{"id":40234,"date":"2026-06-18T15:36:52","date_gmt":"2026-06-18T07:36:52","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=40234"},"modified":"2026-06-18T15:39:31","modified_gmt":"2026-06-18T07:39:31","slug":"%e4%b9%b3%e8%85%ba%e7%99%8c%e6%9c%af%e5%90%8e%e6%80%95%e5%a4%8d%e5%8f%91%ef%bc%9f%e8%bf%99%e6%ac%be%e5%8f%a3%e6%9c%8d%e6%96%b0%e8%8d%afiii%e6%9c%9f%e8%af%81%e5%ae%9e%ef%bc%8c%e6%98%be%e8%91%97","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e4%b9%b3%e8%85%ba%e7%99%8c%e6%9c%af%e5%90%8e%e6%80%95%e5%a4%8d%e5%8f%91%ef%bc%9f%e8%bf%99%e6%ac%be%e5%8f%a3%e6%9c%8d%e6%96%b0%e8%8d%afiii%e6%9c%9f%e8%af%81%e5%ae%9e%ef%bc%8c%e6%98%be%e8%91%97\/","title":{"rendered":"\u4e73\u817a\u764c\u672f\u540e\u6015\u590d\u53d1\uff1f\u8fd9\u6b3e\u53e3\u670d\u65b0\u836fIII\u671f\u8bc1\u5b9e\uff0c\u663e\u8457\u964d\u4f4e\u8fdc\u671f\u590d\u53d1\u6982\u7387"},"content":{"rendered":"\n

\u6839\u636e\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff08IARC\uff092022\u5e74\u5168\u7403\u80bf\u7624\u7edf\u8ba1\u6570\u636e\uff0c\u4e73\u817a\u764c\u4e3a\u5168\u7403\u5973\u6027\u53d1\u75c5\u7387\u3001\u6b7b\u4ea1\u7387\u9996\u4f4d\u6076\u6027\u80bf\u7624\uff0c<\/strong>\u968f\u7740\u65e9\u7b5b\u4e0e\u7efc\u5408\u6cbb\u7597\u666e\u53ca\uff0c\u65e9\u671f\u60a3\u8005\u672f\u540e\u957f\u671f\u751f\u5b58\u6bd4\u4f8b\u6301\u7eed\u63d0\u5347\uff0c\u4f46\u672f\u540e\u590d\u53d1\u8f6c\u79fb\u4ecd\u662f\u5f71\u54cd\u8fdc\u671f\u9884\u540e\u7684\u6838\u5fc3\u98ce\u9669\u56e0\u7d20\u3002<\/p>\n\n\n\n

\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\/HER2-\uff09\u662f\u4e34\u5e8a\u6700\u5e38\u89c1\u4e73\u817a\u764c\u5206\u5b50\u4e9a\u578b\uff0c\u5360\u65e9\u671f\u4e73\u817a\u764c\u60a3\u800570%\u4ee5\u4e0a\uff0c\u8be5\u7fa4\u4f53\u9700\u957f\u671f\u63a5\u53d7\u8f85\u52a9\u5185\u5206\u6ccc\u6cbb\u7597\u4ee5\u63a7\u5236\u6f5c\u5728\u5fae\u8f6c\u79fb\u7076\u3001\u964d\u4f4e\u590d\u53d1\u98ce\u9669\u3002\u73b0\u6709\u6807\u51c6\u5185\u5206\u6ccc\u65b9\u6848\u5b58\u5728\u90e8\u5206\u4eba\u7fa4\u7597\u6548\u6709\u9650\u3001\u957f\u671f\u670d\u836f\u808c\u8089\u9aa8\u9abc\u4e0d\u826f\u53cd\u5e94\u660e\u663e\u3001\u4f9d\u4ece\u6027\u4e0d\u8db3\u7b49\u5ba2\u89c2\u4e34\u5e8a\u5c40\u9650\uff0c\u4e34\u5e8a\u4ecd\u5b58\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002<\/p>\n\n\n\n

