{"id":37350,"date":"2026-01-08T15:03:18","date_gmt":"2026-01-08T07:03:18","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=37350"},"modified":"2026-01-08T15:03:18","modified_gmt":"2026-01-08T07:03:18","slug":"%e6%82%a3%e8%80%85%e5%bf%85%e8%af%bb%e6%b1%87%e6%80%bb%ef%bc%9a2025%e5%b9%b4%e6%9c%80%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8%e7%9a%848%e5%a4%a7%e6%8a%97%e7%99%8c%e6%b2%bb%e7%96%97%e6%96%b0%e9%80%89","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e6%82%a3%e8%80%85%e5%bf%85%e8%af%bb%e6%b1%87%e6%80%bb%ef%bc%9a2025%e5%b9%b4%e6%9c%80%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8%e7%9a%848%e5%a4%a7%e6%8a%97%e7%99%8c%e6%b2%bb%e7%96%97%e6%96%b0%e9%80%89\/","title":{"rendered":"\u60a3\u8005\u5fc5\u8bfb\u6c47\u603b\uff1a2025\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u76848\u5927\u6297\u764c\u6cbb\u7597\u65b0\u9009\u62e9"},"content":{"rendered":"\n

\u5728\u80bf\u7624\u6cbb\u7597\u9886\u57df\uff0c2025\u5e74\u53ef\u4ee5\u8bf4\u662f\u6536\u83b7\u9887\u4e30\u7684\u4e00\u5e74\u3002\u4f5c\u4e3a\u8d1f\u8d23\u5ba1\u6279\u65b0\u836f\u548c\u533b\u7597\u4ea7\u54c1\u7684\u6743\u5a01\u673a\u6784\uff0cFDA\u5728\u4e25\u683c\u8bc4\u4f30\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u57fa\u7840\u4e0a\uff0c\u6279\u51c6\u4e86\u591a\u6b3e\u8986\u76d6\u4e0d\u540c\u764c\u79cd\u3001\u4e0d\u540c\u6cbb\u7597\u65b9\u5f0f\u7684\u6297\u764c\u65b0\u836f\u548c\u65b0\u6280\u672f\uff0c\u7ed9\u66f4\u591a\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n\n\n\n

\u4e0b\u9762\u6574\u7406\u7684\u662fCancerNetwork\u8bc4\u9009\u5e76\u91cd\u70b9\u62a5\u9053\u76842025\u5e74\u6700\u6709\u5206\u91cf\u3001\u6700\u503c\u5f97\u60a3\u8005\u5173\u6ce8\u76848\u5927FDA\u80bf\u7624\u6279\u51c6\uff0c\u5e2e\u52a9\u5927\u5bb6\u4e86\u89e3\u8fd9\u4e00\u5e74\u6297\u764c\u6cbb\u7597\u53d6\u5f97\u4e86\u54ea\u4e9b\u5173\u952e\u8fdb\u5c55\u3002<\/p>\n\n\n\n

1. FDA\u6279\u51c6\u7d22Sotorasib\u8054\u5408Panitumumab\u7528\u4e8eKRAS G12C\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c<\/strong>

\u57fa\u4e8e3\u671fCodeBreaK300\u8bd5\u9a8c\u7684\u6570\u636e\uff0cFDA\u6279\u51c6Sotorasib\u8054\u5408Panitumumab\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u6c1f\u5627\u5576\u3001\u5965\u6c99\u5229\u94c2\u6216\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u7684KRAS G12C\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u3002<\/strong><\/p>\n\n\n\n

\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u63091:1:1\u968f\u673a\u5206\u914d\uff0c\u5206\u522b\u63a5\u53d7Sotorasib 960mg\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u8054\u5408Panitumumab 6mg\/kg\u6bcf2\u5468\u9759\u8109\u7ed9\u836f\uff0cSotorasib 240mg\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u8054\u5408Panitumumab 6mg\/kg\u6bcf2\u5468\u9759\u8109\u7ed9\u836f\uff0c\u6216\u7814\u7a76\u8005\u9009\u62e9\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff08SOC\uff09\u3002<\/p>\n\n\n\n

\u7597\u6548\u6570\u636e\u663e\u793a\uff1a<\/strong>
\u2022 \u5728\u63a5\u53d7Sotorasib 960mg\u8054\u5408 Panitumumab 6mg\/kg\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a5.6\u4e2a\u6708<\/strong>\uff0c\u610f\u5473\u7740\u4e00\u534a\u60a3\u8005\u57285.6\u4e2a\u6708\u5185\u75c5\u60c5\u6ca1\u6709\u6076\u5316\uff1b\u800c\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff08SOC\uff09\u7ec4\u4e3a2.0\u4e2a\u6708<\/strong>\u3002<\/p>\n\n\n\n

