{"id":37271,"date":"2026-01-05T14:33:50","date_gmt":"2026-01-05T06:33:50","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=37271"},"modified":"2026-01-05T16:40:29","modified_gmt":"2026-01-05T08:40:29","slug":"%e8%83%b0%e8%85%ba%e7%99%8c%e8%80%90%e8%8d%af%e6%9c%ba%e5%88%b6%e6%96%b0%e7%aa%81%e7%a0%b4%ef%bc%9aatm-tgs1-brca1%e4%bf%a1%e5%8f%b7%e8%bd%b4%e7%9a%84%e8%b0%83%e6%8e%a7%e4%b8%8e%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e8%83%b0%e8%85%ba%e7%99%8c%e8%80%90%e8%8d%af%e6%9c%ba%e5%88%b6%e6%96%b0%e7%aa%81%e7%a0%b4%ef%bc%9aatm-tgs1-brca1%e4%bf%a1%e5%8f%b7%e8%bd%b4%e7%9a%84%e8%b0%83%e6%8e%a7%e4%b8%8e%e4%b8%b4%e5%ba%8a\/","title":{"rendered":"\u80f0\u817a\u764c\u8010\u836f\u673a\u5236\u65b0\u7a81\u7834\uff1aATM-TGS1-BRCA1\u4fe1\u53f7\u8f74\u7684\u8c03\u63a7\u4e0e\u4e34\u5e8a\u8f6c\u5316\u4ef7\u503c"},"content":{"rendered":"\n

\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u4f5c\u4e3a\u201c\u764c\u738b\u201d\uff0c\u4ee5\u65e9\u671f\u8bca\u65ad\u56f0\u96be\u3001\u653e\u5316\u7597\u8010\u53d7\u5ea6\u9ad8\u4e3a\u6838\u5fc3\u4e34\u5e8a\u7279\u5f81\uff0c\u51765\u5e74\u603b\u4f53\u751f\u5b58\u7387\u4e0d\u8db315%\uff0c\u4e25\u91cd\u5a01\u80c1\u4eba\u7c7b\u5065\u5eb7\u3002\u4e34\u5e8a\u5e38\u7528\u7684\u653e\u7597\u53ca\u987a\u94c2\u3001\u5409\u897f\u4ed6\u6ee8\u7b49\u5316\u7597\u836f\u7269\uff0c\u867d\u80fd\u901a\u8fc7\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80deDNA\u635f\u4f24\u53d1\u6325\u6740\u4f24\u4f5c\u7528\uff0c\u4f46\u80bf\u7624\u7ec6\u80de\u53ef\u901a\u8fc7\u6fc0\u6d3b\u540c\u6e90\u91cd\u7ec4\uff08Homologous Recombination\uff0cHR\uff09\u4fee\u590d\u901a\u8def\u62b5\u6d88\u635f\u4f24\uff0c\u5f62\u6210\u987d\u56fa\u7684\u6cbb\u7597\u62b5\u6297\uff0c\u6210\u4e3a\u5236\u7ea6\u4e34\u5e8a\u7597\u6548\u7684\u5173\u952e\u74f6\u9888\u3002<\/p>\n\n\n\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u4e0e\u7f8e\u56fd\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\u5408\u4f5c\uff0c\u5728\u300aCancer Research\u300b\u671f\u520a\u53d1\u8868\u91cd\u78c5\u7814\u7a76\u6210\u679c\u3002\u8be5\u7814\u7a76\u7cfb\u7edf\u63ed\u793a\u4e86\u80f0\u817a\u764c\u653e\u5316\u7597\u62b5\u6297\u7684\u5168\u65b0\u5206\u5b50\u673a\u5236\uff0c\u660e\u786e\u4e86ATM-TGS1-BRCA1\u4fe1\u53f7\u8f74\u7684\u6838\u5fc3\u8c03\u63a7\u4f5c\u7528\uff0c\u5e76\u63d0\u51fa\u9488\u5bf9\u6027\u9776\u5411\u6cbb\u7597\u7b56\u7565\uff0c\u4e3a\u4e34\u5e8a\u514b\u670d\u80f0\u817a\u764c\u8010\u836f\u63d0\u4f9b\u4e86\u91cd\u8981\u7406\u8bba\u4f9d\u636e\u4e0e\u8f6c\u5316\u65b9\u5411\u3002<\/p>\n\n\n\n

1. <\/strong>TGS1\u4ecb\u5bfc\u80f0\u817a\u764c\u6cbb\u7597\u62b5\u6297\u7684\u5173\u952e\u4f5c\u7528<\/strong><\/strong><\/p>\n\n\n\n

