{"id":40952,"date":"2026-07-10T14:03:14","date_gmt":"2026-07-10T06:03:14","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=40952"},"modified":"2026-07-10T14:03:51","modified_gmt":"2026-07-10T06:03:51","slug":"%e3%80%8anejm%e3%80%8b%e5%8d%81%e5%b9%b4%e9%9a%8f%e8%ae%bf%ef%bc%81%e6%8f%ad%e7%a4%ba-car-t-%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95%e7%9a%84%e9%95%bf%e6%9c%9f%e6%95%88%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e3%80%8anejm%e3%80%8b%e5%8d%81%e5%b9%b4%e9%9a%8f%e8%ae%bf%ef%bc%81%e6%8f%ad%e7%a4%ba-car-t-%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95%e7%9a%84%e9%95%bf%e6%9c%9f%e6%95%88%e6%9e%9c\/","title":{"rendered":"\u300aNEJM\u300b\u5341\u5e74\u968f\u8bbf\uff01\u63ed\u793a CAR-T \u7ec6\u80de\u7597\u6cd5\u7684\u957f\u671f\u6548\u679c"},"content":{"rendered":"\n

CD19 \u9776\u5411\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff0c\u5df2\u7eb3\u5165\u590d\u53d1\u3001\u96be\u6cbb\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6807\u51c6\u633d\u6551\u6cbb\u7597\u4f53\u7cfb\uff0c\u4f46\u8be5\u7597\u6cd5\u8f93\u6ce8\u540e\u7684\u957f\u671f\u6297\u80bf\u7624\u7597\u6548\u7684\u6301\u7eed\u6027\u3001\u8fdc\u671f\u514d\u75ab\u7a33\u6001\u52a8\u6001\u6f14\u53d8\u3001\u8fdf\u53d1\u6027\u4e0d\u826f\u53cd\u5e94\u3001\u957f\u671f\u9884\u540e\u9884\u6d4b\u6807\u5fd7\u7269\uff0c\u7f3a\u4e4f10\u5e74\u53ca\u4ee5\u4e0a\u8d85\u957f\u5468\u671f\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u652f\u6491\u3002<\/p>\n\n\n\n

2026\u5e746\u670824\u65e5\uff0c\u7f8e\u56fd\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7814\u7a76\u56e2\u961f\u4e8e\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u53d1\u8868\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5ef6\u957f\u968f\u8bbf\u7814\u7a76\uff0c\u9488\u5bf9 tisagenlecleucel\uff08CTL019\uff0c4-1BB\u5171\u523a\u6fc0\u7ed3\u6784\u57df CD19 CAR-T\uff09\u5355\u6b21\u8f93\u6ce8\u7ec4\u522b\u5f00\u5c55\u4e2d\u4f4d10.1\u5e74\u968f\u8bbf\uff0c\u7cfb\u7edf\u91cf\u5316\u957f\u671f\u7597\u6548\u3001\u590d\u53d1\u65f6\u95f4\u7279\u5f81\u3001\u8fdc\u671f\u5b89\u5168\u6027\u53ca\u9884\u540e\u5173\u8054\u751f\u7269\u5b66\u6307\u6807\uff0c\u4e3aCAR-T\u672f\u540e\u957f\u671f\u4e34\u5e8a\u7ba1\u7406\u3001\u60a3\u8005\u9884\u540e\u5206\u5c42\u63d0\u4f9b\u9ad8\u7ea7\u522b\u5faa\u8bc1\u4f9d\u636e\u3002<\/p>\n\n\n\n

\u4e00. \u7814\u7a76\u8bbe\u8ba1\u4e0e\u5165\u7ec4\u57fa\u7ebf\u7279\u5f81<\/strong><\/p>\n\n\n\n

1. \u7814\u7a76\u7c7b\u578b\u4e0e\u968f\u8bbf\u65f6\u9650<\/strong><\/strong><\/p>\n\n\n\n

