{"id":40947,"date":"2026-07-10T14:03:30","date_gmt":"2026-07-10T06:03:30","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=40947"},"modified":"2026-07-10T14:03:45","modified_gmt":"2026-07-10T06:03:45","slug":"%e5%b9%bf%e4%b8%9c%e9%ab%98%e5%8f%91%e9%bc%bb%e5%92%bd%e7%99%8c%e8%bf%8e%e6%9d%a5%e6%96%b0%e9%80%89%e6%8b%a9%ef%bc%9a%e5%85%a8%e7%90%83%e9%a6%96%e4%b8%aa%e5%8f%8c%e6%8a%97adc%e4%bc%a6%e5%ba%b7","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e5%b9%bf%e4%b8%9c%e9%ab%98%e5%8f%91%e9%bc%bb%e5%92%bd%e7%99%8c%e8%bf%8e%e6%9d%a5%e6%96%b0%e9%80%89%e6%8b%a9%ef%bc%9a%e5%85%a8%e7%90%83%e9%a6%96%e4%b8%aa%e5%8f%8c%e6%8a%97adc%e4%bc%a6%e5%ba%b7\/","title":{"rendered":"\u5e7f\u4e1c\u9ad8\u53d1\u9f3b\u54bd\u764c\u8fce\u6765\u65b0\u9009\u62e9\uff1a\u5168\u7403\u9996\u4e2a\u53cc\u6297ADC\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u83b7\u6279\u4e0a\u5e02"},"content":{"rendered":"\n

\u8fd1\u65e5\uff0c\u7531\u4e2d\u56fd\u5185\u5730\u836f\u4f01\u81ea\u4e3b\u7814\u53d1\u7684\u521b\u65b0\u6297\u80bf\u7624\u836f\u7269\u2014\u2014\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\uff08Izalontamab brengitecan\uff0c\u7b80\u79f0iza-bren\uff09\u6b63\u5f0f\u83b7\u6279\u4e0a\u5e02\uff0c\u4e3a\u7ecf\u591a\u7ebf\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n\n\n\n

\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u83b7\u6279\u540e\uff0c\u9996\u4f4d\u6e2f\u7c4d\u60a3\u8005\u5df2\u4e8e\u6df1\u5733\u65b0\u98ce\u548c\u7766\u5bb6\u5b8c\u6210\u7528\u836f\u8bc4\u4f30\uff0c\u533b\u9662\u5c06\u6301\u7eed\u4e3a\u5927\u6e7e\u533a\u60a3\u8005\u63d0\u4f9b\u89c4\u8303\u3001\u4e13\u4e1a\u3001\u4e2a\u4f53\u5316\u7684\u521b\u65b0\u836f\u8bca\u7597\u652f\u6301\u3002<\/strong><\/strong><\/p>\n\n\n\n

1. <\/strong>\u4e3a\u4ec0\u4e48\u5e7f\u4e1c\u4eba\u5c24\u5176\u9700\u8981\u5173\u6ce8\u9f3b\u54bd\u764c\uff1f<\/strong><\/strong><\/p>\n\n\n\n

\u9f3b\u54bd\u764c\u662f\u53d1\u751f\u4e8e\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e0eEB\u75c5\u6bd2\u611f\u67d3\u3001\u9057\u4f20\u6613\u611f\u6027\u53ca\u73af\u5883\u56e0\u7d20\u7b49\u5bc6\u5207\u76f8\u5173\uff0c\u5177\u6709\u975e\u5e38\u660e\u663e\u7684\u5730\u57df\u805a\u96c6\u7279\u5f81\u3002<\/p>\n\n\n\n