2026\u5e74ASCO\u5e74\u4f1a\u516c\u5e03\u5168\u7403\u591a\u4e2d\u5fc3III\u671f lidERA \u7814\u7a76\u5b8c\u6574\u5206\u5c42\u6570\u636e\uff0c\u65b0\u4e00\u4ee3\u53e3\u670d\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53\u964d\u89e3\u5242\uff08SERD\uff09Giredestrant \u7684\u8f85\u52a9\u6cbb\u7597\u5faa\u8bc1\u8bc1\u636e\u843d\u5730\uff1b\u540c\u671f\u836f\u5382\u65d7\u4e0b\u57fa\u56e0\u6cf0\u514b\u5ba3\u5e03\u8be5\u836f\u7269\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u83b7\u7f8e\u56fdFDA\u4f18\u5148\u5ba1\u8bc4\uff0c\u4e3a\u65e9\u671f HR \u9633\u6027\u4e73\u817a\u764c\u672f\u540e\u5185\u5206\u6ccc\u7ba1\u7406\u63d0\u4f9b\u5168\u65b0\u6cbb\u7597\u9009\u62e9\u3002\u672c\u6587\u57fa\u4e8e\u516c\u5f00III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5ba2\u89c2\u6570\u636e\uff0c\u4e25\u8c28\u68b3\u7406\u836f\u7269\u7597\u6548\u3001\u5b89\u5168\u6027\u4e0e\u4e34\u5e8a\u9002\u7528\u573a\u666f\u3002<\/p>\n\n\n\n

***\u672c\u836f\u7269\u76ee\u524d\u5c1a\u672a\u83b7FDA\u4e0a\u5e02\u8bb8\u53ef\uff0c\u51ed\u501f2026 ASCO\u516c\u5e03\u7684\u2162\u671f\u4e34\u5e8a\u7ed3\u679c\u53ca2026\u5e746\u67081\u65e5FDA\u4f18\u5148\u5ba1\u8bc4\u516c\u544a\uff0c\u836f\u7269\u6709\u671b\u5728\u77ed\u671f\u5185\u901a\u8fc7FDA\u5ba1\u6279\u3002\u836f\u7269\u83b7\u6279FDA\u540e\uff0c\u6709\u76f8\u5173\u6cbb\u7597\u9700\u6c42\u7684\u60a3\u8005\uff0c\u5728\u7ecf\u533b\u751f\u9762\u8bca\u8bc4\u4f30\u540e\uff0c\u53ef\u901a\u8fc7\u9999\u6e2f\u201c\u6307\u5b9a\u836f\u7269\u4f7f\u7528\u8ba1\u5212\uff08NPA\uff09\u201d<\/strong>\u7533\u8bf7\u76f8\u5173\u6cbb\u7597\u7528\u836f\uff0c\u6709\u9700\u8981\u5373\u53ef\u8054\u7cfb\u6211\u4eec\u9999\u6e2f\u7efc\u5408\u80bf\u7624\u4e2d\u5fc3\u7684\u5ba2\u670d\u67e5\u8be2\u4e86\u89e3\u66f4\u591a\u3002<\/p>\n\n\n\n

*Name Patient Access Program\uff08\u5373NPA\uff09\u201c\u6307\u5b9a\u836f\u7269\u4f7f\u7528\u8ba1\u5212\u201d\uff0c\u4fd7\u79f0\u201c\u65b0\u836f\u7eff\u8272\u901a\u9053\u201d\uff0c\u7b26\u5408\u4ee5\u4e0b\u4e24\u4e2a\u60c5\u51b5\u7684\u75c5\u4eba\uff0c\u53ef\u4ee5\u900f\u8fc7NPA\u4f7f\u7528\u8fd9\u4e9b\u521b\u65b0\u764c\u75c7\u836f\u7269\uff1a<\/p>\n\n\n\n

1. \u75c5\u4eba\u9700\u8981\u7684\u521b\u65b0\u836f\u7269\u5728\u9999\u6e2f\u4ecd\u672a\u6ce8\u518c\uff0c\u4f46\u5728\u6b27\u7f8e\u6216\u5185\u5730\u5df2\u4e0a\u5e02\u3002<\/p>\n\n\n\n

2. \u5fc5\u987b\u7ecf\u9999\u6e2f\u7684\u533b\u751f\uff08\u4e3b\u8981\u662f\u4e34\u5e8a\/\u5185\u79d1\u80bf\u7624\u79d1\u4e13\u79d1\u533b\u751f\uff09\u8bca\u65ad\u548c\u8bc4\u4f30\u540e\uff0c\u786e\u5b9a\u75c5\u4eba\u7684\u60c5\u51b5\u9002\u5408\u6216\u6709\u5fc5\u8981\u4f7f\u7528\u8be5\u9879\u521b\u65b0\u836f\u7269\u3002<\/p>\n\n\n\n

1. <\/strong>\u4e34\u5e8a\u80cc\u666f\uff1aHR\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u672f\u540e\u590d\u53d1\u73b0\u72b6<\/strong><\/strong><\/p>\n\n\n\n

