{"id":23831,"date":"2025-10-03T14:24:47","date_gmt":"2025-10-03T06:24:47","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=23831"},"modified":"2025-11-14T11:54:12","modified_gmt":"2025-11-14T03:54:12","slug":"%e8%84%82%e8%b4%a8%e4%bd%93%e4%bc%8a%e7%ab%8b%e6%9b%bf%e5%ba%b7%e7%94%a8%e4%ba%8e%e6%97%a2%e5%be%80%e6%8e%a5%e5%8f%97%e8%bf%87%e6%b2%bb%e7%96%97%e7%9a%84%e8%83%86%e7%ae%a1%e7%99%8c%e6%82%a3%e8%80%85","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e8%84%82%e8%b4%a8%e4%bd%93%e4%bc%8a%e7%ab%8b%e6%9b%bf%e5%ba%b7%e7%94%a8%e4%ba%8e%e6%97%a2%e5%be%80%e6%8e%a5%e5%8f%97%e8%bf%87%e6%b2%bb%e7%96%97%e7%9a%84%e8%83%86%e7%ae%a1%e7%99%8c%e6%82%a3%e8%80%85\/","title":{"rendered":"\u8102\u8d28\u4f53\u4f0a\u7acb\u66ff\u5eb7\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u80c6\u7ba1\u764c\u60a3\u8005\uff1aNIFTY\u4e0eNALIRICC\u8bd5\u9a8c\u7684\u6c47\u603b\u5206\u6790"},"content":{"rendered":"\n

\u672c\u6587\u62a5\u9053\u5c06\u5e26\u5927\u5bb6\u4e86\u89e3\u4e00\u9879\u6c47\u603b\u5206\u6790\uff1a\u7814\u7a76\u4eba\u5458\u5bf9\u4e24\u9879\u8bd5\u9a8c\u8fdb\u884c\u4e86\u60a3\u8005\u4e2a\u4f53\u6c34\u5e73\u7684\u6570\u636e\u6c47\u603b\u5206\u6790\uff0c\u6bd4\u8f83\u665a\u671f\u80c6\u7ba1\u764c\u60a3\u8005\u5728\u4e00\u7ebf\u5409\u897f\u4ed6\u6ee8\u5316\u7597\u8fdb\u5c55\u540e\uff0c\u4f7f\u7528nal-IRI\u8054\u54085-FU\/LV\u4e0e\u5355\u75285-FU\/LV\u5728\u7597\u6548\u548c\u5b89\u5168\u6027\u65b9\u9762\u7684\u7ed3\u679c\u3002<\/p>\n\n\n\n

\u80c6\u7ba1\u764c\uff08BilliaryTractCancer,BTC\uff09\u5206\u4e3a\u809d\u5185\u548c\u809d\u5916\u80c6\u7ba1\u764c\u4ee5\u53ca\u80c6\u56ca\u764c\u3002\u5c5e\u4e8e\u6076\u6027\u80bf\u7624\uff0c\u4e14\u5177\u6709\u590d\u6742\u7684\u4e34\u5e8a\u3001\u5206\u5b50\u7279\u5f81\u4ee5\u53ca\u4fb5\u7565\u6027\uff0c\u901a\u5e38\u5bfc\u81f4\u9884\u540e\u4e0d\u826f\u3002\u5168\u8eab\u6cbb\u7597\u4ecd\u7136\u662f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u665a\u671f\u80c6\u7ba1\u764c\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u987a\u94c2\uff08Gemcitabinepluscisplatin,GemCis\uff09\u5df2\u4f5c\u4e3a\u4e00\u7ebf\u5168\u8eab\u6cbb\u7597\u7684\u6807\u51c6\u65b9\u6848\u5df2\u5e94\u7528\u4e86\u5341\u591a\u5e74\uff0c\u76f4\u5230\u6700\u8fd1\u7684TOPAZ-1\u548cKeynote-966III\u671f\u8bd5\u9a8c\u8868\u660e\uff0c\u5728GemCis\u4e2d\u8054\u5408\u6297PD-L1\uff08\u5ea6\u4f10\u5229\u5c24\u5355\u6297durvalumab\uff09\u6216\u6297PD-1\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297pembrolizumab\uff09\u53ef\u663e\u8457\u6539\u5584\u4e00\u7ebf\u6cbb\u7597\u7684\u603b\u751f\u5b58\u671f\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u8fd9\u4e9b\u8fdb\u5c55\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u6700\u7ec8\u4ecd\u4f1a\u9762\u5bf9\u590d\u53d1\u6216\u75c5\u60c5\u8fdb\u5c55\u7684\u60c5\u51b5\u3002<\/p>\n\n\n\n

