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2019\u5e74\uff0c\u6cd5\u56fd\u5df4\u9eceGustave Roussy\u533b\u9662\u7684\u4e00\u5f20CT\u5f71\u50cf\u5bf9\u6bd4\u56fe\u5728\u80bf\u7624\u5b66\u754c\u5f15\u53d1\u8f70\u52a8\uff1a\u4e00\u4f4d\u5386\u7ecf\u5316\u7597\u3001\u514d\u75ab\u6cbb\u7597\u5747\u544a\u5931\u8d25\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u5728\u5165\u7ec4\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff08T-DXd\uff09\u4e34\u5e8a\u8bd5\u9a8c\u540e\uff0c\u5168\u8eab\u8f6c\u79fb\u75c5\u7076\u4ec52\u4e2a\u6708\u4fbf\u663e\u8457\u7f29\u5c0f\uff0c\u9885\u5185\u75c5\u7076\u8fbe\u5230\u5f71\u50cf\u5b66\u660e\u663e\u7f13\u89e3\uff0c\u540e\u7eed\u5efa\u8bae\u957f\u671f\u968f\u8bbf\u89c2\u5bdf\u3002\u8fd9\u5f20\u5f71\u50cf\u8ba9\u4e34\u5e8a\u533b\u751f\u770b\u5230\u4e86\u80ba\u764c\u7cbe\u51c6\u6cbb\u7597\u7684\u5168\u65b0\u53ef\u80fd\u3002<\/p>\n\n\n\n

\u4e09\u4e2a\u5173\u952e\u8bcd\uff0c\u5feb\u901f\u4e86\u89e3ADC\u836f\u7269<\/strong><\/strong><\/p>\n\n\n\n

ADC\u7684\u5168\u79f0\u662f\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff08antibody-drug conjugate\uff09\uff0c\u662f\u4e00\u7c7b\u7531\u8fde\u63a5\u5b50\u5c06\u6297\u4f53\u548c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\uff08\u6709\u6548\u8f7d\u8377\uff09\u7ec4\u5408\u5728\u4e00\u8d77\u7684\u9776\u5411\u751f\u7269\u836f\u5242\u3002ADC\u7684\u6bcf\u4e2a\u7ec4\u6210\u90e8\u5206\u90fd\u53d1\u6325\u7740\u4e0d\u540c\u7684\u529f\u80fd\uff1a<\/p>\n\n\n\n

\u7cbe\u51c6\u9776\u5411\uff1a\u6297\u4f53<\/strong>\u90e8\u5206\u662fADC\u836f\u7269\u7684\u4e3b\u4f53\u6846\u67b6\u7ed3\u6784\u548c\u5bfc\u822a\u7cfb\u7edf\uff0c\u8d1f\u8d23\u5c06ADC\u5206\u5b50\u9009\u62e9\u6027\u5730\u9012\u9001\u81f3\u80bf\u7624\u7ec6\u80de\u8868\u9762\uff0c\u540c\u65f6\u901a\u8fc7\u9776\u70b9\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u8fdb\u5165\u5230\u7ec6\u80de\u5185\u3002<\/p>\n\n\n\n

\u5b89\u5168\u4f20\u9012\uff1a\u8fde\u63a5\u5b50<\/strong>\u8d1f\u8d23\u5728\u80bf\u7624\u7ec6\u80de\u5185\u6216\u8005\u8868\u9762\u9ad8\u6548\u91ca\u653e\u6bd2\u7d20\u5c0f\u5206\u5b50\uff0c\u5176\u5316\u5b66\u6027\u8d28\u51b3\u5b9a\u4e86\u6bd2\u7d20\u5c0f\u5206\u5b50\u5982\u4f55\u53ca\u4f55\u65f6\u91ca\u653e\u51fa\u6765\u3002\u8fde\u63a5\u5b50\u7684\u7a33\u5b9a\u6027\u51b3\u5b9a\u4e86ADC\u836f\u7269\u4e2d\u7684\u6bd2\u7d20\u5c0f\u5206\u5b50\u662f\u4f20\u9012\u5230\u80bf\u7624\u7ec6\u80de\u5185\u90e8\uff0c\u8fd8\u662f\u6709\u53ef\u80fd\u5728\u8fd0\u8f93\u8fc7\u7a0b\u4e2d\u8fc7\u65e9\u91ca\u653e\u5e76\u8ddf\u968f\u8840\u6d46\u4f20\u9012\u5230\u5176\u4ed6\u7ec4\u7ec7\u800c\u4ea7\u751f\u6bd2\u6027\u3002\u8fde\u63a5\u5b50\u7684\u7a33\u5b9a\u6027\u663e\u8457\u5f71\u54cdADC\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n\n\n\n

