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1. <\/strong>\u653e\u5c04\u914d\u4f53\u7597\u6cd5\u7684\u56db\u4e2a\u4e16\u4ee3\uff1a\u4e00\u6bb5\u79d1\u5b66\u5f81\u7a0b<\/strong><\/p>\n\n\n\n

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Tb-161\u662f\u4e00\u79cd\u7269\u7406\u534a\u8870\u671f\u4e3a6.89\u5929\u7684\u653e\u5c04\u6027\u6838\u7d20\u2014\u2014\u4e0eLu-177\u76846.64\u5929\u51e0\u4e4e\u5b8c\u5168\u76f8\u540c\uff0c\u610f\u5473\u7740\u540c\u6837\u5b9e\u7528\u7684\u4e34\u5e8a\u7ed9\u836f\u8ba1\u5212\u548c\u6cbb\u7597\u540e\u76d1\u6d4b\u7a97\u53e3\u5747\u53ef\u9002\u7528\u3002\u5176\u5316\u5b66\u6027\u8d28\u4e0eLu-177\u8db3\u591f\u76f8\u4f3c\uff0c\u53ef\u4ee5\u7528\u51e0\u4e4e\u5b8c\u5168\u76f8\u540c\u7684\u653e\u5c04\u6027\u6807\u8bb0\u5316\u5b66\u65b9\u6cd5\uff0c\u6807\u8bb0\u81f3\u540c\u6837\u7684PSMA\u9776\u5411\u914d\u4f53\u2014\u2014PSMA-I&T\u53caPSMA-617\u3002<\/p>\n\n\n\n

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\u8499\u7279\u5361\u6d1b\u7269\u7406\u6a21\u62df\u53ca\u4e34\u5e8a\u524d\u6bd4\u8f83\u7814\u7a76\u5df2\u786e\u8ba4\uff0c\u65e0\u8bba\u653e\u5c04\u914d\u4f53\u5728\u764c\u7ec6\u80de\u4e0a\u6216\u7ec6\u80de\u5185\u7684\u5206\u5e03\u60c5\u51b5\u5982\u4f55\uff0cTB-161\u5411\u5355\u4e2a\u80bf\u7624\u7ec6\u80de\u6838\u548c\u5c0f\u7ec6\u80de\u96c6\u7fa4\u9012\u9001\u7684\u8f90\u5c04\u5242\u91cf\u5747\u663e\u8457\u9ad8\u4e8eLu-177\u3002\u800c\u7531\u4e8e\u4fc4\u6b47\u7535\u5b50\u7684\u5c04\u7a0b\u5982\u6b64\u4e4b\u77ed\u2014\u2014\u4e9a\u7ec6\u80de\u7ea7\u522b\u2014\u2014\u989d\u5916\u7684\u8f90\u5c04\u80fd\u91cf\u4e0d\u4f1a\u5bf9\u8fdc\u5904\u6b63\u5e38\u7ec4\u7ec7\u9020\u6210\u6709\u610f\u4e49\u7684\u5f71\u54cd\u3002\u4fc4\u6b47\u7535\u5b50\u7ec4\u5206\u5e26\u6765\u7684\u9884\u671f\u6bd2\u6027\u589e\u52a0\u5fae\u4e4e\u5176\u5fae\uff1b\u5bf9\u5c0f\u80bf\u7624\u75c5\u7076\u7684\u7597\u6548\u63d0\u5347\u5219\u6216\u8bb8\u76f8\u5f53\u53ef\u89c2\u3002<\/p>\n\n\n\n

\u8fd9\u4f7fTB-161<\/strong>\u5360\u636e\u4e86\u4e00\u4e2a\u72ec\u7279\u4e14\u9887\u5177\u5438\u5f15\u529b\u7684\u4e34\u5e8a\u7a7a\u95f4\uff1a\u901a\u8fc7\u5176\u4fc4\u6b47\u7535\u5b50\u7ec4\u5206\uff0c\u5bf9\u5fae\u8f6c\u79fb\u6027\u75be\u75c5\u7684\u751f\u7269\u5b66\u6027\u80fd\u5f3a\u4e8eLu-177\uff0c\u540c\u65f6\u5168\u8eab\u6bd2\u6027\u8fdc\u4f4e\u4e8e\u9515-225\uff0c\u4e25\u91cd\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u4e34\u5e8a\u5e94\u7528\u3002\u5bf9\u4e8e\u5927\u591a\u6570\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u2014\u2014\u5c24\u5176\u662f\u6df7\u5408\u4f53\u79ef\u75be\u75c5\u60a3\u8005\u3001\u75be\u75c5\u8fdb\u7a0b\u8f83\u65e9\u671f\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u53ef\u80fd\u65e0\u6cd5\u8010\u53d7\u03b1\u7597\u6cd5\u8981\u6c42\u7684\u60a3\u8005\u2014\u2014Tb-161\u6216\u8bb8\u4ee3\u8868\u7740\u6700\u4f18\u7684\u8f90\u5c04\u8d28\u91cf\uff0c\u4ee5\u53ca\u6700\u5747\u8861\u7684\u6cbb\u7597\u6307\u6570\u3002<\/p>\n\n\n\n