\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff08IARC\uff09\u6c47\u603b\u591a\u56fd\u80bf\u7624\u767b\u8bb0\u7cfb\u7edf\u968f\u8bbf\u6570\u636e\u663e\u793a\uff0c\u975e\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u672f\u540e\u590d\u53d1\u5b58\u5728\u65f6\u95f4\u5206\u5c42\u7279\u5f81\uff1a\u591a\u6570\u590d\u53d1\u4e8b\u4ef6\u53d1\u751f\u4e8e\u672f\u540e\u524d5\u5e74\uff0c\u9ad8\u98ce\u9669\u4eba\u7fa410\u5e74\u7d2f\u79ef\u8fdc\u5904\u8f6c\u79fb\u590d\u53d1\u7387\u6700\u9ad8\u53ef\u8fbe28.3%\uff1b\u5176\u4e2d HR \u9633\u6027\u4e9a\u578b\u590d\u53d1\u5468\u671f\u66f4\u957f\uff0c\u90e8\u5206\u60a3\u8005\u672f\u540e10\u5e74\u4ecd\u5b58\u5728\u8fdc\u671f\u590d\u53d1\u98ce\u9669\u3002<\/p>\n\n\n\n

\u4f20\u7edf\u8f85\u52a9\u5185\u5206\u6ccc\u6cbb\u7597\u5305\u542b\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\uff08AI\uff09\u3001\u4ed6\u83ab\u6614\u82ac\u3001\u6ce8\u5c04\u578b SERD \u6c1f\u7ef4\u53f8\u7fa4<\/strong>\u4e09\u7c7b\u65b9\u6848\uff0c\u5b58\u5728\u4e24\u70b9\u4e34\u5e8a\u5c40\u9650\uff1a<\/p>\n\n\n\n

1. \u7edd\u7ecf\u524d\u3001\u7edd\u7ecf\u540e\u60a3\u8005\u9700\u5dee\u5f02\u5316\u7528\u836f\u7b56\u7565\uff0c\u90e8\u5206\u9ad8\u5371\u4eba\u7fa4\u6807\u51c6\u65b9\u6848\u4e0b\u4ecd\u5b58\u5728\u8f83\u9ad8\u4fb5\u88ad\u6027\u590d\u53d1\u98ce\u9669\uff1b<\/p>\n\n\n\n

2. AI\u7c7b\u836f\u7269\u957f\u671f\u4f7f\u7528\u6613\u5f15\u53d1\u6301\u7eed\u6027\u5173\u8282\u808c\u8089\u75bc\u75db\uff0c\u56e0\u4e0d\u826f\u53cd\u5e94\u505c\u836f\u6bd4\u4f8b\u7ea68.2%\uff0c\u7528\u836f\u4e2d\u65ad\u4f1a\u76f4\u63a5\u62ac\u5347\u590d\u53d1\u6982\u7387\u3002<\/p>\n\n\n\n

\u5168\u7403\u8303\u56f4\u5185\uff0c\u8fd120\u5e74\u6682\u65e0\u53e3\u670d SERD \u836f\u7269\u5728\u65e9\u671f\u4e73\u817a\u764c\u8f85\u52a9\u6cbb\u7597III\u671f\u5173\u952e\u6027\u7814\u7a76\u4e2d\u53d6\u5f97\u9633\u6027\u7ec8\u70b9\uff0c\u76f4\u81f3 lidERA \u7814\u7a76\u6570\u636e\u516c\u5e03\u3002<\/p>\n\n\n\n

2. III\u671f lidERA \u4e34\u5e8a\u8bd5\u9a8c\u57fa\u7840\u8bbe\u8ba1<\/strong><\/strong><\/p>\n\n\n\n

lidERA \u4e3a\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5bf9\u7167\u3001III\u671f\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff08\u8bd5\u9a8c\u7f16\u53f7 NCT04961996\uff09\uff0c\u7814\u7a76\u6838\u5fc3\u76ee\u7684\uff1a\u5bf9\u6bd4 Giredestrant \u4e0e\u4e34\u5e8a\u6807\u51c6\u5185\u5206\u6ccc\u6cbb\u7597\uff0c\u7528\u4e8e I\u2013III \u671f ER+\/HER2 – \u65e9\u671f\u4e73\u817a\u764c\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u65e0\u4fb5\u88ad\u6027\u75be\u75c5\u751f\u5b58\u83b7\u76ca\u4e0e\u5b89\u5168\u6027\u5dee\u5f02\u3002<\/p>\n\n\n\n

1. \u5165\u7ec4\u4eba\u7fa4\u89c4\u6a21\uff1a<\/strong>\u603b\u8ba1\u7eb3\u51654143\u4f8b\u4e2d\u9ad8\u5371\u65e9\u671f\u4e73\u817a\u764c\u6210\u5e74\u60a3\u80051687\u4f8b\u7edd\u7ecf\u524d\u30012456\u4f8b\u7edd\u7ecf\u540e\uff1b\u5165\u7ec4\u5206\u671fI\u671f10%\u3001II\u671f50%\u3001III\u671f40%\uff0c\u8d85\u534a\u6570\u60a3\u8005\u672f\u524d\u63a5\u53d7\u5316\u7597\uff1b<\/p>\n\n\n\n