\u672c\u7814\u7a76\u4e3a\u5355\u4e2d\u5fc3\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e8b\u540e\u5ef6\u957f\u968f\u8bbf\u5206\u6790\uff0c\u6570\u636e\u9501\u5b9a\u622a\u6b62\u81f3 2025\u5e7410\u67081\u65e5\uff0c\u6574\u4f53\u968f\u8bbf\u533a\u95f47.9\uff5e11.5\u5e74\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u957f10.1\u5e74\uff1b\u91c7\u7528 Kaplan-Meier \u751f\u5b58\u5206\u6790\u6cd5\u8bc4\u4f30\u751f\u5b58\u7ec8\u70b9\uff0c\u4ee5 Aalen-Johansen \u7ade\u4e89\u98ce\u9669\u6a21\u578b\u6821\u6b63\u975e\u80bf\u7624\u6b7b\u4ea1\u5bf9\u7597\u6548\u7ec8\u70b9\u7684\u5e72\u6270\u3002<\/p>\n\n\n\n

2. \u53d7\u8bd5\u8005\u57fa\u7ebf\u60c5\u51b5<\/strong><\/strong><\/p>\n\n\n\n

\u6700\u7ec8\u7eb3\u516538\u4f8b\u53ef\u8bc4\u4f30\u590d\u53d1\/\u96be\u6cbb\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u53d7\u8bd5\u8005\uff0c\u75c5\u7406\u4e9a\u578b\u5206\u5c42\uff1a\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08LBCL\uff0924\u4f8b\u3001\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08FL\uff0914\u4f8b\u3002\u53d7\u8bd5\u8005\u4e2d\u4f4d\u65e2\u5f80\u7cfb\u7edf\u6cbb\u7597\u7ebf\u6570\u4e3a4\u7ebf\uff0c\u8d85\u534a\u6570\u53d7\u8bd5\u8005\u65e2\u5f80\u63a5\u53d7\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff0c\u5747\u5c5e\u4e8e\u5e38\u89c4\u5316\u7597\u3001\u633d\u6551\u9776\u5411\u6cbb\u7597\u5931\u8d25\u7684\u9ad8\u5ea6\u96be\u6cbb\u75c5\u4f8b\uff0c\u5165\u7ec4\u4eba\u7fa4\u4ee5\u6b27\u7f8e\u767d\u79cd\u4eba\u7fa4\u4e3a\u4e3b\u3002<\/p>\n\n\n\n

3. \u6807\u51c6\u5316\u5e72\u9884\u65b9\u6848<\/strong><\/strong><\/p>\n\n\n\n

\u5168\u90e8\u53d7\u8bd5\u8005\u4ec5\u63a5\u53d7\u5355\u6b21\u81ea\u4f53 tisagenlecleucel \u7ec6\u80de\u8f93\u6ce8\uff0c\u9884\u5904\u7406\u65b9\u6848\u7edf\u4e00\u91c7\u7528\u6c1f\u8fbe\u62c9\u6ee8\u8054\u5408\u73af\u78f7\u9170\u80fa\u6dcb\u5df4\u7ec6\u80de\u6e05\u9664\u5316\u7597\uff1b\u7ec6\u80de\u8f93\u6ce8\u5b8c\u6210\u540e\uff0c\u53d7\u8bd5\u8005\u672a\u63a5\u53d7\u5de9\u56fa\u5316\u7597\u3001\u9776\u5411\u7ef4\u6301\u6cbb\u7597\uff0c\u4ea6\u672a\u8fdb\u884c CAR-T \u4e8c\u6b21\u7ec6\u80de\u8f93\u6ce8\u3002\u8be5CAR-T\u4ea7\u54c1\u4f9d\u6258\u6162\u75c5\u6bd2\u8f7d\u4f53\u4fee\u9970\u81ea\u4f53T\u7ec6\u80de\uff0c\u5b9a\u5411\u8868\u8fbeCD19\u6297\u539f\u8bc6\u522b\u53d7\u4f53\u4e0e4-1BB \u5171\u523a\u6fc0\u4fe1\u53f7\u57df\u3002<\/p>\n\n\n\n