\u591a\u5e74\u6765\uff0c\u4e8c\u7ebf\u53ca\u540e\u7eed\u6cbb\u7597\u65b9\u6848\u7684\u5408\u7406\u6027\u57fa\u4e8e\u5c0f\u578b\u524d\u77bb\u6027\u548c\u56de\u987e\u6027\u7814\u7a76\uff0c\u76f4\u5230III\u671fABC-06\u8bd5\u9a8c\u8bc1\u660e\uff0c\u4f7f\u7528\u6c1f\u5c3f\u5627\u5576\u548c\u4e9a\u53f6\uff08fluorouracil&leucovorin,5-FU\/LV\uff09\u8054\u5408\u5965\u6c99\u5229\u94c2\uff08oxaliplatin\uff09\uff08\u4ee5\u4e0a\u79f0FOLFOX\u5316\u7597\u65b9\u6848\uff09\uff0c\u4e0e\u4f7f\u7528\u79ef\u6781\u75c7\u72b6\u63a7\u5236\u6cbb\u7597\u76f8\u6bd4\uff0cFOLFOX\u5316\u7597\u65b9\u6848\u5728\u603b\u751f\u5b58\u671f\uff08OS\uff09\u65b9\u9762\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u83b7\u76ca\u3002\u6b64\u540e\uff0cFOLFOX\u88ab\u56fd\u5bb6\u548c\u56fd\u9645\u6307\u5357\u5e7f\u6cdb\u91c7\u7eb3\u4e3a\u4e8c\u7ebf\u6cbb\u7597\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u7279\u522b\u662f\u5e94\u7528\u5728\u7f3a\u4e4f\u53ef\u64cd\u4f5c\u9776\u70b9\uff08\u5982IDH-1\u7a81\u53d8\u3001FGFR2\u57fa\u56e0\u878d\u5408\u6216HER2\u6269\u589e\/\u8fc7\u8868\u8fbe\uff09\u7684\u75c5\u4eba\u5f53\u4e2d\u3002<\/p>\n\n\n\n

\u5728III\u671fNAPOLI-1\u8bd5\u9a8c\u4e4b\u540e\uff0c\u8102\u8d28\u4f53\u4f0a\u7acb\u66ff\u5eb7\uff08Liposomalirinotecan,nal-IRI\uff09\u8054\u54085-FU\/LV\u83b7\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u6cbb\u7597\u8fdb\u5c55\u7684\u665a\u671f\u80f0\u817a\u764c\u60a3\u8005\u3002\u8fd9\u79cd\u8054\u5408\u5316\u7597\u968f\u540e\u88ab\u7528\u4e8e\u665a\u671fBTC\u60a3\u8005\u7684\u7814\u7a76\u3002\u4e24\u9879\u968f\u673a\u8bd5\u9a8c\uff0c\u97e9\u56fd\u7684NIFTY\u8bd5\u9a8c\u548c\u5fb7\u56fd\u7684NALIRICC\u8bd5\u9a8c\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u65b9\u6848\u6cbb\u7597\u7684\u665a\u671fBTC\u60a3\u8005\u4e2d\u6bd4\u8f83\u4e86nal-IRI\u8054\u54085-FU\/LV\u4e0e5-FU\/LV\u7684\u7597\u6548\u3002<\/p>\n\n\n\n

\u867d\u7136\u97e9\u56fd\u7684NIFTY\u8bd5\u9a8c\u53d6\u5f97\u4e86\u9633\u6027\u7ed3\u679c\uff0c\u4f46\u5fb7\u56fd\u7684NALIRICC\u8bd5\u9a8c\u5374\u5f97\u51fa\u4e86\u9634\u6027\u7ed3\u679c\u3002\u4e3a\u4e86\u8c03\u67e5\u8fd9\u4e9b\u77db\u76fe\u7ed3\u679c\u7684\u6f5c\u5728\u539f\u56e0\uff0c\u5e76\u5728\u66f4\u5927\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u660e\u786e\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4e00\u9879\u7efc\u5408\u6c47\u603b\u5206\u6790\u3002<\/p>\n\n\n\n

\u5728\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5bf9NIFTY\u548cNALIRICC\u8bd5\u9a8c\u8fdb\u884c\u4e86\u4e2a\u4f53\u60a3\u8005\u6c34\u5e73\u7684\u6c47\u603b\u5206\u6790\uff0c\u4ee5\u6bd4\u8f83\u665a\u671fBTC\u60a3\u8005\u5728\u4e00\u7ebf\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u5316\u7597\u8fdb\u5c55\u540e\uff0c\u7814\u7a76nal-IRI\u8054\u54085-FU\/LV\u4e0e\u5355\u72ec5-FU\/LV\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7ed3\u679c\u3002<\/p>\n\n\n\n