\u6839\u636e\u5168\u7403\u764c\u75c7\u7edf\u8ba1\u6570\u636e\uff0c2022\u5e74\u5168\u7403\u7ea6\u670912\u4e07\u4f8b\u9f3b\u54bd\u764c\u65b0\u53d1\u75c5\u4f8b\uff0c<\/strong>\u5e76\u9020\u6210\u7ea67.3\u4e07\u4eba\u6b7b\u4ea1\u3002<\/strong>\u9f3b\u54bd\u764c\u5728\u4e16\u754c\u591a\u6570\u5730\u533a\u76f8\u5bf9\u5c11\u89c1\uff0c\u4f46\u4e2d\u56fd\u5357\u65b9\u662f\u5168\u7403\u75be\u75c5\u8d1f\u62c5\u6700\u96c6\u4e2d\u7684\u5730\u533a\u4e4b\u4e00\uff0c\u5e7f\u4e1c\u3001\u5e7f\u897f\u53ca\u9999\u6e2f\u7b49\u5730\u5c24\u4e3a\u9ad8\u53d1\u3002<\/p>\n\n\n\n

\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u7b5b\u67e5\u3001\u653e\u7597\u6280\u672f\u53ca\u7efc\u5408\u6cbb\u7597\u6c34\u5e73\u4e0d\u65ad\u63d0\u5347\uff0c\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6574\u4f53\u9884\u540e\u5df2\u7ecf\u660e\u663e\u6539\u5584\u3002\u4f46\u4e00\u65e6\u75be\u75c5\u590d\u53d1\u3001\u53d1\u751f\u8fdc\u5904\u8f6c\u79fb\uff0c\u6216\u5728\u591a\u7ebf\u7cfb\u7edf\u6cbb\u7597\u540e\u518d\u6b21\u8fdb\u5c55\uff0c\u540e\u7eed\u6cbb\u7597\u4ecd\u9762\u4e34\u8f83\u5927\u6311\u6218\u3002<\/p>\n\n\n\n

2. <\/strong>\u4e00\u7ebf\u6cbb\u7597\u4e0d\u65ad\u8fdb\u6b65\uff0c\u540e\u7ebf\u60a3\u8005\u4ecd\u9700\u8981\u65b0\u7684\u9009\u62e9<\/strong><\/strong><\/p>\n\n\n\n

\u5bf9\u4e8e\u5c40\u9650\u671f\u9f3b\u54bd\u764c\uff0c\u653e\u7597\u53ca\u540c\u6b65\u653e\u5316\u7597\u662f\u91cd\u8981\u7684\u6cbb\u7597\u65b9\u5f0f\uff1b\u5bf9\u4e8e\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\uff0c\u514d\u75ab\u6cbb\u7597\u8054\u5408\u542b\u94c2\u5316\u7597\u5df2\u6210\u4e3a\u91cd\u8981\u7684\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n\n\n\n

\u4f46\u90e8\u5206\u60a3\u8005\u4ecd\u4f1a\u5728\u63a5\u53d7\u4ee5\u4e0b\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u542b\u94c2\u5316\u7597<\/p>\n\n\n\n

\u00b7 <\/strong>PD-1\/PD-L1\u514d\u75ab\u6cbb\u7597<\/p>\n\n\n\n

\u00b7 <\/strong>\u591a\u7ebf\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597<\/p>\n\n\n\n

\u8fc7\u53bb\uff0c\u8fd9\u7c7b\u60a3\u8005\u7684\u540e\u7ebf\u6cbb\u7597\u4e3b\u8981\u91c7\u7528\u5361\u57f9\u4ed6\u6ee8\u3001\u5409\u897f\u4ed6\u6ee8\u6216\u591a\u897f\u4ed6\u8d5b\u7b49\u5355\u836f\u5316\u7597\u3002<\/p>\n\n\n\n

\u76f8\u5173\u7814\u7a76\u5927\u591a\u4e3a\u5c0f\u6837\u672c\u3001\u5355\u81c2\u2161\u671f\u7814\u7a76\uff0c\u62a5\u9053\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u7ea6\u4e3a2.9%\u201443.8%\uff0c<\/strong>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7ea6\u4e3a1.5\u20145.3\u4e2a\u6708\uff0c\u957f\u671f\u7f3a\u5c11\u968f\u673a\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u63d0\u4f9b\u7684\u9ad8\u7ea7\u522b\u8bc1\u636e\u3002<\/p>\n\n\n\n