2. \u5bf9\u7167\u7ec4\u6807\u51c6\u65b9\u6848\uff1a<\/strong>84%\u60a3\u8005\u4f7f\u7528\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\uff0c16%\u4f7f\u7528\u4ed6\u83ab\u6614\u82ac\uff1b<\/p>\n\n\n\n

3. \u6570\u636e\u622a\u6b62\u65f6\u95f4\uff1a<\/strong>2025\u5e748\u67088\u65e5\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u957f32.3\u4e2a\u6708\uff1b<\/p>\n\n\n\n

4. \u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff1a<\/strong>\u65e0\u4fb5\u88ad\u6027\u75be\u75c5\u751f\u5b58\u671f\uff08iDFS\uff0c\u5b9a\u4e49\u4e3a\u51fa\u73b0\u5c40\u90e8\u590d\u53d1\u3001\u8fdc\u5904\u8f6c\u79fb\u3001\u5bf9\u4fa7\u65b0\u53d1\u4e73\u817a\u764c\u6216\u5168\u56e0\u6b7b\u4ea1\uff09\uff1b<\/p>\n\n\n\n

5. \u836f\u7269\u5b9a\u4f4d\uff1a<\/strong>Giredestrant \u4e3a\u53e3\u670d SERD\uff0c\u6bcf\u65e5\u53e3\u670d\u7ed9\u836f\uff0c\u533a\u522b\u4e8e\u6c1f\u7ef4\u53f8\u7fa4\u6bcf\u6708\u808c\u8089\u6ce8\u5c04\u7ed9\u836f\u6a21\u5f0f\u3002<\/p>\n\n\n\n

3. III\u671f\u4e34\u5e8a\u5ba2\u89c2\u7597\u6548\u6570\u636e\uff1a\u5168\u4eba\u7fa4\u3001\u5206\u7edd\u7ecf\u4e9a\u7ec4\u590d\u53d1\u98ce\u9669\u4e0b\u964d\u660e\u786e<\/strong><\/strong><\/p>\n\n\n\n

\u6240\u6709\u6570\u636e\u5747\u6765\u81eaASCO 2026\u5b98\u65b9\u516c\u5e03\u7814\u7a76\u5206\u5c42\u5206\u6790\u3001\u57fa\u56e0\u6cf0\u514b\u539f\u5382\u4e34\u5e8a\u62a5\u544a\u3002<\/p>\n\n\n\n

1. \u6574\u4f53\u5168\u4eba\u7fa4\u6838\u5fc3\u7ec8\u70b9<\/strong><\/strong><\/p>\n\n\n\n

\u76f8\u8f83\u6807\u51c6\u5185\u5206\u6ccc\u6cbb\u7597\uff0cGiredestrant \u53ef\u964d\u4f4e30%\u4fb5\u88ad\u6027\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669<\/strong>\uff08HR=0.70\uff0c95% CI\uff1a0.57\u20130.87\uff0cP=0.0014\uff0c\u5dee\u5f02\u5177\u5907\u7edf\u8ba1\u5b66\u610f\u4e49\uff09\u3002<\/p>\n\n\n\n

Giredestrant \u7ec43\u5e74 iDFS \u7387\uff1a92.4%<\/p>\n\n\n\n

\u6807\u51c6\u5185\u5206\u6ccc\u6cbb\u7597\u7ec43\u5e74 iDFS \u7387\uff1a89.6%<\/p>\n\n\n\n

3\u5e74\u968f\u8bbf\u83b7\u76ca\u7ea63%\uff1b\u8fdc\u5904\u65e0\u590d\u53d1\u751f\u5b58\uff08Distant Recurrence-Free Interval\uff09\u540c\u6b65\u83b7\u76ca\uff0c\u964d\u4f4e 31%\u8fdc\u5904\u8f6c\u79fb\u98ce\u9669\uff08HR=0.69\uff09\uff0c\u53ef\u51cf\u5c11\u60a3\u8005\u8fdc\u671f\u8fdc\u5904\u8f6c\u79fb\u4e8b\u4ef6\u53d1\u751f\u6982\u7387\u3002<\/p>\n\n\n\n

2. \u7edd\u7ecf\u524d\/\u7edd\u7ecf\u540e\u5206\u5c42\u4e9a\u7ec4\u6570\u636e\uff082026 ASCO\u66f4\u65b0\u91cd\u70b9\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u8be5\u836f\u7269\u6838\u5fc3\u4e34\u5e8a\u4f18\u52bf\u4e3a\u7597\u6548\u4e0d\u53d7\u60a3\u8005\u7edd\u7ecf\u72b6\u6001\u9650\u5236\uff0c<\/strong>\u4e24\u7c7b\u4eba\u7fa4\u5747\u89c2\u5bdf\u5230\u7a33\u5b9a\u83b7\u76ca\uff1a<\/p>\n\n\n\n

