{"id":39757,"date":"2026-05-15T11:17:36","date_gmt":"2026-05-15T03:17:36","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=39757"},"modified":"2026-05-15T11:17:10","modified_gmt":"2026-05-15T03:17:10","slug":"%e9%87%8d%e7%a3%85%ef%bc%81fda%e6%8f%90%e5%89%8d%e6%89%b9%e5%87%86%e4%b9%b3%e8%85%ba%e7%99%8c%e6%96%b0%e8%8d%afvepdegestrant-esr1%e7%aa%81%e5%8f%98%e6%82%a3%e8%80%85%e8%bf%8e%e6%9d%a5%e7%b2%be","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e9%87%8d%e7%a3%85%ef%bc%81fda%e6%8f%90%e5%89%8d%e6%89%b9%e5%87%86%e4%b9%b3%e8%85%ba%e7%99%8c%e6%96%b0%e8%8d%afvepdegestrant-esr1%e7%aa%81%e5%8f%98%e6%82%a3%e8%80%85%e8%bf%8e%e6%9d%a5%e7%b2%be\/","title":{"rendered":"\u91cd\u78c5\uff01FDA\u63d0\u524d\u6279\u51c6\u4e73\u817a\u764c\u65b0\u836fvepdegestrant\u00a0ESR1\u7a81\u53d8\u60a3\u8005\u8fce\u6765\u7cbe\u51c6\u65b0\u9009\u62e9"},"content":{"rendered":"\n

2026\u5e745\u67081\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5f0f\u6279\u51c6vepdegestrant<\/strong> \u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597 ER\u9633\u6027\u3001HER2\u9634\u6027\u3001ESR1\u7a81\u53d8<\/strong> \u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/strong>\u6210\u4eba\u60a3\u8005\uff0c\u4e3a\u7ecf\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u5e26\u6765\u5168\u65b0\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n

\u672c\u836f\u7269\u76ee\u524d\u5c1a\u672a\u5728\u9999\u6e2f\u53ca\u4e2d\u56fd\u5927\u9646\u83b7\u5f97\u4e0a\u5e02\u6279\u51c6\u3002\u6709\u76f8\u5173\u6cbb\u7597\u9700\u6c42\u7684\u60a3\u8005\uff0c\u5728\u7ecf\u533b\u751f\u9762\u8bca\u8bc4\u4f30\u540e\uff0c\u53ef\u901a\u8fc7\u9999\u6e2f\u201c \u6307\u5b9a\u836f\u7269\u4f7f\u7528\u8ba1\u5212\uff08NPA\uff09 \u201d\u7533\u8bf7\u76f8\u5173\u6cbb\u7597\u65b9\u6848\uff0c\u6709\u9700\u8981\u5373\u53ef\u8054\u7cfb\u6211\u4eec\u9999\u6e2f\u7efc\u5408\u80bf\u7624\u4e2d\u5fc3\u7684\u5ba2\u670d\u67e5\u8be2\u4e86\u89e3\u66f4\u591a\u3002<\/p>\n\n\n\n

 * Name Patient Access Program\uff08\u5373NPA\uff09\u201c\u6307\u5b9a\u836f\u7269\u4f7f\u7528\u8ba1\u5212\u201d\uff0c\u4fd7\u79f0\u201c\u65b0\u836f\u7eff\u8272\u901a\u9053\u201d\uff0c\u7b26\u5408\u4ee5\u4e0b\u4e24\u4e2a\u60c5\u51b5\u7684\u75c5\u4eba\uff0c\u53ef\u4ee5\u900f\u8fc7NPA\u4f7f\u7528\u8fd9\u4e9b\u521b\u65b0\u764c\u75c7\u836f\u7269\uff1a<\/p>\n\n\n\n

1. \u75c5\u4eba\u9700\u8981\u7684\u521b\u65b0\u836f\u7269\u5728\u9999\u6e2f\u4ecd\u672a\u6ce8\u518c\uff0c\u4f46\u5728\u6b27\u7f8e\u6216\u5185\u5730\u5df2\u4e0a\u5e02\u3002<\/p>\n\n\n\n

2. \u5fc5\u987b\u7ecf\u9999\u6e2f\u7684\u533b\u751f\uff08\u4e3b\u8981\u662f\u4e34\u5e8a\/\u5185\u79d1\u80bf\u7624\u79d1\u4e13\u79d1\u533b\u751f\uff09\u8bca\u65ad\u548c\u8bc4\u4f30\u540e\uff0c\u786e\u5b9a\u75c5\u4eba\u7684\u60c5\u51b5\u9002\u5408\u6216\u6709\u5fc5\u8981\u4f7f\u7528\u8be5\u9879\u521b\u65b0\u836f\u7269\u3002<\/p>\n\n\n\n