\u5bf9\u4e8e\u5df2\u7ecf\u7ecf\u5386\u591a\u7ebf\u6cbb\u7597\u7684\u60a3\u8005\u800c\u8a00\uff0c\u5982\u4f55\u63d0\u9ad8\u80bf\u7624\u660e\u663e\u7f29\u5c0f\u7684\u53ef\u80fd\u6027\uff0c\u5e76\u5ef6\u957f\u75be\u75c5\u5f97\u5230\u63a7\u5236\u7684\u65f6\u95f4\uff0c\u662f\u4e34\u5e8a\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n\n\n\n

3. <\/strong>\u4ec0\u4e48\u662f\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\uff1f<\/strong><\/strong><\/p>\n\n\n\n

\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297<\/strong>\uff08\u7814\u53d1\u4ee3\u53f7\uff1aBL-B01D1\uff0c\u7b80\u79f0iza-bren\uff09\uff0c\u662f\u4e00\u6b3e\u5168\u7403\u9996\u521bEGFR\u00d7HER3\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff0c<\/strong>\u5373\u201c\u53cc\u6297ADC\u201d\u3002<\/p>\n\n\n\n

\u8be5\u836f\u5df2\u4e8e2026\u5e746\u670822\u65e5\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u548cPD-1\/PD-L1\u6291\u5236\u5242\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u3002<\/strong><\/p>\n\n\n\n

\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u53cc\u6297ADC\uff0c<\/strong>\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u4e0d\u4ec5\u4ee3\u8868\u4e86\u4e2d\u56fd\u539f\u7814\u521b\u65b0\u836f\u5728ADC\u9886\u57df\u7684\u91cd\u8981\u7a81\u7834\uff0c\u4e5f\u662f\u6211\u56fd\u9996\u6b3e\u201c\u51fa\u6d77\u201d\u6388\u6743\u7ed9\u8de8\u56fd\u836f\u4f01\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u7684\u56fd\u4ea7\u53cc\u6297ADC\u65b0\u836f\u3002<\/p>\n\n\n\n

\u9664\u5df2\u83b7\u6279\u7684\u9f3b\u54bd\u764c\u9002\u5e94\u75c7\u5916\uff0c\u5176\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u4e09\u9634\u6027\u4e73\u817a\u764c\u4e24\u9879\u91cd\u8981\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff0c\u4e5f\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6b63\u5f0f\u53d7\u7406\u3002<\/strong><\/p>\n\n\n\n

\u76ee\u524d\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u6b63\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u5305\u62ec\u4e2d\u56fd\u548c\u7f8e\u56fd\uff0c\u540c\u6b65\u5f00\u5c5540\u4f59\u9879\u8de8\u7624\u79cd\u4e34\u5e8a\u7814\u7a76\uff0c\u6301\u7eed\u63a2\u7d22\u5176\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u7684\u5e7f\u8c31\u6297\u80bf\u7624\u6f5c\u529b\u3002<\/p>\n\n\n\n

ADC\u53ef\u4ee5\u7b80\u5355\u7406\u89e3\u4e3a\uff1a\u5c06\u80fd\u591f\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u7684\u6297\u4f53\uff0c\u4e0e\u80fd\u591f\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u7684\u836f\u7269\u8fde\u63a5\u5728\u4e00\u8d77\uff0c\u901a\u8fc7\u6297\u4f53\u5b9e\u73b0\u66f4\u5177\u9488\u5bf9\u6027\u7684\u836f\u7269\u9012\u9001\u3002<\/p>\n\n\n\n

\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u8fdb\u4e00\u6b65\u91c7\u7528\u4e86\u201c\u53cc\u9776\u70b9\u8bbe\u8ba1\u201d\uff0c\u4e3b\u8981\u7531\u4e09\u90e8\u5206\u7ec4\u6210\uff1a<\/p>\n\n\n\n

1.  EGFR\u00d7HER3\u53cc\u7279\u5f02\u6027\u6297\u4f53<\/strong><\/strong><\/p>\n\n\n\n

\u6297\u4f53\u90e8\u5206\u53ef\u4ee5\u540c\u65f6\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684EGFR\u548cHER3\u3002<\/p>\n\n\n\n

