{"id":37210,"date":"2025-12-29T20:30:33","date_gmt":"2025-12-29T12:30:33","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=37210"},"modified":"2025-12-31T16:12:43","modified_gmt":"2025-12-31T08:12:43","slug":"%e6%99%9a%e6%9c%9f%e8%83%86%e9%81%93%e7%99%8c%e6%b2%bb%e7%96%97%e6%96%b0%e6%9b%99%e5%85%89%ef%bc%9a%e9%9d%b6%e5%90%91%e8%8d%afzanidatamab%e4%b8%baher2%e9%98%b3%e6%80%a7%e6%82%a3%e8%80%85%e5%b8%a6","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e6%99%9a%e6%9c%9f%e8%83%86%e9%81%93%e7%99%8c%e6%b2%bb%e7%96%97%e6%96%b0%e6%9b%99%e5%85%89%ef%bc%9a%e9%9d%b6%e5%90%91%e8%8d%afzanidatamab%e4%b8%baher2%e9%98%b3%e6%80%a7%e6%82%a3%e8%80%85%e5%b8%a6\/","title":{"rendered":"\u665a\u671f\u80c6\u9053\u764c\u6cbb\u7597\u65b0\u66d9\u5149\uff1a\u9776\u5411\u836fZanidatamab\u4e3aHER2\u9633\u6027\u60a3\u8005\u5e26\u6765\u957f\u671f\u751f\u5b58\u5e0c\u671b"},"content":{"rendered":"\n<p><strong>\u80c6\u9053\u764c\uff08BTC\uff09\u662f\u4e00\u79cd\u9ad8\u5ea6\u6076\u6027\u3001\u9884\u540e\u6781\u5dee\u7684\u6d88\u5316\u9053\u80bf\u7624\uff0c<\/strong>\u5c24\u5176\u5728\u8f6c\u79fb\u6027\u9636\u6bb5\uff0c\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u901a\u5e38\u4e0d\u8db313\u4e2a\u6708\uff0c\u4e8c\u7ebf\u5316\u7597\u540e\u7684\u751f\u5b58\u671f\u66f4\u662f\u4ec5\u67096\u81f39\u4e2a\u6708\u3002\u5728\u8fd9\u4e00\u6cbb\u7597\u56f0\u5c40\u4e2d\uff0c\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u7684\u8fc7\u8868\u8fbe\u6210\u4e3a\u4e86\u4e00\u7ebf\u66d9\u5149\u3002\u7ea65%\u81f320%\u7684\u80c6\u9053\u764c\u60a3\u8005\u5b58\u5728HER2\u5f02\u5e38\uff0c\u8fd9\u63d0\u4f9b\u4e86\u7cbe\u51c6\u6cbb\u7597\u7684\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u6765\uff0c\u9488\u5bf9HER2\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53Zanidatamab\uff08\u6cfd\u5c3c\u8fbe\u59a5\u5355\u6297\uff09\u9010\u6e10\u8d70\u5165\u4e34\u5e8a\u89c6\u91ce\uff0c\u5176\u5728II\u671fHERIZON-BTC-01\u7814\u7a76\u4e2d\u5c55\u73b0\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u5df2\u4e8e2025\u5e7411\u670820\u65e5\u5728JAMA Oncology\u4e0a\u53d1\u8868\u6700\u7ec8\u5206\u6790\u62a5\u544a\uff0c\u4e3a\u8fd9\u4e00\u96be\u6cbb\u6027\u75be\u75c5\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u65b9\u5411\u3002<\/p>\n\n\n\n<p><strong>HERIZON-BTC-01\u662f\u4e00\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u3001\u5f00\u653e\u6807\u7b7e\u7684IIb\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c<\/strong>\u5171\u7eb3\u516580\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u5409\u897f\u4ed6\u6ee8\u65b9\u6848\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684HER2\u9633\u6027\uff08IHC 2+\u62163+\u4e14\u4f34\u6709ERBB2\u57fa\u56e0\u6269\u589e\uff09\u665a\u671f\u80c6\u9053\u764c\u60a3\u8005\u3002\u60a3\u8005\u6bcf\u4e24\u5468\u63a5\u53d7\u4e00\u6b21Zanidatamab\uff0820 