\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u4e34\u5e8a\u6837\u672c\u5206\u6790\u3001\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u53ca\u4f53\u5185\u52a8\u7269\u6a21\u578b\u9a8c\u8bc1\u7684\u591a\u5c42\u7ea7\u7814\u7a76\u8bbe\u8ba1\uff0c\u9996\u5148\u660e\u786e\u4e86TGS1\u5728\u80f0\u817a\u764c\u4e2d\u7684\u8868\u8fbe\u7279\u5f81\u4e0e\u4e34\u5e8a\u610f\u4e49\u3002\u7ed3\u679c\u663e\u793a\uff0cTGS1\u5728\u80f0\u817a\u764c\u7ec4\u7ec7\u4e2d\u5448\u663e\u8457\u9ad8\u8868\u8fbe\u72b6\u6001\uff0c\u4e14\u5176\u8868\u8fbe\u6c34\u5e73\u4e0e\u80bf\u7624\u5206\u671f\u8fdb\u5c55\u3001\u6cbb\u7597\u62b5\u6297\u7a0b\u5ea6\u53ca\u60a3\u8005\u4e0d\u826f\u9884\u540e\u5448\u6b63\u76f8\u5173\u3002\u6b64\u5916\uff0cTGS1\u9ad8\u8868\u8fbe\u4e0e\u4e0d\u826f\u9884\u540e\u7684\u5173\u8054\u6027\u5728\u4e73\u817a\u764c\u3001\u5bab\u9888\u764c\u3001\u80be\u764c\u7b49\u591a\u79cd\u6076\u6027\u80bf\u7624\u4e2d\u5747\u5f97\u5230\u9a8c\u8bc1\uff0c\u63d0\u793a\u5176\u53ef\u80fd\u662f\u80bf\u7624\u6076\u6027\u8fdb\u5c55\u7684\u5171\u6027\u8c03\u63a7\u56e0\u5b50\u3002<\/p>\n\n\n\n

\u4e3a\u9610\u660eTGS1\u7684\u529f\u80fd\u673a\u5236\uff0c\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u7ec6\u80de\u7cfb\u5b9e\u9a8c\uff08BxPC-3\u3001AsPC-1\u7b49\uff09\u53ca\u7ec6\u80de\u6765\u6e90\u3001\u60a3\u8005\u6765\u6e90\u7684\u80f0\u817a\u764c\u6a21\u578b\uff0c\u8bc1\u5b9eTGS1\u662f\u80f0\u817a\u764c\u6076\u6027\u8fdb\u5c55\u53ca\u6cbb\u7597\u62b5\u6297\u7684\u6838\u5fc3\u9a71\u52a8\u56e0\u5b50\u3002\u673a\u5236\u7814\u7a76\u8fdb\u4e00\u6b65\u63ed\u793a\uff0cTGS1\u867d\u4f20\u7edf\u88ab\u5b9a\u4e49\u4e3aRNA\u4fee\u9970\u76f8\u5173\u7532\u57fa\u8f6c\u79fb\u9176\uff0c\u4f46\u5176\u5728DNA\u635f\u4f24\u4fee\u590d\u4e2d\u7684\u529f\u80fd\u6b64\u524d\u5c1a\u672a\u88ab\u63ed\u793a\u3002\u5728DNA\u635f\u4f24\u53d1\u751f\u540e\uff0cATM\u6fc0\u9176\u53ef\u7279\u5f02\u6027\u4ecb\u5bfcTGS1\u7684\u4e1d\u6c28\u9178\u6b8b\u57faS389\u4e0eS531\u78f7\u9178\u5316\uff0c\u78f7\u9178\u5316\u540e\u7684TGS1\u4e0eBRCA1\u53d1\u751f\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u5c06BRCA1\u9776\u5411\u62db\u52df\u81f3DNA\u635f\u4f24\u4f4d\u70b9\uff0c\u663e\u8457\u589e\u5f3aHR\u4fee\u590d\u6548\u7387\uff0c\u6700\u7ec8\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u5bf9\u653e\u5316\u7597\u4ea7\u751f\u8010\u53d7\u3002<\/p>\n\n\n\n

2. <\/strong>TGS1\u6291\u5236\u8054\u5408PARP\u6291\u5236\u5242\u7684\u534f\u540c\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/strong><\/p>\n\n\n\n

