{"id":24869,"date":"2025-11-29T15:18:15","date_gmt":"2025-11-29T07:18:15","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=24869"},"modified":"2025-12-01T11:39:15","modified_gmt":"2025-12-01T03:39:15","slug":"%e5%88%9b%e6%96%b0%e8%8d%af%e7%89%a9tinostamustine%e6%9c%89%e6%9c%9b%e6%88%90%e4%b8%ba%e8%83%b6%e8%b4%a8%e6%af%8d%e7%bb%86%e8%83%9e%e7%98%a4%e7%9a%84%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e6%96%b9","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e5%88%9b%e6%96%b0%e8%8d%af%e7%89%a9tinostamustine%e6%9c%89%e6%9c%9b%e6%88%90%e4%b8%ba%e8%83%b6%e8%b4%a8%e6%af%8d%e7%bb%86%e8%83%9e%e7%98%a4%e7%9a%84%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e6%96%b9\/","title":{"rendered":"\u521b\u65b0\u836f\u7269Tinostamustine\u6709\u671b\u6210\u4e3a\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848"},"content":{"rendered":"\n

\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u65b0\u836fTinostamustine\u5b64\u513f\u836f\u8d44\u683c\uff0c\u7528\u4f5c\u6076\u6027\u80f6\u8d28\u7624\u60a3\u8005\u7684\u6f5c\u5728\u6cbb\u7597\u65b9\u6848\u3002<\/strong>Tinostamustine\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u9996\u521b\u836f\u7269\uff0c\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff1a\u53cc\u529f\u80fd\u70f7\u5316\u6d3b\u6027\u548c\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC\uff09\u6291\u5236\u529f\u80fd\u3002\u8be5\u836f\u7269\u5728\u6076\u6027\u795e\u7ecf\u80f6\u8d28\u7624\u7684\u65e9\u671f\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u6f5c\u529b\u3002<\/p>\n\n\n\n

*FDA\u6388\u4e88\u5b64\u513f\u836f\u8d44\u683c\uff0c\u662f\u4e3a\u4e86\u9f13\u52b1\u9488\u5bf9\u5f71\u54cd\u7f8e\u56fd\u4e0d\u8db320\u4e07\u4eba\u7fa4\u7684\u7f55\u89c1\u75be\u75c5\uff0c\u5f00\u53d1\u6709\u6f5c\u529b\u7684\u6cbb\u7597\u3001\u8bca\u65ad\u6216\u9884\u9632\u7528\u836f\u3002<\/p>\n\n\n\n

\u5173\u4e8e\u6076\u6027\u80f6\u8d28\u7624<\/strong><\/strong><\/p>\n\n\n\n

\u6076\u6027\u795e\u7ecf\u80f6\u8d28\u7624\u662f\u4e00\u79cd\u8d77\u6e90\u4e8e\u8111\u90e8\u80f6\u8d28\u7ec6\u80de\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u5177\u6709\u9ad8\u5ea6\u4fb5\u88ad\u6027\uff0c\u5e38\u89c1\u7c7b\u578b\u5305\u62ec\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3002\u8fd9\u7c7b\u80bf\u7624\u751f\u957f\u8fc5\u901f\u3001\u6613\u590d\u53d1\uff0c\u6cbb\u7597\u96be\u5ea6\u5927\u3002\u60a3\u8005\u901a\u5e38\u8868\u73b0\u4e3a\u5934\u75db\u3001\u766b\u75eb\u6216\u795e\u7ecf\u529f\u80fd\u969c\u788d\u3002<\/strong>\u7f8e\u56fd\u6bcf\u5e74\u670915000\u4eba\u88ab\u8bca\u65ad\u4e3a\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3002<\/p>\n\n\n\n

Tinostamustine<\/strong>\u662f\u4e00\u6b3e\u4ec0\u4e48\u836f<\/strong><\/strong><\/p>\n\n\n\n

Tinostamustine\u53ef\u80fd\u662f\u540c\u7c7b\u836f\u91cc\u7b2c\u4e00\u4e2a\u628a\u4e24\u79cd\u6297\u764c\u4f5c\u7528\u5408\u5728\u4e00\u8d77\u7684\u836f\u7269\uff0c\u5177\u6709\u4e24\u79cd\u673a\u5236\uff1a\u53cc\u529f\u80fd\u70f7\u5316\u6d3b\u6027\u548cHDAC\u6291\u5236<\/strong>\uff08\u5373\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff0cHistone Deacetylase,HDAC\uff09\u3002\u4e00\u65b9\u9762\uff0c\u5b83\u80fd\u76f4\u63a5\u7834\u574f\u764c\u7ec6\u80de\u7684DNA\uff0c\u53e6\u4e00\u65b9\u9762\uff0c\u5b83\u80fd\u963b\u65ad\u764c\u7ec6\u80de\u4fee\u590d\u548c\u751f\u957f\u6240\u9700\u7684\u201c\u5f00\u5173\u201dHDAC\u3002\u8fd9\u4e24\u79cd\u4f5c\u7528\u534f\u540c\uff0c\u66f4\u6709\u53ef\u80fd\u589e\u5f3a\u6740\u4f24\u6548\u679c\u3002<\/p>\n\n\n\n