\u2460. \u7edd\u7ecf\u524d\u60a3\u8005\uff08\u590d\u53d1\u98ce\u9669\u66f4\u9ad8\u7fa4\u4f53\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u964d\u4f4e35%\u4fb5\u88ad\u6027\u590d\u53d1\/\u6b7b\u4ea1\u98ce\u9669\uff08HR=0.65\uff09\uff1b3\u5e74 iDFS \u738794.0%\uff0c\u5bf9\u7167\u7ec491.5%\uff1b\u8fdc\u5904\u8f6c\u79fb\u98ce\u9669\u4e0b\u964d42%\u3002 <\/p>\n\n\n\n

\u2461. \u7edd\u7ecf\u540e\u60a3\u8005<\/strong><\/strong><\/p>\n\n\n\n

\u964d\u4f4e26%\u4fb5\u88ad\u6027\u590d\u53d1\/\u6b7b\u4ea1\u98ce\u9669\uff08HR=0.74\uff09\uff1b3\u5e74 iDFS \u738791.3%\uff0c\u5bf9\u7167\u7ec488.3%\u3002<\/p>\n\n\n\n

\u8bd5\u9a8c K-M \u751f\u5b58\u66f2\u7ebf\u663e\u793a\uff0c\u4e24\u7ec4\u751f\u5b58\u66f2\u7ebf\u81ea\u968f\u8bbf\u65e9\u671f\u5373\u51fa\u73b0\u5206\u79bb\uff0c\u4e14\u968f\u968f\u8bbf\u65f6\u95f4\u5ef6\u957f\u5dee\u8ddd\u6301\u7eed\u4fdd\u6301\uff0c\u63d0\u793a\u957f\u671f\u5185\u5206\u6ccc\u7ef4\u6301\u9636\u6bb5\u53ef\u7a33\u5b9a\u63a7\u5236\u590d\u53d1\u98ce\u9669\u3002<\/p>\n\n\n\n

4. III\u671f\u7814\u7a76\u5b89\u5168\u6027\u4e0e\u4f9d\u4ece\u6027\u6570\u636e\uff0c\u89e3\u51b3\u4f20\u7edf\u5185\u5206\u6ccc\u6cbb\u7597\u75db\u70b9<\/strong><\/strong><\/p>\n\n\n\n

\u957f\u671f\u5185\u5206\u6ccc\u6cbb\u7597\u4f9d\u4ece\u6027\u4e0d\u8db3\u662f\u672f\u540e\u590d\u53d1\u7684\u72ec\u7acb\u5371\u9669\u56e0\u7d20\uff0clidERA \u7814\u7a76\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u663e\u793a Giredestrant \u8010\u53d7\u6027\u4f18\u4e8e\u6807\u51c6\u65b9\u6848\uff1a<\/p>\n\n\n\n

1. \u6574\u4f53\u505c\u836f\u7387\uff1a<\/strong>Giredestrant \u7ec4\u56e0\u4e0d\u826f\u53cd\u5e94\u505c\u836f\u6bd4\u4f8b5.3%\uff0c\u6807\u51c6\u6cbb\u7597\u7ec48.2%\uff1b<\/p>\n\n\n\n

2. \u808c\u8089\u9aa8\u9abc\u75bc\u75db\u505c\u836f\u98ce\u9669\uff1a<\/strong>\u4e24\u7c7b\u7edd\u7ecf\u4eba\u7fa4\u4e2d\uff0c\u56e0\u5173\u8282\u3001\u808c\u8089\u75bc\u75db\u505c\u836f\u4eba\u6570\u8f83\u6807\u51c6\u65b9\u6848\u51cf\u5c11\u7ea6\u4e00\u534a\uff0c\u5927\u5e45\u6539\u5584\u957f\u671f\u670d\u836f\u8010\u53d7\u95ee\u9898\uff1b<\/p>\n\n\n\n

3. \u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff1a<\/strong>\u4ee5\u4f4e\u7ea7\u522b\u6f6e\u70ed\u3001\u5173\u8282\u4e0d\u9002\u4e3a\u4e3b\uff0c3\u7ea7\u53ca\u4ee5\u4e0a\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4f4e\uff0c\u4e34\u5e8a\u53ef\u901a\u8fc7\u5bf9\u75c7\u5e72\u9884\u7ba1\u7406\uff0c\u65e0\u65b0\u589e\u672a\u77e5\u957f\u671f\u6bd2\u6027\u98ce\u9669\uff1b<\/p>\n\n\n\n

