{"id":39537,"date":"2026-04-24T09:46:22","date_gmt":"2026-04-24T01:46:22","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=39537"},"modified":"2026-04-24T09:46:03","modified_gmt":"2026-04-24T01:46:03","slug":"%e5%8e%86%e5%8f%b2%e6%80%a7%e4%b8%80%e5%a4%9c%ef%bc%9a%e8%83%b0%e8%85%ba%e7%99%8c%e7%bb%88%e4%ba%8e%e8%a2%ab%e6%94%bb%e7%a0%b4%ef%bc%81%e8%bf%99%e6%ac%be%e6%96%b0%e8%8d%af%e8%ae%a9%e6%99%9a%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e5%8e%86%e5%8f%b2%e6%80%a7%e4%b8%80%e5%a4%9c%ef%bc%9a%e8%83%b0%e8%85%ba%e7%99%8c%e7%bb%88%e4%ba%8e%e8%a2%ab%e6%94%bb%e7%a0%b4%ef%bc%81%e8%bf%99%e6%ac%be%e6%96%b0%e8%8d%af%e8%ae%a9%e6%99%9a%e6%9c%9f\/","title":{"rendered":"\u5386\u53f2\u6027\u4e00\u591c\uff1a\u80f0\u817a\u764c\u7ec8\u4e8e\u88ab\u653b\u7834\uff01\u8fd9\u6b3e\u65b0\u836f\u8ba9\u665a\u671f\u60a3\u8005\u591a\u6d3b\u4e00\u500d\u65f6\u95f4"},"content":{"rendered":"\n

2026\u5e744\u670813\u65e5\uff0c\u6ce8\u5b9a\u88ab\u8f7d\u5165\u80bf\u7624\u6cbb\u7597\u53f2\u518c\u3002<\/strong><\/strong><\/p>\n\n\n\n

\u88ab\u79f0\u4e3a\u201c\u764c\u4e2d\u4e4b\u738b\u201d\u7684\u80f0\u817a\u764c<\/strong>\uff0c\u8fce\u6765\u4e86\u534a\u4e2a\u4e16\u7eaa\uff0850\u591a\u5e74\uff09\u4ee5\u6765\u6700\u9707\u64bc\u7684\u7a81\u7834<\/strong>\u2014\u2014 \u5168\u7403\u9996\u4e2a\u6cdbRAS\u9776\u5411\u836fDaraxonrasib\uff08RMC-6236\uff09<\/strong> \u5173\u952e3\u671f\u4e34\u5e8a\uff08RASolute 302\uff09\u5ba3\u5e03\uff1a\u665a\u671f\u80f0\u817a\u764c\u60a3\u8005\u751f\u5b58\u671f\u76f4\u63a5\u7ffb\u500d<\/strong><\/u><\/strong>\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d60%<\/strong>\uff01<\/p>\n\n\n\n

\u8fd9\u4e0d\u662f\u6982\u5ff5\uff0c\u4e0d\u662f\u65e9\u671f\u6570\u636e\uff0c\u800c\u662f\u5168\u7403\u591a\u4e2d\u5fc33\u671f\u3001\u968f\u673a\u5bf9\u7167\u3001\u4e2d\u671f\u5206\u6790\u5373\u8fbe\u7ec8\u70b9\u3001\u7edf\u8ba1\u5b66\u9ad8\u5ea6\u663e\u8457\u7684\u6700\u7ec8\u7ed3\u8bba\u3002<\/p>\n\n\n\n

*** Daraxonrasib\uff08RMC-6236\uff09\u76ee\u524d\u5c1a\u672a\u5728\u5168\u7403\u4efb\u4f55\u5730\u533a\u6b63\u5f0f\u83b7\u6279\u4e0a\u5e02<\/strong>\uff0c\u4ecd\u5904\u4e8e\u65b0\u836f\u5ba1\u8bc4\u9636\u6bb5\u3002\u4e2d\u5fc3\u5c06\u6301\u7eed\u8ddf\u8e2a\u7f8e\u56fdFDA\u5ba1\u6279\u8fdb\u5c55\uff0c\u7b2c\u4e00\u65f6\u95f4\u4e3a\u5927\u5bb6\u540c\u6b65\u83b7\u6279\u4e0e\u4e0a\u5e02\u52a8\u6001\u3002<\/p>\n\n\n\n