mg\/kg\uff09\u9759\u8109\u8f93\u6ce8\uff0c\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u72ec\u7acb\u4e2d\u592e\u8bc4\u4f30\u786e\u8ba4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08cORR\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u53ca\u5b89\u5168\u6027\u7b49\u3002<\/p>\n\n\n\n<p>\u7ecf\u8fc7\u4e2d\u4f4d33.4\u4e2a\u6708\u7684\u957f\u671f\u968f\u8bbf\u2014\u2014\u8fd9\u4e5f\u662f\u76ee\u524dHER2\u9776\u5411\u6cbb\u7597\u5728\u80c6\u9053\u764c\u4e2d\u968f\u8bbf\u65f6\u95f4\u6700\u957f\u7684\u7814\u7a76\u2014\u2014Zanidatamab\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u3002\u5728\u6240\u6709\u4eba\u7fa4\u4e2d\uff0ccORR\u8fbe\u523041.3%\uff0c\u4e2d\u4f4dDoR\u4e3a14.9\u4e2a\u6708\uff0c\u4e2d\u4f4dOS\u4e3a15.5\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a5.5\u4e2a\u6708\u3002<\/p>\n\n\n\n<p>\u5c24\u4e3a\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728HER2\u9ad8\u8868\u8fbe\uff08IHC 3+\uff09\u7684\u4e9a\u7ec4\u4e2d\uff0c\u7597\u6548\u66f4\u4e3a\u7a81\u51fa\uff1a<strong>cORR\u63d0\u5347\u81f351.6%\uff0c\u4e2d\u4f4dOS\u5ef6\u957f\u81f318.1\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e5f\u8fbe\u5230\u4e867.2\u4e2a\u6708<\/strong>\u3002\u8fd9\u4e00\u751f\u5b58\u6570\u636e\u5728\u7ecf\u6cbb\u665a\u671f\u80c6\u9053\u764c\u60a3\u8005\u4e2d\u582a\u79f0\u7a81\u7834\uff0c\u663e\u8457\u8d85\u8d8a\u4e86\u4f20\u7edf\u5316\u7597\u7684\u5386\u53f2\u6570\u636e\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u7814\u7a76\u4e5f\u63ed\u793a\u51faHER2\u8868\u8fbe\u6c34\u5e73\u5bf9\u7597\u6548\u7684\u5173\u952e\u5f71\u54cd\u3002\u5728IHC 2+\u7684\u60a3\u8005\u4e2d\uff0c<strong>\u4ec51\u4f8b\u51fa\u73b0\u90e8\u5206\u7f13\u89e3<\/strong>\uff0ccORR\u4e3a5.6%\uff0c\u4e2d\u4f4dOS\u4e3a5.2\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4ec5\u4e3a1.7\u4e2a\u6708\u3002\u8fd9\u4e00\u7ed3\u679c\u5f3a\u70c8\u63d0\u793a\uff0c\u672a\u6765\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u5e94\u5c06IHC 3+\u4f5c\u4e3aZanidatamab\u6cbb\u7597\u7684\u4f18\u52bf\u4eba\u7fa4\u9009\u62e9\u6807\u51c6\uff0c\u540c\u65f6\u4e5f\u4e3aIHC 2+\u60a3\u8005\u7fa4\u4f53\u6307\u51fa\u4e86\u8fdb\u4e00\u6b65\u63a2\u7d22\u8054\u5408\u6cbb\u7597\u7b56\u7565\u7684\u5fc5\u8981\u6027\u3002<\/p>\n\n\n\n<p>\u9664\u4e86\u80bf\u7624\u5b66\u7ec8\u70b9\uff0c\u7814\u7a76\u8fd8\u5173\u6ce8\u4e86\u60a3\u8005\u5bf9\u4e8e\u6cbb\u7597\u7684\u53cd\u9988\uff0c<strong>\u53d1\u73b0\u5bf9\u6cbb\u7597\u6709\u53cd\u5e94\u7684\u60a3\u8005\u5176\u201c\u6700\u4e25\u91cd\u75bc\u75db\u201d\u8bc4\u5206\u5728\u6700\u4f73\u7f13\u89e3\u65f6\u8f83\u57fa\u7ebf\u663e\u8457\u4e0b\u964d<\/strong>\uff0c\u5c24\u5176\u5728\u5b8c\u5168\u7f13\u89e3\u8005\u4e2d\u964d\u5e45\u8fbe4\u5206\u3002\u8fd9\u4e00\u53d1\u73b0\u4ece\u751f\u6d3b\u8d28\u91cf\u89d2\u5ea6\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u6cfd\u5c3c\u8fbe\u59a5\u5355\u6297\uff08&nbsp;Zanidatamab\uff09\u7684\u4e34\u5e8a\u4ef7\u503c\u3002<\/p>\n\n\n\n<p>\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c<strong>Zanidatamab\u8868\u73b0\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81<\/strong>\u300276%\u7684\u60a3\u8005\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff0c\u6700\u5e38\u89c1\u7684\u5305\u62ec\u8179\u6cfb\u3001\u8f93\u6ce8\u53cd\u5e94\u3001\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF\uff0c\u5c04\u8840\u5206\u6570\u662f\u8bca\u65ad\u5fc3\u810f\u8870\u7aed\u53ef\u80fd\u6027\u7684\u6307\u6807\uff09\u4e0b\u964d\u3001\u6076\u5fc3\u7b49\u30023