{"id":40239,"date":"2026-06-18T15:36:58","date_gmt":"2026-06-18T07:36:58","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=40239"},"modified":"2026-06-18T15:39:24","modified_gmt":"2026-06-18T07:39:24","slug":"asco%e9%87%8d%e7%a3%85iii%e6%9c%9f%e6%95%b0%e6%8d%ae%ef%bd%9cizalontamab-brengitecan%e4%b8%ba%e9%9a%be%e6%b2%bb%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93%e7%98%a4%e5%b8%a6%e6%9d%a5%e7%94%9f%e5%ad%98","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/asco%e9%87%8d%e7%a3%85iii%e6%9c%9f%e6%95%b0%e6%8d%ae%ef%bd%9cizalontamab-brengitecan%e4%b8%ba%e9%9a%be%e6%b2%bb%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93%e7%98%a4%e5%b8%a6%e6%9d%a5%e7%94%9f%e5%ad%98\/","title":{"rendered":"ASCO\u91cd\u78c5III\u671f\u6570\u636e\uff5cIzalontamab Brengitecan\u4e3a\u96be\u6cbb\u665a\u671f\u5b9e\u4f53\u7624\u5e26\u6765\u751f\u5b58\u83b7\u76ca"},"content":{"rendered":"\n

\u5bf9\u4e8e\u7ecf\u5386\u591a\u7ebf\u7cfb\u7edf\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u4e34\u5e8a\u53ef\u9009\u6cbb\u7597\u65b9\u6848\u6709\u9650\uff0c\u8fdc\u671f\u751f\u5b58\u63d0\u5347\u59cb\u7ec8\u662f\u672a\u88ab\u6ee1\u8db3\u7684\u6838\u5fc3\u533b\u7597\u9700\u6c42\u30022026 ASCO\u5e74\u4f1a\u516c\u5e03\u4e00\u6b3e\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09<\/strong>\u4e24\u9879\u5173\u952e III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u671f\u5206\u6790\u9633\u6027\u6570\u636e \u2014\u2014Izalontamab Brengitecan\uff0c\u7b80\u79f0 Iza-Bren\u3002<\/strong><\/p>\n\n\n\n

\u8be5\u836f\u7269\u9776\u5411EGFR\u3001HER3\u53cc\u9776\u70b9\uff0c\u5728\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u3001\u590d\u53d1\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c<\/strong>\u4e24\u7c7b\u96be\u6cbb\u80bf\u7624\u4e2d\uff0c\u5747\u5b9e\u73b0\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u53cc\u91cd\u7edf\u8ba1\u5b66\u83b7\u76ca\uff0c\u4e3a\u540e\u7ebf\u60a3\u8005\u63d0\u4f9b\u5168\u65b0\u6cbb\u7597\u5faa\u8bc1\u4f9d\u636e\u3002<\/p>\n\n\n\n

1. \u836f\u7269\u4f5c\u7528\u673a\u5236\u6982\u8ff0<\/strong><\/strong><\/p>\n\n\n\n

Izalontamab Brengitecan\uff08Iza-Bren\uff09\u4e3a\u53cc\u9776\u70b9\u7279\u5f02\u6027\u5076\u8054\u836f\u7269\uff0c\u9776\u5411\u4e0a\u76ae\u80bf\u7624\u9ad8\u9891\u8868\u8fbe\u7684EGFR \u4e0e HER3\u9776\u70b9\uff0c\u5177\u5907\u53cc\u91cd\u6297\u80bf\u7624\u4f5c\u7528\u8def\u5f84\uff1a<\/p>\n\n\n\n

1. \u53ef\u540c\u6b65\u963b\u65adEGFR\u3001HER3\u4e24\u6761\u4fc3\u589e\u6b96\u4fe1\u53f7\u901a\u8def\uff0c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u6301\u7eed\u589e\u6b96\u3001\u5b58\u6d3b\uff1b<\/p>\n\n\n\n

2. \u836f\u7269\u4e0e\u80bf\u7624\u7ec6\u80de\u7ed3\u5408\u5e76\u5b8c\u6210\u5185\u541e\u540e\uff0c\u91ca\u653e\u62d3\u6251\u5f02\u6784\u9176 1 \u6291\u5236\u5242\u6bd2\u6027\u8f7d\u8377\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\uff0c\u5b9e\u73b0\u5b9a\u5411\u6740\u4f24\u3002<\/p>\n\n\n\n

