{"id":38838,"date":"2026-03-10T09:51:15","date_gmt":"2026-03-10T01:51:15","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=38838"},"modified":"2026-03-10T09:51:05","modified_gmt":"2026-03-10T01:51:05","slug":"fda%e6%ad%a3%e5%bc%8f%e6%89%b9%e5%87%86%e6%81%a9%e8%80%83%e6%8b%89%e9%9d%9e%e5%b0%bc%ef%bc%88encorafenib%ef%bc%89%e7%94%a8%e4%ba%8ebraf-v600e%e7%aa%81%e5%8f%98%e8%bd%ac%e7%a7%bb%e6%80%a7%e7%bb%93","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/fda%e6%ad%a3%e5%bc%8f%e6%89%b9%e5%87%86%e6%81%a9%e8%80%83%e6%8b%89%e9%9d%9e%e5%b0%bc%ef%bc%88encorafenib%ef%bc%89%e7%94%a8%e4%ba%8ebraf-v600e%e7%aa%81%e5%8f%98%e8%bd%ac%e7%a7%bb%e6%80%a7%e7%bb%93\/","title":{"rendered":"FDA\u6b63\u5f0f\u6279\u51c6\u6069\u8003\u62c9\u975e\u5c3c\uff08encorafenib\uff09\u7528\u4e8eBRAF V600E\u7a81\u53d8\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c"},"content":{"rendered":"\n<p>2026\u5e742\u670824\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5f0f\u6279\u51c6\u6069\u8003\u62c9\u975e\u5c3c\uff08encorafenib\uff09\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u53ca\u6c1f\u5c3f\u5627\u5576(5-Fu)\u7c7b\u5316\u7597\uff0c\u7528\u4e8e\u6cbb\u7597\u7ecfFDA\u6279\u51c6\u68c0\u6d4b\u65b9\u6cd5\u786e\u8ba4\u7684BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n<p>\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u6069\u8003\u62c9\u975e\u5c3c\uff08encorafenib\uff09\u66fe\u4e8e2024\u5e74\u4e0e\u897f\u59a5\u6614\u5355\u6297\uff08Cetuximab\uff09\u8054\u5408mFOLFOX6\u65b9\u6848\u83b7\u5f97\u52a0\u901f\u6279\u51c6\uff0c\u6b64\u6b21\u4e3a\u5b8c\u5168\u6279\u51c6\u3002<\/p>\n\n\n\n<p><strong>1. <\/strong><strong>BREAKWATER\u7814\u7a76<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u672c\u6b21\u6279\u51c6\u57fa\u4e8e\u2162\u671f\u4e34\u5e8a\u7814\u7a76BREAKWATER trial\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u4e3a\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u7eb3\u5165\u672a\u7ecf\u6cbb\u7597\u7684BRAF V600E\u7a81\u53d8\u9633\u6027\u8f6c\u79fb\u6027CRC\u60a3\u8005\u3002\u7a81\u53d8\u72b6\u6001\u901a\u8fc7Qiagen therascreen BRAF V600E RGQ PCR Kit\u68c0\u6d4b\u786e\u8ba4\u3002<\/p>\n\n\n\n<p><strong>\u2162\u671f\u7814\u7a76\u8bbe\u8ba1<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>BREAKWATER \u2162\u671f\u90e8\u5206\u6700\u521d\u63091:1:1\u968f\u673a\u5206\u4e3a\u4e09\u7ec4\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u2022<strong>&nbsp;<\/strong><strong>A\u7ec4\uff08\u5b9e\u9a8c\u7ec4\uff09\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6069\u8003\u62c9\u975e\u5c3c \u6bcf\u65e5\u53e3\u670d\u4e00\u6b21 + \u897f\u59a5\u6614\u5355\u6297 \u6bcf2\u5468\u4e00\u6b21\u9759\u8109\u8f93\u6ce8<\/p>\n\n\n\n<p><strong>\u2022<\/strong><strong>&nbsp;<\/strong><strong>B\u7ec4\uff08\u5b9e\u9a8c\u7ec4\uff09\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6069\u8003\u62c9\u975e\u5c3c \u6bcf\u65e5\u53e3\u670d\u4e00\u6b21 + \u897f\u59a5\u6614\u5355\u6297 \u6bcf2\u5468\u4e00\u6b21\u9759\u8109\u8f93\u6ce8+ mFOLFOX6 \u6bcf2\u5468\u8f93\u6ce81\u6b21<\/p>\n\n\n\n<p><strong>\u2022<\/strong><strong>&nbsp;<\/strong><strong>C\u7ec4\uff08\u5bf9\u7167\u7ec4\uff09\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>mFOLFOX6 \u6216&nbsp;FOLFOXIRI&nbsp;\uff08\u6bcf2\u5468\u4e00\u6b21\uff09\u6216&nbsp;CAPOX&nbsp;\uff08\u6bcf3\u5468\u4e00\u6b21\uff09\uff0c\u53ef\u8054\u5408\u6216\u4e0d\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297<\/p>\n\n\n\n<p>\u968f\u540e\u8bd5\u9a8c\u65b9\u6848\u4fee\u8ba2\u4e3a1:1\u968f\u673a\uff0c\u4ec5\u6bd4\u8f83B\u7ec4\u4e0eC\u7ec4\u3002<\/p>\n\n\n\n<p>\u540c\u65f6\u65b0\u589e\u7b2c\u4e09\u7814\u7a76\u7fa4\u7ec4\uff0c1:1\u968f\u673a\u5206\u4e3a\uff1a<\/p>\n\n\n\n<p><strong>\u2022<\/strong><strong>&nbsp;<\/strong><strong>D\u7ec4\uff08\u5b9e\u9a8c\u7ec4\uff09\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6069\u8003\u62c9\u975e\u5c3c + \u897f\u59a5\u6614\u5355\u6297 + FOLFIRI\uff08\u6bcf2\u5468\u4e00\u6b21\uff09<\/p>\n\n\n\n<p><strong>\u2022<\/strong><strong>&nbsp;<\/strong><strong>E\u7ec4\uff08\u5bf9\u7167\u7ec4\uff09\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>FOLFIRI\uff08\u6bcf2\u5468\u4e00\u6b21\uff09\uff0c\u53ef\u8054\u5408\u6216\u4e0d\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297<\/p>\n\n\n\n<p>\u6240\u6709\u6cbb\u7597\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u3001\u60a3\u8005\u4e0d\u8010\u53d7\u6bd2\u6027\u3001\u60a3\u8005\u62d2\u7edd\u6cbb\u7597\u3001\u5931\u8bbf\u6216\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p><strong><br><\/strong><strong>2. <\/strong><strong>\u2162\u671f\u4e3b\u8981\u7ed3\u679c\uff08B\u7ec4 vs C\u7ec4\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u2022\u00a0\u5168\u90e8\u968f\u673a\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09<br>\u2022\u00a0\u6bcf\u7ec4\u524d110\u4f8b\u60a3\u8005\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff08\u7531\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u5ba1\uff09<br>\u2022\u00a0\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e3a\u9884\u8bbe\u68c0\u9a8c\u7ec8\u70b9\u4e4b\u4e00<\/p>\n\n\n\n<p>\u5171236\u4f8b\u60a3\u8005\u8fdb\u5165\u5b9e\u9a8cB\u7ec4\uff0c243\u4f8b\u8fdb\u5165\u5bf9\u7167C\u7ec4\u3002<\/p>\n\n\n\n<p><strong>\u7ed3\u679c\u663e\u793a\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/03\/image-1.png\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/03\/image-1.png 692w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/03\/image-1-300x84.png 300w\" decoding=\"async\" width=\"692\" height=\"193\" alt=\"\" class=\"wp-image-38839 lazyload\" sizes=\"(max-width: 692px) 100vw, 692px\"><noscript><img decoding=\"async\" width=\"692\" height=\"193\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/03\/image-1.png\" alt=\"\" class=\"wp-image-38839\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/03\/image-1.png 692w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/03\/image-1-300x84.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\"><\/noscript><\/figure>\n\n\n\n<p>\u6570\u636e\u663e\u793a\uff0c\u4e0e\u6807\u51c6\u5316\u7597\u76f8\u6bd4\uff0c\u8054\u5408\u65b9\u6848\u663e\u8457\u5ef6\u957f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f\uff0c\u5e76\u63d0\u9ad8\u5ba2\u89c2\u7f13\u89e3\u7387\u3002<\/p>\n\n\n\n<p><strong><br><\/strong><strong>3. <\/strong><strong>\u7b2c\u4e09\u7814\u7a76\u7fa4\u7ec4\u7ed3\u679c\uff08D\u7ec4 vs E\u7ec4\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u5728\u65b0\u589e\u7684\u7fa4\u7ec4\u4e2d\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u2022\u00a0\u5b9e\u9a8c\u7ec4\uff08D\u7ec4\uff09\u517173\u4f8b<br>\u2022\u00a0\u5bf9\u7167\u7ec4\uff08E\u7ec4\uff09\u517174\u4f8b<\/p>\n\n\n\n<p>\u4e3b\u8981\u7ec8\u70b9\u4e3a\u5ba2\u89c2\u7f13\u89e3\u7387ORR\uff08\u7531\u76f2\u6001\u72ec\u7acb\u8bc4\u5ba1\uff09\u3002<\/p>\n\n\n\n<p><strong>\u7ed3\u679c\u663e\u793a\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u2022&nbsp;ORR\uff1a\u5b9e\u9a8c\u7ec4 