3<\/strong>. <\/strong>VIOLET\u8bd5\u9a8c\uff1a\u7b2c\u4e00\u6ce2\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u8fce\u6765\u65b0\u5e0c\u671b<\/strong><\/p>\n\n\n\n

\u8fd9\u4e00\u7406\u8bba\u6846\u67b6\u5728VIOLET\u8bd5\u9a8c\u4e2d\u8fce\u6765\u4e86\u9996\u6b21\u4e34\u5e8a\u7814\u7a76\u2014\u2014\u8fd9\u662f\u4e00\u9879\u7814\u7a76\u8005\u53d1\u8d77\u7684\u3001\u5728\u6fb3\u5927\u5229\u4e9a\u58a8\u5c14\u672cPeter MacCallum\u764c\u75c7\u4e2d\u5fc3\u5f00\u5c55\u7684\u5355\u4e2d\u5fc3\u3001\u5355\u81c2\u3001I\/II\u671f\u5242\u91cf\u9012\u589e\u53ca\u6269\u5c55\u7814\u7a76\uff0c\u4e8e2022\u5e7410\u6708\u81f32024\u5e742\u6708\u95f4\uff0c\u5171\u62db\u52df\u4e8630\u540d\u8fdb\u5c55\u6027\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7537\u6027\u60a3\u8005\u3002\u6240\u6709\u60a3\u8005\u6b64\u524d\u5747\u5df2\u63a5\u53d7\u8fc7\u96c4\u6fc0\u7d20\u53d7\u4e3b\u6e20\u9053\u6291\u5236\u5242\u6cbb\u7597\uff1b67%\u66fe\u63a5\u53d7\u591a\u897f\u4ed6\u8d5b\u5316\u7597\u3002\u8fd9\u4e9b\u60a3\u8005\u4ee3\u8868\u4e86\u4e00\u4e2a\u63a5\u53d7\u8fc7\u5927\u91cf\u524d\u671f\u6cbb\u7597\u3001\u6cbb\u7597\u9009\u62e9\u786e\u5b9e\u6709\u9650\u7684\u4eba\u7fa4\u3002\u8bd5\u9a8c\u6d4b\u8bd5\u4e86\u4e09\u4e2a\u653e\u5c04\u6d3b\u5ea6\u5242\u91cf\u6c34\u5e73\uff1a4.4 GBq\u30015.5 GBq\u53ca7.4 GBq\uff0c\u6bcf\u516d\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u6700\u591a\u8fdb\u884c\u516d\u4e2a\u5468\u671f\u3002<\/p>\n\n\n\n

\u5b89\u5168\u6027\u7ed3\u679c\u9ad8\u5ea6\u4ee4\u4eba\u653e\u5fc3\uff0c\u5728\u4efb\u4f55\u5242\u91cf\u6c34\u5e73\u5747\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u4ee5\u8f7b\u5ea61\u7ea7\u4e3a\u4e3b\uff1a\u53e3\u5e72\uff0870%\uff09\u3001\u8d2b\u8840\uff0853%\uff09\u53ca\u75b2\u52b3\uff0840%\uff09\u30023\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u4ec5\u9650\u4e8e\u4e00\u540d\u60a3\u8005\u51fa\u73b0\u75bc\u75db\uff083%\uff09\u53ca\u4e00\u540d\u60a3\u8005\u51fa\u73b0\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff083%\uff09\u3002\u65e04\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0c\u65e0\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\uff0c\u65e0\u5242\u91cf\u964d\u4f4e\uff0c\u4ea6\u65e0\u56e0\u6bd2\u6027\u5bfc\u81f4\u7684\u6cbb\u7597\u7ec8\u6b62\u3002II\u671f\u4e34\u5e8a\u7814\u7a76\u63a8\u8350\u7684\u6700\u9ad8\u7ed9\u836f\u5242\u91cf\u8bbe\u5b9a\u4e3a7.4 GBq\uff0c\u4e0e\u6807\u51c6Lu-177 PSMA\u7ed9\u836f\u5242\u91cf\u4e00\u81f4\u3002\u5404\u5668\u5b98\u5438\u6536\u5242\u91cf\u5747\u5728Lu-177 PSMA\u7597\u6cd5\u6240\u62a5\u544a\u7684\u8303\u56f4\u4e4b\u5185\uff0c\u786e\u8ba4\u4e86\u989d\u5916\u7684\u4fc4\u6b47\u7535\u5b50\u53d1\u5c04\u5e76\u672a\u8f6c\u5316\u4e3a\u989d\u5916\u7684\u6b63\u5e38\u7ec4\u7ec7\u6bd2\u6027\u3002\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\uff08PSA\uff09\u964d\u4f4e50%\u6216\u4ee5\u4e0a\uff1b\u572840%\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230PSA\u964d\u4f4e90%\u6216\u4ee5\u4e0a\u3002\u5bf9\u4e8e\u63a5\u53d7\u8fc7\u5927\u91cf\u524d\u671f\u6cbb\u7597\u7684\u4eba\u7fa4\u800c\u8a00\uff0c\u8fd9\u662f\u4e00\u4e2a\u5f15\u4eba\u6ce8\u76ee\u7684\u7ed3\u679c\u3002\u5728\u6309RECIST\u6807\u51c6\u5177\u6709\u53ef\u6d4b\u91cf\u8f6f\u7ec4\u7ec7\u75be\u75c5\u7684\u60a3\u8005\u4e2d\uff0c50%\u8fbe\u5230\u90e8\u5206\u5f71\u50cf\u5b66\u7f13\u89e3\u3002\u4e2d\u4f4d\u5f71\u50cf\u5b66\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a11.1\u4e2a\u6708\uff0c\u4e2d\u4f4dPSA\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a9.0\u4e2a\u6708\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a11.9\u4e2a\u6708\u3002<\/p>\n\n\n\n