1. <\/strong>\u83b7\u6279\u6838\u5fc3\u4fe1\u606f<\/strong><\/strong><\/p>\n\n\n\n

\u672c\u6b21\u83b7\u6279\u7684 vepdegestrant \u662f\u4e00\u6b3e\u5f02\u53cc\u529f\u80fd\u86cb\u767d\u964d\u89e3\u5242<\/strong>\uff0c\u7cbe\u51c6\u9488\u5bf9\u4e73\u817a\u764c\u5173\u952e\u6cbb\u7597\u9776\u70b9\uff0c\u83b7\u6279\u9002\u5e94\u75c7\u660e\u786e\uff1a<\/p>\n\n\n\n

\u25b6 \u9002\u7528\u4eba\u7fa4\uff1a<\/strong>\u7ecfFDA\u6388\u6743\u68c0\u6d4b\u786e\u8ba4 ESR1\u7a81\u53d8<\/strong> \u7684 ER\u9633\u6027\u3001HER2\u9634\u6027\u665a\u671f\/\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005<\/p>\n\n\n\n

\u25b6 \u6cbb\u7597\u524d\u63d0\uff1a<\/strong>\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55<\/p>\n\n\n\n

\u25b6 \u4f34\u968f\u8bca\u65ad\uff1a<\/strong>\u540c\u6b65\u6279\u51c6\u6db2\u4f53\u6d3b\u68c0\u68c0\u6d4b<\/strong>\u4f5c\u4e3a\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\uff0c\u7528\u4e8e\u7b5b\u9009\u9002\u5408\u63a5\u53d7 vepdegestrant \u6cbb\u7597\u7684 ESR1 \u7a81\u53d8\u4e73\u817a\u764c\u60a3\u8005<\/p>\n\n\n\n

FDA\u6b64\u6b21\u5ba1\u6279\u8f83\u76ee\u6807\u65e5\u671f\u63d0\u524d1\u4e2a\u6708\uff0c\u4e3a\u60a3\u8005\u5feb\u901f\u7528\u4e0a\u65b0\u836f\u6253\u901a\u7eff\u8272\u901a\u9053\u3002<\/p>\n\n\n\n

2. <\/strong>\u4e34\u5e8a\u6570\u636e\u4eae\u773c\uff0c\u663e\u8457\u5ef6\u957f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f<\/strong><\/p>\n\n\n\n

\u672c\u6b21\u83b7\u6279\u57fa\u4e8eVERITAC-2\uff08NCT05654623\uff09 <\/strong>\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u5bf9\u7167\u8bd5\u9a8c\uff0c\u5171\u7eb3\u5165624\u4f8b\u7b26\u5408\u6761\u4ef6\u7684\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5176\u4e2d270\u4f8b\u643a\u5e26 ESR1 \u7a81\u53d8\u3002<\/p>\n\n\n\n

\u5173\u952e\u4e34\u5e8a\u7ed3\u679c\uff08ESR1 \u7a81\u53d8\u4eba\u7fa4\uff09<\/strong><\/p>\n\n\n\n

1. \u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>vepdegestrant \u7ec4\uff1a\u4e2d\u4f4d PFS 5\u4e2a\u6708<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u6c1f\u7ef4\u53f8\u7fa4\u5bf9\u7167\u7ec4\uff1a\u4e2d\u4f4d PFS 2.1\u4e2a\u6708<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u98ce\u9669\u6bd4 0.57\uff0c\u5dee\u5f02\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\uff08p=0.0001\uff09<\/p>\n\n\n\n

2. \u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>vepdegestrant \u7ec4\uff1a19%<\/strong><\/p>\n\n\n\n

\u00b7<\/strong> \u6c1f\u7ef4\u53f8\u7fa4\u5bf9\u7167\u7ec4\uff1a4%<\/strong><\/p>\n\n\n\n

3. \u603b\u751f\u5b58\u671f\uff08OS\uff09\u6570\u636e\u5c1a\u4e0d\u6210\u719f\uff0c\u5206\u6790\u65f6\u6b7b\u4ea1\u7387\u4ec5 16%\uff0c\u957f\u671f\u83b7\u76ca\u4ecd\u5728\u6301\u7eed\u968f\u8bbf\u4e2d\u3002<\/p>\n\n\n\n

