{"id":41118,"date":"2026-07-20T14:09:56","date_gmt":"2026-07-20T06:09:56","guid":{"rendered":"https:\/\/www.hkioc.com.hk\/?p=41118"},"modified":"2026-07-20T14:10:30","modified_gmt":"2026-07-20T06:10:30","slug":"%e4%b8%80%e7%ba%bf%e9%9d%b6%e5%8c%96%e8%81%94%e5%90%88%e3%80%81%e5%90%8e%e7%ba%bf%e5%8f%8c%e9%9d%b6%e9%98%bbesmo-gi%e5%85%ac%e5%b8%83kras-g12d%e8%83%b0%e8%85%ba%e7%99%8c%e5%88%86%e5%b1%82%e6%b2%bb","status":"publish","type":"post","link":"https:\/\/www.hkioc.com.hk\/zh-hans\/%e4%b8%80%e7%ba%bf%e9%9d%b6%e5%8c%96%e8%81%94%e5%90%88%e3%80%81%e5%90%8e%e7%ba%bf%e5%8f%8c%e9%9d%b6%e9%98%bbesmo-gi%e5%85%ac%e5%b8%83kras-g12d%e8%83%b0%e8%85%ba%e7%99%8c%e5%88%86%e5%b1%82%e6%b2%bb\/","title":{"rendered":"\u4e00\u7ebf\u9776\u5316\u8054\u5408\u3001\u540e\u7ebf\u53cc\u9776\u963bESMO GI\u516c\u5e03KRAS G12D\u80f0\u817a\u764c\u5206\u5c42\u6cbb\u7597\u65e9\u671f\u8bc1\u636e"},"content":{"rendered":"\n<p>2026\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u80c3\u80a0\u9053\u80bf\u7624\u5927\u4f1a\uff08ESMO GI Congress 2026\uff0c\u5fb7\u56fd\u6155\u5c3c\u9ed17.1\u20137.4\uff09\u5b98\u65b9\u65e5\u62a5 Daily Reporter \u53d1\u5e03\u4e24\u9879\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u805a\u7126 KRAS G12D <strong>\u7a81\u53d8\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08mPDAC\uff09<\/strong>\uff0c\u5206\u522b\u8bc4\u4f30\u9009\u62e9\u6027KRAS G12D\u6291\u5236\u5242 Zoldonrasib \u8054\u5408\u6807\u51c6\u5316\u7597\u4e00\u7ebf\u4f7f\u7528\u3001Zoldonrasib\u8054\u5408\u6cdbRAS\u6291\u5236\u5242 Daraxonrasib \u540e\u7ebf\u4f7f\u7528\u7684\u6297\u80bf\u7624\u6d3b\u6027\u4e0e\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n<p>\u672c\u5c4a\u6155\u5c3c\u9ed1ESMO GI\u5927\u4f1a\u516c\u5e03\u4e24\u9879\u5c0f\u6837\u672c\u65e9\u671f\u4e34\u5e8a\u6570\u636e\uff0c\u8fdb\u4e00\u6b65\u4f50\u8bc1\u8be5\u9776\u5411\u6cbb\u7597\u8def\u5f84\u5177\u5907\u4e34\u5e8a\u6f5c\u529b\u3002<\/p>\n\n\n\n<p>*** Zoldonrasib\u3001Daraxonrasib \u4e24\u6b3e\u836f\u7269\u76ee\u524d\u5c1a\u672a\u83b7\u5f97\u7f8e\u56fdFDA\u4e0a\u5e02\u6279\u51c6\uff0c\u4e2d\u56fd\u5927\u9646\u3001\u4e2d\u56fd\u9999\u6e2f\u5730\u533a\u4ea6\u65e0\u4e0a\u5e02\u8d44\u8d28\u3002\u9488\u5bf9\u8be5\u4e24\u6b3e\u836f\u7269\u7684\u5ba1\u6279\u8fdb\u5c55\uff0c\u672c\u5e73\u53f0\u5c06\u6301\u7eed\u8ffd\u8e2a\u5e76\u53d1\u5e03\u66f4\u65b0\u5185\u5bb9\u3002<\/p>\n\n\n\n<p><strong>\u4e00\u3001\u75be\u75c5\u80cc\u666f\u4e0e\u4e34\u5e8a\u672a\u6ee1\u8db3\u9700\u6c42<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u6574\u4f53\u6cbb\u7597\u5f62\u52bf\u4e25\u5cfb\uff0c\u76ee\u524d\u5c1a\u65e0\u83b7\u6279\u9776\u5411\u6cbb\u7597\u836f\u7269\uff0c\u60a3\u80055\u5e74\u751f\u5b58\u7387\u4ec5\u7ea63%\uff08\u300a\u6b27\u6d32\u764c\u75c7\u6742\u5fd7\u300b2024\uff1b198:113471\uff09\u3002\u7ea690%\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u5b58\u5728KRAS\u7a81\u53d8\uff0c\u5176\u4e2dKRAS