\u2022 \u6700\u7ec8\u603b\u751f\u5b58\u671f\uff08OS\uff09\u6570\u636e\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff0c\u4f46\u4e24\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u5206\u522b\u4e3a26%\u548c0%<\/strong>\uff0c\u610f\u5473\u7740Sotorasib\u8054\u5408Panitumumab\u7ec4\u670926%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\uff0c\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff08SOC\uff09\u7ec4\u4e3a0%\u3002<\/p>\n\n\n\n

2. FDA\u6279\u51c6Mesylate\u4e09\u4e2a\u6708\u5236\u5242\u7528\u4e8e\u665a\u671f\u524d\u5217\u817a\u764c<\/strong>

FDA\u6279\u51c6\u4e86\u4e00\u79cd\u4e09\u4e2a\u6708\u4e00\u6b21\u7ed9\u836f\u7684\u6ce8\u5c04\u7528Mesylate\uff0c\u7528\u4e8e\u665a\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u3002\u8be5\u51b3\u5b9a\u57fa\u4e8e3\u671fFP-001LMIS\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u8bd5\u9a8c\u4e2d\uff0c144\u4f8b\u60a3\u8005\u63a5\u53d7\u4e861\u6b21\u62162\u6b21\u7ed9\u836f\uff0c\u5176\u4e2d132\u4f8b\u60a3\u8005\u63a5\u53d7\u4e862\u6b21\u7ed9\u836f\u3002<\/p>\n\n\n\n

\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff1a<\/strong>
\u2022 \u4ece\u7b2c28\u5929\u5230\u7b2c168\u5929\uff0c97.9%\u7684\u60a3\u8005\u777e\u916e\u6c34\u5e73\u88ab\u6291\u5236\u81f3\u53bb\u52bf\u6c34\u5e73<\/strong>\uff0c\u537397.9%\u7684\u60a3\u8005\u4f53\u5185\u4fc3\u4f7f\u524d\u5217\u817a\u764c\u751f\u957f\u7684\u201c\u7537\u6027\u6fc0\u7d20\u201d\u88ab\u6210\u529f\u538b\u5230\u5f88\u4f4e\u7684\u6cbb\u7597\u76ee\u6807\u6c34\u5e73<\/strong>\uff0c\u8fbe\u5230\u4e86\u524d\u5217\u817a\u764c\u6cbb\u7597\u4e2d\u5e38\u8bf4\u7684\u201c\u53bb\u52bf\u6c34\u5e73\u201d\u3002<\/p>\n\n\n\n

\u2022 \u5e73\u5747\u777e\u916e\u6d53\u5ea6\u4e3a17.8ng\/dL<\/strong>\uff0c\u5373\u60a3\u8005\u4f53\u5185\u7684\u777e\u916e\u5e73\u5747\u5df2\u7ecf\u964d\u5230\u4e86\u4e00\u4e2a\u975e\u5e38\u4f4e\u7684\u6c34\u5e73<\/strong>\uff0c\u8fd9\u4e2a\u6570\u503c\u901a\u5e38\u88ab\u8ba4\u4e3a\u8db3\u4ee5\u6291\u5236\u524d\u5217\u817a\u764c\u7684\u751f\u957f\u3002<\/p>\n\n\n\n

\u2022 \u6291\u5236\u7387\u4e3a98.6%<\/strong>\uff0c\u5373\u7edd\u5927\u591a\u6570\u60a3\u8005\u7684\u6fc0\u7d20\u6c34\u5e73\u90fd\u88ab\u6301\u7eed\u3001\u6709\u6548\u63a7\u5236\u3002<\/p>\n\n\n\n

\u2022 \u5728\u7b2c\u4e8c\u6b21\u6ce8\u5c04\u65f6\u672a\u89c2\u5bdf\u5230\u777e\u916e\u53cd\u5f39\uff0c\u610f\u5473\u7740\u836f\u6548\u7a33\u56fa<\/strong>\u3002\u4ec5\u67093\u4f8b\u60a3\u8005\u5728\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u5206\u6790\u65f6\u672a\u8fbe\u5230\u777e\u916e\u6291\u5236\uff0c\u5373\u6ca1\u6709\u8fbe\u5230\u7406\u60f3\u7684\u777e\u916e\u6291\u5236\u6548\u679c<\/strong>\u3002<\/p>\n\n\n\n