\u8be5\u9776\u70b9\u7ec4\u5408\u5728\u591a\u79cd\u4e0a\u76ae\u6765\u6e90\u80bf\u7624\u4e2d\u5b58\u5728\u9ad8\u8868\u8fbe\uff0c\u5177\u5907\u591a\u7624\u79cd\u62d3\u5c55\u5e94\u7528\u6f5c\u529b\uff0c\u6b64\u524d\u9488\u5bf9\u590d\u53d1\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684III\u671f\u7814\u7a76\u4e5f\u5df2\u516c\u5e03\u79ef\u6781\u4e34\u5e8a\u7ed3\u679c\u3002<\/p>\n\n\n\n

2. III\u671f\u7814\u7a76\u4e00\uff1a\u4e0d\u53ef\u5207\u9664\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u540e\u7ebf\u6cbb\u7597\u6570\u636e<\/strong><\/strong><\/p>\n\n\n\n

\u8be5\u9879 III \u671f\u7814\u7a76\u7eb3\u5165\u65e2\u5f80\u63a5\u53d71-2\u7ebf\u665a\u671f\u5168\u8eab\u6cbb\u7597\u3001\u4e14\u4f7f\u7528\u8fc7\u7d2b\u6749\u7c7b\u836f\u7269\u7684\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f \/ \u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u6210\u5e74\u53d7\u8bd5\u8005\uff0c\u53d7\u8bd5\u8005\u6309 1:1 \u968f\u673a\u5206\u7ec4\uff0c\u5206\u522b\u63a5\u53d7 Iza-Bren \u6cbb\u7597\u6216\u4e34\u5e8a\u533b\u5e08\u81ea\u9009\u6807\u51c6\u5316\u7597\u65b9\u6848\u3002\u5316\u7597\u5bf9\u7167\u7ec4\u53ef\u9009\u65b9\u6848\u5305\u542b\u827e\u7acb\u5e03\u6797\u3001\u5361\u57f9\u4ed6\u6ee8\u3001\u5409\u897f\u4ed6\u6ee8\u3001\u957f\u6625\u745e\u6ee8\u3002<\/p>\n\n\n\n

1. \u5165\u7ec4\u89c4\u6a21\uff1a<\/strong>Iza-Bren \u6cbb\u7597\u7ec4207\u4f8b\uff0c\u5316\u7597\u5bf9\u7167\u7ec4211\u4f8b\uff1b\u4e2d\u671f\u5206\u6790\u4e2d\u4f4d\u968f\u8bbf\u65f6\u957f11\u4e2a\u6708\uff1b<\/p>\n\n\n\n

2. \u53cc\u4e3b\u8981\u7ec8\u70b9\u5747\u8fbe\u5230\u7edf\u8ba1\u5b66\u9633\u6027\u7ed3\u679c<\/strong>\uff08\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u5ba1 BICR \u8bc4\u4f30\uff09<\/p>\n\n\n\n

\u2022 \u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff1a<\/strong>Iza-Bren\u7ec415.9\u4e2a\u6708\uff0c\u5316\u7597\u7ec412.5\u4e2a\u6708\uff0c\u98ce\u9669\u6bd4HR=0.60\uff0895% CI\uff1a0.42~0.85\uff0cP=0.0019\uff09<\/p>\n\n\n\n

\u2022 \u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1a<\/strong>Iza-Bren \u7ec48.5\u4e2a\u6708\uff0c\u5316\u7597\u7ec43.1\u4e2a\u6708\uff0c\u98ce\u9669\u6bd4HR=0.29\uff0895% CI\uff1a0.22~0.38\uff0cP\uff1c0.0001\uff09<\/p>\n\n\n\n

3. \u80bf\u7624\u7f13\u89e3\u60c5\u51b5\uff1a<\/strong>\u7ecf\u8bc4\u5ba1\u786e\u8ba4\u5ba2\u89c2\u7f13\u89e3\u7387 ORR\uff0cIza-Bren \u7ec4 51.7%\uff0c\u5316\u7597\u5bf9\u7167\u7ec4 20.5%<\/p>\n\n\n\n

4. \u5b89\u5168\u6027\u7279\u5f81<\/strong><\/strong><\/p>\n\n\n\n

\u6574\u4f53\u4e0d\u826f\u53cd\u5e94\u53ef\u63a7\uff0c\u672a\u51fa\u73b0\u672a\u77e5\u65b0\u589e\u5b89\u5168\u98ce\u9669\uff0c3\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u4ee5\u8840\u6db2\u5b66\u6bd2\u6027\u4e3a\u4e3b\uff0c\u4e0e\u836f\u7269\u5df2\u77e5\u5b89\u5168\u7279\u5f81\u4fdd\u6301\u4e00\u81f4\u3002<\/p>\n\n\n\n