Tinostamustine\u6b63\u5728\u7814\u7a76\u7528\u4e8e\u65b0\u8bca\u65ad\u8111\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u4e2d\uff0c\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\uff08\u624b\u672f\u3001\u5316\u7597\u548c\u653e\u7597\uff09\u540e\u7684\u8f85\u52a9\u6cbb\u7597\uff1b\u4e5f\u5c06\u5728\u590d\u53d1\u60a3\u8005\u4e2d\u8fdb\u884c\u7814\u7a76\u3002<\/strong>Tinostamustine\u6709\u671b\u6210\u4e3a\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n

Tinostamustine<\/strong>\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/strong><\/p>\n\n\n\n

Tinostamustine\u5c06\u4f5c\u4e3aGBM AGILE II\/III\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u4e00\u90e8\u5206\u8fdb\u884c\u8bc4\u4f30\u3002\u8be5\u8bd5\u9a8c\u662f\u4e00\u9879\u9488\u5bf9\u65b0\u8bca\u65ad\u548c\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u7684\u591a\u7597\u6cd5\u7814\u7a76\u5e73\u53f0\u3002<\/strong>2025\u5e749\u6708\uff0cTinostamustine\u5df2\u88ab\u7eb3\u5165\u5168\u7403\u9002\u5e94\u6027\u7814\u7a76\u8054\u76df\u7684\u8be5\u8bd5\u9a8c\u6846\u67b6\uff0c\u836f\u7269\u5728\u8bd5\u9a8c\u4e2d\u7684\u6700\u7ec8\u8bc4\u4f30\u53d6\u51b3\u4e8eFDA\u5728\u8bd5\u9a8c\u7528\u65b0\u836f\u7533\u8bf7\u63d0\u4ea4\u540e\u5bf9\u8bd5\u9a8c\u65b9\u6848\u7684\u6279\u51c6\u3002<\/strong><\/p>\n\n\n\n

GBM AGILE\u8bd5\u9a8c\u662f\u4e00\u9879\u9002\u5e94\u6027\u968f\u673a\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u901a\u8fc7\u8bc4\u4f30\u4e0d\u540c\u7597\u6cd5\uff0c\u4e3a\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u7fa4\u4f53\u786e\u5b9a\u6f5c\u5728\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/strong><\/p>\n\n\n\n

\u8bd5\u9a8c\u9488\u5bf9\u65b0\u8bca\u65ad\u60a3\u8005\u7684\u8981\u6c42\u5305\u62ec\uff1a\u5e74\u9f84\u4e0d\u5c0f\u4e8e18\u5c81\uff0c\u7ecf\u7ec4\u7ec7\u5b66\u786e\u8bca\u4e3aIV\u7ea7\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff0c\u968f\u673a\u5206\u7ec4\u524d14\u5929\u5185\u5361\u6c0f\u529f\u80fd\u72b6\u6001\u8bc4\u5206\u4e0d\u4f4e\u4e8e60%\u3002\u6392\u9664\u6807\u51c6\u5305\u62ec\uff1a\u65e2\u5f80\u63a5\u53d7\u8fc7\u795e\u7ecf\u80f6\u8d28\u7624\u6cbb\u7597\u3001\u5e7f\u6cdb\u8f6f\u8111\u819c\u75be\u75c5\u3001QTc\u95f4\u671f\uff08\u7ecf\u5fc3\u7387\u6821\u6b63\u540e\u7684QT\u95f4\u671f\uff0cCorrected QT Interval\uff09\u8d85\u8fc7\u89c4\u5b9a\u503c\uff08\u7537\u6027450\u6beb\u79d2\uff0c\u5973\u6027470\u6beb\u79d2\uff09\uff0c\u6216\u5728\u5165\u7ec4\u524d\u4e24\u5e74\u5185\u6709\u5176\u4ed6\u6076\u6027\u80bf\u7624\u75c5\u53f2\uff08\u7279\u5b9a\u76ae\u80a4\u764c\u9664\u5916\uff09\u3002<\/p>\n\n\n\n