4. \u9884\u8bbe\u7814\u7a76\u7ec8\u70b9<\/strong><\/strong><\/p>\n\n\n\n

\u2460 \u4e3b\u8981\u7ec8\u70b9\uff1a<\/strong>\u65e0\u6dcb\u5df4\u7624\u751f\u5b58\u671f\uff08LFS\uff09\uff0c\u5b9a\u4e49\u4e3a\u7ec6\u80de\u8f93\u6ce8\u81f3\u6dcb\u5df4\u7624\u590d\u53d1\u3001\u6dcb\u5df4\u7624\u7279\u5f02\u6027\u6b7b\u4ea1\u7684\u65f6\u95f4\u95f4\u9694\uff1b<\/p>\n\n\n\n

\u2461 \u6b21\u8981\u7ec8\u70b9\uff1a<\/strong>\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u975e\u590d\u53d1\u76f8\u5173\u6b7b\u4ea1\u7d2f\u79ef\u53d1\u751f\u7387\u3001\u7b2c\u4e8c\u539f\u53d1\u6076\u6027\u80bf\u7624\u53d1\u751f\u98ce\u9669\u3001\u5916\u5468\u8840 CAR \u8f6c\u57fa\u56e0\u7ec6\u80de\u5b58\u7eed\u6c34\u5e73\u3001\u4f53\u6db2\u514d\u75ab\u91cd\u5efa\u72b6\u6001\u3002<\/p>\n\n\n\n

\u4e8c. <\/strong>\u957f\u671f\u6297\u80bf\u7624\u7597\u6548\u5ba2\u89c2\u6570\u636e<\/strong><\/p>\n\n\n\n

1. \u80bf\u7624\u590d\u53d1\u65f6\u95f4\u5206\u5e03\u89c4\u5f8b<\/strong><\/strong><\/p>\n\n\n\n

\u7ec4\u522b\u5185\u6240\u6709\u6dcb\u5df4\u7624\u590d\u53d1\u4e8b\u4ef6\u5747\u53d1\u751f\u4e8e\u7ec6\u80de\u8f93\u6ce8\u6cbb\u7597\u540e5.4\u5e74\u4ee5\u5185\uff1b\u81ea5.4\u5e74\u968f\u8bbf\u8282\u70b9\u81f3\u6700\u957f11.5\u5e74\u89c2\u5bdf\u7ec8\u70b9\uff0c\u65e0\u65b0\u589e\u80bf\u7624\u590d\u53d1\u75c5\u4f8b\u3002<\/strong>\u5176\u4e2d\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u672b\u6b21\u590d\u53d1\u53d1\u751f\u4e8e\u8f93\u6ce8\u540e2.7\u5e74\uff0c\u60f0\u6027\u75c5\u7406\u4e9a\u578b\u7684\u8fdc\u671f\u590d\u53d1\u7ec8\u6b62\u7a97\u53e3\u671f\u66f4\u65e9\uff0c\u63d0\u793a\u8fbe\u5230\u65e9\u671f\u6301\u7eed\u7f13\u89e3\u540e\uff0c\u80bf\u7624\u518d\u6fc0\u6d3b\u98ce\u9669\u663e\u8457\u4e0b\u964d\u3002<\/p>\n\n\n\n

2. \u5341\u5e74\u751f\u5b58\u7ec8\u70b9\u91cf\u5316\u7ed3\u679c\uff08\u9644\u5e26 95% \u7f6e\u4fe1\u533a\u95f4\uff09<\/strong><\/strong><\/p>\n\n\n\n

\u25b6 \u65e0\u6dcb\u5df4\u7624\u751f\u5b58\u7387\uff08LFS\uff09<\/strong><\/p>\n\n\n\n

\u2022 \u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff1a32%\uff0895% CI\uff1a14%\uff5e51%\uff09<\/p>\n\n\n\n

\u2022 \u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff1a47%\uff0895% CI\uff1a20%\uff5e71%\uff09<\/p>\n\n\n\n