EGFR\u548cHER3\u5747\u53c2\u4e0e\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u3002\u901a\u8fc7\u540c\u65f6\u8bc6\u522b\u4e24\u4e2a\u9776\u70b9\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u80fd\u591f\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u8bc6\u522b\u548c\u7ed3\u5408\uff0c\u5e76\u534f\u540c\u963b\u65ad\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n\n\n\n

2. \u53ef\u88c2\u89e3\u8fde\u63a5\u5b50<\/strong><\/strong><\/p>\n\n\n\n

\u8fde\u63a5\u5b50\u5c06\u6297\u4f53\u4e0e\u7ec6\u80de\u6bd2\u6027\u8f7d\u8377\u7a33\u5b9a\u8fde\u63a5\uff0c\u4f7f\u836f\u7269\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u4fdd\u6301\u76f8\u5bf9\u7a33\u5b9a\uff1b\u836f\u7269\u8fdb\u5165\u80bf\u7624\u7ec6\u80de\u540e\uff0c\u8fde\u63a5\u5b50\u88ab\u7279\u5f02\u6027\u5207\u5272\uff0c\u91ca\u653e\u6709\u6548\u8f7d\u8377\u3002<\/p>\n\n\n\n

3. Ed-04\u8f7d\u8377<\/strong><\/strong><\/p>\n\n\n\n

Ed-04\u662f\u4e00\u79cd\u65b0\u578b\u62d3\u6251\u5f02\u6784\u9176\u2160\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u5e72\u6270\u80bf\u7624\u7ec6\u80de\u7684DNA\u590d\u5236\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n

\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7684\u836f\u7269\u6297\u4f53\u6bd4\uff08DAR\uff09\u7ea6\u4e3a8\uff0c\u5373\u6bcf\u4e2a\u6297\u4f53\u5206\u5b50\u5e73\u5747\u53ef\u4ee5\u643a\u5e26\u7ea68\u4e2a\u8f7d\u8377\u5206\u5b50\u3002<\/p>\n\n\n\n

\u7b80\u5355\u6765\u8bf4\uff0c\u5b83\u5c31\u50cf\u4e00\u5957\u5177\u6709\u201c\u53cc\u91cd\u5bfc\u822a\u201d\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff1a<\/p>\n\n\n\n

\u9996\u5148\u901a\u8fc7EGFR\u548cHER3\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\uff0c\u968f\u540e\u8fdb\u5165\u7ec6\u80de\u5185\u90e8\u5e76\u91ca\u653e\u8f7d\u8377\uff0c\u5b9e\u73b0\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u3002<\/strong><\/strong><\/p>\n\n\n\n

\u91ca\u653e\u51fa\u7684Ed-04\u8fd8\u53ef\u4ee5\u7a7f\u8fc7\u7ec6\u80de\u819c\uff0c\u5f71\u54cd\u90bb\u8fd1\u80bf\u7624\u7ec6\u80de\uff0c\u4ea7\u751f\u201c\u65c1\u89c2\u8005\u6548\u5e94\u201d\uff1b\u540c\u65f6\uff0c\u5176\u6297\u4f53\u90e8\u5206\u8fd8\u53ef\u53d1\u6325EGFR\/HER3\u53cc\u901a\u8def\u963b\u65ad\u53ca\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u4f5c\u7528\uff0c\u4ece\u591a\u4e2a\u73af\u8282\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n\n\n\n

4. <\/strong>\u5168\u7403\u9996\u4e2a\u9f3b\u54bd\u764c\u540e\u7ebf\u786e\u8bc1\u6027\u2162\u671f\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u6b64\u6b21\u83b7\u6279\u7684\u6838\u5fc3\u4e34\u5e8a\u8bc1\u636e\u6765\u81eaBL-B01D1-303\u7814\u7a76\u3002<\/strong><\/p>\n\n\n\n

\u8fd9\u662f\u4e00\u9879\u5728\u4e2d\u56fd55\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5f00\u5c55\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u7eb3\u5165386\u4f8b\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

\u5165\u7ec4\u60a3\u8005\u6b64\u524d\u5747\u5df2\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e24\u7ebf\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u81f3\u5c11\u4e00\u79cd\u542b\u94c2\u5316\u7597\u65b9\u6848<\/p>\n\n\n\n