\u9ad8\u6548\u6740\u4f24\uff1a\u7ec6\u80de\u6bd2\u6027\u836f\u7269<\/strong>\u662fADC\u5185\u5316\u5230\u764c\u7ec6\u80de\u540e\u53d1\u6325\u7ec6\u80de\u6bd2\u6027\u3001\u6467\u6bc1\u764c\u7ec6\u80de\u7684\u5f39\u5934\uff0c\u53ef\u5b9e\u73b0\u5bf9\u764c\u7ec6\u80de\u7684\u9ad8\u6548\u6e05\u9664\u3002<\/p>\n\n\n\n

\u7cbe\u51c6\u9776\u5411\u80ba\u764c\uff0cADC\u836f\u7269\u7684\u6cbb\u7597\u9769\u547d<\/strong><\/strong><\/p>\n\n\n\n

\u867d\u7136\u5168\u8eab\u5316\u7597\u3001\u9776\u5411\u6cbb\u7597\u548c\u514d\u75ab\u7597\u6cd5\u53ef\u4ee5\u6cbb\u7597\u665a\u671f\u80ba\u764c\uff0c\u4f46\u8bb8\u591a\u60a3\u8005\u6700\u7ec8\u4f1a\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3002\u73b0\u5728\uff0cADC\u8fd9\u4e00\u65b0\u5174\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6cd5\uff0c\u901a\u8fc7\u5c06\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u76f4\u63a5\u9012\u9001\u5230\u764c\u7ec6\u80de\uff0c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u8131\u9776\u6548\u5e94\uff0c\u4e3a\u80ba\u764c\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6709\u5e0c\u671b\u7684\u65b0\u6cbb\u7597\u9009\u62e9\uff08Tawfiq RK 2025\uff09\u3002<\/p>\n\n\n\n

ADC\u836f\u7269\u7684\u6cbb\u7597\u4f18\u52bf\u4e3b\u8981\u8868\u73b0\u5728\uff1a<\/strong><\/strong><\/p>\n\n\n\n

\u2022 ADC\u836f\u7269\u5355\u9776\u70b9\u7279\u5f02\u6027\u7ed3\u5408\u4f7f\u8131\u9776\u6bd2\u6027\u663e\u8457\u964d\u4f4e\uff0c\u6cbb\u7597\u7a97\u53e3\u5927\u5e45\u62d3\u5bbd\u3002<\/p>\n\n\n\n

\u2022 \u7ec6\u80de\u6bd2\u7d20\u5728\u80bf\u7624\u5c40\u90e8\u7684\u9ad8\u6d53\u5ea6\u91ca\u653e\uff0c\u65e2\u589e\u5f3a\u4e86\u6740\u4f24\u6548\u529b\uff0c\u53c8\u907f\u514d\u4e86\u836f\u7269\u4f24\u5bb3\u8eab\u4f53\u6b63\u5e38\u7ec6\u80de\u3002<\/p>\n\n\n\n

\u2022 \u5f53\u67d0\u4e9bADC\u836f\u7269\u91ca\u653e\u7684\u6709\u6548\u8f7d\u8377\u5177\u6709\u6e17\u900f\u6027\u6216\u8de8\u819c\u6027\u65f6\uff0c\u8fd8\u53ef\u80fd\u8bf1\u53d1\u65c1\u89c2\u8005\u6548\u5e94*\uff0c\u4ece\u800c\u589e\u5f3aADC\u7684\u7597\u6548\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u836f\u7269\u7684\u65c1\u89c2\u8005\u6548\u5e94\u4e5f\u53ef\u80fd\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u589e\u5f3aADC\u7684\u6740\u4f24\u4f5c\u7528\u3002<\/p>\n\n\n\n