\u25b6 \u65e0\u8fdb\u5c55\u751f\u5b58\u7387\uff08PFS\uff09<\/strong><\/p>\n\n\n\n

\u2022 \u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff1a17%\uff0895% CI\uff1a5%\uff5e34%\uff09<\/p>\n\n\n\n

\u2022 \u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff1a29%\uff0895% CI\uff1a9%\uff5e52%\uff09<\/p>\n\n\n\n

\u25b6 \u603b\u751f\u5b58\u7387\uff08OS\uff09<\/strong><\/p>\n\n\n\n

\u2022 \u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff1a17%\uff0895% CI\uff1a5%\uff5e34%\uff09<\/p>\n\n\n\n

\u2022 \u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff1a50%\uff0895% CI\uff1a23%\uff5e72%\uff09<\/p>\n\n\n\n

\u6570\u636e\u63d0\u793a\uff0c\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u63a5\u53d7\u8be5\u6b3eCAR-T\u6cbb\u7597\u540e\u7684\u957f\u671f\u751f\u5b58\u83b7\u76ca\u4f18\u4e8e\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u5355\u6b21\u7ec6\u80de\u6cbb\u7597\u53ef\u4f7f\u8fd1\u534a\u6570\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u7ef4\u6301\u5341\u5e74\u65e0\u80bf\u7624\u8d1f\u8377\u72b6\u6001\u3002<\/p>\n\n\n\n

3\u3001\u957f\u671f\u5e94\u7b54\u76f8\u5173\u751f\u7269\u5b66\u7279\u5f81<\/strong><\/p>\n\n\n\n

\u2460 \u5b9e\u73b0\u5341\u5e74\u6301\u7eed\u7f13\u89e3\u7684\u53d7\u8bd5\u8005\uff0c\u5916\u5468\u8840\u53ef\u7a33\u5b9a\u68c0\u51fa\u529f\u80fd\u6027CAR\u8f6c\u57fa\u56e0\u7ec6\u80de\uff0cCAR-T\u7ec6\u80de\u4f53\u5185\u957f\u671f\u5b58\u7eed\u662f\u7ef4\u6301\u6301\u7eed\u6027\u6297\u80bf\u7624\u6548\u5e94\u7684\u6838\u5fc3\u57fa\u7840\uff1b<\/p>\n\n\n\n

\u2461 \u957f\u671f\u5e94\u7b54\u4eba\u7fa4\u4e2d\uff0c44%\u53d7\u8bd5\u8005\u5b58\u5728\u6301\u7eed\u6027B\u7ec6\u80de\u518d\u751f\u969c\u788d\uff0cCD19\u9633\u6027\u6210\u719fB\u7ec6\u80de\u6301\u7eed\u53d7\u6291\uff0c\u8be5\u4f53\u5f81\u53ef\u4f5c\u4e3aCAR-T\u7ec6\u80de\u6301\u7eed\u6d3b\u5316\u3001\u8fdc\u671f\u5e94\u7b54\u7a33\u5b9a\u7684\u65e0\u521b\u53c2\u8003\u6807\u5fd7\u7269\uff1b<\/p>\n\n\n\n

\u2462 \u6cbb\u7597\u65e9\u671f\u8fbe\u5230\u5f71\u50cf\u5b66\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff0c\u662f\u72ec\u7acb\u6b63\u5411\u9884\u6d4b\u5341\u5e74\u957f\u671f\u751f\u5b58\u7684\u4e34\u5e8a\u6307\u6807\u3002<\/p>\n\n\n\n

\u4e09. <\/strong>\u5341\u5e74\u8fdc\u671f\u5b89\u5168\u6027\u4e0e\u514d\u75ab\u8fdc\u671f\u72b6\u6001\u8bc4\u4f30<\/strong><\/p>\n\n\n\n

1. \u8fdf\u53d1\u6027\u8840\u6db2\u7cfb\u7edf\u6bd2\u6027<\/strong><\/strong><\/p>\n\n\n\n

