{"id":39636,"date":"2026-04-30T14:00:33","date_gmt":"2026-04-30T06:00:33","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=39636"},"modified":"2026-04-30T14:00:13","modified_gmt":"2026-04-30T06:00:13","slug":"%e9%9d%a2%e5%af%b9%e6%99%9a%e6%9c%9f%e4%b9%b3%e8%85%ba%e7%99%8c%ef%bc%8c%e8%bf%9b%e5%b1%95-%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9%e9%99%8d%e4%bd%8e67%ef%bc%81hr%e4%b9%b3%e8%85%ba%e7%99%8c%e6%82%a3","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e9%9d%a2%e5%af%b9%e6%99%9a%e6%9c%9f%e4%b9%b3%e8%85%ba%e7%99%8c%ef%bc%8c%e8%bf%9b%e5%b1%95-%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9%e9%99%8d%e4%bd%8e67%ef%bc%81hr%e4%b9%b3%e8%85%ba%e7%99%8c%e6%82%a3\/","title":{"rendered":"\u9762\u5bf9\u665a\u671f\u4e73\u817a\u764c\uff0c\u8fdb\u5c55\/\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e67%\uff01HR+\u4e73\u817a\u764c\u60a3\u8005\u5c06\u8fce\u6765AKT\u6291\u5236\u5242"},"content":{"rendered":"\n

\u8fd1\u65e5\uff0cLAE002\uff08Afuresertib\uff09 \u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\uff0c\u6cbb\u7597HR+\/HER2- \u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684 III \u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff08AFFIRM-205\uff09\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5c55\u73b0\u51fa\u9ad8\u5ea6\u7edf\u8ba1\u5b66\u663e\u8457\u4e14\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u6539\u5584\u3002<\/p>\n\n\n\n

1. <\/strong>\u7814\u7a76\u6982\u51b5\uff1a\u7cbe\u51c6\u9776\u5411\u8010\u836f\u4eba\u7fa4<\/strong><\/strong><\/p>\n\n\n\n

AFFIRM-205\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167<\/strong>\u7684\u5173\u952e\u6027 III \u671f\u7814\u7a76\uff0c\u5171\u7eb3\u5165261\u4f8b<\/strong>\u60a3\u8005\uff0c\u6838\u5fc3\u4eba\u7fa4\u4e3a\uff1a<\/p>\n\n\n\n

\u25b6 HR+\/HER2- \u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/p>\n\n\n\n

\u25b6 \u4f34\u968f PIK3CA\/AKT1\/PTEN \u57fa\u56e0\u6539\u53d8\uff08PAM \u901a\u8def\u5f02\u5e38\uff09<\/p>\n\n\n\n

\u25b6 \u65e2\u5f80\u63a5\u53d7\u5185\u5206\u6ccc\u6cbb\u7597 \u00b1 CDK4\/6 \u6291\u5236\u5242 \u540e\u75be\u75c5\u8fdb\u5c55<\/p>\n\n\n\n

\u5176\u4e2d\uff0c70.5%\u7684\u60a3\u8005\u66fe\u63a5\u53d7\u8fc7 CDK4\/6\u6291\u5236\u5242\u6cbb\u7597\uff0c\u5c5e\u4e8e\u4e34\u5e8a\u4e2d\u9ad8\u5ea6\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u8010\u836f\u4eba\u7fa4\u3002<\/p>\n\n\n\n

2. <\/strong>\u6838\u5fc3\u7597\u6548\u6570\u636e\uff082026\u5e744\u670815\u65e5\u9876\u7ebf\u7ed3\u679c\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u2022 LAE002 + \u6c1f\u7ef4\u53f8\u7fa4\u7ec4\uff1a\u4e2d\u4f4d PFS 7.6 \u4e2a\u6708<\/strong><\/strong><\/p>\n\n\n\n

\u2022 \u5b89\u6170\u5242 + \u6c1f\u7ef4\u53f8\u7fa4\u7ec4\uff1a\u4e2d\u4f4d PFS 2.0 \u4e2a\u6708<\/strong><\/strong><\/p>\n\n\n\n

\u2022 \u98ce\u9669\u6bd4\uff08HR\uff09= 0.33\uff0cP\uff1c0.0001<\/strong><\/strong><\/p>\n\n\n\n

\u2192 <\/strong>\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u663e\u8457\u964d\u4f4e67%<\/strong><\/u><\/strong><\/p>\n\n\n\n

3. <\/strong>\u5b89\u5168\u6027\u7279\u5f81<\/strong><\/strong><\/p>\n\n\n\n

\u2022 \u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\uff0c\u4f7f\u7528\u4fbf\u6377<\/p>\n\n\n\n