4<\/strong>. <\/strong>Tb-161\u4f5c\u4e3a\u65e9\u671f\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7684\u613f\u666f<\/strong><\/p>\n\n\n\n

Tb-161\u6700\u4ee4\u4eba\u632f\u594b\u3001\u6700\u5177\u4e34\u5e8a\u53d8\u9769\u610f\u4e49\u7684\u957f\u671f\u89d2\u8272\uff0c\u6216\u8bb8\u4e0d\u5728\u4e8e\u63a5\u53d7\u8fc7\u6700\u5927\u91cf\u524d\u671f\u6cbb\u7597\u7684\u4eba\u7fa4\u2014\u2014\u800c\u5728\u4e8e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7684\u6700\u65e9\u671f\u9636\u6bb5\u3002\u8fd9\u4e00\u524d\u77bb\u6027\u613f\u666f\u690d\u6839\u4e8e\u4e00\u4e2a\u57fa\u672c\u653e\u5c04\u751f\u7269\u5b66\u539f\u7406\uff1a\u4fc4\u6b47\u7535\u5b50\u5728\u80bf\u7624\u8d1f\u8377\u6700\u5c0f\u65f6\uff0c\u5176\u76f8\u5bf9\u751f\u7269\u5b66\u4f18\u52bf\u6070\u6070\u6700\u4e3a\u663e\u8457\u3002\u5728\u65e9\u671fmCRPC\u4e2d\u2014\u2014\u60a3\u8005\u53ef\u80fd\u75c5\u7076\u4f53\u79ef\u5c0f\u3001\u5728PSMA-PET\u6210\u50cf\u4e0a\u4ec5\u6709\u6709\u9650\u6570\u91cf\u7684\u53ef\u68c0\u6d4b\u75c5\u7076\uff0cTb-161\u4fc4\u6b47\u7535\u5b50\u989d\u5916\u7684\u8f90\u5c04\u80fd\u91cf\u5bf9\u5c0f\u80bf\u7624\u75c5\u7076\u7684\u7597\u6548\u63d0\u5347\u5219\u6700\u5177\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0cVIOLET\u8bd5\u9a8c\u6240\u5c55\u793a\u7684\u5b89\u5168\u6027\u7279\u5f81\u2014\u2014\u65e0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u8010\u53d7\u6027\u7279\u5f81\u4e0e\u5df2\u786e\u7acb\u7684Lu-177\u7ecf\u9a8c\u9ad8\u5ea6\u76f8\u8fd1\u2014\u2014\u8868\u660eTb-161\u53ef\u5728\u6cbb\u7597\u5e8f\u5217\u4e2d\u66f4\u65e9\u5f15\u5165\uff0c\u7528\u4e8e\u524d\u671f\u6cbb\u7597\u8f83\u5c11\u3001\u66f4\u6709\u53ef\u80fd\u8010\u53d7\u5e76\u4ece\u5b8c\u6574\u653e\u5c04\u914d\u4f53\u7597\u6cd5\u5468\u671f\u4e2d\u5145\u5206\u83b7\u76ca\u7684\u60a3\u8005\u3002\u4e0e\u9515-225\u76f8\u6bd4\uff0cTb-161\u7684\u826f\u597d\u8010\u53d7\u6027\u5728\u6b64\u60c5\u5883\u4e0b\u5c24\u4e3a\u5173\u952e\uff1a\u65e9\u671fmCRPC\u60a3\u8005\u901a\u5e38\u9884\u671f\u751f\u5b58\u671f\u66f4\u957f\uff0c\u7d2f\u79ef\u6bd2\u6027\u66b4\u9732\u7684\u65f6\u95f4\u8de8\u5ea6\u66f4\u5927\uff0c\u4ee4Tb-161\u5728\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u5ea6\u6d3b\u8dc3\u4f46\u6bd2\u6027\u4e0eLu-177\u76f8\u7ea6\u7684\u524d\u5217\u817a\u764c\u653e\u5c04\u914d\u4f53\u6cbb\u7597\uff0c\u5c06\u4f1a\u662f\u53ef\u4ee5\u826f\u597d\u7ba1\u7406\u7684\u836f\u7269\u5d2d\u65b0\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/p>\n","protected":false},"excerpt":{"rendered":"

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