3. FDA\u6279\u51c6T-DXd\u7528\u4e8eHER2\u4f4e\u8868\u8fbe\/\u8d85\u4f4e\u8868\u8fbe\u4e73\u817a\u764c<\/strong>

Trastuzumab deruxtecan\uff08\u53c8\u540dT-DXd\uff09\u83b7FDA\u6279\u51c6\uff0c\u7528\u4e8e\u65e2\u5f80\u5728\u8f6c\u79fb\u9636\u6bb5\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027HER2\u4f4e\u8868\u8fbe\u6216HER2\u8d85\u4f4e\u8868\u8fbe\u4e73\u817a\u764c\u60a3\u8005<\/strong>\u3002<\/p>\n\n\n\n

\u8be5\u76d1\u7ba1\u51b3\u5b9a\u57fa\u4e8e3\u671fDESTINY-Breast06\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u6bd4\u8f83\u4e86T-DXd\u4e0e\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\uff0c\u5728\u6fc0\u7d20\u53d7\u4f53\uff08HR\uff09\u9633\u6027\u3001HER2\u4f4e\u6216\u8d85\u4f4e\u8868\u8fbe\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002<\/p>\n\n\n\n

ASCO\u5e74\u4f1a\u7ed3\u679c\u663e\u793a\uff1a<\/strong>
\u2022 \u5728HER2\u4f4e\u8868\u8fbe\u7ec4\u4e2d\uff0cT-DXd\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a13.2\u4e2a\u6708<\/strong>\uff0c\u610f\u5473\u7740\u4e00\u534a\u60a3\u8005\u572813.2\u4e2a\u6708\u5185\u75c5\u60c5\u6ca1\u6709\u6076\u5316\uff0c\u800c\u5316\u7597\u7ec4\u4e3a8.1\u4e2a\u6708<\/strong>\u3002T-DXd\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a56.5%<\/strong>\uff0c\u610f\u5473\u7740\u670956.5%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\uff1b\u800c\u5316\u7597\u7ec4\u4e3a32.2%<\/strong>\u3002<\/p>\n\n\n\n

\u2022 \u5728HER2\u8d85\u4f4e\u8868\u8fbe\u7ec4\u4e2d\uff0cT-DXd\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a13.2\u4e2a\u6708<\/strong>\uff0c\u610f\u5473\u7740\u4e00\u534a\u60a3\u8005\u572813.2\u4e2a\u6708\u5185\u75c5\u60c5\u6ca1\u6709\u6076\u5316\uff0c\u800c\u5316\u7597\u7ec4\u4e3a8.3\u4e2a\u6708<\/strong>\u3002T-DXd\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a61.8%<\/strong>\uff0c\u610f\u5473\u7740\u670961.8%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\uff1b\u800c\u5316\u7597\u7ec4\u4e3a26.3%<\/strong>\u3002<\/p>\n\n\n\n

\u2022 \u5728\u610f\u5411\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u4e2d\uff0cT-DXd\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a13.2\u4e2a\u6708<\/strong>\uff0c\u610f\u5473\u7740\u4e00\u534a\u60a3\u8005\u572813.2\u4e2a\u6708\u5185\u75c5\u60c5\u6ca1\u6709\u6076\u5316\uff0c\u800c\u5316\u7597\u7ec4\u4e3a8.1\u4e2a\u6708<\/strong>\u3002T-DXd\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a57.3%<\/strong>\uff0c\u610f\u5473\u7740\u670957.3%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\uff1b\u800c\u5316\u7597\u7ec4\u4e3a31.2%<\/strong>\u3002<\/p>\n\n\n\n

\u6ce8\uff1a\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\uff08ITT\uff09\u662f\u6307\u6240\u6709\u88ab\u968f\u673a\u5206\u5230\u8bd5\u9a8c\u7ec4\u6216\u5bf9\u7167\u7ec4\u7684\u60a3\u8005\uff0c\u4e0d\u8bba\u4ed6\u4eec\u540e\u6765\u6709\u6ca1\u6709\u771f\u6b63\u5b8c\u6210\u6cbb\u7597\uff0c\u90fd\u8981\u7b97\u8fdb\u5206\u6790\u3002<\/p>\n\n\n\n