\u4ec55%\u53d7\u8bd5\u8005\u51fa\u73b0\u6301\u7eed\u60272\uff5e3\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0c\u5168\u7a0b\u672a\u89c2\u6d4b\u5230\u8fdf\u53d1\u6027\u6301\u7eed\u6027\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3002\u6cbb\u7597\u6025\u6027\u671f\u51fa\u73b0\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u3001\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u6bd2\u6027\uff08ICANS\uff09\uff0c\u5747\u5728\u8f93\u6ce8\u540e\u6570\u6708\u5185\u5b8c\u5168\u7f13\u89e3\uff0c\u65e0\u8fdc\u671f\u795e\u7ecf\u7cfb\u7edf\u5668\u8d28\u6027\u540e\u9057\u75c7\u3001\u6162\u6027\u9020\u8840\u529f\u80fd\u8870\u7aed\u8868\u73b0\u3002<\/p>\n\n\n\n

2. \u7b2c\u4e8c\u539f\u53d1\u6076\u6027\u80bf\u7624\u53d1\u751f\u98ce\u9669<\/strong><\/strong><\/p>\n\n\n\n

10\u5e74\u7b2c\u4e8c\u539f\u53d1\u6076\u6027\u80bf\u7624\u7d2f\u79ef\u53d1\u751f\u7387\u4e3a21%\uff0c\u5171\u8ba19\u4f8b\u53d7\u8bd5\u8005\u65b0\u53d1\u5b9e\u4f53\u6216\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u3002\u7814\u7a76\u539f\u6587\u660e\u786e\u8bf4\u660e\uff1a\u6240\u6709\u5165\u7ec4\u53d7\u8bd5\u8005\u524d\u671f\u63a5\u53d7\u591a\u5468\u671f\u7ec6\u80de\u6bd2\u6027\u5316\u7597\uff0c\u65e0\u6cd5\u533a\u5206\u7ee7\u53d1\u80bf\u7624\u8bf1\u56e0\u5c5e\u4e8eCAR-T\u8f7d\u4f53\u63d2\u5165\u7a81\u53d8\u3001\u65e2\u5f80\u66fe\u63a5\u53d7\u5316\u7597\u6216\u5148\u5929\u80bf\u7624\u9057\u4f20\u6613\u611f\u503e\u5411\uff0c\u6682\u65e0\u6cd5\u5224\u5b9a\u4e3aCAR-T\u6cbb\u7597\u76f4\u63a5\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n\n\n\n

3. \u975e\u590d\u53d1\u76f8\u5173\u6b7b\u4ea1\u4e0e\u8fdc\u671f\u4f53\u6db2\u514d\u75ab\u7f3a\u9677<\/strong><\/strong><\/p>\n\n\n\n

\u6574\u4f5310\u5e74\u975e\u590d\u53d1\u76f8\u5173\u6b7b\u4ea1\u7387\u4e3a18%\uff0c\u5254\u9664\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u6b7b\u4ea1\u75c5\u4f8b\u540e\u6821\u6b63\u503c\u4e3a14%\uff0c\u6b7b\u4ea1\u539f\u56e0\u96c6\u4e2d\u4e8e\u6162\u6027\u53cd\u590d\u611f\u67d3\u3001\u8001\u5e74\u810f\u5668\u529f\u80fd\u9000\u884c\u6027\u8870\u9000\u3001\u7b2c\u4e8c\u539f\u53d1\u80bf\u7624\uff0c\u65e0CAR-T\u6cbb\u7597\u76f4\u63a5\u81f4\u6b7b\u75c5\u4f8b\u3002\u5b58\u5728\u6301\u7eed\u6027B\u7ec6\u80de\u7f3a\u4e4f\u7684\u957f\u671f\u7f13\u89e3\u53d7\u8bd5\u8005\u4e2d\uff0c42%\u9700\u95f4\u65ad\u63a5\u53d7\u9759\u8109\u514d\u75ab\u7403\u86cb\u767d\u8f93\u6ce8\uff0c\u4ee5\u5f25\u8865\u4f53\u6db2\u514d\u75ab\u7f3a\u9677\u3001\u964d\u4f4e\u611f\u67d3\u98ce\u9669\uff1b\u7814\u7a76\u672a\u89c2\u6d4b\u5230\u5e7f\u6cdb\u6027\u6301\u7eed\u6027T\u7ec6\u80de\u514d\u75ab\u529f\u80fd\u7f3a\u9677\u3002<\/p>\n\n\n\n

