{"id":39688,"date":"2026-05-08T17:49:52","date_gmt":"2026-05-08T09:49:52","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=39688"},"modified":"2026-05-08T18:11:35","modified_gmt":"2026-05-08T10:11:35","slug":"eftilagimod-alfa%e8%8e%b7fda%e5%ad%a4%e5%84%bf%e8%8d%af%e8%b5%84%e6%a0%bc%e7%94%a8%e4%ba%8e%e8%bd%af%e7%bb%84%e7%bb%87%e8%82%89%e7%98%a4%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/eftilagimod-alfa%e8%8e%b7fda%e5%ad%a4%e5%84%bf%e8%8d%af%e8%b5%84%e6%a0%bc%e7%94%a8%e4%ba%8e%e8%bd%af%e7%bb%84%e7%bb%87%e8%82%89%e7%98%a4%e6%b2%bb%e7%96%97\/","title":{"rendered":"Eftilagimod alfa\u83b7FDA\u5b64\u513f\u836f\u8d44\u683c\u7528\u4e8e\u8f6f\u7ec4\u7ec7\u8089\u7624\u6cbb\u7597"},"content":{"rendered":"\n

\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6388\u4e88 Eftilagimod alfa\uff08\u53c8\u540d IMP321\uff0c\u7b80\u79f0 Efti\uff09\u5b64\u513f\u836f\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6f\u7ec4\u7ec7\u8089\u7624\uff08STS\uff09\u3002<\/p>\n\n\n\n

*\u6ce8\uff1a\u5b64\u513f\u836f\u8d44\u683c\u9002\u7528\u4e8e\u6cbb\u7597\u7f8e\u56fd\u60a3\u8005\u4eba\u6570\u5c11\u4e8e20\u4e07\u7684\u7f55\u89c1\u75be\u75c5\uff0c\u65e8\u5728\u9f13\u52b1\u9488\u5bf9\u91cd\u5927\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u75be\u75c5\u7684\u836f\u7269\u7814\u53d1\u3002<\/p>\n\n\n\n

1. <\/strong>\u6388\u4e88\u4f9d\u636e<\/strong><\/strong><\/p>\n\n\n\n

\u8fd9\u4e00\u8d44\u683c\u662f\u57fa\u4e8e 2 \u671f EFTISARC-NEO \u4e34\u5e8a\u8bd5\u9a8c\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u4e2d\u7684\u79ef\u6781\u6570\u636e\u3002\u65b0\u8f85\u52a9\u6cbb\u7597\u662f\u6307\u5728\u624b\u672f\u524d\u8fdb\u884c\u7684\u5316\u7597\u3001\u653e\u7597\u6216\u514d\u75ab\u6cbb\u7597\uff0c\u76ee\u7684\u662f\u7f29\u5c0f\u80bf\u7624\u3001\u63d0\u9ad8\u624b\u672f\u6210\u529f\u7387\uff0c\u5e76\u5e2e\u52a9\u63a7\u5236\u5fae\u5c0f\u8f6c\u79fb\u3002\u8be5 2 \u671f\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u8bc4\u4f30\u7684\u75c5\u7406\u53cd\u5e94\u7387\u3002\u5728 Eftilagimod alfa \u8054\u5408\u653e\u7597\u53ca PD-1 \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08pembrolizumab\uff09\u6cbb\u7597\u7ec4\u4e2d\uff0c\u76f8\u8f83\u653e\u7597\u5355\u72ec\u7684\u5386\u53f2\u6570\u636e\u6709\u663e\u8457\u63d0\u5347\u3002<\/p>\n\n\n\n

2. <\/strong>\u5173\u4e8e Eftilagimod alfa<\/strong><\/strong><\/p>\n\n\n\n

Eftilagimod alfa \u662f\u4e00\u79cd\u5728\u7814\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u901a\u8fc7\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53 II \u7c7b\uff08MHC II\uff09\u901a\u8def\u76f4\u63a5\u6fc0\u6d3b\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APCs\uff09\uff0c\u5305\u62ec\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\u3002\u8be5\u4f5c\u7528\u53ef\u4ee5\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de\u542f\u52a8\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u548c\u5148\u5929\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u5168\u9762\u514d\u75ab\u53cd\u5e94\uff0c\u5305\u62ec\u6269\u589e\u80fd\u591f\u8bc6\u522b\u653e\u7597\u8bf1\u5bfc\u80bf\u7624\u6297\u539f\u7684 CD8 \u9633\u6027\u7ec6\u80de\u6bd2\u6027 T \u7ec6\u80de\u3002Eftilagimod alfa \u5229\u7528 LAG-3 \u76f8\u5173\u673a\u5236\u6765\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u53cd\u5e94\u80fd\u529b\u3002<\/p>\n\n\n\n

