{"id":40415,"date":"2026-07-02T17:47:14","date_gmt":"2026-07-02T09:47:14","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=40415"},"modified":"2026-07-02T17:49:19","modified_gmt":"2026-07-02T09:49:19","slug":"asco%e6%9c%80%e6%96%b0%e7%9c%9f%e5%ae%9e%e4%b8%96%e7%95%8c%e7%a0%94%e7%a9%b6%ef%bc%9aglp-1%e5%8f%97%e4%bd%93%e6%bf%80%e5%8a%a8%e5%89%82%e6%88%96%e9%99%8d%e4%bd%8e%e5%9b%9b%e7%b1%bb%e8%82%a5%e8%83%96","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/asco%e6%9c%80%e6%96%b0%e7%9c%9f%e5%ae%9e%e4%b8%96%e7%95%8c%e7%a0%94%e7%a9%b6%ef%bc%9aglp-1%e5%8f%97%e4%bd%93%e6%bf%80%e5%8a%a8%e5%89%82%e6%88%96%e9%99%8d%e4%bd%8e%e5%9b%9b%e7%b1%bb%e8%82%a5%e8%83%96\/","title":{"rendered":"ASCO\u6700\u65b0\u771f\u5b9e\u4e16\u754c\u7814\u7a76\uff1aGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6216\u964d\u4f4e\u56db\u7c7b\u80a5\u80d6\u76f8\u5173\u80bf\u7624\u8f6c\u79fb\u98ce\u9669"},"content":{"rendered":"\n

\u80a5\u80d6\u30012\u578b\u7cd6\u5c3f\u75c5\u662f\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u7684\u9ad8\u5371\u8bf1\u56e0\uff0c\u4ee3\u8c22\u7d0a\u4e71\u5e26\u6765\u7684\u6162\u6027\u708e\u75c7\u3001\u9ad8\u80f0\u5c9b\u7d20\u73af\u5883\uff0c\u4f1a\u5f62\u6210\u5229\u4e8e\u80bf\u7624\u589e\u6b96\u4e0e\u4fb5\u88ad\u7684\u5fae\u73af\u5883\u3002\u80f0\u9ad8\u7cd6\u7d20\u6837\u80bd-1\uff08GLP-1\uff09\u53d7\u4f53\u6fc0\u52a8\u5242\u4f5c\u4e3a\u4e34\u5e8a\u4e3b\u6d41\u964d\u7cd6\u3001\u51cf\u91cd\u836f\u7269\uff0c\u6297\u708e\u4e0e\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u5df2\u88ab\u57fa\u7840\u533b\u5b66\u8bc1\u5b9e\u3002<\/p>\n\n\n\n

2026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u516c\u5e03\u4e00\u9879\u5927\u6837\u672c\u771f\u5b9e\u4e16\u754c\u7814\u7a76\uff0c\u9996\u6b21\u7cfb\u7edf\u6027\u5bf9\u6bd4GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4e0eDPP-4\u6291\u5236\u5242\uff0c\u5728\u65e9\u671f\u80bf\u7624\u5408\u5e76\u4ee3\u8c22\u75be\u75c5\u4eba\u7fa4\u4e2d\u5bf9\u80bf\u7624\u8fdc\u5904\u8f6c\u79fb\u8fdb\u5c55\u7684\u5f71\u54cd\uff0c\u4e3a\u5408\u5e76\u6162\u75c5\u80bf\u7624\u60a3\u8005\u7684\u7528\u836f\u9009\u62e9\u63d0\u4f9b\u5168\u65b0\u79d1\u7814\u53c2\u8003\u3002<\/p>\n\n\n\n

1. <\/strong>\u7814\u7a76\u80cc\u666f\uff1a\u4ee3\u8c22\u836f\u7269\u4e0e\u80bf\u7624\u9884\u540e\u7684\u63a2\u7d22\u521d\u8877<\/strong><\/strong><\/p>\n\n\n\n