\u56db. <\/strong>\u7814\u7a76\u4e34\u5e8a\u89e3\u8bfb\u4e0e\u56fa\u6709\u5c40\u9650\u6027<\/strong><\/p>\n\n\n\n

1. \u4e34\u5e8a\u5faa\u8bc1\u4ef7\u503c<\/strong><\/strong><\/p>\n\n\n\n

\u2460 \u9996\u6b21\u901a\u8fc7 10 \u5e74\u8d85\u957f\u968f\u8bbf\u8bc1\u5b9e\uff0c\u90e8\u5206\u590d\u53d1\u96be\u6cbb B \u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u53ef\u4f9d\u6258\u5355\u6b21 tisagenlecleucel \u8f93\u6ce8\u83b7\u5f97\u6301\u4e45\u6027\u80bf\u7624\u63a7\u5236\uff0c5.4 \u5e74\u53ef\u4f5c\u4e3a\u8fdc\u671f\u590d\u53d1\u4f4e\u5371\u5206\u754c\u8282\u70b9\uff0c\u53ef\u4f18\u5316 CAR-T \u672f\u540e\u957f\u671f\u968f\u8bbf\u76d1\u6d4b\u9891\u6b21\u89c4\u5212\uff1b<\/p>\n\n\n\n

\u2461 \u660e\u786e\u6301\u7eed\u6027 B \u7ec6\u80de\u7f3a\u5931\u3001\u5916\u5468\u8840 CAR \u8f6c\u57fa\u56e0\u7559\u5b58\u6c34\u5e73\u53ef\u4f5c\u4e3a\u65e0\u521b\u9884\u540e\u76d1\u6d4b\u6307\u6807\uff0c\u5b8c\u5584 CAR-T \u672f\u540e\u957f\u671f\u968f\u8bbf\u8bc4\u4f30\u4f53\u7cfb\uff1b<\/p>\n\n\n\n

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2. \u7814\u7a76\u5ba2\u89c2\u5c40\u9650<\/strong><\/strong><\/p>\n\n\n\n

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\u2461 \u7814\u7a76\u4ec5\u9488\u5bf94-1BB\u5171\u523a\u6fc0\u7ed3\u6784\u57df\u7684 tisagenlecleucel \u4ea7\u54c1\uff0c\u7ed3\u8bba\u65e0\u6cd5\u76f4\u63a5\u63a8\u5e7f\u81f3CD28\u5171\u523a\u6fc0\u6784\u578b\u7684\u5176\u4ed6CD19 CAR-T\u4ea7\u54c1\uff1b<\/p>\n\n\n\n

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\u4e94. <\/strong>\u4e34\u5e8a\u5b9e\u8df5\u53c2\u8003<\/strong><\/p>\n\n\n\n

1. \u9488\u5bf9\u591a\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\u96be\u6cbb\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff0cCAR-T\u53ef\u4f5c\u4e3a\u5177\u5907\u957f\u671f\u75be\u75c5\u63a7\u5236\u6f5c\u529b\u7684\u633d\u6551\u65b9\u6848\uff1b\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u957f\u671f\u7f13\u89e3\u5360\u6bd4\u504f\u4f4e\uff0c\u4f46\u4ecd\u662f\u665a\u671f\u96be\u6cbb\u75c5\u4f8b\u6709\u9650\u7684\u6839\u6cbb\u6027\u5907\u9009\u65b9\u6848\uff1b<\/p>\n\n\n\n