G12D\u662f\u6700\u5e38\u89c1\u7a81\u53d8\u4e9a\u578b\uff0c\u5360\u5168\u90e8\u7a81\u53d8\u75c5\u4f8b\u8fd140%\uff08\u300a\u764c\u75c7\u53d1\u73b0\u300b2022\uff1b12:924\u2013937\uff09\u3002\u9488\u5bf9KRAS\u7a81\u53d8\u7684\u9776\u5411\u836f\u7269\u7814\u53d1\uff0c\u6709\u671b\u63a8\u52a8\u80f0\u817a\u764c\u6cbb\u7597\u6a21\u5f0f\u53d1\u751f\u53d8\u9769\u3002<\/p>\n\n\n\n<p><strong>\u672c\u6b21\u5927\u4f1a\u62a5\u9053\u4e24\u6b3e\u5728\u7814\u53e3\u670d RAS \u6291\u5236\u5242\uff1a<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>1. Zoldonrasib\uff08RMC-9805\uff09\uff1a<\/strong>\u9009\u62e9\u6027\u5171\u4ef7KRAS (ON) G12D\u6291\u5236\u5242\uff1b<\/p>\n\n\n\n<p><strong>2. Daraxonrasib\uff1a<\/strong>\u5e7f\u8c31RAS (ON) \u4e09\u5143\u590d\u5408\u7269\u6291\u5236\u5242\uff0c\u5176\u4e8c\u7ebf\u5355\u836fIII\u671f RASolute 302\u7814\u7a76\u5df2\u8bc1\u5b9e\u5bf9\u6bd4\u5316\u7597\u53ef\u663e\u8457\u6539\u5584\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005OS\u4e0ePFS\u3002<\/p>\n\n\n\n<p><strong>\u4e8c\u3001I\/II \u671f\u7814\u7a76\uff1a\uff08\u6458\u8981 340O\uff09 <\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u521d\u6cbb\u8f6c\u79fb\u6027\u80f0\u817a\u764c\uff0cZoldonrasib \u8054\u5408\u6807\u51c6\u5316\u7597<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u8be5\u7814\u7a76\u5171\u7eb3\u516581\u4f8b\u672a\u63a5\u53d7\u8f6c\u79fb\u7076\u7cfb\u7edf\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u60a3\u8005\uff0c\u7ed9\u836f\u65b9\u6848\u4e3a\u53e3\u670d KRAS (ON) G12D \u9009\u62e9\u6027\u6291\u5236\u5242 Zoldonrasib\uff0c\u8054\u5408\u6539\u826f FOLFIRINOX\uff08mFOLFIRINOX\uff09\u6216\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u767d\u86cb\u767d\u7d2b\u6749\u9187\uff08GnP\uff09\u5316\u7597\u3002<\/p>\n\n\n\n<p><strong>\u7597\u6548\u6570\u636e<\/strong><strong><\/strong><\/p>\n\n\n\n<p>Zoldonrasib \u8054\u5408 mFOLFIRINOX \u7ec4\u5ba2\u89c2\u7f13\u89e3\u738782%\uff0c\u75be\u75c5\u63a7\u5236\u738796%\uff1bZoldonrasib \u8054\u5408 GnP \u7ec4\u5ba2\u89c2\u7f13\u89e3\u738761%\uff0c\u75be\u75c5\u63a7\u5236\u7387 90%\u3002<\/p>\n\n\n\n<p>\u4e24\u7ec4\u5168\u90e8\u53ef\u8bc4\u4f30\u60a3\u8005\u7684\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u4e2d KRAS G12D \u53d8\u5f02\u7b49\u4f4d\u57fa\u56e0\u4e30\u5ea6\u4e0b\u964d\u5e45\u5ea6\u5747\u226550%\uff1bZoldonrasib+mFOLFIRINOX \u7ec4 ctDNA \u5b8c\u5168\u6e05\u9664\u7387 47%\uff0cZoldonrasib+GnP \u7ec4 ctDNA \u5b8c\u5168\u6e05\u9664\u7387 71%\u3002<\/p>\n\n\n\n<p>\u6765\u81ea\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u4e34\u5e8a\u533b\u9662\u7684 Teresa Macarulla Mercade 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\u65b9\u6848\u6700\u5e38\u89c1\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff1a\u4e4f\u529b80%\u3001\u6076\u5fc370%\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c1155%\uff1b\u22653\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u738780%\uff0c\u65e05\u7ea7\u81f4\u6b7b\u6027\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n\n\n\n<p><strong>\u4e09\u3001I \u671f\u7814\u7a76\uff1a\uff08\u6458\u8981 341O\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u7ecf\u6cbb\u8f6c\u79fb\u6027\u80f0\u817a\u764c\uff0cZoldonrasib \u8054\u5408 Daraxonrasib \u53cc\u9776\u5411\u6cbb\u7597<\/strong><\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u91c7\u7528\u53cc\u9776\u5411\u8054\u5408\u7b56\u7565\uff0c\u5c06 Zoldonrasib \u4e0e\u53e3\u670d\u6cdb RAS (ON) \u4e09\u5143\u590d\u5408\u7269\u6291\u5236\u5242 Daraxonrasib \u8054\u7528\uff0c\u5165\u7ec460\u4f8b\u65e2\u5f80\u63a5\u53d7\u22651\u7ebf\u7cfb\u7edf\u6cbb\u7597\u7684 KRAS G12D \u7a81\u53d8\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n<p>\u6b64\u524d III \u671f RASolute 302 \u7814\u7a76\uff08\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2026\u5e745 \u6708\uff09\u5171\u7eb3\u5165500\u4f8b\u540e\u7ebf\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\uff0c\u5176\u4e2d 92% \u643a\u5e26 RAS G12D \u7a81\u53d8\uff0c\u7814\u7a76\u8bc1\u5b9e Daraxonrasib \u5355\u836f\u5bf9\u6bd4\u5316\u7597\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005\u603b\u751f\u5b58\u671f\u4e0e\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002<\/p>\n\n\n\n<p><strong>\u5206\u5c42\u7597\u6548\u6570\u636e<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u25b6 \u65e2\u5f80\u63a5\u53d7 2 \u7ebf\u7cfb\u7edf\u6cbb\u7597\u4eba\u7fa4\uff08n=30\uff09\uff1a\u5ba2\u89c2\u7f13\u89e3\u7387 50%\uff0c\u75be\u75c5\u63a7\u5236\u7387 97%\uff1b6 \u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387 71%\uff0c6 \u4e2a\u6708\u603b\u751f\u5b58\u7387 89%\u3002<\/p>\n\n\n\n<p>\u25b6 \u65e2\u5f80\u63a5\u53d7\u22653 \u7ebf\u7cfb\u7edf\u6cbb\u7597\u4eba\u7fa4\uff08n=30\uff09\uff1a\u5ba2\u89c2\u7f13\u89e3\u7387 47%\uff0c\u75be\u75c5\u63a7\u5236\u7387 90%\uff1b6 \u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387 59%\uff0c6 \u4e2a\u6708\u603b\u751f\u5b58\u7387 82%\u3002<\/p>\n\n\n\n<p>\u8be6\u7ec6\u89c1\u56fe\u8868\uff1a<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"729\" height=\"283\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/07\/\u56fe\u72471.png\" alt=\"\" class=\"wp-image-41115 lazyload\" data-srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/07\/\u56fe\u72471.png 729w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-300x116.png 300w\" sizes=\"(max-width: 729px) 100vw, 729px\" \/><noscript><img decoding=\"async\" width=\"729\" height=\"283\" src=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/07\/\u56fe\u72471.png\" alt=\"\" class=\"wp-image-41115 lazyload\" srcset=\"https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/07\/\u56fe\u72471.png 729w, https:\/\/www.hkioc.com.hk\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-300x116.png 300w\" sizes=\"(max-width: 729px) 100vw, 729px\" 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