4. \u7edd\u7ecf\u524d\u4e9a\u7ec4\u5b89\u5168\u6027\u8868\u73b0\u66f4\u7a81\u51fa\uff0c\u8be5\u7ec4\u56e0\u4e0d\u826f\u53cd\u5e94\u505c\u836f\u7387\u4ec51.5%\u3002<\/p>\n\n\n\n

5. \u665a\u671f\u4e73\u817a\u764c\u4e00\u7ebf\u3001\u540e\u7ebf\u6cbb\u7597\u4e34\u5e8a\u6570\u636e\u53c2\u8003<\/strong><\/strong><\/p>\n\n\n\n

\u9664\u65e9\u671f\u8f85\u52a9\u6cbb\u7597\u5916\uff0c2026\u5e74 ASCO \u5e74\u4f1a\u540c\u671f\u516c\u5e03\u4e86 Giredestrant \u7528\u4e8e\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u4e24\u9879III\u671f\u7814\u7a76\uff08persevERA BC\u3001evERA BC\uff09\u6570\u636e\uff0c\u8fdb\u4e00\u6b65\u5370\u8bc1\u8be5\u836f\u7269\u5728\u4e73\u817a\u764c\u5168\u7a0b\u7ba1\u7406\u4e2d\u7684\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n\n\n\n

1. \u665a\u671f\u4e00\u7ebf\u6cbb\u7597\uff08persevERA BC \u7814\u7a76\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u8be5\u7814\u7a76\u5171\u7eb3\u5165992\u4f8b\u5185\u5206\u6ccc\u654f\u611f\u7684 ER+\/HER2 – \u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u6bd4 Giredestrant \u8054\u5408\u54cc\u67cf\u897f\u5229\u3001\u6765\u66f2\u5511\u8054\u5408\u54cc\u67cf\u897f\u5229\u7684\u7597\u6548\u3002\u622a\u81f32026\u5e741\u670830\u65e5\uff0c\u4e2d\u4f4d\u968f\u8bbf\u7ea652\u4e2a\u6708\uff1a<\/p>\n\n\n\n

\u2022 \u4e3b\u8981\u7ec8\u70b9\uff1a<\/strong>Giredestrant \u8054\u5408\u7ec4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08INV-PFS\uff09\u4e3a 33.1\u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a28.2\u4e2a\u6708\uff0c\u6570\u503c\u5ef6\u957f4.9\u4e2a\u6708\uff08\u5206\u5c42 HR \u4e3a 0.89\uff0c95% CI\uff1a0.76\u20131.05\uff0c P=0.1553\uff09\uff0c\u8be5\u7ed3\u679c\u672a\u8fbe\u5230\u9884\u8bbe\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u9608\u503c\uff0c\u4f46\u5c55\u73b0\u51fa\u660e\u786e\u7684\u4e34\u5e8a\u6d3b\u6027\uff0c\u5404\u4e9a\u7ec4\u8868\u73b0\u7a33\u5b9a\uff1b<\/p>\n\n\n\n

\u2022 \u6b21\u8981\u7ec8\u70b9\uff1a<\/strong>Giredestrant \u8054\u5408\u7ec4\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u8fbe38.5 \u4e2a\u6708\uff0c\u8f83\u5bf9\u7167\u7ec430.4\u4e2a\u6708\u5ef6\u957f8.1\u4e2a\u6708\uff0c\u63d0\u793a\u8be5\u65b9\u6848\u53ef\u5b9e\u73b0\u66f4\u6301\u4e45\u7684\u80bf\u7624\u63a7\u5236\uff1b<\/p>\n\n\n\n

\u2022 \u5b89\u5168\u6027\uff1a<\/strong>\u4e24\u7ec43-4\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u76f8\u8fd1\uff0880.4% vs 77.4%\uff09\uff1bGiredestrant \u7ec4\u7aa6\u6027\u5fc3\u52a8\u8fc7\u7f13\u53d1\u751f\u7387\u66f4\u9ad8\uff0811.7% vs 1.8%\uff09\uff0c\u4f4695%\u4ee5\u4e0a\u4e3a1\u7ea7\u65e0\u75c7\u72b6\u4e8b\u4ef6\uff0c\u672a\u51fa\u73b03\u7ea7\u53ca\u4ee5\u4e0a\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n\n\n\n