2. CAR-T\u7ec6\u80de\u8f93\u6ce8\u540e\u524d5.4\u5e74\u4e3a\u80bf\u7624\u590d\u53d1\u9ad8\u98ce\u9669\u671f\uff0c\u9700\u89c4\u8303\u5f71\u50cf\u5b66\u3001\u6d41\u5f0f\u5fae\u5c0f\u6b8b\u7559\u75c5\u8054\u5408\u76d1\u6d4b\uff1b\u8d85\u8fc7\u8be5\u65f6\u95f4\u8282\u70b9\u540e\uff0c\u968f\u8bbf\u91cd\u5fc3\u8f6c\u5411\u611f\u67d3\u9632\u63a7\u3001\u7ee7\u53d1\u80bf\u7624\u7b5b\u67e5\u3001\u4f4e\u4e19\u79cd\u7403\u86cb\u767d\u8840\u75c7\u7ba1\u7406\uff1b<\/p>\n\n\n\n

3. \u6301\u7eed\u6027B\u7ec6\u80de\u518d\u751f\u969c\u788d\u4e0d\u5c5e\u4e8e\u7edd\u5bf9\u4e0d\u826f\u9884\u540e\u4fe1\u53f7\uff0c\u9700\u7ed3\u5408CAR\u7ec6\u80de\u5916\u5468\u7559\u5b58\u6c34\u5e73\u7efc\u5408\u5224\u65ad\u9884\u540e\uff0c\u5bf9\u5408\u5e76\u4f4e\u4e19\u79cd\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u89c4\u8303\u5316\u514d\u75ab\u7403\u86cb\u767d\u66ff\u4ee3\u6cbb\u7597\uff0c\u964d\u4f4e\u8fdc\u671f\u611f\u67d3\u98ce\u9669\u3002<\/p>\n\n\n\n

\u7ed3\u8bed<\/strong><\/strong><\/p>\n\n\n\n

\u8be5\u9879NEJM\u5341\u5e74\u968f\u8bbf\u7814\u7a76\u586b\u8865\u4e86CD19 CAR-T\u7ec6\u80de\u7597\u6cd5\u8d85\u957f\u5468\u671f\u8fdc\u671f\u6cbb\u7597\u6210\u6548\u7684\u5faa\u8bc1\u7a7a\u767d\uff0c\u8bc1\u5b9e\u5355\u6b21 tisagenlecleucel \u8f93\u6ce8\u53ef\u4f7f\u90e8\u5206\u590d\u53d1\u96be\u6cbbB\u7ec6\u80de\u6dcb\u5df4\u7624\u83b7\u5f97\u5341\u5e74\u7a33\u5b9a\u80bf\u7624\u63a7\u5236\uff0c\u8fdc\u671f\u6574\u4f53\u4e0d\u826f\u53cd\u5e94\u53ef\u63a7\uff0c\u540c\u65f6\u5212\u5b9a\u80bf\u7624\u590d\u53d1\u65f6\u95f4\u9608\u503c\u3001\u9884\u540e\u5173\u8054\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n\n\n\n

\u53d7\u9650\u4e8e\u6837\u672c\u89c4\u6a21\u3001\u4eba\u7fa4\u79cd\u65cf\u6784\u6210\u3001\u4ea7\u54c1\u7279\u5f02\u6027\uff0c\u8be5\u7ed3\u8bba\u4ecd\u9700\u540e\u7eed\u591a\u4e2d\u5fc3\u524d\u77bb\u6027\u7814\u7a76\u8865\u5145\u9a8c\u8bc1\uff0c\u4e34\u5e8a\u5e94\u7528\u9700\u4e25\u683c\u9075\u5faa\u836f\u54c1\u9002\u5e94\u75c7\u5206\u5c42\uff0c\u7ed3\u5408\u60a3\u8005\u4f53\u80fd\u72b6\u6001\u3001\u65e2\u5f80\u6cbb\u7597\u66b4\u9732\u53f2\u3001\u57fa\u7ebf\u514d\u75ab\u72b6\u6001\u4e2a\u4f53\u5316\u51b3\u7b56\u3002<\/p>\n\n\n\n

\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u6216\u6ce8\u660e\u6765\u6e90\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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