\u65e2\u5f80\u57fa\u7840\u7814\u7a76\u5df2\u8bc1\u5b9e\uff0cGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u53ef\u901a\u8fc7\u5e73\u7a33\u8840\u7cd6\u3001\u51cf\u8f7b\u6162\u6027\u4f4e\u5ea6\u708e\u75c7\uff0c\u964d\u4f4e\u666e\u901a\u4eba\u7fa4\u65b0\u53d1\u7ed3\u76f4\u80a0\u764c\u7b49\u80a5\u80d6\u76f8\u5173\u80bf\u7624\u7684\u53d1\u75c5\u98ce\u9669\u3002\u4f46\u5728\u5df2\u786e\u8bca\u2160-\u2162\u671f\u5c40\u9650\u6027\u80bf\u7624\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u8be5\u7c7b\u836f\u7269\u662f\u5426\u80fd\u591f\u6291\u5236\u80bf\u7624\u8fdb\u5c55\u3001\u964d\u4f4e\u8fdc\u7aef\u8f6c\u79fb\u6982\u7387\uff0c\u6b64\u524d\u7f3a\u4e4f\u5927\u6837\u672c\u771f\u5b9e\u4e16\u754c\u6570\u636e\u4f50\u8bc1\u3002<\/p>\n\n\n\n

\u4e34\u5e8a\u4e2d\u5927\u91cf\u65e9\u671f\u80bf\u7624\u60a3\u8005\u540c\u65f6\u5408\u5e762\u578b\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\uff0c\u9700\u957f\u671f\u4f7f\u7528\u964d\u7cd6\u836f\u7269\uff0cDPP-4\u6291\u5236\u5242\u4e0eGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5747\u4e3a\u4e00\u7ebf\u964d\u7cd6\u9009\u62e9\uff0c\u4e24\u7c7b\u836f\u7269\u4ee3\u8c22\u8c03\u8282\u3001\u6297\u708e\u6d3b\u6027\u5b58\u5728\u660e\u786e\u5dee\u5f02\uff0c\u56e0\u6b64\u7814\u7a76\u56e2\u961f\u5f00\u5c55\u56de\u987e\u6027\u961f\u5217\u7814\u7a76\uff0c\u5bf9\u6bd4\u4e24\u7c7b\u836f\u7269\u5bf9\u80bf\u7624\u5206\u671f\u8fdb\u5c55\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n

2. <\/strong>\u7814\u7a76\u8bbe\u8ba1\u4e0e\u7eb3\u5165\u57fa\u7ebf<\/strong><\/strong><\/p>\n\n\n\n

1. \u6570\u636e\u6765\u6e90\u4e0e\u6837\u672c\u91cf\u672c<\/strong><\/strong><\/p>\n\n\n\n

\u7814\u7a76\u4f9d\u6258 TriNetX \u5927\u578b\u771f\u5b9e\u4e16\u754c\u533b\u7597\u6570\u636e\u5e93\uff0c\u5171\u7eb3\u516512112\u540d\u2160\u3001\u2161\u3001\u2162\u671f\u5c40\u90e8\u8fdb\u5c55\u671f\u80bf\u7624\u60a3\u8005\uff0c\u8986\u76d6\u4e03\u5927\u80a5\u80d6\u76f8\u5173\u5b9e\u4f53\u7624\uff1a\u4e73\u817a\u817a\u764c\u3001\u524d\u5217\u817a\u817a\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u817a\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u80f0\u817a\u817a\u764c\u3002\u53d7\u8bd5\u8005\u4eba\u79cd\u5305\u542b\u767d\u4eba\u3001\u975e\u88d4\u3001\u4e9a\u88d4\u591a\u65cf\u7fa4\uff0c\u6837\u672c\u5177\u5907\u4eba\u7fa4\u4ee3\u8868\u6027\u3002<\/p>\n\n\n\n