4. Zongertinib\u83b7FDA\u52a0\u901f\u6279\u51c6\u7528\u4e8eHER2\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/strong>

FDA\u52a0\u901f\u6279\u51c6Zongertinib\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u5207\u9664\u7684\u3001\u643a\u5e26HER2\u916a\u6c28\u9178\u6fc0\u9176\u7ed3\u6784\u57df\uff08TKD\uff09\u6fc0\u6d3b\u7a81\u53d8\u7684\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005<\/strong>\u3002<\/p>\n\n\n\n

\u8be5\u76d1\u7ba1\u51b3\u5b9a\u57fa\u4e8e1b\u671fBeamionLUNG-1\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e8671\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684\u60a3\u8005\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/strong>
\u2022 \u5728\u672a\u63a5\u53d7\u8fc7\u6297HER2\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u6216\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u7684\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a75%<\/strong>\uff0c\u610f\u5473\u7740\u670975%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\uff1b\u5176\u4e2d58%\u7684\u60a3\u8005\u7f13\u89e3\u6301\u7eed\u81f3\u5c116\u4e2a\u6708<\/strong>\u3002<\/p>\n\n\n\n

\u2022 \u5728\u65e2\u5f80\u63a5\u53d7\u8fc7HER2\u9776\u5411\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09<\/strong>\u7684\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09<\/strong>\u4e3a44%\uff0c\u610f\u5473\u7740\u670944%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\uff1b\u5176\u4e2d27%\u7684\u60a3\u8005\u7f13\u89e3\u6301\u7eed\u81f3\u5c116\u4e2a\u6708<\/strong>\u3002<\/p>\n\n\n\n

5. FDA\u6279\u51c6\u56f4\u624b\u672f\u671f\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u653e\u7597\u7528\u4e8e\u5934\u9888\u9cde\u764c<\/strong>

\u57fa\u4e8e3\u671fKEYNOTE-689\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0cFDA\u6279\u51c6\u5728PD-L1\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u5934\u9888\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u60a3\u8005\u4e2d\uff0c\u4f7f\u7528\u65b0\u8f85\u52a9\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08Pembrolizumab\uff09\u5355\u836f\u6cbb\u7597\uff0c\u672f\u540e\u7ed9\u4e88\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u653e\u7597\uff08\u53ef\u5408\u5e76\u6216\u4e0d\u5408\u5e76\u5316\u7597\u836f\u987a\u94c2\uff09\uff0c\u968f\u540e\u7ee7\u7eed\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u6ce8\uff1a
\u2022 \u56f4\u624b\u672f\u671f\uff08Perioperative Period\uff09\u662f\u6307\u6db5\u76d6\u624b\u672f\u524d\u3001\u624b\u672f\u4e2d\u548c\u624b\u672f\u540e\u6574\u4e2a\u6cbb\u7597\u8fc7\u7a0b\u7684\u65f6\u95f4\u6bb5\u3002<\/p>\n\n\n\n

\u2022 \u65b0\u8f85\u52a9\u6cbb\u7597\u662f\u6307\u5728\u624b\u672f\u524d\u8fdb\u884c\u7684\u5316\u7597\u3001\u653e\u7597\u6216\u514d\u75ab\u6cbb\u7597\uff0c\u76ee\u7684\u662f\u7f29\u5c0f\u80bf\u7624\u3001\u63d0\u9ad8\u624b\u672f\u6210\u529f\u7387\uff0c\u5e76\u5e2e\u52a9\u63a7\u5236\u5fae\u5c0f\u8f6c\u79fb\u3002<\/p>\n\n\n\n

\u5728\u8be5\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5355\u7eaf\u672f\u540e\u653e\u7597\uff08\u53ef\u5408\u5e76\u6216\u4e0d\u5408\u5e76\u987a\u94c2\uff09\uff0c\u6216\u5728\u6b64\u57fa\u7840\u4e0a\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/strong>
\u2022 \u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\uff0c\u4e2d\u4f4d\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u4e3a59.7\u4e2a\u6708<\/strong>\uff0c\u610f\u5473\u7740\u4e00\u534a\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u540e\uff0c\u80fd\u6709\u5c06\u8fd15\u5e74\u7684\u65f6\u95f4\u6ca1\u6709\u51fa\u73b0\u75c5\u60c5\u6076\u5316\u6216\u5176\u4ed6\u4e3b\u8981\u4e0d\u826f\u4e8b\u4ef6\uff1b\u5bf9\u7167\u7ec4\u4e3a29.6\u4e2a\u6708<\/strong>\u3002<\/p>\n\n\n\n