\u7ea7TRAE\u53d1\u751f\u7387\u8f83\u4f4e\uff0c\u4ee5\u8179\u6cfb\uff085%\uff09\u3001\u5c04\u8840\u5206\u6570\u4e0b\u964d\uff083.8%\uff09\u548c\u8d2b\u8840\uff083.8%\uff09\u4e3a\u4e3b\uff0c\u672a\u89c1\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\u4e8b\u4ef6\uff0c\u4ec52\u4f8b\u60a3\u8005\u56e0TRAE\u505c\u836f\u3002<\/p>\n\n\n\n<p>\u9999\u6e2f\u7efc\u5408\u80bf\u7624\u4e2d\u5fc3\u4e00\u76f4\u5bc6\u5207\u5173\u6ce8\u56fd\u9645\u524d\u6cbf\u521b\u65b0\u7597\u6cd5\u7b49\u7684\u540e\u7eed\u7814\u7a76\u52a8\u6001\uff0c\u5305\u62ec\u66f4\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u4e3a\u9002\u5408\u7684\u60a3\u8005\u63d0\u4f9b\u524d\u6cbf\u6cbb\u7597\u8bc4\u4f30\u3002<\/p>\n\n\n\n<p>HERIZON-BTC-01\u7684\u6700\u7ec8\u5206\u6790\u786e\u7acb\u4e86Zanidatamab\u5728HER2\u9633\u6027\u665a\u671f\u80c6\u9053\u764c\u540e\u7ebf\u6cbb\u7597\u4e2d\u7684\u663e\u8457\u7597\u6548\u4e0e\u826f\u597d\u5b89\u5168\u6027\uff0c<strong>\u5c24\u5176\u4e3aIHC 3+\u60a3\u8005\u5e26\u6765\u4e86\u524d\u6240\u672a\u6709\u7684\u751f\u5b58\u5ef6\u957f\u4e0e\u75c7\u72b6\u6539\u5584<\/strong>\u3002Zanidatamab\u6301\u4e45\u7684\u7f13\u89e3\u4e0e\u53ef\u63a7\u7684\u6bd2\u6027\u7279\u5f81\uff0c\u4f7f\u5176\u6210\u4e3a\u8be5\u9886\u57df\u5907\u53d7\u671f\u5f85\u7684\u65b0\u661f\u3002\u76ee\u524d\uff0cIII\u671fHERIZON-BTC-302\u7814\u7a76\u5df2\u542f\u52a8\uff0c\u65e8\u5728\u63a2\u7d22Zanidatamab\u8054\u5408\u4e00\u7ebf\u6807\u51c6\u5316\u7597\u7684\u7597\u6548\uff0c\u672a\u6765\u6709\u671b\u8fdb\u4e00\u6b65\u6539\u5199HER2\u9633\u6027\u80c6\u9053\u764c\u7684\u6cbb\u7597\u683c\u5c40\u3002<\/p>\n\n\n\n<p>\u539f\u59cb\u51fa\u5904<\/p>\n\n\n\n<p>Pant S,&nbsp;Fan J,&nbsp;Oh D,&nbsp;et al.&nbsp;Zanidatamab in HER2-Positive Metastatic Biliary Tract Cancer:&nbsp;Final Results From HERIZON-BTC-01.&nbsp;JAMA Oncol.&nbsp;Published online November&nbsp;20,&nbsp;2025.&nbsp;doi:10.1001\/jamaoncol.2025.4736<\/p>\n\n\n\n<p>\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u80c6\u9053\u764c\uff08BTC\uff09\u662f\u4e00\u79cd\u9ad8\u5ea6\u6076\u6027\u3001\u9884\u540e\u6781\u5dee\u7684\u6d88\u5316\u9053\u80bf\u7624\uff0c\u5c24\u5176\u5728\u8f6c\u79fb\u6027\u9636\u6bb5\uff0c\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u901a\u5e38\u4e0d\u8db313\u4e2a\u6708\uff0c\u4e8c<\/p>\n","protected":false},"author":14,"featured_media":37214,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769],"tags":[],"yst_prominent_words":[],"class_list":["post-37210","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/37210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=37210"}],"version-history":[{"count":1,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/37210\/revisions"}],"predecessor-version":[{"id":37217,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/37210\/revisions\/37217"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/37214"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=37210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=37210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=37210"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=37210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}