2. \u665a\u671f\u540e\u7ebf\u6cbb\u7597\uff08evERA BC \u7814\u7a76\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u8be5\u7814\u7a76\u9762\u5411 CDK4\/6 \u6291\u5236\u5242\u6cbb\u7597\u8fdb\u5c55\u540e\u7684 ER+\/HER2 – \u665a\u671f\u4e73\u817a\u764c\u4eba\u7fa4\uff0c\u63a2\u7d22 Giredestrant \u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u7684\u6cbb\u7597\u6548\u679c\u3002\u7814\u7a76\u8fdb\u5c55\u540e\u63a2\u7d22\u6027\u5206\u6790\u663e\u793a\uff1a<\/p>\n\n\n\n

\u2022 \u7b2c\u4e8c\u6b21\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS2\uff09\uff1a<\/strong>Giredestrant \u8054\u5408\u7ec4\u4e2d\u4f4d PFS2 \u4e3a 19.02\u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a13.17\u4e2a\u6708\uff08HR=0.69; 95% CI: 0.51\u20130.92\uff09\uff1b<\/p>\n\n\n\n

\u2022 \u65e0\u5316\u7597\u751f\u5b58\u671f\uff1a<\/strong>Giredestrant \u8054\u5408\u7ec4\u4e2d\u4f4d\u65e0\u5316\u7597\u751f\u5b58\u671f\u5ef6\u957f\u81f311.10 \u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a7.89\u4e2a\u6708\uff08HR=0.61; 95% CI: 0.47\u20130.78\uff09\uff0c\u6709\u6548\u63a8\u8fdf\u60a3\u8005\u4f7f\u7528\u5316\u7597\u7684\u65f6\u95f4\uff1b<\/p>\n\n\n\n

\u2022 \u4e9a\u7ec4\u8868\u73b0\uff1a<\/strong>\u65e0\u8bba\u60a3\u8005\u662f\u5426\u643a\u5e26 ESR1 \u7a81\u53d8\uff0c\u5747\u53ef\u89c2\u5bdf\u5230\u4e0a\u8ff0\u83b7\u76ca\uff0c\u4e3a\u5185\u5206\u6ccc\u8010\u836f\u4eba\u7fa4\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002<\/p>\n\n\n\n

6. <\/strong>\u9002\u5408\u8bc4\u4f30 Giredestrant \u65b9\u6848\u7684\u60a3\u8005\u4eba\u7fa4<\/strong><\/strong><\/p>\n\n\n\n

\u7ed3\u5408 lidERA \u5165\u7ec4\u6807\u51c6\u4e0e\u4e9a\u7ec4\u83b7\u76ca\u7279\u5f81\uff0c\u4ee5\u4e0b\u65e9\u671f\u4e73\u817a\u764c\u672f\u540e\u4eba\u7fa4\u53ef\u54a8\u8be2\u4e13\u79d1\u533b\u751f\u5f00\u5c55\u4e2a\u4f53\u5316\u65b9\u6848\u8bc4\u4f30\uff1a<\/p>\n\n\n\n

1. I\u2013III \u671f ER \u9633\u6027\u3001HER2\u9634\u6027\uff0c\u5b8c\u6210\u624b\u672f\u00b1\u8f85\u52a9\u5316\u7597\u7684\u672f\u540e\u60a3\u8005\uff1b<\/p>\n\n\n\n

2. \u7edd\u7ecf\u524d\u5e74\u8f7b\u3001\u4e2d\u9ad8\u590d\u53d1\u98ce\u9669\uff0c\u65e0\u6cd5\u8010\u53d7\u5375\u5de2\u529f\u80fd\u6291\u5236\u8054\u5408AI\u6807\u51c6\u65b9\u6848\uff1b<\/p>\n\n\n\n

3. \u957f\u671f\u670d\u7528\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\uff0c\u6301\u7eed\u6027\u9aa8\u75db\u3001\u5173\u8282\u4e0d\u9002\u96be\u4ee5\u575a\u6301\u670d\u836f\uff1b<\/p>\n\n\n\n

4. \u62c5\u5fe7\u672f\u540e\u8fdc\u671f\u8fdc\u5904\u8f6c\u79fb\uff0c\u5e0c\u671b\u4f18\u5316\u957f\u671f\u5185\u5206\u6ccc\u7ef4\u6301\u65b9\u6848\u3002<\/p>\n\n\n\n

\u91cd\u8981\u533b\u5b66\u63d0\u793a<\/strong><\/strong><\/p>\n\n\n\n

1. Giredestrant \u73b0\u9636\u6bb5\u4ec5\u5177\u5907III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9633\u6027\u6570\u636e\uff0c\u672a\u83b7 FDA\u3001\u9999\u6e2f\u536b\u751f\u7f72\u6b63\u5f0f\u4e0a\u5e02\u6279\u51c6\uff0c\u4e0d\u5c5e\u4e8e\u5e38\u89c4\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\uff1b<\/p>\n\n\n\n