\u2022 \u6b64\u5916\uff0c\u5728PD-L1\u9633\u6027\u4eba\u7fa4\u4e2d\uff0c\u5728\u7eb3\u516576%\u7684\u9884\u8bbe\u6b7b\u4ea1\u4e8b\u4ef6\u540e\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u65b9\u6848\u5e76\u672a\u663e\u793a\u51fa\u4e0d\u5229\u7ed3\u5c40\u8d8b\u52bf\uff0c\u5373\u4f7f\u8003\u8651\u5230\u5df2\u7ecf\u53d1\u751f\u768476%\u7684\u9884\u671f\u6b7b\u4ea1\u4e8b\u4ef6\uff0c\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u6cbb\u7597\u65b9\u6848\u4e5f\u6ca1\u6709\u5e26\u6765\u4e0d\u597d\u7684\u7ed3\u679c\u6216\u589e\u52a0\u98ce\u9669<\/strong>\u3002<\/p>\n\n\n\n

6. FDA\u6279\u51c6Acalabrutinib\u8054\u5408\u65b9\u6848\u7528\u4e8e\u521d\u6cbb\u5957\u7ec6\u80de\u6dcb\u5df4\u7624<\/strong>

FDA\u6279\u51c6\u5c06Acalabrutinib\u8054\u5408Bendamustine\u548cRituximab\uff0c\u7528\u4e8e\u65e2\u5f80\u672a\u6cbb\u7597\u3001\u4e14\u4e0d\u9002\u5408\u63a5\u53d7\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005<\/strong>\u3002<\/p>\n\n\n\n

\u8fd9\u4e00\u6279\u51c6\u57fa\u4e8e3\u671fECHO\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u63a5\u53d7Acalabrutinib\u8054\u5408Bendamustine\u548cRituximab\uff0c\u6216\u5b89\u6170\u5242\u8054\u5408Bendamustine\u548cRituximab\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/strong>
\u2022 Acalabrutinib\u8054\u5408Bendamustine\u548cRituximab\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a66.4\u4e2a\u6708<\/strong>\uff0c\u610f\u5473\u7740\u4e00\u534a\u60a3\u8005\u572866.4\u4e2a\u6708\u5185\u75c5\u60c5\u6ca1\u6709\u6076\u5316\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a49.6\u4e2a\u6708<\/strong>\u3002<\/p>\n\n\n\n

\u2022 Acalabrutinib\u8054\u5408\u7ec4\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8627%<\/strong>\u3002<\/p>\n\n\n\n

\u2022 \u6b64\u5916\uff0c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7ed3\u679c\u4e5f\u503e\u5411\u4e8eAcalabrutinib\u8054\u5408\u65b9\u6848<\/strong>\uff0c\u4f46\u6570\u636e\u5728\u5206\u6790\u65f6\u5c1a\u4e0d\u6210\u719f\u3002<\/p>\n\n\n\n

7. FDA\u6279\u51c6Lutetium Lu 177\u7528\u4e8ePSMA\u9633\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c<\/strong>

FDA\u6269\u5927\u4e86\u653e\u5c04\u6027\u914d\u4f53\u7597\u6cd5Lutetium Lu 177\u7684\u9002\u5e94\u8bc1\uff0c\u7528\u4e8ePSMA\u9633\u6027\u3001\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08CRPC\uff09\u6210\u4eba\u60a3\u8005<\/strong>\uff0c\u8fd9\u4e9b\u60a3\u8005\u6b64\u524d\u5df2\u63a5\u53d7\u96c4\u6fc0\u7d20\u53d7\u4f53\u901a\u8def\u6291\u5236\u5242\uff08ARPI\uff09\u6cbb\u7597\uff0c\u4e14\u88ab\u8ba4\u4e3a\u9002\u5408\u5ef6\u540e\u7d2b\u6749\u7c7b\u5316\u7597\u3002<\/p>\n\n\n\n