2. \u5206\u7ec4\u65b9\u6848<\/strong><\/strong><\/p>\n\n\n\n

\u53d7\u8bd5\u8005\u786e\u8bca\u6076\u6027\u80bf\u7624\u540e\uff0c\u5206\u4e3a\u4e24\u7ec4\u5e72\u9884\uff1a\u4e00\u7ec4\u4f7f\u7528GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff08\u53f8\u7f8e\u683c\u9c81\u80bd\u3001\u5229\u62c9\u9c81\u80bd\u3001\u5ea6\u62c9\u7cd6\u80bd\u3001\u66ff\u5c14\u6cca\u80bd\u7b49\uff09\uff0c\u5bf9\u7167\u7ec4\u91c7\u7528DPP-4\u6291\u5236\u5242\u7c7b\u964d\u7cd6\u836f\u7269\uff0c\u957f\u671f\u968f\u8bbf\u80bf\u7624\u662f\u5426\u8fdb\u5c55\u81f3 \u2163 \u671f\u8f6c\u79fb\u6027\u764c\u75c7\u3002<\/p>\n\n\n\n

3. \u914d\u5957\u57fa\u56e0\u6570\u636e\u5206\u6790<\/strong><\/strong><\/p>\n\n\n\n

\u8054\u5408 TCGA \u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff0c\u5206\u67907\u7c7b\u80bf\u7624\u7ec4\u7ec7\u5185GLP-1\u53d7\u4f53\uff08GLP-1R\uff09\u8868\u8fbe\u6c34\u5e73\uff0c\u4e0e\u60a3\u8005\u603b\u751f\u5b58\u671f\u7684\u5ba2\u89c2\u5173\u8054\uff0c\u4ece\u5206\u5b50\u5c42\u9762\u9a8c\u8bc1\u901a\u8def\u4f5c\u7528\u673a\u5236\u3002<\/p>\n\n\n\n

3. <\/strong>\u6838\u5fc3\u5ba2\u89c2\u7814\u7a76\u7ed3\u679c<\/strong><\/strong><\/p>\n\n\n\n

\uff08\u4e00\uff09\u56db\u7c7b\u80bf\u7624\u4f7f\u7528GLP<\/strong>–<\/strong>1\u836f\u7269\uff0c\u8f6c\u79fb\u8fdb\u5c55\u98ce\u9669\u663e\u8457\u4e0b\u964d<\/strong><\/strong><\/p>\n\n\n\n

\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u809d\u7ec6\u80de\u764c\u56db\u7c7b\u764c\u79cd\u4e2dGLP-1\u7528\u836f\u7ec4\u8fdb\u5c55\u4e3a\u2163\u671f\u8f6c\u79fb\u764c\u7684\u6bd4\u4f8b\u663e\u8457\u4f4e\u4e8eDPP-4\u6291\u5236\u5242\u7ec4\uff0c\u98ce\u9669\u964d\u5e45\u533a\u95f4\u4e3a38%~50%\uff0c\u5404\u7ec4\u5177\u4f53\u6570\u636e\uff1a<\/p>\n\n\n\n

\u2022 \u80ba\u764c\uff1aGLP-1 \u7ec4\u8f6c\u79fb\u53d1\u751f\u738710%\uff0c\u5bf9\u7167\u7ec422%<\/p>\n\n\n\n

\u2022 \u4e73\u817a\u764c\uff1aGLP-1 \u7ec4\u8f6c\u79fb\u53d1\u751f\u738710%\uff0c\u5bf9\u7167\u7ec420%<\/p>\n\n\n\n

\u2022 \u7ed3\u76f4\u80a0\u764c\uff1aGLP-1 \u7ec4\u8f6c\u79fb\u53d1\u751f\u738713%\uff0c\u5bf9\u7167\u7ec422%<\/p>\n\n\n\n

\u2022 \u809d\u7ec6\u80de\u764c\uff1aGLP-1 \u7ec4\u8f6c\u79fb\u53d1\u751f\u738719%\uff0c\u5bf9\u7167\u7ec428%<\/p>\n\n\n\n

\uff08\u4e8c\uff09\u4e09\u7c7b\u80bf\u7624\u672a\u89c2\u5bdf\u5230\u7edf\u8ba1\u5b66\u83b7\u76ca<\/strong><\/strong><\/p>\n\n\n\n