\u00b7 <\/strong>PD-1\u6216PD-L1\u6291\u5236\u5242\u6cbb\u7597<\/p>\n\n\n\n

\u00b7 <\/strong>\u6cbb\u7597\u540e\u518d\u6b21\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55<\/p>\n\n\n\n

\u4e0d\u5c11\u60a3\u8005\u7684\u75c5\u60c5\u8f83\u4e3a\u590d\u6742\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u8d85\u8fc7\u56db\u6210\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e09\u7ebf\u6cbb\u7597<\/p>\n\n\n\n

\u00b7 <\/strong>\u63a5\u8fd1\u4e00\u534a\u60a3\u8005\u4f34\u6709\u809d\u8f6c\u79fb<\/p>\n\n\n\n

\u00b7 <\/strong>\u7ea6\u4e00\u534a\u60a3\u8005\u4f34\u6709\u9aa8\u8f6c\u79fb<\/p>\n\n\n\n

\u60a3\u8005\u6309\u71671:1\u968f\u673a\u63a5\u53d7\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u6cbb\u7597<\/p>\n\n\n\n

\u00b7 <\/strong>\u533b\u751f\u9009\u62e9\u7684\u5355\u836f\u5316\u7597\uff0c\u5305\u62ec\u5361\u57f9\u4ed6\u6ee8\u3001\u5409\u897f\u4ed6\u6ee8\u6216\u591a\u897f\u4ed6\u8d5b<\/p>\n\n\n\n

\u7814\u7a76\u4e2d\u7684\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7ed9\u836f\u65b9\u6848\u4e3a2.5 mg\/kg\uff0c\u7b2c1\u5929\u548c\u7b2c8\u5929\u7ed9\u836f\uff0c\u6bcf3\u5468\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f<\/strong>\uff08\u5b9e\u9645\u4e34\u5e8a\u7528\u836f\u5e94\u4ee5\u6b63\u5f0f\u83b7\u6279\u8bf4\u660e\u4e66\u53ca\u533b\u751f\u8bc4\u4f30\u4e3a\u51c6\u3002\uff09<\/p>\n\n\n\n

5. <\/strong>\u80bf\u7624\u7f13\u89e3\u7387\u63a5\u8fd1\u5316\u7597\u7ec4\u4e24\u500d<\/strong><\/strong><\/p>\n\n\n\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u663e\u8457\u9ad8\u4e8e\u5316\u7597\u7ec4\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7ec4\uff1a54.6%<\/strong><\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u5316\u7597\u7ec4\uff1a27.0%<\/strong><\/strong><\/p>\n\n\n\n

\u5ba2\u89c2\u7f13\u89e3\u7387\u662f\u6307\u80bf\u7624\u8fbe\u5230\u5b8c\u5168\u6d88\u5931\u6216\u660e\u663e\u7f29\u5c0f\u6807\u51c6\u7684\u60a3\u8005\u6bd4\u4f8b\u3002<\/p>\n\n\n\n

\u8fd9\u610f\u5473\u7740\uff0c\u5728\u8fd9\u7ec4\u7ecf\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u4e2d\uff0c\u63a5\u53d7\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u7ea6\u6709\u4e00\u534a\u8fbe\u5230\u80bf\u7624\u660e\u663e\u7f29\u5c0f\u7684\u6807\u51c6\u3002<\/p>\n\n\n\n

\u5176\u4ed6\u7597\u6548\u6307\u6807\u540c\u6837\u663e\u793a\u83b7\u76ca\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u75be\u75c5\u63a7\u5236\u7387\uff1a82.4% vs 69.6%<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff1a8.5\u4e2a\u6708 vs 4.8\u4e2a\u6708<\/strong><\/strong><\/p>\n\n\n\n

\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7ec4\u4e2d\uff0c74.8%\u7684\u60a3\u8005\u89c2\u5bdf\u5230\u80bf\u7624\u7f29\u5c0f\uff0c\u4e2d\u4f4d\u7f29\u5c0f\u5e45\u5ea6\u8fbe\u523045.5%\u3002<\/p>\n\n\n\n