\u652f\u6301\u8be5\u51b3\u5b9a\u7684\u6570\u636e\u6765\u81ea3\u671fPSMAfore\u8bd5\u9a8c\u3002\u8be5\u7814\u7a76\u5c06\u60a3\u8005\u63091:1\u968f\u673a\u5206\u914d\uff0c\u5206\u522b\u63a5\u53d7Lutetium Lu 177\u6216\u53e6\u4e00\u79cdARPI\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/strong>
\u2022 \u5728Lutetium Lu 177\u7ec4\u4e2d\uff0c\u4e2d\u4f4d\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a9.3\u4e2a\u6708<\/strong>\uff0c\u610f\u5473\u7740\u4e00\u534a\u60a3\u8005\u5728\u5f00\u59cb\u6cbb\u7597\u540e\u7ea69.3\u4e2a\u6708\u5185\u764c\u75c7\u5f71\u50cf\u5b66\u4e0a\u51fa\u73b0\u8fdb\u5c55\uff1bARPI\u7ec4\u4e3a5.6\u4e2a\u6708<\/strong>\u3002<\/p>\n\n\n\n

\u2022 Lutetium Lu 177\u7ec4\u7684\u4e2d\u4f4d\uff08\u5e73\u5747\uff09\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e3a24.5\u4e2a\u6708<\/strong>\uff0cARPI\u7ec4\u4e3a23.1\u4e2a\u6708<\/strong>\uff0c\u4e14\u6700\u521d\u5206\u914d\u81f3ARPI\u7ec4\u7684\u60a3\u8005\u4e2d\uff0c\u670960%\u5728\u75be\u75c5\u8fdb\u5c55\u540e\u4ea4\u53c9\u63a5\u53d7\u4e86Lutetium Lu 177\u6cbb\u7597\u3002<\/p>\n\n\n\n

8. FDA\u6279\u51c6Belzutifan\u7528\u4e8e\u6210\u4eba\u53ca\u513f\u7ae5\u55dc\u94ec\u7ec6\u80de\u7624\u548c\u526f\u795e\u7ecf\u8282\u7624<\/strong>

FDA\u6279\u51c6\u53e3\u670dHIF-2\u03b1\u6291\u5236\u5242Belzutifan\uff0c\u7528\u4e8e12\u5c81\u53ca\u4ee5\u4e0a\u3001\u60a3\u6709\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u55dc\u94ec\u7ec6\u80de\u7624\u6216\u526f\u795e\u7ecf\u8282\u7624\uff08PPGL\uff09\u7684\u60a3\u8005<\/strong>\u3002<\/p>\n\n\n\n

\u8be5\u51b3\u5b9a\u57fa\u4e8e2\u671fLITESPARK-015\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u60a3\u8005\u53e3\u670d120mg Belzutifan\u7684\u7597\u6548\u3002<\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/strong>
\u2022 \u5728\u6240\u6709\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a26%<\/strong>\uff0c\u610f\u5473\u7740\u670926%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\u3002<\/p>\n\n\n\n

\u2022 \u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u4e3a20.4\u4e2a\u6708<\/strong>\uff0c\u610f\u601d\u662f\u5728\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u4e00\u534a\u60a3\u8005\u7684\u80bf\u7624\u7f13\u89e3\u72b6\u6001\u6301\u7eed\u4e86\u81f3\u5c1120.4\u4e2a\u6708\u3002<\/p>\n\n\n\n

\u2022 \u5171\u670932%\u7684\u60a3\u8005\u5728\u81f3\u5c116\u4e2a\u6708\u5185\u5c06\u964d\u538b\u836f\u7528\u91cf\u51cf\u5c11\u4e8650%\u4ee5\u4e0a<\/strong>\u3002<\/p>\n\n\n\n

\u2022 \u5728\u5408\u5e76\u80be\u7ec6\u80de\u764c\u7684\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a83%<\/strong>\uff0c\u610f\u5473\u7740\u670983%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\u3002<\/p>\n\n\n\n

\u2022 \u5728\u5b9e\u4f53\u578b\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u8840\u7ba1\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a100%<\/strong>\uff0c\u610f\u5473\u7740\u6709100%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\u3002<\/p>\n\n\n\n

\u2022 \u5728\u5b9e\u4f53\u5408\u5e76\u56ca\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u8840\u7ba1\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a60%<\/strong>\uff0c\u610f\u5473\u7740\u670960%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\u3002<\/p>\n\n\n\n

\u2022 \u5728\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a67%<\/strong>\uff0c\u610f\u5473\u7740\u670967%\u7684\u60a3\u8005\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\u3002<\/p>\n\n\n\n

\u8d44\u6599\u6765\u6e90\uff1a<\/strong><\/strong><\/p>\n\n\n\n

https:\/\/www.cancernetwork.com\/view\/spotlighting-the-top-10-fda-oncology-approvals-in-2025<\/a><\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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