\u7b80\u5355\u6765\u8bf4\uff0c\u8be5\u836f\u53ef\u501f\u52a9\u81ea\u8eab\u4f5c\u7528\u673a\u5236\u5524\u9192\u5e76\u6fc0\u6d3b\u673a\u4f53\u81ea\u8eab\u514d\u75ab\u7ec6\u80de\uff0c\u8ba9\u514d\u75ab\u7ec6\u80de\u66f4\u6709\u6548\u5730\u8bc6\u522b\u5e76\u653b\u51fb\u80bf\u7624\u7ec6\u80de\uff0c\u4ece\u800c\u63d0\u5347\u6297\u80bf\u7624\u514d\u75ab\u6548\u679c\u3002<\/p>\n\n\n\n

Eftilagimod alfa \u76ee\u524d\u6b63\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u8fdb\u884c\u8bc4\u4f30\uff0c\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u3001\u8f6f\u7ec4\u7ec7\u8089\u7624\u4ee5\u53ca\u4e73\u817a\u764c\u3002\u7531\u4e8e\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u5b83\u53ef\u4ee5\u4e0e\u591a\u79cd\u7597\u6cd5\u8054\u5408\u4f7f\u7528\uff0c\u4f8b\u5982 PD-1\/PD-L1 \u6291\u5236\u5242\u3001\u653e\u7597\u548c \/ \u6216\u5316\u7597\u3002Eftilagimod alfa \u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u4e00\u7ebf\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u4e00\u7ebf\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5feb\u901f\u901a\u9053\u8d44\u683c\u3002<\/strong><\/p>\n\n\n\n

3. <\/strong>\u5173\u4e8e EFTISARC-NEO \u8bd5\u9a8c<\/strong><\/strong><\/p>\n\n\n\n

\u6b63\u5728\u8fdb\u884c\u7684 2 \u671f EFTISARC-NEO \u8bd5\u9a8c\u7814\u7a76\uff0c\u8bc4\u4f30\u4e86 Eftilagimod alfa \u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08pembrolizumab\uff09\u53ca\u653e\u7597\uff0c\u7528\u4e8e\u6cbb\u7597\u56db\u80a2\u6216\u8eaf\u5e72 2 \u7ea7\u6216 3 \u7ea7 III \u671f\u8f6f\u7ec4\u7ec7\u8089\u7624\u60a3\u8005\u3002\u60a3\u8005\u5728\u7b2c 1 \u81f3\u7b2c 9 \u5468\u63a5\u53d7\u7cfb\u7edf\u6cbb\u7597\uff0c\u5728\u7b2c 2 \u81f3\u7b2c 6 \u5468\u63a5\u53d7\u653e\u7597\uff0c\u5e76\u5728\u7b2c 11 \u81f3\u7b2c 12 \u5468\u8fdb\u884c\u624b\u672f\u5207\u9664\u3002\u8fd9\u662f\u9996\u6b21\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u73af\u5883\u4e2d\u8bc4\u4f30 Eftilagimod alfa\uff0c\u4e5f\u662f\u9996\u6b21\u5c06\u8be5\u836f\u7269\u4e0e\u653e\u7597\u8054\u5408\u4f7f\u7528\u3002<\/strong><\/p>\n\n\n\n

\u8bd5\u9a8c\u5df2\u5b8c\u6210\u5165\u7ec4\uff0c\u5171\u7eb3\u5165 40 \u4f8b\u60a3\u8005\u3002\u8be5\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u4e3a\u75c5\u7406\u53cd\u5e94\uff0c\u901a\u8fc7\u624b\u672f\u5207\u9664\u65f6\u80bf\u7624\u7684\u73bb\u7483\u6837\u53d8 \/ \u7ea4\u7ef4\u5316\u7a0b\u5ea6\u8fdb\u884c\u8861\u91cf\u3002\u8fd9\u662f\u4e00\u79cd\u65e9\u671f\u66ff\u4ee3\u7ec8\u70b9\uff0c\u5df2\u88ab\u8bc1\u5b9e\u4e0e\u8f6f\u7ec4\u7ec7\u8089\u7624\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u548c\u65e0\u590d\u53d1\u751f\u5b58\u671f\u7684\u6539\u5584\u76f8\u5173\u3002<\/p>\n\n\n\n

4. <\/strong>\u7814\u7a76\u7ed3\u679c<\/strong><\/strong><\/p>\n\n\n\n

\u5728 38 \u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\uff08\u6db5\u76d6\u591a\u4e2a\u8f6f\u7ec4\u7ec7\u8089\u7624\u4e9a\u578b\uff09\uff0c\u4e09\u8054\u65b9\u6848\u663e\u8457\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002\u8be5\u7ec4\u5408\u6cbb\u7597\u4f7f\u75c5\u7406\u73bb\u7483\u6837\u53d8 \/ \u7ea4\u7ef4\u5316\u4e2d\u4f4d\u6bd4\u4f8b\u8fbe\u5230 51.5%\uff0c\u8d85\u8fc7\u9884\u8bbe\u76ee\u6807 35%\uff0c\u5e76\u4e14\u662f\u653e\u7597\u5355\u72ec\u5386\u53f2\u57fa\u51c6 15% \u7684 3 \u500d\u4ee5\u4e0a\u3002\u6cbb\u7597\u540e\u624b\u672f\u5207\u9664\u7684\u80bf\u7624\u7ec4\u7ec7\u4e2d\uff0c\u8d85\u8fc7\u534a\u6570\u5df2\u53d1\u751f\u660e\u663e\u574f\u6b7b\u53ca\u73bb\u7483\u6837\u53d8 \/ \u7ea4\u7ef4\u5316\u6539\u53d8\uff0c\u7597\u6548\u663e\u8457\u4f18\u4e8e\u5355\u7eaf\u653e\u7597\u7684\u5386\u53f2\u6c34\u5e73\u3002<\/p>\n\n\n\n