\u672c\u6587\u65e8\u5728\u62a5\u9053\u8be5\u6c47\u603b\u5206\u6790\u7684\u7ed3\u679c<\/strong><\/p>\n\n\n\n

\u65b9\u6cd5<\/strong>\uff1a<\/strong><\/strong><\/p>\n\n\n\n

\u4eceNIFTY\u548cNALIRICC\u8bd5\u9a8c\u7684\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\u4e2d\u6c47\u603b\u4e2a\u4f53\u60a3\u8005\u6570\u636e\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u662f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c<\/strong>\uff1a<\/strong><\/strong><\/p>\n\n\n\n

\u5171\u7eb3\u5165278\u4f8b\u60a3\u8005\uff1anal-IRI\u8054\u54085-FU\/LV\u7ec4137\u4f8b\uff0c5-FU\/LV\u7ec4141\u4f8b\u3002nal-IRI\u8054\u54085-FU\/LV\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u663e\u8457\u66f4\u957f\uff0c\u4e3a3.6\u4e2a\u6708\uff0c\u800c5-FU\/LV\u7ec4\u4e3a1.8\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u5206\u522b\u4e3a8.1\u4e2a\u6708\u548c6.1\u4e2a\u6708\u3002nal-IRI\u8054\u54085-FU\/LV\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u4e5f\u9ad8\u4e8e5-FU\/LV\u7ec4\u3002<\/p>\n\n\n\n

\u7814\u7a76\u540e\u63a5\u53d7\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u7684\u60a3\u8005\u5728nal-IRI\u8054\u54085-FU\/LV\u7ec4\u548c5-FU\/LV\u7ec4\u4e2d\u5206\u522b\u67094\u4f8b\uff082.9%\uff09\u548c21\u4f8b\u51fa\u73b0\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5f53\u4e2d\u5b58\u5728\u75c5\u4eba\u79cd\u65cf\u5dee\u5f02\uff1b\u4f8b\u5982\u5fb7\u56fd\u4eba\u66f4\u5e38\u89c1\u80c3\u80a0\u9053\u6bd2\u6027\uff0c\u97e9\u56fd\u4eba\u66f4\u5e38\u89c1\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff1b\u56e0\u75c5\u60c5\u8fdb\u5c55\u800c\u8981\u4e2d\u65ad\u6cbb\u7597\u5206\u522b\u53d1\u751f\u572831.3%\u548c8.0%\u7684\u60a3\u8005\u4e2d\u3002<\/p>\n\n\n\n

\u7ed3\u8bed\uff1a<\/strong>
<\/p>\n\n\n\n

\u57285-FU\/LV\u4e2d\u6dfb\u52a0nal-IRI\u663e\u8457\u6539\u5584\u4e86\u665a\u671f\u80c6\u7ba1\u764c\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff0c\u652f\u6301\u5176\u4f5c\u4e3a\u540e\u7eed\u6cbb\u7597\u7684\u6f5c\u529b\u3002\u800c\u4e0d\u540c\u79cd\u65cf\u7684\u80c6\u7ba1\u764c\uff08BTC\uff09\u60a3\u8005\u5bf9nal-IRI\u6cbb\u7597\u7684\u5b89\u5168\u7279\u5f81\u662f\u6709\u5dee\u5f02\u7684\u3002<\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90\u3002<\/em><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u672c\u6587\u62a5\u9053\u5c06\u5e26\u5927\u5bb6\u4e86\u89e3\u4e00\u9879\u6c47\u603b\u5206\u6790\uff1a\u7814\u7a76\u4eba\u5458\u5bf9\u4e24\u9879\u8bd5\u9a8c\u8fdb\u884c\u4e86\u60a3\u8005\u4e2a\u4f53\u6c34\u5e73\u7684\u6570\u636e\u6c47\u603b\u5206\u6790\uff0c\u6bd4\u8f83\u665a\u671f\u80c6\u7ba1\u764c\u60a3\u8005\u5728\u4e00\u7ebf<\/p>\n","protected":false},"author":14,"featured_media":23832,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6650],"tags":[],"yst_prominent_words":[],"class_list":["post-23831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-holangiocarcinoma-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/23831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=23831"}],"version-history":[{"count":2,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/23831\/revisions"}],"predecessor-version":[{"id":23864,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/23831\/revisions\/23864"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/23832"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=23831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=23831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=23831"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=23831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}