\u524d\u5217\u817a\u817a\u764c\u3001\u80f0\u817a\u817a\u764c\u3001\u80be\u7ec6\u80de\u764c\u961f\u5217\u4e2d\uff0cGLP-1\u7ec4\u8f6c\u79fb\u75c5\u4f8b\u6570\u503c\u867d\u7565\u4f4e\u4e8e\u5bf9\u7167\u7ec4\uff0c\u4f46\u7ec4\u95f4\u5dee\u5f02\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u6807\u51c6\uff0c\u6682\u65e0\u6cd5\u786e\u8ba4\u8be5\u7c7b\u836f\u7269\u5bf9\u6b64\u4e09\u7c7b\u80bf\u7624\u5b58\u5728\u660e\u786e\u4fdd\u62a4\u6548\u5e94\u3002<\/p>\n\n\n\n

\uff08\u4e09\uff09\u80bf\u7624GLP<\/strong>–<\/strong>1\u53d7\u4f53\u8868\u8fbe\u4e0e\u9884\u540e\u6b63\u5411\u76f8\u5173<\/strong><\/strong><\/p>\n\n\n\n

\u6574\u4f53\u961f\u5217\u6570\u636e\u663e\u793a\uff0c\u80bf\u7624\u75c5\u7076GLP-1R\u9ad8\u8868\u8fbe\u4eba\u7fa4\uff0c\u5168\u56e0\u6b7b\u4ea1\u98ce\u9669\u8f83\u4f4e\u8868\u8fbe\u4eba\u7fa4\u4e0b\u964d33%\uff1b\u5176\u4e2d\u4e73\u817a\u764c\u4e9a\u7ec4\u83b7\u76ca\u5173\u8054\u6027\u6700\u5f3a\uff0c\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d45%\u3002\u8be5\u7ed3\u679c\u4f50\u8bc1GLP-1\u4fe1\u53f7\u901a\u8def\u53ef\u53c2\u4e0e\u8c03\u63a7\u80bf\u7624\u8fdb\u5c55\u8fdb\u7a0b\uff0c\u662f\u8be5\u836f\u7269\u6f5c\u5728\u6297\u80bf\u7624\u4f5c\u7528\u7684\u5206\u5b50\u4f9d\u636e\u3002<\/p>\n\n\n\n

\uff08\u56db\uff09\u4e24\u7ec4\u7528\u836f\u5b89\u5168\u6027\u65e0\u663e\u8457\u5dee\u5f02<\/strong><\/strong><\/p>\n\n\n\n

\u968f\u8bbf\u671f\u5185\uff0cGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7ec4\u80c3\u80a0\u9053\u4e0d\u9002\u3001\u80f0\u817a\u708e\u7b49\u5df2\u77e5\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\uff0c\u672a\u9ad8\u4e8eDPP-4\u6291\u5236\u5242\u5bf9\u7167\u7ec4\uff0c\u5728\u5408\u5e76\u80bf\u7624\u7684\u6162\u75c5\u7fa4\u4f53\u4e2d\u5177\u5907\u57fa\u7840\u7528\u836f\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n

4. <\/strong>\u7814\u7a76\u6743\u5a01\u89e3\u8bfb<\/strong><\/strong><\/p>\n\n\n\n

\u672c\u7814\u7a76\u7b2c\u4e00\u4f5c\u8005\u3001\u9676\u897f\u683c\u764c\u75c7\u7814\u7a76\u6240 Mark David Orland \u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u8be5\u771f\u5b9e\u4e16\u754c\u961f\u5217\u6570\u636e\u521d\u6b65\u8bc1\u5b9e\uff0c\u76f8\u8f83\u4e8eDPP-4\u6291\u5236\u5242\uff0cGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u53ef\u5ef6\u7f13\u7279\u5b9a\u56db\u7c7b\u5b9e\u4f53\u7624\u7684\u5206\u671f\u8fdb\u5c55\uff0c\u4f46\u8be5\u7ed3\u8bba\u4ec5\u4e3a\u89c2\u5bdf\u6027\u7814\u7a76\u7ed3\u679c\uff0c\u4e0d\u80fd\u76f4\u63a5\u7b49\u540c\u4e8e\u4e34\u5e8a\u6cbb\u7597\u63a8\u8350\u3002<\/p>\n\n\n\n