6. <\/strong>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u8fbe\u52308.38\u4e2a\u6708<\/strong><\/strong><\/p>\n\n\n\n

\u7ecf\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u4f30\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7ec4\uff1a8.38\u4e2a\u6708<\/strong><\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u5316\u7597\u7ec4\uff1a4.34\u4e2a\u6708<\/strong><\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u98ce\u9669\u6bd4\uff1aHR=0.44<\/strong><\/strong><\/p>\n\n\n\n

\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u7ea656%\uff0c<\/strong>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u63a5\u8fd1\u5316\u7597\u7ec4\u7684\u4e24\u500d\u3002<\/p>\n\n\n\n

\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5e76\u4e0d\u7b49\u540c\u4e8e\u60a3\u8005\u7684\u603b\u751f\u5b58\u65f6\u95f4\uff0c\u800c\u662f\u6307\u4ece\u5f00\u59cb\u6cbb\u7597\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u65f6\u95f4\u3002<\/p>\n\n\n\n

\u5176\u5ef6\u957f\u610f\u5473\u7740\uff0c\u60a3\u8005\u5e73\u5747\u53ef\u4ee5\u83b7\u5f97\u66f4\u957f\u7684\u75be\u75c5\u63a7\u5236\u65f6\u95f4\u3002<\/p>\n\n\n\n

7. <\/strong>\u5b89\u5168\u6027\u5982\u4f55\uff1f\u6574\u4f53\u53ef\u76d1\u6d4b\u3001\u53ef\u7ba1\u7406<\/strong><\/strong><\/p>\n\n\n\n

\u5728BL-B01D1-303\u7814\u7a76\u4e2d\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5176ADC\u4f5c\u7528\u673a\u5236\u4e00\u81f4\uff0c\u8f83\u9ad8\u7ea7\u522b\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u8868\u73b0\u4e3a\u8d2b\u8840\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u53ca\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u7b49\u8840\u6db2\u5b66\u4e8b\u4ef6\u3002<\/strong><\/p>\n\n\n\n

\u7814\u7a76\u4e2d\uff0c\u22653\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a79.9%\u3002\u901a\u8fc7\u5b9a\u671f\u8840\u5e38\u89c4\u76d1\u6d4b\u3001\u652f\u6301\u6cbb\u7597\u3001\u6682\u505c\u7ed9\u836f\u6216\u5242\u91cf\u8c03\u6574\u7b49\u89c4\u8303\u7ba1\u7406\uff0c\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u80fd\u591f\u5f97\u5230\u53ca\u65f6\u8bc6\u522b\u548c\u5904\u7406\uff1b\u56e0\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u6c38\u4e45\u505c\u836f\u7684\u60a3\u8005\u6bd4\u4f8b\u4ec5\u4e3a2.6%<\/strong>\uff0c\u4e14\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n\n\n\n

\u8fd9\u610f\u5473\u7740\uff0c\u5728\u4e13\u4e1a\u533b\u7597\u56e2\u961f\u7684\u5168\u7a0b\u76d1\u6d4b\u548c\u7ba1\u7406\u4e0b\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7684\u6cbb\u7597\u98ce\u9669\u6574\u4f53\u53ef\u63a7\uff0c\u6709\u52a9\u4e8e\u60a3\u8005\u5728\u83b7\u5f97\u7597\u6548\u7684\u540c\u65f6\uff0c\u5c3d\u53ef\u80fd\u7ef4\u6301\u6cbb\u7597\u7684\u8fde\u7eed\u6027\u3002<\/p>\n\n\n\n

8. <\/strong>\u4e24\u9879\u2162\u671f\u7814\u7a76\u4eae\u76f82026 ASCO\uff0c\u5c55\u73b0\u591a\u7624\u79cd\u6f5c\u529b<\/strong><\/strong><\/p>\n\n\n\n

\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u7684\u7814\u53d1\u5e76\u672a\u5c40\u9650\u4e8e\u9f3b\u54bd\u764c\u3002<\/p>\n\n\n\n