\u57fa\u4e8e\u4e0a\u8ff0\u673a\u5236\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u5c55\u4e86\u9488\u5bf9\u6027\u9776\u5411\u5e72\u9884\u7814\u7a76\u3002\u7ed3\u679c\u8868\u660e\uff0c\u901a\u8fc7\u57fa\u56e0\u6c89\u5bc2\u6216\u836f\u7269\u6291\u5236TGS1\u8868\u8fbe\uff0c\u53ef\u663e\u8457\u963b\u65adBRCA1\u5411DNA\u635f\u4f24\u4f4d\u70b9\u7684\u52df\u96c6\u8fc7\u7a0b\uff0c\u964d\u4f4e\u80bf\u7624\u7ec6\u80deHR \uff08 \u540c\u6e90\u91cd\u7ec4\uff0cHomologous Recombination\uff09\u4fee\u590d\u80fd\u529b\uff0c\u4ece\u800c\u663e\u8457\u63d0\u5347\u80f0\u817a\u764c\u7ec6\u80de\u5bf9\u653e\u7597\u3001\u987a\u94c2\u53caPARP\u6291\u5236\u5242\u7684\u654f\u611f\u6027\u3002\u5728\u80f0\u817a\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cTGS1\u4f4e\u8868\u8fbe\u7ec4\u5c0f\u9f20\u5bf9\u987a\u94c2\u53caPARP\u6291\u5236\u5242\u7684\u6cbb\u7597\u54cd\u5e94\u7387\u663e\u8457\u63d0\u9ad8\uff0c\u8868\u73b0\u4e3a\u80bf\u7624\u4f53\u79ef\u663e\u8457\u7f29\u5c0f\u3001\u751f\u5b58\u5468\u671f\u660e\u663e\u5ef6\u957f\uff0c\u8bc1\u5b9e\u4e86TGS1\u4f5c\u4e3a\u6cbb\u7597\u9776\u70b9\u7684\u6709\u6548\u6027\u3002<\/p>\n\n\n\n

\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u7532\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242Sinefungin\u53ef\u901a\u8fc7\u4e0b\u8c03TGS1\u86cb\u767d\u6c34\u5e73\uff0c\u6a21\u62dfTGS1\u6572\u4f4e\u7684\u751f\u7269\u5b66\u6548\u5e94\u3002\u5728\u591a\u79cd\u80f0\u817a\u764c\u6a21\u578b\u4e2d\uff0cSinefungin\u4e0ePARP\u6291\u5236\u5242\u5965\u62c9\u5e15\u5229\u8054\u5408\u5e94\u7528\u65f6\uff0c\u5c55\u73b0\u51fa\u663e\u8457\u7684\u534f\u540c\u6297\u80bf\u7624\u6548\u5e94\uff0c\u4e14\u672a\u89c2\u5bdf\u5230\u660e\u663e\u7684\u7cfb\u7edf\u6027\u6bd2\u6027\uff0c\u4e3a\u4e34\u5e8a\u8054\u5408\u7528\u836f\u65b9\u6848\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u91cd\u8981\u5b9e\u9a8c\u4f9d\u636e\u3002<\/p>\n\n\n\n

3. <\/strong>\u7814\u7a76\u610f\u4e49\u4e0e\u4e34\u5e8a\u8f6c\u5316\u4ef7\u503c<\/strong><\/strong><\/p>\n\n\n\n

\u8be5\u7814\u7a76\u9996\u6b21\u63ed\u793a\u4e86ATM-TGS1-BRCA1\u4fe1\u53f7\u8f74\u5728DNA\u635f\u4f24\u4fee\u590d\u4e2d\u7684\u5168\u65b0\u529f\u80fd\uff0c\u9610\u660e\u4e86\u80f0\u817a\u764c\u653e\u5316\u7597\u62b5\u6297\u7684\u5173\u952e\u5206\u5b50\u673a\u5236\uff0c\u7a81\u7834\u4e86\u4f20\u7edf\u8ba4\u77e5\u4e2dTGS1\u4ec5\u53c2\u4e0eRNA\u4fee\u9970\u7684\u529f\u80fd\u8fb9\u754c\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7814\u7a76\u63d0\u51fa\u4e86\u4ee5TGS1\u4e3a\u6838\u5fc3\u7684\u9776\u5411\u6cbb\u7597\u7b56\u7565\uff0c\u5c24\u5176\u662fSinefungin\u4e0ePARP\u6291\u5236\u5242\u7684\u8054\u5408\u65b9\u6848\uff0c\u4e3a\u514b\u670d\u80f0\u817a\u764c\u6cbb\u7597\u8010\u836f\u63d0\u4f9b\u4e86\u5207\u5b9e\u53ef\u884c\u7684\u65b0\u8def\u5f84\u3002\u8be5\u6210\u679c\u4e0d\u4ec5\u6df1\u5316\u4e86\u533b\u5b66\u754c\u5bf9\u201c\u764c\u738b\u201d\u8010\u836f\u673a\u5236\u7684\u7406\u89e3\uff0c\u66f4\u4e3a\u4e34\u5e8a\u8f6c\u5316\u7814\u7a76\u5960\u5b9a\u4e86\u575a\u5b9e\u57fa\u7840\u3002\u672a\u6765\uff0c\u968f\u7740\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u8fdb\u4e00\u6b65\u63a8\u8fdb\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5f00\u5c55\uff0c\u8fd9\u4e00\u9776\u5411\u7b56\u7565\u6709\u671b\u8f6c\u5316\u4e3a\u4e34\u5e8a\u53ef\u7528\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4e3a\u80f0\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u663e\u8457\u6539\u5584\u60a3\u8005\u9884\u540e\uff0c\u63a8\u52a8\u80f0\u817a\u764c\u6cbb\u7597\u9886\u57df\u7684\u7a81\u7834\u6027\u8fdb\u5c55\u3002<\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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