ASCO \u80bf\u7624\u652f\u6301\u6cbb\u7597\u4e13\u5bb6 Marcin Chwistek \u535a\u58eb\u8865\u5145\uff1aGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u6297\u708e\u3001\u514d\u75ab\u8c03\u8282\u7279\u6027\u662f\u6f5c\u5728\u83b7\u76ca\u6838\u5fc3\uff0c\u73b0\u6709\u6570\u636e\u4ec5\u80fd\u652f\u6491\u540e\u7eed\u524d\u77bb\u6027\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u5f00\u5c55\uff0c\u4e0d\u53ef\u8131\u79bb\u89c4\u8303\u6297\u80bf\u7624\u6cbb\u7597\u5355\u72ec\u4f7f\u7528\u8be5\u836f\u7269\u6297\u764c\u3002<\/p>\n\n\n\n

5. <\/strong>\u7814\u7a76\u5c40\u9650\u6027\u4e0e\u4e34\u5e8a\u91cd\u8981\u63d0\u9192<\/strong><\/strong><\/p>\n\n\n\n

1. \u672c\u7814\u7a76\u4e3a\u56de\u987e\u6027\u771f\u5b9e\u4e16\u754c\u89c2\u5bdf\u7814\u7a76\uff0c\u4ec5\u80fd\u4f53\u73b0\u76f8\u5173\u6027\uff0c\u65e0\u6cd5\u76f4\u63a5\u786e\u7acb\u836f\u7269\u4e0e\u80bf\u7624\u8f6c\u79fb\u964d\u4f4e\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u4e0d\u80fd\u66ff\u4ee3\u2160\/\u2161\/\u2162\u671f\u524d\u77bb\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u8bba\uff1b<\/p>\n\n\n\n

2. GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u83b7\u6279\u9002\u5e94\u75c7\u4ec5\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u4f53\u91cd\u7ba1\u7406\uff0c\u5168\u7403\u836f\u76d1\u673a\u6784\u6682\u672a\u6279\u51c6\u5176\u4f5c\u4e3a\u6297\u80bf\u7624\u3001\u9632\u8f6c\u79fb\u6cbb\u7597\u836f\u7269\uff0c\u4e25\u7981\u80bf\u7624\u60a3\u8005\u81ea\u884c\u66ff\u6362\u6b63\u89c4\u653e\u5316\u7597\u3001\u9776\u5411\u3001\u514d\u75ab\u6cbb\u7597\u65b9\u6848\uff1b<\/p>\n\n\n\n

3. \u524d\u5217\u817a\u764c\u3001\u80f0\u817a\u764c\u3001\u80be\u764c\u6682\u672a\u8bc1\u5b9e\u83b7\u76ca\uff0c\u4e0d\u5b58\u5728\u5e7f\u8c31\u6297\u80bf\u7624\u4f5c\u7528\uff1b<\/p>\n\n\n\n

4. \u80bf\u7624\u5408\u5e76\u7cd6\u5c3f\u75c5\u60a3\u8005\u8c03\u6574\u964d\u7cd6\u65b9\u6848\uff0c\u5fc5\u987b\u7531\u80bf\u7624\u79d1\u3001\u5185\u5206\u6ccc\u79d1\u8054\u5408\u8bc4\u4f30\uff0c\u7ed3\u5408\u57fa\u7840\u75be\u75c5\u3001\u809d\u80be\u529f\u80fd\u3001\u80bf\u7624\u6cbb\u7597\u65b9\u6848\u7efc\u5408\u5224\u65ad\uff0c\u7981\u6b62\u81ea\u4e3b\u6362\u836f\u3002<\/p>\n\n\n\n

6. <\/strong>\u540e\u7eed\u79d1\u7814\u65b9\u5411<\/strong><\/strong><\/p>\n\n\n\n

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\u7ed3\u8bed<\/strong><\/strong><\/p>\n\n\n\n

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