\u2022 \u5168\u7ea7\u522b\u95f4\u8d28\u6027\u80ba\u75c5\uff1a<\/strong>Iza-Bren \u7ec4 1.4%\uff081\u4f8b1\u7ea7\u30012\u4f8b2\u7ea7\uff09\uff0c\u5316\u7597\u7ec4\u65e0\u76f8\u5173\u75c5\u4f8b\uff1b<\/p>\n\n\n\n

\u2022 \u56e0\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u6c38\u4e45\u505c\u836f\uff1a<\/strong>Iza-Bren\u7ec41.9%\uff0c\u5316\u7597\u7ec4 0.5%\u3002<\/p>\n\n\n\n

\u4e34\u5e8a\u4e13\u5bb6\u89e3\u8bfb\u63d0\u5230\uff0c\u8be5\u7814\u7a76\u4e3a\u5168\u7403\u9996\u4e2a\u9488\u5bf9\u4e09\u9634\u6027\u4e73\u817a\u764c\u3001\u540c\u65f6\u8fbe\u6210 OS \u4e0e PFS \u53cc\u7ec8\u70b9\u9633\u6027\u7ed3\u679c\u7684\u53cc\u7279\u5f02 ADC III \u671f\u7814\u7a76\uff0c\u6709\u671b\u4f18\u5316\u8be5\u4eba\u7fa4\u540e\u7ebf\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n\n\n\n

3. III\u671f\u7814\u7a76\u4e8c\uff1a\u590d\u53d1\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u540e\u7ebf\u6cbb\u7597\u6570\u636e<\/strong><\/strong><\/p>\n\n\n\n

\u672c\u7814\u7a76\u5165\u7ec4\u4eba\u7fa4\u4e3a\u4e00\u7ebf\u63a5\u53d7PD-1\/PD-L1\u6291\u5236\u5242\u8054\u5408\u94c2\u7c7b\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u590d\u53d1\u3001\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\uff0c\u5168\u90e8\u53d7\u8bd5\u80051:1\u5206\u4e3a Iza-Bren \u6cbb\u7597\u7ec4\u4e0e\u533b\u5e08\u81ea\u9009\u5316\u7597\u5bf9\u7167\u7ec4\u3002<\/p>\n\n\n\n

1. \u5165\u7ec4\u89c4\u6a21\uff1a<\/strong>Iza-Bren \u7ec4249\u4f8b\uff0c\u5316\u7597\u5bf9\u7167\u7ec4248\u4f8b\uff1b<\/p>\n\n\n\n

2. \u4e24\u9879\u4e3b\u8981\u7ec8\u70b9\u540c\u6b65\u53d6\u5f97\u5177\u5907\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u4e34\u5e8a\u83b7\u76ca<\/strong><\/strong><\/p>\n\n\n\n

\u2022 \u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff1a<\/strong>Iza-Bren \u7ec49.8\u4e2a\u6708\uff0c\u5316\u7597\u7ec47.2\u4e2a\u6708\uff0cHR=0.64\uff0895% CI\uff1a0.49~0.83\uff0cP=0.0004\uff09<\/p>\n\n\n\n

\u2022 \u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1a<\/strong>Iza-Bren \u7ec44.2\u4e2a\u6708\uff0c\u5316\u7597\u7ec42.0\u4e2a\u6708\uff0cHR=0.50\uff0895% CI\uff1a0.40~0.63\uff0cP\uff1c0.0001\uff09<\/p>\n\n\n\n

3. \u80bf\u7624\u7f13\u89e3\u8868\u73b0\uff1a<\/strong>Iza-Bren\u7ec4\u5ba2\u89c2\u7f13\u89e3\u738735.3%\uff0c\u5316\u7597\u5bf9\u7167\u7ec413.1%<\/p>\n\n\n\n

4. \u5b89\u5168\u6027\u7279\u5f81<\/strong><\/strong><\/p>\n\n\n\n

3\u7ea7\u53ca\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u6574\u4f53\u53d1\u751f\u7387 Iza-Bren \u7ec4\u9ad8\u4e8e\u5316\u7597\u7ec4\uff0c\u4e0d\u826f\u53cd\u5e94\u4ee5\u8840\u6db2\u5b66\u6bd2\u6027\u4e3a\u4e3b\uff0c\u6574\u4f53\u8010\u53d7\u7a0b\u5ea6\u53ef\u7ba1\u7406\u3002<\/p>\n\n\n\n

