005Hirota\u7b49\u53d1\u73b0GIST\u7684\u53d1\u751f\u4e0ec-Kit\u57fa\u56e0\u7a81\u53d8\u76f8\u5173\uff0c\u4ece\u800c\u5c06GIST\u4ece\u201c\u5e73\u6ed1\u808c\u80bf\u7624\u201d\u3001\u201c\u795e\u7ecf\u6e90\u6027\u80bf\u7624\u201d\u4e2d\u533a\u5206\u51fa\u6765\u30022000\u5e74\uff0c\u7f8e\u56fd\u5b66\u8005Heinrich\u7b49\u62a5\u544a\uff0c\u5728c-Kit\u7a81\u53d8\u7f3a\u5931\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u4e2d\u51fa\u73b0\u4e86\u53ef\u6fc0\u6d3bPDGFR\u03b1\u53d7\u4f53\u57fa\u56e0\u7a81\u53d8\u3002<\/p>\n\n\n\n

Q3\u80c3\u80a0\u95f4\u8d28\u7624\u5982\u4f55\u6cbb\u7597\u5462\uff1f<\/strong><\/strong><\/p>\n\n\n\n

\u80c3\u80a0\u95f4\u8d28\u7624\uff08GIST\uff09\u5bf9\u4e8e\u5316\u7597\u548c\u653e\u7597\u90fd\u662f\u4e0d\u654f\u611f\u7684\uff0c\u9996\u9009\u624b\u672f\u5207\u9664\uff0c\u5bf9\u4e8e\u5c40\u90e8\u8fdb\u5c55\u6216\u4e0d\u53ef\u5207\u9664\u7684GIST\u53ef\u4f7f\u7528\u9776\u5411\u6cbb\u7597\uff0c\u5f85\u80bf\u7624\u7f29\u5c0f\u540e\u518d\u884c\u624b\u672f\u3002\u76ee\u524d\u5728\u4e2d\u56fd\u5df2\u4e0a\u5e02\u7684\u7528\u4e8eGIST\u9776\u5411\u6cbb\u7597\u7684\u836f\u7269\u6709\uff1a\u4f0a\u9a6c\u66ff\u5c3cImatinib\uff0c\u8212\u5c3c\u66ff\u5c3cSunitinib\uff0c\u745e\u6208\u975e\u5c3cRegorafenib\uff0c\u963f\u4f10\u66ff\u5c3cAvapritinib\u4ee5\u53ca\u745e\u6d3e\u66ff\u5c3cRipretinib\u3002\u5f53\u7136\u6bcf\u79cd\u836f\u7269\u7684\u9002\u5e94\u75c7\u4e5f\u5404\u6709\u4e0d\u540c\uff0c\u8be6\u89c1\u5982\u4e0b\uff1a<\/p>\n\n\n\n

1.<\/strong>2002\uff1aB2222\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

\u4f0a\u9a6c\u66ff\u5c3c<\/strong>\u83b7\u6279\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597Kit(CD117)\u9633\u6027<\/strong>\u4e0d\u53ef\u5207\u9664\u548c\/\u6216\u8f6c\u79fb\u6027\u7684\u6076\u6027GIST\u60a3\u8005\u3002<\/p>\n\n\n\n

2.<\/strong>2006\uff1aSTUDY-1\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

\u8212\u5c3c\u66ff\u5c3c<\/strong>\u83b7\u6279\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u5931\u8d25\u6216\u4e0d\u80fd\u8010\u53d7\u7684GIST\u60a3\u8005\u3002<\/p>\n\n\n\n

3.<\/strong>2013\uff1aGRID\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

\u745e\u6208\u975e\u5c3c<\/strong>\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u4f0a\u9a6c\u66ff\u5c3c\u53ca\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u7684\u3001\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u6216\u8f6c\u79fb\u6027\u7684GIST\u60a3\u8005\u3002<\/p>\n\n\n\n

4.<\/strong>2020.01\uff1aNAVIGATOR\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

\u963f\u4f10\u66ff\u5c3c<\/strong>\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u643a\u5e26PDGFRA\u57fa\u56e018\u53f7\u5916\u663e\u5b50\u7a81\u53d8\u7684\u4e0d\u53ef\u5207\u9664\u6027\u6216\u8f6c\u79fb\u6027GIST\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n

5.<\/strong>2020.05\uff1aINVICTUS\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

\u745e\u6d3e\u66ff\u5c3c<\/strong>\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc73\u79cd\u6216\u4ee5\u4e0aTKI\u5305\u62ec\u4f0a\u9a6c\u66ff\u5c3c)\u6cbb\u7597\u7684\u665a\u671fGIST\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n

6.<\/strong>2021<\/strong><\/strong><\/p>\n\n\n\n

\u745e\u6d3e\u66ff\u5c3c\u5728\u4e2d\u56fd\u83b7\u6279\u56db\u7ebf\u6cbb\u7597GIST<\/strong>\u3002<\/strong><\/strong><\/p>\n\n\n\n