\u5f85\u836f\u7269\u6b63\u5f0f\u83b7FDA\u6279\u51c6\u540e\uff0c\u4e2d\u56fd\u5185\u5730\u53ca\u9999\u6e2f\u60a3\u8005\u53ef\u901a\u8fc7\u9999\u6e2fName Patient Access Program\uff08NPA\uff0c\u6307\u5b9a\u836f\u7269\u4f7f\u7528\u8ba1\u5212\uff09\uff0c\u7ecf\u9999\u6e2f\u80bf\u7624\u79d1\u4e13\u79d1\u533b\u751f\u8bc4\u4f30\u5904\u65b9\uff0c\u5408\u6cd5\u7533\u8bf7\u8fdb\u53e3\u4f7f\u7528\u3002<\/p>\n\n\n\n

1. <\/strong>\u764c\u738b\u6709\u591a\u7edd\u671b\uff1f\u4ee5\u524d\u6709\u591a\u96be<\/strong><\/strong><\/p>\n\n\n\n

\u80f0\u817a\u764c\uff08\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff0cPDAC\uff09\u662f\u9884\u540e\u6700\u5dee\u7684\u5b9e\u4f53\u7624\uff1a<\/p>\n\n\n\n

\u2022 85%\u60a3\u8005\u786e\u8bca\u5373\u665a\u671f\uff0c\u65e0\u6cd5\u624b\u672f <\/p>\n\n\n\n

\u2022 5\u5e74\u751f\u5b58\u7387\u4ec52%\u20133% <\/p>\n\n\n\n

\u2022 \u4e00\u7ebf\u5316\u7597\uff08FOLFIRINOX\/AG\uff09\u52c9\u5f3a\u6491\u52308\u201311\u4e2a\u6708 <\/p>\n\n\n\n

\u2022 \u4e00\u65e6\u8010\u836f\u8fdb\u5c55\uff08\u4e8c\u7ebf\uff09\uff1a\u6807\u51c6\u5316\u7597\u4e2d\u4f4d OS \u4ec56.6\u20137.7\u4e2a\u6708 <\/p>\n\n\n\n

\u2022 \u6bd2\u6027\u5927\u3001\u53cd\u590d\u8f93\u6db2\u3001\u751f\u6d3b\u8d28\u91cf\u6781\u5dee <\/p>\n\n\n\n

\u8fc7\u53bb\u51e0\u5341\u5e74\uff0c\u80f0\u817a\u764c\u4e8c\u7ebf\u6cbb\u7597\u51e0\u4e4e\u539f\u5730\u8e0f\u6b65\uff0c\u6240\u6709\u65b0\u836f3\u671f\u5168\u90e8\u5931\u8d25\u3002\u201c\u534a\u5e74\u751f\u5b58\u671f\u201d\u50cf\u4e00\u9053\u6b7b\u5211\u5ba3\u5224\uff0c\u538b\u5728\u65e0\u6570\u5bb6\u5ead\u8eab\u4e0a\u3002<\/p>\n\n\n\n

2. <\/strong>\u4e09\u671f\u6570\u636e\uff1a6.7\u4e2a\u6708\u219213.2\u4e2a\u6708\uff0c\u76f4\u63a5\u7ffb\u500d<\/strong><\/p>\n\n\n\n

\u5168\u74033\u671f RASolute 302\uff08n=460\uff09\uff1a<\/strong><\/strong><\/p>\n\n\n\n

\u2022 \u5165\u7ec4\uff1a\u65e2\u5f80\u6cbb\u7597\u5931\u8d25\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\uff08\u542bRAS G12\u7a81\u53d8+\u91ce\u751f\u578b\uff09<\/p>\n\n\n\n

\u2022 \u5206\u7ec4\uff1aDaraxonrasib 300mg \u53e3\u670d\u6bcf\u65e51\u6b21 VS \u533b\u751f\u9009\u62e9\u6807\u51c6\u9759\u8109\u5316\u7597<\/p>\n\n\n\n

\u2022 \u4e3b\u8981\u7ec8\u70b9\uff1aRAS G12 \u7a81\u53d8\u4eba\u7fa4 PFS\u3001OS\uff1b\u5168\u4eba\u7fa4 ITT\u540c\u6b65\u9a8c\u8bc1<\/p>\n\n\n\n

\u6838\u5fc3\u7ed3\u679c\uff1a<\/strong><\/p>\n\n\n\n

\u2022 \u4e2d\u4f4d OS\uff1a13.2\u4e2a\u6708 vs 6.7\u4e2a\u6708 \u2192 \u8fd1\u4e4e\u7ffb\u500d<\/p>\n\n\n\n

\u2022 \u6b7b\u4ea1\u98ce\u9669 HR=0.40 \u2192 \u964d\u4f4e60%\u6b7b\u4ea1\u98ce\u9669\uff08p<0.0001\uff09<\/p>\n\n\n\n