\u2022 \u6574\u4f53\u8010\u53d7\u6027\u826f\u597d<\/p>\n\n\n\n

\u2022 \u56e0\u4e0d\u826f\u4e8b\u4ef6\u7ec8\u6b62\u6cbb\u7597\u6bd4\u4f8b\u6781\u4f4e<\/p>\n\n\n\n

\u2022 \u5b89\u5168\u6027\u7279\u5f81\u4e0e\u524d\u671f\u7814\u7a76\u4e00\u81f4<\/p>\n\n\n\n

4<\/strong>. <\/strong>\u4e34\u5e8a\u610f\u4e49\u4e0e\u4ef7\u503c<\/strong><\/strong><\/p>\n\n\n\n

HR+\/HER2 – \u4e9a\u578b\u7ea6\u5360\u6240\u6709\u4e73\u817a\u764c\u768470%\uff0c\u5185\u5206\u6ccc\u8054\u5408CDK4\/6\u6291\u5236\u5242\u662f\u6807\u51c6\u4e00\u7ebf\u65b9\u6848\uff0c\u4f46\u8010\u836f\u540e\u6cbb\u7597\u9009\u62e9\u6709\u9650\u3002<\/p>\n\n\n\n

PAM\u901a\u8def\uff08PI3K\/AKT\/mTOR\uff09\u5f02\u5e38\u662f\u5185\u5206\u6ccc\u8010\u836f\u3001CDK4\/6\u6291\u5236\u5242\u8010\u836f\u7684\u6838\u5fc3\u673a\u5236\u4e4b\u4e00\uff0c\u4e2d\u56fd\u60a3\u8005\u4e2d* \u7ea657%*\u5b58\u5728\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u3002<\/p>\n\n\n\n

LAE002\uff08Afuresertib\uff09\u4f5c\u4e3a\u5f3a\u6548\u6cdbAKT\u6291\u5236\u5242\uff0c\u53ef\u540c\u65f6\u6291\u5236 AKT1\/2\/3 \u4e09\u79cd\u4e9a\u578b\uff0c\u4ece\u901a\u8def\u5173\u952e\u8282\u70b9\u963b\u65ad\u5f02\u5e38\u4fe1\u53f7\u3002AFFIRM-205 \u7814\u7a76\u7684\u6210\u529f\uff0c\u4e3aCDK4\/6\u6291\u5236\u5242\u8fdb\u5c55\u540e\u3001\u4f34PAM\u901a\u8def\u7a81\u53d8\u7684 HR+\/HER2 – \u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u7cbe\u51c6\u9776\u5411\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n\n\n\n

\u7ed3\u8bed<\/strong><\/strong><\/p>\n\n\n\n

\u622a\u81f3\u76ee\u524d\uff0c\u9488\u5bf9PI3K\/AKT\/PTEN\u901a\u8def\u7684\u9776\u5411\u836f\u5df2\u6709capivasertib\uff08Truqap\uff09\u83b7\u6279\uff0c\u5982\u679cafuresertib\u672a\u6765\u4e5f\u80fd\u83b7\u6279\uff0c\u5219\u5c06\u4f1a\u6210\u4e3a\u6b64\u7c7b\u7b2c\u4e8c\u4e2a\u4e0a\u5e02\u836f\u7269\u3002<\/p>\n\n\n\n

AFFIRM-205\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u5728\u4e73\u817a\u764c\u7cbe\u51c6\u6cbb\u7597\u9886\u57df\u7684\u91cd\u8981\u7a81\u7834\u3002\u968f\u7740\u7cbe\u51c6\u533b\u5b66\u53d1\u5c55\u4e0e\u57fa\u56e0\u68c0\u6d4b\u666e\u53ca\uff0c\u5148\u68c0\u6d4b\u3001\u540e\u9776\u5411\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u6a21\u5f0f\uff0c\u5c06\u4e3a\u66f4\u591a\u8010\u836f\u4e73\u817a\u764c\u60a3\u8005\u5e26\u6765\u957f\u671f\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n\n\n\n

\u53c2\u8003\u8d44\u6599\u6765\u6e90\uff1ahttps:\/\/www1.hkexnews.hk\/listedco\/listconews\/sehk\/2026\/0415\/ 2026041500099.pdf<\/a><\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u65e5\uff0cLAE002\uff08Afuresertib\uff09 \u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\uff0c\u6cbb\u7597HR+\/HER2- \u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684 <\/p>\n","protected":false},"author":14,"featured_media":39617,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769,1735],"tags":[],"yst_prominent_words":[],"class_list":["post-39636","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans","category-breast-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39636","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=39636"}],"version-history":[{"count":4,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39636\/revisions"}],"predecessor-version":[{"id":39660,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39636\/revisions\/39660"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/39617"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=39636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=39636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=39636"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=39636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}