Q4\u60a3\u8005\u65e5\u5e38\u5e94\u6ce8\u610f\u54ea\u4e9b\uff1f<\/strong><\/strong><\/p>\n\n\n\n

1.<\/strong>\u4f4e\u5371\u53ca\u6781\u4f4e\u5371\u60a3\u8005\uff1a<\/strong>\u5e94\u6bcf6\u4e2a\u6708\u8fdb\u884cCT\u6216MRI\u68c0\u67e5\uff0c\u6301\u7eed5\u5e74\uff1b<\/p>\n\n\n\n

2.<\/strong>\u4e2d\u3001\u9ad8\u5371\u60a3\u8005\uff1a<\/strong>\u6bcf3\u4e2a\u6708\u8fdb\u884cCT\u6216MRI\u68c0\u67e5\uff0c\u6301\u7eed3\u5e74\uff0c\u7136\u540e\u6bcf6\u4e2a\u67081\u6b21\uff0c\u76f4\u81f35\u5e74\uff1b<\/p>\n\n\n\n

3.<\/strong>\u5efa\u8bae\u6bcf\u5e74\u505a\u4e00\u6b21\u80f8\u90e8X\u5c04\u7ebf\u68c0\u67e5<\/strong>\uff0c\u6216\u5728\u51fa\u73b0\u80ba\u90e8\u548c\u9aa8\u8f6c\u79fb\u76f8\u5173\u75c7\u72b6\u65f6\u8fdb\u884cECT\u9aa8\u626b\u63cf<\/strong>\uff1b<\/p>\n\n\n\n

4.<\/strong>\u8f6c\u79fb\u590d\u53d1\/\u4e0d\u53ef\u5207\u9664\u6216\u672f\u524d\u6cbb\u7597\u8005\uff1a<\/strong>\u5f00\u59cb\u6cbb\u7597\u540e\u81f3\u5c11\u6bcf3\u4e2a\u6708\u968f\u8bbf\uff0c\u590d\u67e5\u589e\u5f3aCT\u6216MRI\uff0c\u5982\u6d89\u53ca\u6cbb\u7597\u51b3\u7b56\uff0c\u589e\u52a0\u968f\u8bbf\u6b21\u6570\uff1b<\/p>\n\n\n\n

5.<\/strong>\u8425\u517b\u6cbb\u7597\u5e94\u8d2f\u7a7fGIST\u8bca\u7597\u7684\u5168\u5468\u671f\uff0c\u5e76\u5efa\u8bae\u6709\u8425\u517b\u5e08\u5168\u7a0b\u53c2\u4e0e\u3002<\/strong>\u8865\u5145\u8425\u517b\u9996\u9009\u53e3\u670d\u65b9\u5f0f\uff0c\u5e94\u591a\u8fdb\u98df\u9ad8\u7ef4\u751f\u7d20\u3001\u4f4e\u8102\u80aa\u3001\u6613\u6d88\u5316\u7684\u98df\u7269\uff0c\u591a\u98df\u7528\u4f18\u8d28\u86cb\u767d\u5982\u86cb\u3001\u725b\u5976\u3001\u9c7c\u3001\u7626\u8089\u7b49\u3002\u65e0\u6cd5\u53e3\u670d\u53ef\u9009\u7528\u5168\u80a0\u5185\u8425\u517b\uff08TEN\uff09\u3001\u90e8\u5206\u80a0\u5916\u8425\u517b\uff08PPN\uff09\u3001\u5168\u80a0\u5916\u8425\u517b\uff08TPN\uff09\u7b49\u8425\u517b\u652f\u6301\u65b9\u6848\uff1b<\/p>\n\n\n\n

6.<\/strong>\u9002\u5f53\u8fd0\u52a8<\/strong>\uff0c\u5728GIST\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u60a3\u8005\u5e38\u51fa\u73b0\u75b2\u4e4f\u3001\u7126\u8651\u3001\u6291\u90c1\u7b49\u5fc3\u7406\u95ee\u9898\uff0c\u800c\u89c4\u5f8b\u8fd0\u52a8\u53ef\u7f13\u89e3\u75b2\u4e4f\u611f\uff0c\u51cf\u8f7b\u5fc3\u7406\u56f0\u6270\u3001\u6291\u90c1\u7a0b\u5ea6\uff0c\u63d0\u9ad8\u8eab\u4f53\u673a\u80fd\u548c\u751f\u6d3b\u8d28\u91cf\u3002<\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/em><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Q1\u4ec0\u4e48\u662f\u80c3\u80a0\u95f4\u8d28\u7624\uff1f \u80c3\u80a0\u95f4\u8d28\u7624\uff08Gastrointestinal Stromal Tumor\uff0c\u4ee5\u4e0b\u7b80\u79f0GI<\/p>\n","protected":false},"author":14,"featured_media":22819,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1756],"tags":[],"yst_prominent_words":[],"class_list":["post-22809","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-stomach-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/22809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=22809"}],"version-history":[{"count":2,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/22809\/revisions"}],"predecessor-version":[{"id":22811,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/22809\/revisions\/22811"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/22819"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=22809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=22809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=22809"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=22809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}