\u2022 PFS \u663e\u8457\u4f18\u6548\u3001ORR \u66f4\u9ad8\u3001\u751f\u6d3b\u8d28\u91cf\u663e\u8457\u66f4\u597d<\/p>\n\n\n\n

\u2022 \u4e2d\u671f\u5206\u6790\u5373\u5168\u90e8\u8fbe\u6807\uff0c\u7ed3\u679c\u89c6\u4e3a\u6700\u7ec8<\/p>\n\n\n\n

\u4e00\u53e5\u8bdd\u603b\u7ed3\uff1a<\/strong><\/p>\n\n\n\n

\u4ee5\u524d\u4e8c\u7ebf\u5316\u7597\u5e73\u5747\u6d3b\u534a\u5e74\u591a\uff1b\u73b0\u5728\u5403\u53e3\u670d\u836f\uff0c\u5e73\u5747\u6d3b1\u5e74\u591a\u3002<\/p>\n\n\n\n

3. <\/strong>\u4e3a\u4ec0\u4e48\u662f\u5b83\uff1f\u5168\u7403\u9996\u4e2a\u201c\u6cdbRAS\uff08ON\uff09\u201d\u9776\u5411\u836f<\/strong><\/p>\n\n\n\n

\u80f0\u817a\u764c90%\u4ee5\u4e0a\u662f RAS \u7a81\u53d8\u9a71\u52a8\uff08\u6700\u5e38\u89c1 KRAS G12D\/V\uff09\uff0c\u957f\u671f\u88ab\u89c6\u4e3a\u201c\u4e0d\u53ef\u6210\u836f\u201d\u9776\u70b9\u3002<\/p>\n\n\n\n

Daraxonrasib\uff08RMC-6236\uff09\u662f\u5168\u7403\u9996\u521b\uff1a<\/strong><\/p>\n\n\n\n

\u2022 \u53e3\u670d\u3001\u6bcf\u65e5 1 \u6b21\u3001300mg<\/p>\n\n\n\n

\u2022 \u975e\u5171\u4ef7\u3001\u591a\u9009\u62e9\u6027 RAS (ON) \u6291\u5236\u5242<\/p>\n\n\n\n

\u2022 \u72ec\u7279\u4e09\u5143\u590d\u5408\u7269\u673a\u5236\uff1a\u4e0e\u4eb2\u73af\u86cb\u767d A\uff08CypA\uff09\u7ed3\u5408 \u2192 \u9776\u5411\u6d3b\u5316 RAS\uff08RAS-ON\uff09\u2192\u963b\u65ad\u4e0b\u6e38 RAF\/PI3K \u4fe1\u53f7<\/p>\n\n\n\n

\u2022 \u5e7f\u8c31\u8986\u76d6\uff1aG12D\/V\/R\/C\u3001\u91ce\u751f\u578b RAS\uff0c\u51e0\u4e4e\u8986\u76d6\u6240\u6709\u80f0\u817a\u764c<\/p>\n\n\n\n

\u2022 \u5df2\u83b7 FDA\uff1a\u7a81\u7834\u6027\u7597\u6cd5+\u5b64\u513f\u836f+\u4f18\u5148\u8bc4\u5ba1\uff0c\u4e0a\u5e02\u5c06\u5927\u5e45\u63d0\u901f<\/p>\n\n\n\n

4. <\/strong>\u5b89\u5168\u6027\uff1a\u53e3\u670d\u66f4\u53cb\u597d\uff0c\u6bd2\u6027\u53ef\u63a7<\/strong><\/strong><\/p>\n\n\n\n

\u2022 \u6574\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u65e0\u65b0\u5b89\u5168\u4fe1\u53f7<\/p>\n\n\n\n

\u2022 \u53e3\u670d\u6bcf\u65e51\u6b21\uff0c\u4e0d\u7528\u4f4f\u9662\u8f93\u6db2<\/p>\n\n\n\n

\u2022 \u76f8\u6bd4\u5316\u7597\uff1a\u66f4\u5c11\u9aa8\u9ad3\u6291\u5236\u3001\u66f4\u5c11\u5455\u5410\u8179\u6cfb\u3001\u66f4\u5c11\u795e\u7ecf\u6bd2\u6027<\/p>\n\n\n\n

\u2022 \u652f\u6301\u957f\u671f\u7ef4\u6301\uff0c\u663e\u8457\u63d0\u5347\u665a\u671f\u60a3\u8005\u751f\u6d3b\u8d28\u91cf<\/p>\n\n\n\n

5. <\/strong>\u6539\u5199\u80f0\u817a\u764c\u6cbb\u7597\u683c\u5c40\uff0c\u771f\u6b63\u7684 \u201c\u7834\u51b0\u201d<\/strong><\/p>\n\n\n\n