\u5bf9\u4e8e\u590d\u53d1\u6027\u75be\u75c5\u60a3\u8005\uff0c\u8981\u6c42\u5305\u62ec\uff1a\u75c5\u7406\u62a5\u544a\u8bc1\u5b9e\u75c5\u4eba\u4e3aIV\u7ea7\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e14\u5728\u9996\u6b21\u6216\u7b2c\u4e8c\u6b21\u590d\u53d1\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u6807\u51c6\u6216\u5b9e\u9a8c\u6027\u6cbb\u7597\uff0c\u75be\u75c5\u8fdb\u5c55\u7b26\u5408\u795e\u7ecf\u80bf\u7624\u5b66\u53cd\u5e94\u8bc4\u4f30\u6807\u51c6\u4fee\u6b63\u7248\uff0c\u4e14\u66fe\u63a5\u53d7\u8fc7\u653e\u7597\u3002\u5176\u4ed6\u5173\u952e\u7eb3\u5165\u6807\u51c6\u5305\u62ec\uff1a\u4e24\u6b21\u626b\u63cf\u786e\u8ba4\u75be\u75c5\u8fdb\u5c55\uff0c\u5361\u6c0f\u529f\u80fd\u72b6\u6001\u8bc4\u5206\u4e0d\u4f4e\u4e8e70%\u3002\u6392\u9664\u6807\u51c6\u4e0e\u65b0\u8bca\u65ad\u60a3\u8005\u76f8\u4f3c\uff0c\u5e76\u989d\u5916\u5305\u62ec\u653e\u7597\u7ed3\u675f\u540e3\u4e2a\u6708\u5185\u65e9\u671f\u8fdb\u5c55\u3001\u63a5\u53d7\u8fc7\u8d85\u8fc72\u7ebf\u5316\u7597\u3001\u4ee5\u53ca\u66fe\u4f7f\u7528\u6d1b\u83ab\u53f8\u6c40\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u6216\u5176\u4ed6VEGF\/VEGFR\u9776\u5411\u836f\u7269\u7b49\u3002<\/p>\n\n\n\n

\u5728GBM AGILE\u8bd5\u9a8c\u4e2d\uff0c\u6240\u6709\u6cbb\u7597\u5747\u5206\u4e24\u4e2a\u9636\u6bb5\u8fdb\u884c\u8bc4\u4f30\uff1a\u7b2c\u4e00\u9636\u6bb5\u4e3a\u9002\u5e94\u6027\u968f\u673a\u7b5b\u9009\u9636\u6bb5\uff0c\u5c06\u6cbb\u7597\u65b9\u6cd5\u4e0e\u5171\u540c\u5bf9\u7167\u7ec4\u8fdb\u884c\u6bd4\u8f83\uff1b\u7b26\u5408\u8d44\u683c\u8fdb\u5165\u7b2c\u4e8c\u9636\u6bb5\u7684\u7597\u6cd5\u5c06\u5728\u56fa\u5b9a\u968f\u673a\u6269\u5c55\u7ec4\u4e2d\u8fdb\u884c\u7814\u7a76\u3002<\/p>\n\n\n\n

\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u603b\u751f\u5b58\u671f<\/strong>\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4<\/strong>\u3002<\/p>\n\n\n\n

\u603b\u7ed3<\/strong><\/strong><\/p>\n\n\n\n

FDA\u6388\u4e88Tinostamustine\u5b64\u513f\u836f\u8d44\u683c\u7684\u8ba4\u5b9a\u80cc\u540e\uff0c\u662f\u6076\u6027\u795e\u7ecf\u80f6\u8d28\u7624\u60a3\u8005\u53ca\u5bb6\u5ead\u7684\u8feb\u5207\u9700\u6c42\uff0cTinostamustine\u4e3a\u8fd9\u7c7b\u6cbb\u7597\u9009\u62e9\u6709\u9650\u7684\u4fb5\u88ad\u6027\u764c\u75c7\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\uff0c\u662f\u5e94\u5bf9\u76f8\u5173\u6cbb\u7597\u9700\u6c42\u7684\u91cd\u8981\u63a2\u7d22\u3002<\/p>\n\n\n\n

\u8d44\u6599\u6765\u6e90\uff1a<\/p>\n\n\n\n

[1]https:\/\/www.onclive.com\/view\/tinostamustine-snags-fda-orphan-drug-designation-for-malignant-glioma
[2]https:\/\/www.purduepharma.com\/news\/2025\/11\/10\/fda-grants-orphan-drug-designation-for-tinostamustine-in-malignant-glioma<\/p>\n\n\n\n



\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90\u3002<\/em><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u65b0\u836fTinostamustine\u5b64\u513f\u836f\u8d44\u683c\uff0c\u7528\u4f5c\u6076\u6027\u80f6\u8d28\u7624\u60a3\u8005\u7684\u6f5c\u5728\u6cbb\u7597\u65b9<\/p>\n","protected":false},"author":14,"featured_media":24858,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769,2],"tags":[],"yst_prominent_words":[],"class_list":["post-24869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans","category-2"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/24869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=24869"}],"version-history":[{"count":1,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/24869\/revisions"}],"predecessor-version":[{"id":24870,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/24869\/revisions\/24870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/24858"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=24869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=24869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=24869"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=24869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}