Arm D&nbsp;64% vs&nbsp;\u5bf9\u7167\u7ec4 Arm E&nbsp;39%<\/p>\n\n\n\n<p>\u8be5\u7fa4\u7ec4\u4e3b\u8981\u8bc4\u4f30\u5ba2\u89c2\u7f13\u89e3\u7387\uff0c\u7ed3\u679c\u663e\u793a\u5728FOLFIRI\u5316\u7597\u80cc\u666f\u4e0b\uff0c\u8054\u5408\u65b9\u6848\u540c\u6837\u663e\u8457\u4f18\u4e8e\u5bf9\u7167\u7ec4\u3002<\/p>\n\n\n\n<p><strong>\u63a8\u8350\u5242\u91cf\u4e3a\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u6069\u8003\u62c9\u975e\u5c3c300 mg\uff0875 mg \u00d7 4\u7c92<\/strong><strong>\uff09<\/strong><strong>\u6bcf\u65e5\u4e00\u6b21<\/strong>\uff0c\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u53camFOLFOX6\u6216FOLFIRI\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u6bd2\u6027\u3002<\/p>\n\n\n\n<p><strong><br><\/strong><strong>4. <\/strong><strong>\u5b89\u5168\u6027\u4e0e\u6ce8\u610f\u4e8b\u9879<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u90e8\u5206\u60a3\u8005\u4e0d\u9002\u7528\u4e8e\u8be5\u5904\u65b9\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n<p>\u2022\u00a0\u65b0\u53d1\u539f\u53d1\u6027\u6076\u6027\u80bf\u7624\uff08\u76ae\u80a4\u53ca\u975e\u76ae\u80a4\uff09<br>\u2022\u00a0BRAF\u91ce\u751f\u578b\u80bf\u7624\u4e2d\u7684\u80bf\u7624\u4fc3\u8fdb\u98ce\u9669<br>\u2022\u00a0\u5fc3\u808c\u75c5<br>\u2022\u00a0\u809d\u6bd2\u6027<br>\u2022\u00a0\u51fa\u8840<br>\u2022\u00a0\u8461\u8404\u819c\u708e<br>\u2022\u00a0QT\u95f4\u671f\u5ef6\u957f<br>\u2022\u00a0\u80da\u80ce-\u80ce\u513f\u6bd2\u6027<\/p>\n\n\n\n<p><strong>\u603b\u7ed3<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6b64\u6b21\u5b8c\u5168\u6279\u51c6\u57fa\u4e8e\u660e\u786e\u7684\u2162\u671f\u4e34\u5e8a\u83b7\u76ca\u6570\u636e\uff0c\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u6069\u8003\u62c9\u975e\u5c3c\uff08encorafenib\uff09\u8054\u5408\u6cbb\u7597\u5728BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u4e34\u5e8a\u5e94\u7528\u5730\u4f4d\u3002<\/p>\n\n\n\n<p>\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2026\u5e742\u670824\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5f0f\u6279\u51c6\u6069\u8003\u62c9\u975e\u5c3c\uff08encorafenib\uff09\u8054\u5408\u897f\u59a5\u6614\u5355<\/p>\n","protected":false},"author":14,"featured_media":38830,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6751],"tags":[],"yst_prominent_words":[],"class_list":["post-38838","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-6751"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/38838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=38838"}],"version-history":[{"count":1,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/38838\/revisions"}],"predecessor-version":[{"id":38842,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/38838\/revisions\/38842"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/38830"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=38838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=38838"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=38838"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=38838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}