*\u65c1\u89c2\u8005\u6548\u5e94\uff1aADC\u7684\u65c1\u89c2\u8005\u6548\u5e94\u662f\u6307\u67d0\u4e9bADC\u836f\u7269\u80fd\u591f\u5c06\u6709\u6548\u8f7d\u8377\u4ece\u6297\u539f\u9633\u6027\u80bf\u7624\u7ec6\u80de\u6269\u6563\u5230\u90bb\u8fd1\u7684\u6297\u539f\u9634\u6027\u80bf\u7624\u7ec6\u80de\uff0c\u4ece\u800c\u589e\u5f3a\u6297\u80bf\u7624\u6d3b\u6027\u3002\u8fd9\u79cd\u6548\u5e94\u4f7f\u5f97ADC\u5373\u4f7f\u5728\u9776\u6297\u539f\u8868\u8fbe\u4e0d\u5747\u5300\u7684\u80bf\u7624\u4e2d\u4e5f\u80fd\u53d1\u6325\u4f5c\u7528\uff0c\u56e0\u4e3a\u6709\u6548\u8f7d\u8377\u53ef\u4ee5\u4ece\u7ed3\u5408\u4e86ADC\u7684\u6297\u539f\u9633\u6027\u7ec6\u80de\u6269\u6563\u5230\u90bb\u8fd1\u7684\u6297\u539f\u9634\u6027\u7ec6\u80de\uff0c\u8fdb\u800c\u6740\u6b7b\u5b83\u4eec\u3002<\/p>\n\n\n\n

\u6210\u529f\u7684ADC\u836f\u7269\u5f00\u53d1\u4f9d\u8d56\u4e8e\u9009\u62e9\u6b63\u786e\u7684\u6297\u539f\u9776\u70b9\u548c\u8bbe\u8ba1\u7cbe\u786e\u7684\u6297\u4f53\uff0c\u7406\u60f3\u7684\u9776\u70b9\u662f\u5728\u764c\u7ec6\u80de\u4e0a\u9ad8\u5ea6\u8868\u8fbe\uff0c\u800c\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u8f83\u4f4e\u3002\u76ee\u524d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u70ed\u95e8\u9776\u70b9\u4e3b\u8981\u5305\u62ecHER2\u3001TROP2\u3001c-MET\u548cEGFR\u7b49\uff0cHER2\u7684\u4f4e\u5185\u5316\u548c\u964d\u89e3\u7387\u4f7f\u5176\u6210\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e3b\u8981ADC\u9776\u70b9\uff08Tawfiq RK 2025\uff09\u3002<\/p>\n\n\n\n

\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u662f\u5168\u7403\u9996\u4e2a\u80ba\u764c\u9886\u57df\u9776\u5411HER2\u7684ADC\u836f\u7269\u3002\u8be5\u836f\u7269\u91c7\u7528\u9ad8\u6d3b\u6027\u8f7d\u836f\u7cfb\u7edf\u4e0e\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u6280\u672f\uff0c\u5c06\u4eba\u6e90\u5316HER2\u5355\u514b\u9686\u6297\u4f53\u4e0e\u6bd2\u7d20\u5c0f\u5206\u5b50\uff08DXd\uff09\u7ed3\u5408\uff0c\u5177\u5907\u7cbe\u51c6\u9776\u5411\u548c\u9ad8\u6548\u4f4e\u6bd2\u7684\u53cc\u91cd\u4f18\u52bf\u3002\u901a\u8fc7\u91c7\u7528\u534a\u80f1\u6c28\u9178\u5076\u8054\uff0c\u836f\u7269\u6297\u4f53\u6bd4\uff08DAR\uff09\u8fbe\u5230\u7406\u8bba\u4e0a\u6700\u9ad8\u503c8\uff1a1\u3002\u76f8\u6bd4\u65e9\u671f\u7814\u53d1\u7684ADC\uff0c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u5177\u6709\u9ad8\u5ea6\u7a33\u5b9a\u6027\uff0c\u76f4\u5230\u88ab\u764c\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\u7684\u80bd\u5185\u5316\u5e76\u9009\u62e9\u6027\u88c2\u89e3\uff0c\u4ece\u800c\u91ca\u653e\u51fa\u5f3a\u6548\u7684\u6709\u6548\u8f7d\u8377\u6765\u8bf1\u5bfcDNA\u635f\u4f24\u548c\u7ec6\u80de\u51cb\u4ea1\uff0c\u5e76\u53ef\u5bf9\u90bb\u8fd1\u7684\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u201c\u65c1\u89c2\u8005\u201d\u6740\u4f24\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u9664\u4e86\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5916\uff0c\u66f4\u591a\u9488\u5bf9\u80ba\u764c\u7684ADC\u836f\u7269\u6b63\u5728\u8fce\u6765\u7a81\u7834\uff0c\u6216\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u52a0\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n\n\n\n