1. \u5386\u53f2\u6027\u7a81\u7834\uff1a\u80f0\u817a\u764c\u6cbb\u7597\u53f2\u4e0a\u9996\u6b21\u51fa\u73b0 OS \u7ffb\u500d\u7684\u9776\u5411\u836f<\/p>\n\n\n\n

2. \u8986\u76d6\u6781\u5e7f\uff1a90%\u80f0\u817a\u764c\u60a3\u8005\uff08RAS \u7a81\u53d8+\u91ce\u751f\u578b\uff09\u90fd\u53ef\u80fd\u83b7\u76ca<\/p>\n\n\n\n

3. \u53e3\u670d\u4fbf\u5229\uff1a\u4ece \u201c\u53cd\u590d\u8f93\u6db2\u5316\u7597\u201d \u5230 \u201c\u5728\u5bb6\u6bcf\u5929\u4e00\u7247\u201d\uff0c\u6cbb\u7597\u6a21\u5f0f\u5f7b\u5e95\u6539\u53d8<\/p>\n\n\n\n

4. \u5168\u7403\u6807\u51c6\uff1a\u6570\u636e\u5c06\u57282026 ASCO\u516c\u5e03\uff0c\u968f\u540e\u63d0\u4ea4\u5168\u7403\u4e0a\u5e02\u7533\u8bf7<\/p>\n\n\n\n

5. RAS \u6291\u5236\u5242\u65b0\u65f6\u4ee3\uff1a\u9a8c\u8bc1\u6cdb RAS \u9776\u5411\u6210\u836f\uff0c\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u7b49 RAS \u7a81\u53d8\u764c\u79cd\u5c06\u5168\u9762\u53d7\u76ca<\/p>\n\n\n\n

\u7ed3\u8bed<\/strong><\/p>\n\n\n\n

\u8fd9\u4e00\u591c\uff0c\u80f0\u817a\u764c\u4e0d\u518d\u662f\u201c\u5224\u534a\u5e74\u201d\u7684\u7edd\u75c7\u3002<\/p>\n\n\n\n

Daraxonrasib 3\u671f\u6570\u636e\u544a\u8bc9\u6211\u4eec\uff1a<\/p>\n\n\n\n

\u2022 \u665a\u671f\u80f0\u817a\u764c\uff0c\u751f\u5b58\u671f\u53ef\u4ee5\u7ffb\u500d<\/p>\n\n\n\n

\u2022 \u4e0d\u7528\u5929\u5929\u5316\u7597\uff0c\u5728\u5bb6\u53e3\u670d\u4e5f\u80fd\u957f\u671f\u751f\u5b58<\/p>\n\n\n\n

\u2022 90%\u60a3\u8005\uff0c\u90fd\u6709\u673a\u4f1a\u7528\u4e0a\u8fd9\u6b3e\u65b0\u836f<\/p>\n\n\n\n

\u76ee\u524d\uff0cDaraxonrasib4 \u9879\u5168\u74033\u671f\u540c\u6b65\u63a8\u8fdb\uff083\u9879\u80f0\u817a\u764c + 1\u9879\u80ba\u764c\uff09\uff0c\u8986\u76d6\u4e8c\u7ebf\u3001\u4e00\u7ebf\u3001\u8f85\u52a9\u6cbb\u7597\u3002\u4e0a\u5e02\u5df2\u8fdb\u5165\u5012\u8ba1\u65f6\u3002<\/p>\n\n\n\n

\u53c2\u8003\u8d44\u6599\u6765\u6e90\uff1ahttps:\/\/ir.revmed.com\/news-releases\/news-release-details\/daraxonrasib-demonstrates-unprecedented-overall-survival-benefit<\/a><\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/p>\n","protected":false},"excerpt":{"rendered":"

2026\u5e744\u670813\u65e5\uff0c\u6ce8\u5b9a\u88ab\u8f7d\u5165\u80bf\u7624\u6cbb\u7597\u53f2\u518c\u3002 \u88ab\u79f0\u4e3a\u201c\u764c\u4e2d\u4e4b\u738b\u201d\u7684\u80f0\u817a\u764c\uff0c\u8fce\u6765\u4e86\u534a\u4e2a\u4e16\u7eaa\uff0850\u591a\u5e74\uff09\u4ee5\u6765\u6700\u9707<\/p>\n","protected":false},"author":14,"featured_media":39528,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769,1750],"tags":[],"yst_prominent_words":[],"class_list":["post-39537","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans","category-pancreatic-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=39537"}],"version-history":[{"count":2,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39537\/revisions"}],"predecessor-version":[{"id":39539,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39537\/revisions\/39539"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/39528"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=39537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=39537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=39537"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=39537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}