\u2022 \u56e0\u4e0d\u826f\u53cd\u5e94\u505c\u836f\u6bd4\u4f8b\uff1aIza-Bren \u7ec4 2%\uff0c\u5316\u7597\u7ec4 3.3%\uff1b<\/p>\n\n\n\n

\u2022 \u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\u4e8b\u4ef6\uff1aIza-Bren \u7ec4 1.2%\uff0c\u5316\u7597\u7ec4 1.6%\uff1b<\/p>\n\n\n\n

\u2022 \u95f4\u8d28\u6027\u80ba\u75c5\u53d1\u751f\u7387\u6574\u4f53\u504f\u4f4e\uff0c\u4e24\u7ec4\u65e0\u660e\u663e\u9ad8\u5371\u98ce\u9669\u4fe1\u53f7\u3002<\/p>\n\n\n\n

\u4e34\u5e8a\u4e13\u5bb6\u8868\u793a\uff0c\u665a\u671f\u98df\u7ba1\u9cde\u764c\u6076\u6027\u7a0b\u5ea6\u9ad8\uff0c\u4e00\u7ebf\u514d\u75ab\u5316\u7597\u8fdb\u5c55\u540e\u6cbb\u7597\u9009\u62e9\u7a00\u7f3a\uff0cIza-Bren\u7684\u751f\u5b58\u83b7\u76ca\u6570\u636e\uff0c\u53ef\u4e3a\u8fd9\u7c7b\u96be\u6cbb\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002<\/p>\n\n\n\n

4. \u65b9\u6848\u8bc4\u4f30\u7684\u9002\u914d\u4eba\u7fa4<\/strong><\/strong><\/p>\n\n\n\n

\u7ed3\u5408\u4e24\u9879 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u6807\u51c6\uff0c\u4ee5\u4e0b\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u53ef\u9884\u7ea6MDT\u591a\u5b66\u79d1\u4f1a\u8bca\uff0c\u8bc4\u4f30\u8be5\u53cc\u9776\u70b9ADC \u4f53\u5316\u6cbb\u7597\u53ef\u884c\u6027\uff1a<\/p>\n\n\n\n

1. \u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\uff0c\u65e2\u5f80\u5b8c\u62101~2\u7ebf\u665a\u671f\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\uff0c\u542b\u7d2b\u6749\u7c7b\u836f\u7269\u6cbb\u7597\u53f2\uff1b<\/p>\n\n\n\n

2. \u590d\u53d1\u3001\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u4e00\u7ebfPD-1\/PD-L1\u8054\u5408\u94c2\u7c7b\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\uff1b<\/p>\n\n\n\n

3. \u591a\u7ebf\u6cbb\u7597\u540e\u80bf\u7624\u6301\u7eed\u8fdb\u5c55\uff0c\u4f20\u7edf\u5316\u7597\u8010\u53d7\u5dee\u3001\u5e0c\u671b\u5bfb\u6c42ADC\u65b0\u578b\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n

\u7ed3\u8bed<\/strong><\/strong><\/p>\n\n\n\n

Izalontamab Brengitecan (Iza-Bren)<\/strong>\u5f53\u524d\u4ec5\u5b8c\u6210III\u671f\u4e34\u5e8a\u4e2d\u671f\u5206\u6790\uff0c\u836f\u7269\u5c1a\u672a\u4e0a\u5e02\uff0c\u82e5\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u63a8\u8fdb\uff0c\u8be5\u836f\u7269\u6709\u671b\u77ed\u671f\u5185\u83b7\u5f97FDA\u4e0a\u5e02\u6279\u51c6\u3002<\/p>\n\n\n\n

\u540e\u7eed\u6211\u4eec\u4f1a\u6301\u7eed\u8ffd\u8e2a\u8be5\u836f\u7269\u5b8c\u6574\u7814\u7a76\u7ed3\u679c\u4e0e\u5ba1\u6279\u52a8\u6001\uff0c\u53ca\u65f6\u5206\u4eab\u65b0\u836f\u8d44\u8baf\u3002\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u53ef\u4f9d\u6258\u73b0\u6709\u5df2\u83b7\u6279\u6b63\u89c4\u6cbb\u7597\u624b\u6bb5\uff0c\u4e0e\u4e13\u79d1\u533b\u751f\u6c9f\u901a\u9002\u914d\u81ea\u8eab\u75c5\u60c5\u7684\u6210\u719f\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n

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