\u5b89\u5168\u6027\u65b9\u9762\uff1a92.5% \u7684\u60a3\u8005\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5927\u591a\u6570\u4e0e\u624b\u672f\u6216\u653e\u7597\u76f8\u5173\uff0c\u5176\u4e2d 20.0% \u4e3a 3 \u7ea7\u6216 4 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5305\u62ec 17.5% \u7684 3 \u7ea7\u6216 4 \u7ea7\u624b\u672f\u5e76\u53d1\u75c7\u3002\u8fd9\u4e9b\u7ed3\u679c\u5728\u591a\u4e2a\u8f6f\u7ec4\u7ec7\u8089\u7624\u4e9a\u578b\u4e2d\u5747\u6709\u89c2\u5bdf\u5230\uff0c\u540c\u65f6\u8f6c\u5316\u533b\u5b66\u6570\u636e\u4e5f\u663e\u793a\u51fa\u4e0e Eftilagimod alfa \u4f5c\u7528\u673a\u5236\u4e00\u81f4\u7684\u514d\u75ab\u6fc0\u6d3b\u4fe1\u53f7\u3002\u6574\u4f53\u5b89\u5168\u6027\u826f\u597d\uff0c\u5e76\u672a\u5f71\u54cd\u8ba1\u5212\u4e2d\u7684\u624b\u672f\u65f6\u95f4\u5b89\u6392\u3002<\/p>\n\n\n\n

5. <\/strong>\u4e0b\u4e00\u6b65\u8ba1\u5212<\/strong><\/p>\n\n\n\n

\u8f6f\u7ec4\u7ec7\u8089\u7624\u662f\u4e00\u79cd\u7f55\u89c1\u4e14\u4fb5\u88ad\u6027\u5f3a\u7684\u6076\u6027\u80bf\u7624\uff0c\u6cbb\u7597\u9009\u62e9\u6709\u9650\uff0c\u5c24\u5176\u662f\u590d\u53d1\u6216\u5bf9\u73b0\u6709\u6cbb\u7597\u8010\u836f\u7684\u60a3\u8005\u3002\u73b0\u6709\u6807\u51c6\u7684\u65b0\u8f85\u52a9\u653e\u7597\u75c5\u7406\u53cd\u5e94\u7387\u6709\u9650\uff0c\u51f8\u663e\u4e86\u65b0\u7597\u6cd5\u7684\u9700\u6c42\u3002<\/p>\n\n\n\n

EFTISARC-NEO \u7814\u7a76\u7684\u79ef\u6781\u6570\u636e\u83b7\u5f97\u4e86 FDA \u7684\u8ba4\u53ef\uff0c\u672c\u6b21\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u4e3a Eftilagimod alfa \u5728\u8f6f\u7ec4\u7ec7\u8089\u7624\u65b0\u8f85\u52a9\u6cbb\u7597\u9886\u57df\u7684\u540e\u7eed\u4e34\u5e8a\u7814\u7a76\u63d0\u4f9b\u4e86\u53ef\u884c\u7684\u63a8\u8fdb\u8def\u5f84\u3002<\/p>\n\n\n\n

\u8d44\u6599\u6765\u6e90\uff1a<\/p>\n\n\n\n

[1]https:\/\/www.targetedonc.com\/view\/fda-grants-orphan-drug-designation-to-eftilagimod-alfa-for-soft-tissue-sarcoma<\/a><\/p>\n\n\n\n

[2]https:\/\/www.biospace.com\/press-releases\/immutep-receives-fda-orphan-drug-designation-for-eftilagimod-alfa-in-soft-tissue-sarcoma<\/a><\/p>\n\n\n\n

[3]https:\/\/www.immutep.com\/11560-2\/<\/a><\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6388\u4e88 Eftilagimod alfa\uff08\u53c8\u540d IMP321\uff0c\u7b80\u79f0 Efti\uff09<\/p>\n","protected":false},"author":14,"featured_media":39676,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769],"tags":[],"yst_prominent_words":[],"class_list":["post-39688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=39688"}],"version-history":[{"count":2,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39688\/revisions"}],"predecessor-version":[{"id":39731,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39688\/revisions\/39731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/39676"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=39688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=39688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=39688"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=39688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}