\u57282026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO\uff09\u4e0a\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u6709\u4e24\u9879\u2162\u671f\u7814\u7a76\u5165\u9009\u53e3\u5934\u62a5\u544a\uff0c\u5206\u522b\u8986\u76d6\u4e09\u9634\u6027\u4e73\u817a\u764c\u548c\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u3002<\/p>\n\n\n\n

\u9700\u8981\u7279\u522b\u8bf4\u660e\u7684\u662f\uff1a\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u76ee\u524d\u83b7\u6279\u7684\u662f\u9f3b\u54bd\u764c\u9002\u5e94\u75c7\uff0c\u4ee5\u4e0b\u6570\u636e\u4ee3\u8868\u5176\u5728\u5176\u4ed6\u7624\u79cd\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\uff0c\u5c1a\u4e0d\u7b49\u540c\u4e8e\u76f8\u5173\u9002\u5e94\u75c7\u5df2\u7ecf\u83b7\u6279\u3002<\/strong><\/p>\n\n\n\n

9. <\/strong>\u4e09\u9634\u6027\u4e73\u817a\u764c\uff1aPANKU-Breast02\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

PANKU-Breast02\u662f\u4e00\u9879\u5728\u4e2d\u56fd81\u5bb6\u4e2d\u5fc3\u5f00\u5c55\u7684\u968f\u673a\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7eb3\u5165\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d2b\u6749\u7c7b\u836f\u7269\uff0c\u5e76\u5728\u665a\u671f\u9636\u6bb5\u63a5\u53d7\u8fc71\u20142\u7ebf\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

\u7814\u7a76\u540c\u65f6\u8fbe\u5230\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f\u53cc\u4e3b\u8981\u7ec8\u70b9\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff1a8.5\u4e2a\u6708 vs 3.1\u4e2a\u6708<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u7ea671%<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a15.9\u4e2a\u6708 vs 12.5\u4e2a\u6708<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u7ea640%<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u7ecf\u786e\u8ba4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff1a51.7% vs 20.5%<\/strong><\/p>\n\n\n\n

10. <\/strong>\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff1aPANKU-Esophagus01\u7814\u7a76<\/strong><\/strong><\/p>\n\n\n\n

PANKU-Esophagus01\u7814\u7a76\u7eb3\u5165\u4e00\u7ebf\u63a5\u53d7PD-1\/PD-L1\u6291\u5236\u5242\u8054\u5408\u542b\u94c2\u5316\u7597\u540e\u8fdb\u5c55\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

\u7814\u7a76\u540c\u6837\u8fbe\u5230\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f\u53cc\u4e3b\u8981\u7ec8\u70b9\uff1a<\/p>\n\n\n\n

\u00b7 <\/strong>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff1a4.17\u4e2a\u6708 vs 1.97\u4e2a\u6708<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u7ea650%<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a9.79\u4e2a\u6708 vs 7.20\u4e2a\u6708<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u7ea636%<\/strong><\/p>\n\n\n\n

\u00b7 <\/strong>\u5ba2\u89c2\u7f13\u89e3\u7387\uff1a35.3% vs 13.1%<\/strong><\/strong><\/p>\n\n\n\n

\u4ece\u9f3b\u54bd\u764c\uff0c\u5230\u4e09\u9634\u6027\u4e73\u817a\u764c\u548c\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u5df2\u7ecf\u5728\u591a\u4e2a\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e5f\u8fdb\u4e00\u6b65\u4f53\u73b0\u4e86EGFR\u00d7HER3\u53cc\u6297ADC\u5728\u4e0d\u540c\u5b9e\u4f53\u7624\u4e2d\u7684\u5f00\u53d1\u6f5c\u529b\u3002<\/p>\n\n\n\n

11. <\/strong>\u54ea\u4e9b\u9f3b\u54bd\u764c\u60a3\u8005\u53ef\u80fd\u9002\u5408\uff1f<\/strong><\/strong><\/p>\n\n\n\n

\u6839\u636e\u6b64\u6b21\u83b7\u6279\u9002\u5e94\u75c7\uff0c\u4f26\u5eb7\u4f9d\u9686\u59a5\u5355\u6297\u4e3b\u8981\u9762\u5411\u7ecf\u591a\u7ebf\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

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