\u8bd5\u9a8c\u7eb3\u5165\u60a3\u8005\u5747\u63a5\u53d7\u8fc71-2\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\uff08\u542b1\u7ebf CDK4\/6 \u6291\u5236\u5242\u6cbb\u7597\uff09\uff0c\u9a8c\u8bc1\u4e86 vepdegestrant \u5728\u7ecf\u6cbb\u4eba\u7fa4\u4e2d\u7684\u53ef\u9760\u7597\u6548\u3002<\/p>\n\n\n\n

3. <\/strong>\u7528\u6cd5\u7528\u91cf\u4e0e\u5b89\u5168\u63d0\u793a<\/strong><\/p>\n\n\n\n

\u63a8\u8350\u5242\u91cf<\/strong><\/p>\n\n\n\n

\u2022 200mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5 1 \u6b21\uff0c\u968f\u9910\u670d\u7528<\/p>\n\n\n\n

\u2022 \u6301\u7eed\u7528\u836f\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027<\/p>\n\n\n\n

\u91cd\u8981\u5b89\u5168\u8b66\u793a<\/strong><\/p>\n\n\n\n

\u836f\u54c1\u8bf4\u660e\u4e66\u660e\u786e\u6807\u6ce8\u4e24\u9879\u6838\u5fc3\u6ce8\u610f\u4e8b\u9879\uff1a<\/p>\n\n\n\n

1. QT \u95f4\u671f\u5ef6\u957f\uff1a<\/strong>\u7528\u836f\u671f\u95f4\u9700\u5173\u6ce8\u5fc3\u810f\u76f8\u5173\u76d1\u6d4b<\/p>\n\n\n\n

2. \u80da\u80ce – \u80ce\u513f\u6bd2\u6027\uff1a<\/strong>\u5177\u6709\u80ce\u513f\u4f24\u5bb3\u98ce\u9669\uff0c\u80b2\u9f84\u671f\u60a3\u8005\u9700\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd <\/p>\n\n\n\n

4. <\/strong>\u4e34\u5e8a\u610f\u4e49<\/strong><\/p>\n\n\n\n

ESR1 \u7a81\u53d8\u662f ER \u9633\u6027\u4e73\u817a\u764c\u5185\u5206\u6ccc\u6cbb\u7597\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0\uff0c\u8fd9\u7c7b\u60a3\u8005\u65e2\u5f80\u6cbb\u7597\u9009\u62e9\u6709\u9650\u3002vepdegestrant \u4f5c\u4e3a\u65b0\u578b\u86cb\u767d\u964d\u89e3\u5242\uff0c\u7cbe\u51c6\u76f4\u51fb ESR1 \u7a81\u53d8\u9776\u70b9\uff0c\u51ed\u501f\u66f4\u4f18\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e0e\u7f13\u89e3\u7387\uff0c\u6210\u4e3aESR1 \u7a81\u53d8\u665a\u671f\u4e73\u817a\u764c\u7684\u5168\u65b0\u6807\u51c6\u6cbb\u7597\u9009\u62e9\uff0c\u586b\u8865\u4e34\u5e8a\u6cbb\u7597\u7a7a\u767d\u3002<\/p>\n\n\n\n

\u7ed3\u8bed<\/strong><\/strong><\/p>\n\n\n\n

\u968f\u7740 Vepdegestrant<\/strong> \u83b7 FDA \u6b63\u5f0f\u83b7\u6279\uff0cESR1\u7a81\u53d8 \u665a\u671f\u4e73\u817a\u764c<\/strong>\u60a3\u8005\u8fce\u6765\u5168\u65b0\u6cbb\u7597\u9009\u62e9\uff0c\u4e5f\u4e3a\u4e34\u5e8a\u7cbe\u51c6\u9776\u5411\u6cbb\u7597\u518d\u6dfb\u91cd\u78c5\u5229\u5668\uff0c\u671f\u5f85\u672a\u6765\u60e0\u53ca\u66f4\u591a\u60a3\u8005\u3002<\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/p>\n","protected":false},"excerpt":{"rendered":"

2026\u5e745\u67081\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6b63\u5f0f\u6279\u51c6vepdegestrant \u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb<\/p>\n","protected":false},"author":14,"featured_media":39748,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769,1735],"tags":[],"yst_prominent_words":[],"class_list":["post-39757","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans","category-breast-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=39757"}],"version-history":[{"count":2,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39757\/revisions"}],"predecessor-version":[{"id":39763,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/39757\/revisions\/39763"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/39748"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=39757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=39757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=39757"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=39757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}