\u6311\u6218\u72b9\u5b58\uff0c\u672a\u6765\u53ef\u671f\u2014\u2014ADC\u836f\u7269\u5728\u80ba\u764c\u9886\u57df\u7684\u53d1\u5c55\u65b9\u5411<\/strong><\/strong><\/p>\n\n\n\n

ADC\u836f\u7269\u7684\u672a\u6765\u6b63\u6cbf\u7740\u4e00\u6761\u6e05\u6670\u7684\u53d1\u5c55\u8f68\u8ff9\u6f14\u8fdb\uff0c\u4f46\u73b0\u5b58\u7684\u6311\u6218\u4e9f\u5f85\u89e3\u51b3\u3002\u5982\u80bf\u7624\u6297\u539f\u8868\u8fbe\u5f02\u8d28\u6027\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u4e0d\u4e00\u81f4\u7684\u53cd\u5e94\u548c\u6cbb\u7597\u7ed3\u679c\u3002\u5176\u4ed6\u7684\u91cd\u8981\u6311\u6218\u8fd8\u5305\u62ec\u4e0d\u826f\u53cd\u5e94\u548c\u6cbb\u7597\u8010\u836f\u6027\u7b49\u3002\u56e0\u6b64ADC\u836f\u7269\u5728\u80ba\u764c\u9886\u57df\u7684\u53d1\u5c55\u65b9\u5411\u4e3b\u8981\u96c6\u4e2d\u5728\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a<\/p>\n\n\n\n

\u5f00\u53d1\u65b0\u7684\u9776\u70b9<\/strong> <\/strong><\/strong><\/p>\n\n\n\n

\u5728ADC\u836f\u7269\u7684\u9776\u70b9\u9009\u62e9\u65b9\u9762\uff0c\u9664\u4e86\u80bf\u7624\u7ec6\u80de\u8868\u9762\u9776\u70b9\u5916\uff0c\u80bf\u7624\u5fae\u73af\u5883\u7684\u9776\u70b9\u662f\u8be5\u9886\u57df\u7684\u65b0\u70ed\u70b9\u4e4b\u4e00\u3002\u6b64\u7c7b\u9776\u70b9\uff0c\u56e0\u5176\u5206\u5e03\u5728\u80bf\u7624\u7ec4\u7ec7\u5468\u56f4\uff0c\u6bd4\u80bf\u7624\u7ec4\u7ec7\u66f4\u5bb9\u6613\u4ece\u8840\u6db2\u5faa\u73af\u63a5\u89e6\u5230ADC\u5206\u5b50\u3002\u9664\u4e86\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6548\u679c\u5916\uff0c\u4ea7\u751f\u8010\u836f\u6027\u7684\u53ef\u80fd\u6027\u4e5f\u53ef\u964d\u4f4e\u3002<\/p>\n\n\n\n

\u4ece\u5355\u836f\u7a81\u7834\u8d70\u5411\u8054\u5408\u589e\u6548<\/strong><\/strong><\/p>\n\n\n\n

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