2. \u672c\u6587\u6240\u6709\u7597\u6548\u63cf\u8ff0\u4ec5\u5bf9\u5e94 lidERA \u4e34\u5e8a\u8bd5\u9a8c\u4eba\u7fa4\u6574\u4f53\u7edf\u8ba1\u5b66\u8d8b\u52bf\uff0c\u6bcf\u4f4d\u60a3\u8005\u80bf\u7624\u5206\u671f\u3001\u57fa\u56e0\u5206\u578b\u3001\u8eab\u4f53\u57fa\u7840\u6761\u4ef6\u5b58\u5728\u4e2a\u4f53\u5dee\u5f02\uff0c\u65e0\u6cd5\u4fdd\u8bc1\u540c\u7b49\u83b7\u76ca\uff1b<\/p>\n\n\n\n

3. \u5185\u5206\u6ccc\u6cbb\u7597\u4e3a\u4e73\u817a\u764c\u7efc\u5408\u7ba1\u7406\u73af\u8282\u4e4b\u4e00\uff0c\u4e0d\u53ef\u66ff\u4ee3\u624b\u672f\u3001\u653e\u7597\u3001\u5b9a\u671f\u5f71\u50cf\u590d\u67e5\u7b49\u89c4\u8303\u968f\u8bbf\u6d41\u7a0b\u3002<\/p>\n\n\n\n

\u7ed3\u8bed<\/strong><\/strong><\/p>\n\n\n\n

\u82e5\u4e3a ER+\/HER2 – \u65e9\u671f\u4e73\u817a\u764c\u672f\u540e\u60a3\u8005\uff0c\u5e0c\u671b\u7ed3\u5408\u81ea\u8eab\u75c5\u7406\u62a5\u544a\u8bc4\u4f30\u5185\u5206\u6ccc\u65b9\u6848\uff0c\u53ef\u63d0\u4ea4\u5b8c\u6574\u672f\u540e\u75c5\u7406\u3001\u57fa\u56e0\u68c0\u6d4b\u3001\u65e2\u5f80\u5185\u5206\u6ccc\u7528\u836f\u8bb0\u5f55\uff0c\u9884\u7ea6\u4e2d\u5fc3\u80bf\u7624\u79d1\u591a\u5b66\u79d1\u4f1a\u8bca\uff0c\u7531\u4e13\u79d1\u533b\u751f\u5b9a\u5236\u957f\u671f\u590d\u53d1\u7ba1\u63a7\u65b9\u6848\u3002<\/p>\n\n\n\n

\u53c2\u8003\u8d44\u6599\u6765\u6e90\uff1a<\/strong><\/strong><\/p>\n\n\n\n

1. https:\/\/medically.roche.com\/content\/dam\/pdmahub\/restricted\/oncology\/annual-meeting-2026\/oncology-annual-meeting-2026-presentation-schmid-efficacy-and-safety-of-giredestrant-in-patients.pdf<\/u><\/a><\/p>\n\n\n\n

2. https:\/\/www.gene.com\/media\/press-releases\/15115\/2026-06-01\/fda-accepts-new-drug-application-for-gen<\/u><\/a><\/p>\n\n\n\n

3. https:\/\/ascopost.com\/issues\/january-25-2026\/novel-endocrine-therapy-giredestrant-improves-invasive-disease-free-survival-in-estrogen-receptor-positive-her2-negative-early-breast-cancer\/<\/u><\/a><\/p>\n\n\n\n

4.\u00a0https:\/\/www.onclive.com\/view\/giredestrant-cuts-recurrence-risk-across-menopausal-status-in-er-her2–early-breast-cancer<\/a><\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6839\u636e\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff08IARC\uff092022\u5e74\u5168\u7403\u80bf\u7624\u7edf\u8ba1\u6570\u636e\uff0c\u4e73\u817a\u764c\u4e3a\u5168\u7403\u5973\u6027\u53d1\u75c5\u7387\u3001\u6b7b\u4ea1\u7387\u9996\u4f4d\u6076\u6027\u80bf\u7624\uff0c\u968f\u7740\u65e9<\/p>\n","protected":false},"author":14,"featured_media":40221,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1769,1735],"tags":[],"yst_prominent_words":[],"class_list":["post-40234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-zh-hans","category-breast-cancer-zh-hans"],"_links":{"self":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/40234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/comments?post=40234"}],"version-history":[{"count":1,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/40234\/revisions"}],"predecessor-version":[{"id":40235,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/posts\/40234\/revisions\/40235"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media\/40221"}],"wp:attachment":[{"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/media?parent=40234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/categories?post=40234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/tags?post=40234"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/www.hkioc.com.hk\/zh-hans\/wp-json\/wp\/v2\/yst_prominent_words?post=40234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}